MEHRAN SADEGHI

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis
    Jiasheng Zhang
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Arterioscler Thromb Vasc Biol 32:1849-55. 2012
  2. pmc Integrin-targeted imaging of inflammation in vascular remodeling
    Mahmoud Razavian
    Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Arterioscler Thromb Vasc Biol 31:2820-6. 2011
  3. ncbi request reprint ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis
    M M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Yale University School of Medicine, New Haven, CT, USA
    Am J Transplant 7:2098-105. 2007
  4. ncbi request reprint Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo
    Mehran M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn, USA
    Circulation 110:84-90. 2004
  5. ncbi request reprint Activated alphavbeta3 integrin targeting in injury-induced vascular remodeling
    Mehran M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Trends Cardiovasc Med 17:5-10. 2007
  6. ncbi request reprint Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature
    M M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Department of Dermatology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Transplant Proc 36:1585-91. 2004
  7. ncbi request reprint The pathobiology of the vessel wall: implications for imaging
    Mehran M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    J Nucl Cardiol 13:402-14. 2006
  8. ncbi request reprint Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors
    M M Sadeghi
    Section of Cardiovascular Medicine, Yale University, New Haven, Connecticut 06520, USA
    Transplantation 71:1262-8. 2001
  9. pmc Matrix metalloproteinase activation predicts amelioration of remodeling after dietary modification in injured arteries
    Sina Tavakoli
    Veterans Affairs, Connecticut Healthcare System, West Haven, CT 06516, USA
    Arterioscler Thromb Vasc Biol 31:102-9. 2011
  10. ncbi request reprint Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study
    Jiasheng Zhang
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    FASEB J 19:1857-9. 2005

Research Grants

  1. Molecular Imaging of Vascular Remodeling
    MEHRAN SADEGHI; Fiscal Year: 2007
  2. Molecular Imaging of Vascular Remodeling
    Mehran M Sadeghi; Fiscal Year: 2010

Collaborators

Detail Information

Publications17

  1. pmc Molecular imaging of vascular endothelial growth factor receptors in graft arteriosclerosis
    Jiasheng Zhang
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Arterioscler Thromb Vasc Biol 32:1849-55. 2012
    ..We used molecular near-infrared fluorescent imaging with an engineered Cy5.5-labeled single-chain VEGF tracer (scVEGF/Cy) to detect VEGF receptors and vascular remodeling in human coronary artery grafts by molecular imaging...
  2. pmc Integrin-targeted imaging of inflammation in vascular remodeling
    Mahmoud Razavian
    Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Arterioscler Thromb Vasc Biol 31:2820-6. 2011
    ..Monocytes and macrophages express α(v)β(3) integrin. We used an α(v) integrin-specific tracer, (99m)Tc-NC100692, to investigate integrin-targeted imaging for detection vessel wall inflammation...
  3. ncbi request reprint ESDN is a marker of vascular remodeling and regulator of cell proliferation in graft arteriosclerosis
    M M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Yale University School of Medicine, New Haven, CT, USA
    Am J Transplant 7:2098-105. 2007
    ..We conclude that ESDN is a marker of vascular remodeling and regulator of VSMC proliferation. ESDN may serve as a therapeutic or diagnostic target for GA...
  4. ncbi request reprint Detection of injury-induced vascular remodeling by targeting activated alphavbeta3 integrin in vivo
    Mehran M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Conn, USA
    Circulation 110:84-90. 2004
    ..We hypothesized that vascular cell proliferation, a hallmark of injury-induced remodeling, can be tracked by targeting alpha(v)beta3 integrin expression in vivo...
  5. ncbi request reprint Activated alphavbeta3 integrin targeting in injury-induced vascular remodeling
    Mehran M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Trends Cardiovasc Med 17:5-10. 2007
    ..In a model of injury-induced vascular remodeling in apoE null mice, RP748 localization to the injured carotid arteries parallels vascular cell proliferation, providing an opportunity to image the remodeling process in vivo...
  6. ncbi request reprint Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature
    M M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Department of Dermatology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Transplant Proc 36:1585-91. 2004
    ..Although I-125-E1/6 F(ab')2 localized to human skin grafts, the limited number of VCAM-1 molecules/endothelial cell adversely affects its suitability as a target for in vivo imaging of endothelial activation...
  7. ncbi request reprint The pathobiology of the vessel wall: implications for imaging
    Mehran M Sadeghi
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    J Nucl Cardiol 13:402-14. 2006
  8. ncbi request reprint Inhibition of interferon-gamma-mediated microvascular endothelial cell major histocompatibility complex class II gene activation by HMG-CoA reductase inhibitors
    M M Sadeghi
    Section of Cardiovascular Medicine, Yale University, New Haven, Connecticut 06520, USA
    Transplantation 71:1262-8. 2001
    ..This inhibitory effect occurs at the level of transcription and is directed, at least in part, at the CIITA promoter IV. These results explain some of the beneficial effects of HMG-CoA reductase inhibitors in cardiac transplantation...
  9. pmc Matrix metalloproteinase activation predicts amelioration of remodeling after dietary modification in injured arteries
    Sina Tavakoli
    Veterans Affairs, Connecticut Healthcare System, West Haven, CT 06516, USA
    Arterioscler Thromb Vasc Biol 31:102-9. 2011
    ..To establish and validate early noninvasive imaging of matrix metalloproteinase (MMP) activation for monitoring the progression of vascular remodeling and response to dietary modification...
  10. ncbi request reprint Alphavbeta3-targeted detection of arteriopathy in transplanted human coronary arteries: an autoradiographic study
    Jiasheng Zhang
    Raymond and Beverly Sackler Cardiovascular Molecular Imaging Laboratory, Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    FASEB J 19:1857-9. 2005
    ..In conclusion, alphavbeta3 integrin is transiently up-regulated (and activated) in GA and may be targeted by RP748 for detection of the proliferative process in early GA...
  11. pmc Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction
    David F Meoli
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8017, USA
    J Clin Invest 113:1684-91. 2004
    ..This approach may also have significant clinical utility for noninvasively tracking therapeutic myocardial angiogenesis...
  12. doi request reprint Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction
    Leszek Kalinowski
    Experimental Nuclear Cardiology Laboratory, Division of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8017, USA
    J Appl Physiol 104:1504-12. 2008
    ....
  13. ncbi request reprint Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models
    Daqing Piao
    University of Connecticut, Electrical and Computer Engineering Department, Storrs, Connecticut 06269, USA
    J Biomed Opt 10:44010. 2005
    ..Preliminary data also suggest that coregistered high-resolution OCT images provide imaging of detailed plaque microstructures, which cannot be resolved by positron detection...
  14. ncbi request reprint Noninvasive imaging of angiogenesis with a 99mTc-labeled peptide targeted at alphavbeta3 integrin after murine hindlimb ischemia
    Jing Hua
    Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Conn 06520 8017, USA
    Circulation 111:3255-60. 2005
    ..The alpha(v)beta3 integrin is activated in angiogenic vessels and represents a potential target for noninvasive imaging of angiogenesis...
  15. ncbi request reprint Simvastatin modulates angiotensin II signaling pathway by preventing Rac1-mediated upregulation of p27
    Lixia Zeng
    Division of Nephrology Hypertension, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611, USA
    J Am Soc Nephrol 15:1711-20. 2004
    ..The data presented in this study not only elucidate Ang II-mediated signaling cascade in mesangial cells but also demonstrate for the first time the modulatory effects of SMV on Ang II-induced signaling pathway at the cell cycle level...
  16. ncbi request reprint Simultaneous optical coherence tomography imaging and beta particle detection
    Quing Zhu
    Department of Electrical and Computer Engineering, University of Connecticut, Storrs, Connecticut 06269, USA
    Opt Lett 28:1704-6. 2003
    ..With this prototype device we demonstrate the feasibility of simultaneous optical coherence tomography imaging and detection of beta particles...
  17. ncbi request reprint HMG CoA reductase inhibition modulates VEGF-induced endothelial cell hyperpermeability by preventing RhoA activation and myosin regulatory light chain phosphorylation
    Lixia Zeng
    Division of Nephrology Hypertension, Feinberg School of Medicine, Chicago, Illinois 60611, USA
    FASEB J 19:1845-7. 2005
    ..In summary, this study identifies RhoA and MLC phosphorylation as key mediators of VEGF-induced endothelial cell hyperpermeability and demonstrates the modulatory effects of statins on VEGF signaling pathway...

Research Grants4

  1. Molecular Imaging of Vascular Remodeling
    MEHRAN SADEGHI; Fiscal Year: 2007
    ..Ultimately, this can improve the care of vascular patients through early monitoring and intervention. ..
  2. Molecular Imaging of Vascular Remodeling
    Mehran M Sadeghi; Fiscal Year: 2010
    ..Ultimately, this can improve the care of vascular patients through early monitoring and intervention. ..