Nicola Santoro

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese youth to prediabetes
    Cosimo Giannini
    Corresponding author Nicola Santoro
    Diabetes Care 37:475-82. 2014
  2. pmc Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 7:e37827. 2012
  3. doi request reprint Metabolic syndrome in youth: current insights and novel serum biomarkers
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, 330 Cedar Street, PO Box 208064, New Haven, CT 06520, USA
    Biomark Med 6:719-27. 2012
  4. pmc Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Hepatology 55:781-9. 2012
  5. pmc A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Hepatology 52:1281-90. 2010
  6. pmc Circulating levels of FGF-21 in obese youth: associations with liver fat content and markers of liver damage
    Cosimo Giannini
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 98:2993-3000. 2013
  7. pmc The triglyceride-to-HDL cholesterol ratio: association with insulin resistance in obese youths of different ethnic backgrounds
    Cosimo Giannini
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Diabetes Care 34:1869-74. 2011
  8. pmc Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion
    Ebe D'Adamo
    Department of Pediatrics, Yale University, New Haven, CT, USA
    Am J Clin Nutr 92:500-8. 2010
  9. pmc Longitudinal effects of MRI-measured hepatic steatosis on biomarkers of glucose homeostasis and hepatic apoptosis in obese youth
    Grace Kim
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Diabetes Care 36:130-6. 2013
  10. pmc The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Diabetes Care 36:1353-60. 2013

Collaborators

Detail Information

Publications18

  1. pmc Co-occurrence of risk alleles in or near genes modulating insulin secretion predisposes obese youth to prediabetes
    Cosimo Giannini
    Corresponding author Nicola Santoro
    Diabetes Care 37:475-82. 2014
    ....
  2. pmc Hepatic fat accumulation is modulated by the interaction between the rs738409 variant in the PNPLA3 gene and the dietary omega6/omega3 PUFA intake
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 7:e37827. 2012
    ....
  3. doi request reprint Metabolic syndrome in youth: current insights and novel serum biomarkers
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, 330 Cedar Street, PO Box 208064, New Haven, CT 06520, USA
    Biomark Med 6:719-27. 2012
    ..Thus, in this paper we will discuss the current knowledge in pediatric MetS and the potential role of novel biomarkers in the pathogenesis and diagnosis of MetS...
  4. pmc Variant in the glucokinase regulatory protein (GCKR) gene is associated with fatty liver in obese children and adolescents
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Hepatology 55:781-9. 2012
    ..There was a joint effect between the PNPLA3 and GCKR SNPs, explaining 32% of HFF% variance in Caucasians (P = 0.00161), 39.0% in African Americans (P = 0.00000496), and 15% in Hispanics (P = 0.00342)...
  5. pmc A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Hepatology 52:1281-90. 2010
    ..03) and sirtuin 1 (SIRT1) expression (P = 0.04)...
  6. pmc Circulating levels of FGF-21 in obese youth: associations with liver fat content and markers of liver damage
    Cosimo Giannini
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 98:2993-3000. 2013
    ..5% and HFF% ≥ 5.5%, respectively) and explored their relationship with hepatic fat content, measures of hepatic apoptosis, and insulin sensitivity...
  7. pmc The triglyceride-to-HDL cholesterol ratio: association with insulin resistance in obese youths of different ethnic backgrounds
    Cosimo Giannini
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Diabetes Care 34:1869-74. 2011
    ..We evaluated whether the triglyceride-to-HDL cholesterol (TG/HDL-C) ratio is associated with insulin resistance (IR) in a large multiethnic cohort of obese youths...
  8. pmc Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion
    Ebe D'Adamo
    Department of Pediatrics, Yale University, New Haven, CT, USA
    Am J Clin Nutr 92:500-8. 2010
    ..Recently, the deleterious metabolic effects of visceral fat [visceral adipose tissue (VAT)] deposition were challenged, and liver fat emerged as having a key independent role in the modulation of cardiometabolic risk factors...
  9. pmc Longitudinal effects of MRI-measured hepatic steatosis on biomarkers of glucose homeostasis and hepatic apoptosis in obese youth
    Grace Kim
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Diabetes Care 36:130-6. 2013
    ..We used fast-gradient magnetic resonance imaging (MRI) to determine the longitudinal associations between the hepatic fat content (HFF), glucose homeostasis, and a biomarker of hepatocellular apoptosis in obese youth...
  10. pmc The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Diabetes Care 36:1353-60. 2013
    ....
  11. pmc Central role of fatty liver in the pathogenesis of insulin resistance in obese adolescents
    Ebe D'Adamo
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 33:1817-22. 2010
    ....
  12. pmc Evidence for early defects in insulin sensitivity and secretion before the onset of glucose dysregulation in obese youths: a longitudinal study
    Cosimo Giannini
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes 61:606-14. 2012
    ..Across rising categories of normal 2-h glucose levels, NGT obese adolescents exhibit significant impairment of β-cell function relative to insulin sensitivity associated with the development of IGT...
  13. pmc Oxidized fatty acids: A potential pathogenic link between fatty liver and type 2 diabetes in obese adolescents?
    Nicola Santoro
    1 Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut
    Antioxid Redox Signal 20:383-9. 2014
    ..These observations lead to the hypothesis that the OXFAs may be the pathogenic link between liver injury and T2D and that the novel therapeutic opportunities targeting the OXFAs are possible in adolescents with early-onset NAFLD and T2D...
  14. doi request reprint Predicting metabolic syndrome in obese children and adolescents: look, measure and ask
    Nicola Santoro
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    Obes Facts 6:48-56. 2013
    ....
  15. doi request reprint Metabolic syndrome in pediatrics: old concepts revised, new concepts discussed
    Ebe D'Adamo
    Department of Pediatrics, Yale University School of Medicine, PO Box 208064, New Haven, CT 6520, USA
    Pediatr Clin North Am 58:1241-55, xi. 2011
    ..This article addresses the causes of metabolic syndrome and the relevance of obesity in the pediatric population...
  16. pmc Utility of hemoglobin A(1c) for diagnosing prediabetes and diabetes in obese children and adolescents
    Paulina Nowicka
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes Care 34:1306-11. 2011
    ..This recommendation is based on data in adults showing the relationship between A1C with future development of diabetes and microvascular complications. However, studies in the pediatric population are lacking...
  17. ncbi request reprint Type 2 diabetes mellitus in pediatrics: a new challenge
    Michelle Van Name
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    World J Pediatr 9:293-9. 2013
    ..In this paper, we will review the risk factors and the pathogenic determinants leading to type 2 diabetes in youth...
  18. ncbi request reprint Metabolic syndrome in pediatrics: old concepts revised, new concepts discussed
    Ebe D'Adamo
    Department of Pediatrics, Yale University School of Medicine, PO Box 208064, New Haven, CT 6520, USA
    Endocrinol Metab Clin North Am 38:549-63. 2009
    ..This article addresses the causes of metabolic syndrome and the relevance of obesity in the pediatric population...