Masanori Sasaki

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 29:14932-41. 2009
  2. pmc Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells
    Mary A Dombrowski
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Brain Res 1125:1-8. 2006
  3. ncbi request reprint Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X-irradiated spinal cord not shared by Schwann cells
    Karen L Lankford
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Glia 56:1664-78. 2008
  4. pmc CNPase expression in olfactory ensheathing cells
    Christine Radtke
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    J Biomed Biotechnol 2011:608496. 2011
  5. pmc Convergence of cells from the progenitor fraction of adult olfactory bulb tissue to remyelinating glia in demyelinating spinal cord lesions
    Eleni A Markakis
    Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 4:e7260. 2009
  6. ncbi request reprint Olfactory ensheathing cells, but not Schwann cells, proliferate and migrate extensively within moderately X-irradiated juvenile rat brain
    Karen L Lankford
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut
    Glia 62:52-63. 2014
  7. doi request reprint Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environments
    Masanori Sasaki
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Exp Neurol 229:88-98. 2011
  8. pmc Remyelination of the injured spinal cord
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA, and Research Institute of Surgery, Daping Hospital, Chongqing, P R China
    Prog Brain Res 161:419-33. 2007
  9. pmc Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury
    Jeffery D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, CT, 06516, USA
    Neurosci Lett 456:137-42. 2009
  10. pmc Molecular reconstruction of nodes of Ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cord
    Masanori Sasaki
    Department of Neurology, Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:1803-12. 2006

Collaborators

Detail Information

Publications15

  1. pmc BDNF-hypersecreting human mesenchymal stem cells promote functional recovery, axonal sprouting, and protection of corticospinal neurons after spinal cord injury
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 29:14932-41. 2009
    ..These results indicate that transplantation of hMSCs hypersecreting BDNF results in structural changes in brain and spinal cord, which are associated with improved functional outcome in acute SCI...
  2. pmc Myelination and nodal formation of regenerated peripheral nerve fibers following transplantation of acutely prepared olfactory ensheathing cells
    Mary A Dombrowski
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    Brain Res 1125:1-8. 2006
    ....
  3. ncbi request reprint Olfactory ensheathing cells exhibit unique migratory, phagocytic, and myelinating properties in the X-irradiated spinal cord not shared by Schwann cells
    Karen L Lankford
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Glia 56:1664-78. 2008
    ..These results revealed a clear difference between the migratory properties of OECs and SCs in the X-irradiated spinal cord and demonstrated that engrafted OECs can participate in repair of subsequent lesions...
  4. pmc CNPase expression in olfactory ensheathing cells
    Christine Radtke
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA
    J Biomed Biotechnol 2011:608496. 2011
    ..Thus, while OECs do not normally form myelin on olfactory nerve axons, their expression of CNPase is commensurate with their potential to form myelin when transplanted into injured peripheral nerve...
  5. pmc Convergence of cells from the progenitor fraction of adult olfactory bulb tissue to remyelinating glia in demyelinating spinal cord lesions
    Eleni A Markakis
    Department of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 4:e7260. 2009
    ..Multipotent cells from the progenitor fraction have been isolated from the adult olfactory bulb (OB) but their potential to remyelinate has not been studied...
  6. ncbi request reprint Olfactory ensheathing cells, but not Schwann cells, proliferate and migrate extensively within moderately X-irradiated juvenile rat brain
    Karen L Lankford
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut Center for Neuroscience and Regeneration Research, VA Connecticut Healthcare System, West Haven, Connecticut
    Glia 62:52-63. 2014
    ..These results show that OECs display unique migratory, proliferative, and microglia interaction properties as compared with SCs when transplanted into the moderately X-irradiated brain...
  7. doi request reprint Remyelination after olfactory ensheathing cell transplantation into diverse demyelinating environments
    Masanori Sasaki
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Exp Neurol 229:88-98. 2011
    ..This article is part of a Special Issue entitled: Understanding olfactory ensheathing glia and their prospect for nervous system repair...
  8. pmc Remyelination of the injured spinal cord
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT 06510, USA, and Research Institute of Surgery, Daping Hospital, Chongqing, P R China
    Prog Brain Res 161:419-33. 2007
    ..The biology of the OEC, and recent experimental research and clinical studies using OECs as a potential cell therapy candidate are discussed...
  9. pmc Unique in vivo properties of olfactory ensheathing cells that may contribute to neural repair and protection following spinal cord injury
    Jeffery D Kocsis
    Department of Neurology, Yale University School of Medicine, New Haven, CT, 06516, USA
    Neurosci Lett 456:137-42. 2009
    ..In this review we focus on several unique features of OECs when they are transplanted into the spinal cord...
  10. pmc Molecular reconstruction of nodes of Ranvier after remyelination by transplanted olfactory ensheathing cells in the demyelinated spinal cord
    Masanori Sasaki
    Department of Neurology, Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:1803-12. 2006
    ....
  11. pmc Development of a middle cerebral artery occlusion model in the nonhuman primate and a safety study of i.v. infusion of human mesenchymal stem cells
    Masanori Sasaki
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e26577. 2011
    ....
  12. doi request reprint Focal experimental autoimmune encephalomyelitis in the Lewis rat induced by immunization with myelin oligodendrocyte glycoprotein and intraspinal injection of vascular endothelial growth factor
    Masanori Sasaki
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Glia 58:1523-31. 2010
    ..This model may be useful for the study of transplanted myelin-forming cells in a discrete inflammatory demyelinating lesion...
  13. pmc Protection of corticospinal tract neurons after dorsal spinal cord transection and engraftment of olfactory ensheathing cells
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut, USA
    Glia 53:352-9. 2006
    ..The transplanted OECs associated longitudinally with axons at 4 weeks. Thus, OEC transplantation into the injured spinal cord has distant neuroprotective effects on descending cortical projection neurons...
  14. doi request reprint A rat middle cerebral artery occlusion model and intravenous cellular delivery
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 549:187-95. 2009
    ..One approach has been the intravenous delivery of bone marrow-derived mescenchymal stem cells at various times after MCAO. Histological and magnetic resonance imaging have been used to quantify infarction volume in this model system...
  15. pmc Identified olfactory ensheathing cells transplanted into the transected dorsal funiculus bridge the lesion and form myelin
    Masanori Sasaki
    Department of Neurology and Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 24:8485-93. 2004
    ..Thus, transplanted OECs derived from the adult olfactory bulb can survive and orient longitudinally across a spinal cord transection site and form myelin. This pattern of repair is associated with improved locomotion...