Varman Samuel

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint Fructose induced lipogenesis: from sugar to fat to insulin resistance
    Varman T Samuel
    Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Trends Endocrinol Metab 22:60-5. 2011
  2. pmc The emerging role of oestrogen-related receptor γ as a regulator of energy metabolism
    Varman T Samuel
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA
    Diabetologia 57:2440-3. 2014
  3. pmc Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes
    Sara A Beddow
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Dis Model Mech 5:681-5. 2012
  4. pmc The role of the carbohydrate response element-binding protein in male fructose-fed rats
    Derek M Erion
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Endocrinology 154:36-44. 2013
  5. pmc Mechanisms for insulin resistance: common threads and missing links
    Varman T Samuel
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 148:852-71. 2012
  6. pmc Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle
    Katsutaro Morino
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes 57:2644-51. 2008
  7. pmc The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance
    Yoshio Nagai
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Cell Metab 9:252-64. 2009
  8. pmc SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function
    Michael J Jurczak
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes 60:890-8. 2011
  9. ncbi request reprint Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters
    Stefan Bilz
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 8012, USA
    Am J Physiol Endocrinol Metab 290:E716-22. 2006
  10. pmc Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity
    William A Chutkow
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts, USA
    Diabetes 59:1424-34. 2010

Research Grants

Collaborators

  • Gary W Cline
  • William Philbrick
  • Susanne Neschen
  • Morris White
  • Xing Xian Yu
  • Gerald I Shulman
  • Yoshio Nagai
  • Derek M Erion
  • Michael J Jurczak
  • Katsutaro Morino
  • Stefan Bilz
  • Sara A Beddow
  • Sanjay Bhanot
  • Shin Yonemitsu
  • Jianying Dong
  • Susan F Murray
  • Andreas L Birkenfeld
  • Hui Young Lee
  • David W Frederick
  • William A Chutkow
  • Vara Prasad Manchem
  • Matthew P Gillum
  • Violetta Popov
  • Jennifer J Hsiao
  • Mario Kahn
  • Daniel Vatner
  • Kisha Mitchell
  • Francois R Jornayvaz
  • Jean M Whaley
  • Gilbert W Moeckel
  • Xiaoxian Zhao
  • Rebecca L Pongratz
  • Richard G Kibbey
  • Richard T Lee
  • Jun Yoshioka
  • Samuel W Cushman
  • Parth Patwari
  • Romy Kursawe
  • Jorge Plutzky
  • Jonathan D Brown
  • James Cresswell
  • Jonathan S Bogan
  • Dirk Weismann
  • Dongyan Zhang
  • Romana Stark
  • Brett P Monia
  • Takanori Iwasaki
  • Michael G Löffler
  • David Sebastian
  • Irene Moore
  • Saki Sono
  • Dimitrios Tsirigotis
  • Richard M Reznick
  • Cheol Soo Choi
  • David Savage

Detail Information

Publications10

  1. doi request reprint Fructose induced lipogenesis: from sugar to fat to insulin resistance
    Varman T Samuel
    Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Trends Endocrinol Metab 22:60-5. 2011
    ..As a result, dietary fructose might promote the development of nonalcoholic fatty liver disease, which in and of itself, can result in hepatic insulin resistance, a key feature of type 2 diabetes mellitus...
  2. pmc The emerging role of oestrogen-related receptor γ as a regulator of energy metabolism
    Varman T Samuel
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA
    Diabetologia 57:2440-3. 2014
    ..Taken together with prior studies by this group and others, there is emerging evidence that this protein helps coordinate metabolism and may be a potential therapeutic target...
  3. pmc Fasting hyperglycemia in the Goto-Kakizaki rat is dependent on corticosterone: a confounding variable in rodent models of type 2 diabetes
    Sara A Beddow
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Dis Model Mech 5:681-5. 2012
    ..Thus, hypercorticosteronemia might contribute to the diabetic phenotype of GK rats and should be considered as a potential confounder in rodent models of T2D...
  4. pmc The role of the carbohydrate response element-binding protein in male fructose-fed rats
    Derek M Erion
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Endocrinology 154:36-44. 2013
    ..In summary, these studies suggest that targeting ChREBP may prevent fructose-induced hypertriglyceridemia but without the improvements in hepatic steatosis and hepatic insulin responsiveness...
  5. pmc Mechanisms for insulin resistance: common threads and missing links
    Varman T Samuel
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 148:852-71. 2012
    ....
  6. pmc Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle
    Katsutaro Morino
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes 57:2644-51. 2008
    ..In this study, we examine the role of serine phosphorylation of insulin receptor substrate (IRS)-1 in mediating fat-induced insulin resistance in skeletal muscle in vivo...
  7. pmc The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance
    Yoshio Nagai
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Cell Metab 9:252-64. 2009
    ....
  8. pmc SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function
    Michael J Jurczak
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes 60:890-8. 2011
    ..Here, we used a SGLT2 knockout mouse to investigate the effect of increased renal glucose excretion on glucose homeostasis, insulin sensitivity, and pancreatic β-cell function...
  9. ncbi request reprint Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters
    Stefan Bilz
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 8012, USA
    Am J Physiol Endocrinol Metab 290:E716-22. 2006
    ..Our studies identify activators of FXR as promising new tools in the therapy of hypertriglyceridemic states, including the insulin resistance syndrome and type 2 diabetes...
  10. pmc Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity
    William A Chutkow
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Cambridge, Massachusetts, USA
    Diabetes 59:1424-34. 2010
    ..Here, we tested the hypothesis that Txnip-null (knockout) mice are protected from insulin resistance induced by a high-fat diet...

Research Grants1

  1. Mechanism of Fat Induced Hepatic Insulin Resistance
    Varman Samuel; Fiscal Year: 2006
    ..Finally, with a novel method to directly measure gluconeogenesis, we will determine if hepatic fat accumulation increases hepatic gluconeogenesis...