DOUGLAS LYLE ROTHMAN

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Is there in vivo evidence for amino acid shuttles carrying ammonia from neurons to astrocytes?
    Douglas L Rothman
    Department of Diagnostic Radiology and Biomedical Engineering, Magnetic Resonance Research Center, Yale University School of Medicine, 300 Cedar Street, P O Box 208043, New Haven, CT 06520 8043, USA
    Neurochem Res 37:2597-612. 2012
  2. ncbi request reprint Studies of metabolic compartmentation and glucose transport using in vivo MRS
    D L Rothman
    Department of Diagnostic Radiology, Yale School of Medicine, CT 06520, USA
    NMR Biomed 14:149-60. 2001
  3. pmc 13C MRS studies of neuroenergetics and neurotransmitter cycling in humans
    Douglas L Rothman
    Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT 06520 8043, USA
    NMR Biomed 24:943-57. 2011
  4. ncbi request reprint In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function
    Douglas L Rothman
    Magnetic Resonance Center for Research in Metabolism and Physiology, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Annu Rev Physiol 65:401-27. 2003
  5. pmc Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism
    Vincent Lebon
    Howard Hughes Medical Institute, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:1523-31. 2002
  6. pmc The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy
    Fawzi Boumezbeur
    Departments of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 30:13983-91. 2010
  7. pmc Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using 1H-[13C]-NMR
    Anant B Patel
    Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 30:1200-13. 2010
  8. ncbi request reprint Dynamic fMRI and EEG recordings during spike-wave seizures and generalized tonic-clonic seizures in WAG/Rij rats
    Hrachya Nersesyan
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 24:589-99. 2004
  9. pmc Increased brain monocarboxylic acid transport and utilization in type 1 diabetes
    Graeme F Mason
    Department of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Diabetes 55:929-34. 2006
  10. pmc Mitochondrial dysfunction in the elderly: possible role in insulin resistance
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 300:1140-2. 2003

Detail Information

Publications65

  1. pmc Is there in vivo evidence for amino acid shuttles carrying ammonia from neurons to astrocytes?
    Douglas L Rothman
    Department of Diagnostic Radiology and Biomedical Engineering, Magnetic Resonance Research Center, Yale University School of Medicine, 300 Cedar Street, P O Box 208043, New Haven, CT 06520 8043, USA
    Neurochem Res 37:2597-612. 2012
    ..Future work will be needed, perhaps using methods for selectively labeling nitrogen in neurons, to conclusively establish the rate of amino acid nitrogen shuttles in vivo and their coupling to the glutamate/glutamine cycle...
  2. ncbi request reprint Studies of metabolic compartmentation and glucose transport using in vivo MRS
    D L Rothman
    Department of Diagnostic Radiology, Yale School of Medicine, CT 06520, USA
    NMR Biomed 14:149-60. 2001
    ..The concepts and approaches used in these studies are generally applicable for studying cellular metabolic compartmentation in a wide range of systems...
  3. pmc 13C MRS studies of neuroenergetics and neurotransmitter cycling in humans
    Douglas L Rothman
    Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT 06520 8043, USA
    NMR Biomed 24:943-57. 2011
    ..Future technological developments are discussed that will help to overcome the limitations of (13)C MRS, with special attention given to recent developments in hyperpolarized (13)C MRS...
  4. ncbi request reprint In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function
    Douglas L Rothman
    Magnetic Resonance Center for Research in Metabolism and Physiology, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Annu Rev Physiol 65:401-27. 2003
    ..Here we review and discuss the importance of neurotransmission and neuroenergetics as measured by (13)C MRS for understanding brain function and interpreting fMRI...
  5. pmc Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism
    Vincent Lebon
    Howard Hughes Medical Institute, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 22:1523-31. 2002
    ..The further application of this approach could potentially enlighten the role of astroglia in supporting brain glutamatergic activity and in neurological and psychiatric disease...
  6. pmc The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopy
    Fawzi Boumezbeur
    Departments of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 30:13983-91. 2010
    ..1 ± 2.7 mmol/L and V(MAX) is 0.40 ± 0.13 μmol · g(-1) · min(-1) (68% confidence interval); and (4) the majority of plasma lactate is metabolized in neurons similar to glucose...
  7. pmc Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using 1H-[13C]-NMR
    Anant B Patel
    Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 30:1200-13. 2010
    ..The astrocytic and neuronal tricarboxylic acid cycle fluxes were 0.37+/-0.03 micromol/g/min and 1.41+/-0.11 micromol/g/min, respectively; astrocytes thus comprised approximately 21%+/-3% of total oxidative metabolism...
  8. ncbi request reprint Dynamic fMRI and EEG recordings during spike-wave seizures and generalized tonic-clonic seizures in WAG/Rij rats
    Hrachya Nersesyan
    Department of Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 24:589-99. 2004
    ....
  9. pmc Increased brain monocarboxylic acid transport and utilization in type 1 diabetes
    Graeme F Mason
    Department of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Diabetes 55:929-34. 2006
    ..These data are consistent with the hypothesis that upregulation of MCA transport may contribute to the maintenance of brain energetics during hypoglycemia in patients with type 1 diabetes...
  10. pmc Mitochondrial dysfunction in the elderly: possible role in insulin resistance
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 300:1140-2. 2003
    ..These data support the hypothesis that an age-associated decline in mitochondrial function contributes to insulin resistance in the elderly...
  11. ncbi request reprint Dynamic shim updating on the human brain
    Kevin M Koch
    Magnetic Resonance Research Center, Yale University, New Haven, CT, USA
    J Magn Reson 180:286-96. 2006
    ..Finally, the effect of DSU on susceptibility artifact reduction in single-shot axial-sliced EPI is analyzed using experimental acquisitions...
  12. ncbi request reprint Brain homocarnosine and seizure control of patients taking gabapentin or topiramate
    Ognen A C Petroff
    Department of Neurology, Yale University, New Haven, Connecticut 06520 8018, USA
    Epilepsia 47:495-8. 2006
    ..To assess the relation between seizure control and brain homocarnosine and gamma-aminobutyric acid (GABA) levels of patients with complex partial seizures taking gabapentin (GBP) or topiramate (TPM) as adjunctive therapy...
  13. ncbi request reprint Acute regulation of steady-state GABA levels following GABA-transaminase inhibition in rat cerebral cortex
    Robin A de Graaf
    Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut 06520 8043, USA
    Neurochem Int 48:508-14. 2006
    ..The findings suggest that astroglia may be the site of continuing GABA catabolism after acute vigabatrin treatment...
  14. ncbi request reprint Neuronal-glial glucose oxidation and glutamatergic-GABAergic function
    Fahmeed Hyder
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Cereb Blood Flow Metab 26:865-77. 2006
    ..The relationship observed between DeltaCMR(glc(ox), N) and DeltaV(cyc(tot)) is determined by glial glycolytic ATP as before. Quantitative aspects of the model, which can be tested by experimentation, are discussed...
  15. ncbi request reprint High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo
    Robin A de Graaf
    Magnetic Resonance Research Center, Yale University, School of Medicine, New Haven, Connecticut 06520 8043, USA
    Magn Reson Med 56:386-94. 2006
    ....
  16. ncbi request reprint Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapy
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 59:284-6. 2006
    ..The purpose of this study was to determine whether treatment of major depression with cognitive behavioral therapy (CBT) produces similar changes in cortical GABA concentrations...
  17. pmc The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivo
    Anant B Patel
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 102:5588-93. 2005
    ..The contribution of GABAergic neurons and inhibition to cortical energy metabolism has broad implications for the interpretation of functional imaging signals...
  18. ncbi request reprint Sample-specific diamagnetic and paramagnetic passive shimming
    Kevin M Koch
    Magnetic Resonance Research Center, Yale University, New Haven, CT, USA
    J Magn Reson 182:66-74. 2006
    ..A prototype shim is constructed and shown to significantly homogenize the mouse brain at 9.4 T. Further homogenization capabilities are simulated through alteration of the shim construction...
  19. pmc Dynamics of changes in blood flow, volume, and oxygenation: implications for dynamic functional magnetic resonance imaging calibration
    Ikuhiro Kida
    Department of Diagnostic Radiology, Yale University, New Haven, Connecticut 06510, USA
    J Cereb Blood Flow Metab 27:690-6. 2007
    ....
  20. pmc Magnetic field modeling with a set of individual localized coils
    Christoph Juchem
    Yale University School of Medicine, Department of Diagnostic Radiology, MR Research Center MRRC, 300 Cedar Street, New Haven, CT 06520, USA
    J Magn Reson 204:281-9. 2010
    ....
  21. pmc Magnetic field homogenization of the human prefrontal cortex with a set of localized electrical coils
    Christoph Juchem
    Yale University School of Medicine, Department of Diagnostic Radiology, Magnetic Resonance Research Center, New Haven, Connecticut 06520, USA
    Magn Reson Med 63:171-80. 2010
    ..The experimental realization of the new shim method strongly minimized or even eliminated signal dropout in gradient-echo images acquired at settings typically used in functional magnetic resonance at 4 T...
  22. ncbi request reprint Neurodevelopment of C57B/L6 mouse brain assessed by in vivo diffusion tensor imaging
    Halima Chahboune
    Department of Diagnostic Radiology, Yale University, 300 Cedar Street, New Haven, CT 06510, USA
    NMR Biomed 20:375-82. 2007
    ..In summary, these results show that high-resolution DTI at high magnetic fields allows detection and quantification of brain structures throughout normal development in C57B/L6 mice in vivo...
  23. pmc In situ 3D magnetic resonance metabolic imaging of microwave-irradiated rodent brain: a new tool for metabolomics research
    Robin A de Graaf
    Magnetic Resonance Research Center, Yale University, New Haven, Connecticut 06520 8043, USA
    J Neurochem 109:494-501. 2009
    ....
  24. pmc Natural abundance (17)O NMR spectroscopy of rat brain in vivo
    Robin A de Graaf
    Magnetic Resonance Research Center, Yale University, School of Medicine, New Haven, CT 06520 8043, USA
    J Magn Reson 193:63-7. 2008
    ..74 T. The chemical shifts and line widths of more than 20 oxygen-containing metabolites are established and the sensitivity and potential for (17)O-enriched NMR studies are estimated...
  25. pmc Proposed cycles for functional glutamate trafficking in synaptic neurotransmission
    Paul K Maciejewski
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Neurochem Int 52:809-25. 2008
    ..In light of these newly elaborated alternative cycles, it is premature to presuppose that functional glutamate trafficking in synaptic neurotransmission in vivo is sustained by the glutamate-glutamine cycle alone...
  26. pmc High resolution NMR spectroscopy of rat brain in vivo through indirect zero-quantum-coherence detection
    Robin A de Graaf
    Departments of Diagnostic Radiology and Biomedical Engineering, Magnetic Resonance Research Center, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520, USA
    J Magn Reson 187:320-6. 2007
    ..Unique spectral information which is normally not directly available from regular (1)H NMR spectra can be extracted and used for compound identification or improved prior knowledge during spectral fitting...
  27. ncbi request reprint Glutamatergic and GABAergic neurotransmitter cycling and energy metabolism in rat cerebral cortex during postnatal development
    Golam M I Chowdhury
    Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cereb Blood Flow Metab 27:1895-907. 2007
    ..The findings show that glutamate and GABA neurons undergo large and approximately proportional increases in neurotransmitter cycling and oxidative energy metabolism during this major postnatal growth spurt...
  28. pmc Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose
    Graeme F Mason
    Department of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut 06520 8043, USA
    J Neurochem 100:73-86. 2007
    ..These results are consistent with observations made with arterial-venous differences and radiotracer methods...
  29. ncbi request reprint Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopy
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, University Towers Suite 2H, 100 York Street, New Haven, CT 06511, USA
    Biol Psychiatry 57:44-8. 2005
    ..Given that nicotine modulates amino acid neurotransmission, we sought to examine the impact of nicotine on cortical gamma-aminobutyric acid (GABA) levels in male and female smokers...
  30. ncbi request reprint Cerebral pyruvate carboxylase flux is unaltered during bicuculline-seizures
    Anant B Patel
    Department of Diagnostic Radiology and Magnetic Resonance Research Center, Yale University School of Medicine, PO Box 208043, 300 Cedar Street, New Haven, CT 06520, USA
    J Neurosci Res 79:128-38. 2005
    ..2004b)...
  31. pmc Total neuroenergetics support localized brain activity: implications for the interpretation of fMRI
    Fahmeed Hyder
    Magnetic Resonance Research Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:10771-6. 2002
    ..The disregard of baseline activity in fMRI experiments by differencing removes a large and necessary component of the total activity. Implications of these results for understanding brain function and fMRI experiments are discussed...
  32. ncbi request reprint Biophysical basis of brain activity: implications for neuroimaging
    Robert G Shulman
    Magnetic Resonance Center for Research in Metabolism and Physiology, Departments of Molecular Biophysics and Biochemistry, Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Q Rev Biophys 35:287-325. 2002
    ..These biophysical experiments have established relationships between energy consumption and neuronal activity that provide novel insights into the nature of brain function and the interpretation of fMRI data...
  33. ncbi request reprint Smoking impairs muscle recovery from exercise
    Thomas B Price
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Am J Physiol Endocrinol Metab 285:E116-22. 2003
    ..217 +/- 0.019 (C) mmol/l, P = 0.0212]. We conclude that cigarette smoking impairs the insulin-dependent portion of muscle recovery from glycogen-depleting exercise. This impairment likely results from a reduction in glucose uptake...
  34. ncbi request reprint Clinical studies implementing glutamate neurotransmission in mood disorders
    Gerard Sanacora
    Department of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut 06519, USA
    Ann N Y Acad Sci 1003:292-308. 2003
    ..Here we review the available literature in the field and suggest a possible pathophysiological model that may account for the many of the findings...
  35. ncbi request reprint Coupling of glutamatergic neurotransmission and neuronal glucose oxidation over the entire range of cerebral cortex activity
    Anant B Patel
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Ann N Y Acad Sci 1003:452-3. 2003
  36. ncbi request reprint Basic principles of metabolic modeling of NMR (13)C isotopic turnover to determine rates of brain metabolism in vivo
    Graeme F Mason
    Department of Psychiatry, School of Medicine, Yale University, N 141 CAB Magnetic Resonance Center, 300 Cedar Street, PO Box 208043, New Haven, CT 06520 8043, USA
    Metab Eng 6:75-84. 2004
    ..This article is meant to provide a general background for investigators to begin to apply metabolic modeling analysis to (13)C isotopic labeling studies performed in vivo...
  37. ncbi request reprint Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depression
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Arch Gen Psychiatry 61:705-13. 2004
    ..An initial report, using this technique, suggested that occipital cortex GABA concentrations are reduced in patients with major depressive disorder (MDD) relative to healthy comparison subjects...
  38. pmc Regional glucose metabolism and glutamatergic neurotransmission in rat brain in vivo
    Robin A de Graaf
    Magnetic Resonance Research Center and Departments of Diagnostic Radiology and Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:12700-5. 2004
    ..02 +/- 0.04, and 0.18 +/- 0.12 micromol/min per g, respectively. The exchange rate between the mitochondrial and cytosolic metabolite pools was fast relative to the neuronal tricarboxylic acid cycle flux for all cerebral tissue types...
  39. pmc Chronic riluzole treatment increases glucose metabolism in rat prefrontal cortex and hippocampus
    Golam M I Chowdhury
    Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 28:1892-7. 2008
    ..2). Our findings indicate that contrary to expectation chronic riluzole enhanced glucose oxidative metabolism and glutamate/glutamine cycling...
  40. pmc Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals
    Douglas E Befroy
    Departments of Internal Medicine, Diagnostic Radiology, Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 105:16701-6. 2008
    ..Increased mitochondrial uncoupling may represent another mechanism by which exercise training enhances muscle insulin sensitivity via increased fatty acid oxidation in the resting state...
  41. ncbi request reprint A comparison of (13)C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-(13)C]glucose
    Graeme F Mason
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Brain Res Brain Res Protoc 10:181-90. 2003
    ..The conclusion is that oral administration does yield the same result as intravenous administration but with lower precision. That sensitivity of the oral protocol may be improved by several ways that are available today...
  42. pmc Recurrent antecedent hypoglycemia alters neuronal oxidative metabolism in vivo
    Lihong Jiang
    Department of Diagnostic Radiology, Yale University School of Medicine, The Anlyan Center, New Haven, Connecticut, USA
    Diabetes 58:1266-74. 2009
    ....
  43. ncbi request reprint Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H-[13C]-NMR spectroscopy
    Robin A de Graaf
    Magnetic Resonance Center, Department of Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8043, USA
    Magn Reson Med 49:37-46. 2003
    ..52 +/- 0.04 micromol/min/g, while the glutamatergic neurotransmitter flux equaled 0.25 +/- 0.05 micromol/min/g, in good correspondence with previously determined values...
  44. pmc Baseline brain energy supports the state of consciousness
    Robert G Shulman
    Magnetic Resonance Research Center, Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 106:11096-101. 2009
    ..This usage of high brain energies when the person is in the "state" of consciousness differs from most studies, which attend the smaller energy increments observed during the stimulations that form the "contents" of that state...
  45. pmc Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy
    Fawzi Boumezbeur
    Department of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut 06520 8020, USA
    J Cereb Blood Flow Metab 30:211-21. 2010
    ..Taken together, these studies show that healthy aging is associated with reduced neuronal mitochondrial metabolism and altered glial mitochondrial metabolism, which may in part be responsible for declines in brain function...
  46. ncbi request reprint Neuronal and glial metabolite content of the epileptogenic human hippocampus
    Ognen A C Petroff
    Department of Neurology, Yale University, 333 Cedar Street, New Haven, CT 06520 8018, USA
    Ann Neurol 52:635-42. 2002
    ..The epileptic human hippocampus has increased intracellular glutamate content that may contribute to the epileptogenic nature of hippocampal sclerosis...
  47. ncbi request reprint Graded image segmentation of brain tissue in the presence of inhomogeneous radio frequency fields
    Graeme F Mason
    Department of Psychiatry, New Haven, CT, USA
    Magn Reson Imaging 20:431-6. 2002
    ..The T(1) observed by this method is a continuous function across mixtures of WM/GM and GM/CSF, and this function was measured and used to convert the images of T(1) to maps of percent GM, WM, and CSF...
  48. ncbi request reprint Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activation
    Anant B Patel
    Department of Psychiatry, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Cereb Blood Flow Metab 24:972-85. 2004
    ..These results indicate that neuronal glucose oxidation and not total glucose utilization is coupled to the glutamate/glutamine cycle during intense cortical activation...
  49. ncbi request reprint Glutamate-glutamine cycling in the epileptic human hippocampus
    Ognen A C Petroff
    Department of Neurology, Yale University, New Haven, Connecticut 06520 8018, USA
    Epilepsia 43:703-10. 2002
    ..We hypothesized that the glutamate-glutamine cycle between neurons and glia may be decreased in the epileptic human hippocampus...
  50. ncbi request reprint Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 159:663-5. 2002
    ..The goal of this study was to determine whether these occipital cortex GABA concentrations are altered after administration of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression...
  51. ncbi request reprint Adiabatic RARE imaging
    Robin A de Graaf
    Department of Diagnostic Radiology, Magnetic Resonance Center, Yale University School of Medicine, New Haven, Connecticut 06520 8043, USA
    NMR Biomed 16:29-35. 2003
    ..A two-scan RARE implementation provides sufficient spatial and temporal resolution for most applications. Quantitative mapping of T(1) relaxation and cerebral blood flow changes during forepaw stimulation in the rat are demonstrated...
  52. ncbi request reprint Dynamic shim updating (DSU) for multislice signal acquisition
    Robin A de Graaf
    Magnetic Resonance Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Magn Reson Med 49:409-16. 2003
    ....
  53. ncbi request reprint In vivo 1H-[13C]-NMR spectroscopy of cerebral metabolism
    Robin A de Graaf
    Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520 8043, USA
    NMR Biomed 16:339-57. 2003
    ..Finally, (1)H-[(13)C]-NMR spectroscopy allows the detection of energy metabolism and neurotransmission during functional activation, thereby further strengthening our understanding of the neurochemical basis of brain function...
  54. ncbi request reprint Reproducibility of odor maps by fMRI in rodents
    James R Schafer
    Department of Neurobiology, Magnetic Resonance Research Center, Yale University, New Haven, CT 06510, USA
    Neuroimage 31:1238-46. 2006
    ..These results demonstrate the robustness of high-field fMRI as a tool for assaying olfactory bulb function and provide evidence that equivalent perceptual outcomes may arise from divergent neural substrates...
  55. ncbi request reprint Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS study
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, and Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 186:425-33. 2006
    ..Childbirth is associated with rapid neuroendocrine fluctuations, which are thought to contribute to the phatogenesis of postpartum major depression (PPD)...
  56. ncbi request reprint Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smoking
    Graeme F Mason
    NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University, School of Medicine, New Haven, CT 06520, USA
    Biol Psychiatry 59:85-93. 2006
    ..This study's objective was to measure time-dependent cortical GABA levels with sobriety in ethanol-dependent patients with mild to moderate withdrawal severity, controlling for alcoholism-related neurotoxicity and smoking...
  57. pmc Odor maps of aldehydes and esters revealed by functional MRI in the glomerular layer of the mouse olfactory bulb
    Fuqiang Xu
    Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:11029-34. 2003
    ..Insights into possible relations between the functional patterns, molecular projections, and odor perception may now be obtained based on the global from the olfactory epithelium to the OB glomerular activity patterns...
  58. ncbi request reprint Magnetic resonance spectroscopy of neurotransmitters in human brain
    Edward J Novotny
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Ann Neurol 54:S25-31. 2003
    ..Here, we review the MRS techniques and studies of neurotransmitters in the human brain. A discussion of the potential use of these techniques in the context of certain pediatric neurotransmitter disorders will be presented...
  59. ncbi request reprint Cerebral metabolism and consciousness
    Robert G Shulman
    Magnetic Resonance Research Center, Yale University, Schools of Medicine and Engineering, New Haven, CT 06510, USA
    C R Biol 326:253-73. 2003
    ....
  60. pmc A BOLD search for baseline
    Robert G Shulman
    Quantitative Neuroscience with Magnetic Resonance QNMR and Magnetic Resonance Research Center MRRC, Department of Diagnostic Radiology, Yale University, New Haven, CT 06510, USA
    Neuroimage 36:277-81. 2007
    ....
  61. pmc Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients
    Douglas E Befroy
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 8012, USA
    Diabetes 56:1376-81. 2007
    ....
  62. ncbi request reprint Dynamically shimmed multivoxel 1H magnetic resonance spectroscopy and multislice magnetic resonance spectroscopic imaging of the human brain
    Kevin M Koch
    Yale Magnetic Resonance Research Center, New Haven, Connecticut 06520 8043, USA
    Magn Reson Med 57:587-91. 2007
    ..These results demonstrate that DSU can increase multivoxel MRS acquisition capabilities and significantly improve the quality of multislice MRSI data...
  63. ncbi request reprint Energetic basis of brain activity: implications for neuroimaging
    Robert G Shulman
    Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, CT 06510, USA
    Trends Neurosci 27:489-95. 2004
    ..MRS and fMRI experiments show that the majority of cerebral activity, which is often disregarded in imaging experiments, is ongoing even when the brain appears to be doing nothing...
  64. ncbi request reprint Increased cortical GABA concentrations in depressed patients receiving ECT
    Gerard Sanacora
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 160:577-9. 2003
    ..The purpose of this study was to determine if cortical GABA concentrations increase following a course of ECT...
  65. pmc Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy
    Douglas E Befroy
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Methods Enzymol 457:373-93. 2009
    ..We will also examine applications of the techniques to investigate how these parameters of muscle mitochondrial metabolism are modulated in insulin resistant and endurance trained individuals...

Research Grants17

  1. MRS Studies of Brain Metabolic Adaptations in Diabetes
    Douglas Rothman; Fiscal Year: 2007
    ..If MCAs or alternatively medium chain fatty acids can protect against hypoglycemic energy failure they may potentially be administered as a protective therapy for nocturnal hypoglycemic episodes. ..
  2. MRS STUDIES OF NEUROTRANSMITTER CYCLING IN HUMAN BRAIN
    Douglas Rothman; Fiscal Year: 2007
    ..Although no patient studies are proposed, our goal is for these studies to provide validated methodology and normative values to be used in future studies of neuronal-glial neurotransmitter cycles in development, aging, and disease. ..
  3. Acquisition of a 7T human MR system for the development of ultra high resolution
    Douglas Rothman; Fiscal Year: 2006
    ....
  4. MRS STUDIES OF NEUROTRANSMITTER CYCLING IN HUMAN BRAIN
    Douglas Rothman; Fiscal Year: 2002
    ....
  5. 11.74T/210 Millimeter NMR Magnet System/In VivO MRS/MRI
    Douglas Rothman; Fiscal Year: 2002
    ..74T in vivo MRS/MRI system and the application to transgenic mouse and other small animal models for understanding the molecular control of metabolism and physiology in health and disease. ..
  6. 13C MRS Studies of Human Brain Mitochondrial Metabolism in Healthy Aging
    DOUGLAS LYLE ROTHMAN; Fiscal Year: 2010
    ....