H A Risch

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer
    H A Risch
    Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, CT, 06520, USA
    Am J Hum Genet 68:700-10. 2001
  2. pmc Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, AB, Canada
    BMC Cancer 13:28. 2013
  3. pmc ABO blood group and risk of pancreatic cancer: a study in Shanghai and meta-analysis
    Harvey A Risch
    Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA
    Am J Epidemiol 177:1326-37. 2013
  4. pmc Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome
    Lingeng Lu
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Breast Cancer Res 13:R56. 2011
  5. pmc ABO blood group, Helicobacter pylori seropositivity, and risk of pancreatic cancer: a case-control study
    Harvey A Risch
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, PO Box 208034, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 102:502-5. 2010
  6. ncbi request reprint Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada
    Harvey A Risch
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, PO Box 208034, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 98:1694-706. 2006
  7. ncbi request reprint PGR +331 A/G and increased risk of epithelial ovarian cancer
    Harvey A Risch
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, P O Box 208034, New Haven, CT 06520 8034, USA
    Cancer Epidemiol Biomarkers Prev 15:1738-41. 2006
  8. ncbi request reprint It's time to accept that intake of dairy foods is not related to risk of ovarian cancer
    Harvey A Risch
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, PO Box 208034, New Haven, CT 06520 8034, USA
    Nat Clin Pract Oncol 3:472-3. 2006
  9. ncbi request reprint Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity
    Harvey A Risch
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, P O Box 208034, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 95:948-60. 2003
  10. ncbi request reprint Carbonated soft drink consumption and risk of esophageal adenocarcinoma
    Susan T Mayne
    Department of Epidemiology and Public Health, Yale University School of Medicine and Cancer Center, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 98:72-5. 2006

Collaborators

Detail Information

Publications28

  1. pmc Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer
    H A Risch
    Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, CT, 06520, USA
    Am J Hum Genet 68:700-10. 2001
    ..As well, BRCA2 mutations may prove to be a greater cause of cancer in male carriers than previously has been thought...
  2. pmc Recent alcohol consumption and risk of incident ovarian carcinoma: a pooled analysis of 5,342 cases and 10,358 controls from the Ovarian Cancer Association Consortium
    Linda E Kelemen
    Department of Population Health Research, Alberta Health Services Cancer Care, AB, Canada
    BMC Cancer 13:28. 2013
    ..Because OC and ovarian borderline tumor histologic types differ genetically, molecularly and clinically, large numbers are needed to estimate risk associations...
  3. pmc ABO blood group and risk of pancreatic cancer: a study in Shanghai and meta-analysis
    Harvey A Risch
    Department of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, Connecticut, USA
    Am J Epidemiol 177:1326-37. 2013
    ..pylori strains...
  4. pmc Telomerase expression and telomere length in breast cancer and their associations with adjuvant treatment and disease outcome
    Lingeng Lu
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Breast Cancer Res 13:R56. 2011
    ..This study aimed to investigate the role of telomere length and telomerase activity in breast cancer prognosis...
  5. pmc ABO blood group, Helicobacter pylori seropositivity, and risk of pancreatic cancer: a case-control study
    Harvey A Risch
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, PO Box 208034, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 102:502-5. 2010
    ..49 to 5.20, P = .0014; OR = 1.28, 95% CI = 0.62 to 2.64, P = .51, respectively). This study demonstrates an association between pancreatic cancer and H pylori colonization, particularly for individuals with non-O blood types...
  6. ncbi request reprint Population BRCA1 and BRCA2 mutation frequencies and cancer penetrances: a kin-cohort study in Ontario, Canada
    Harvey A Risch
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, PO Box 208034, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 98:1694-706. 2006
    ..We investigated the presence of these mutations in unselected patients with newly diagnosed incident ovarian cancer in Ontario, Canada, with respect to cancers reported among their relatives...
  7. ncbi request reprint PGR +331 A/G and increased risk of epithelial ovarian cancer
    Harvey A Risch
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, P O Box 208034, New Haven, CT 06520 8034, USA
    Cancer Epidemiol Biomarkers Prev 15:1738-41. 2006
    ..These findings have been observed before for breast and endometrial cancer, although not for ovary, but still suggest that an hPR-B mechanism may be involved in ovarian neoplasia...
  8. ncbi request reprint It's time to accept that intake of dairy foods is not related to risk of ovarian cancer
    Harvey A Risch
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, PO Box 208034, New Haven, CT 06520 8034, USA
    Nat Clin Pract Oncol 3:472-3. 2006
  9. ncbi request reprint Etiology of pancreatic cancer, with a hypothesis concerning the role of N-nitroso compounds and excess gastric acidity
    Harvey A Risch
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, P O Box 208034, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 95:948-60. 2003
    ..Many features of the evidence bearing on the pathophysiology of pancreatic cancer appear to support connections with N-nitroso compounds and with gastric acidity...
  10. ncbi request reprint Carbonated soft drink consumption and risk of esophageal adenocarcinoma
    Susan T Mayne
    Department of Epidemiology and Public Health, Yale University School of Medicine and Cancer Center, New Haven, CT 06520 8034, USA
    J Natl Cancer Inst 98:72-5. 2006
    ..These findings indicate that CSD consumption (especially diet CSD) is inversely associated with risk of esophageal adenocarcinoma, and thus it is not likely to have contributed to the rising incidence rates...
  11. ncbi request reprint Nutrient intake and risk of subtypes of esophageal and gastric cancer
    S T Mayne
    Yale University School of Medicine, Department of Epidemiology and Public Health, New Haven, Connecticut 06520 8034, USA
    Cancer Epidemiol Biomarkers Prev 10:1055-62. 2001
    ....
  12. ncbi request reprint The relationship of insulin-like growth factor-II, insulin-like growth factor binding protein-3, and estrogen receptor-alpha expression to disease progression in epithelial ovarian cancer
    Lingeng Lu
    Department of Epidemiology and Public Health, Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520 8034, USA
    Clin Cancer Res 12:1208-14. 2006
    ..To assess the role of IGF-II in cancer, we analyzed IGF-II expression in ovarian cancer and examined its association with disease characteristics and prognosis...
  13. ncbi request reprint Excess diagnosis of non-Hodgkin's lymphoma during spring in the USA
    Stella Koutros
    Division of Chronic Disease Epidemiology, Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, USA
    Leuk Lymphoma 48:357-66. 2007
    ..043, P = 0.0001) but not among patients >or= 65 years. Future studies are needed to discern if a spring peak is due to diagnostic bias or other uncontrolled factors...
  14. ncbi request reprint Occupation and risk of esophageal and gastric cardia adenocarcinoma
    Lawrence S Engel
    Occupational Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA
    Am J Ind Med 42:11-22. 2002
    ..Adenocarcinomas of the esophagus and gastric cardia have risen dramatically in incidence over the past few decades, however, little research has been conducted on the occupational risk factors for these cancers...
  15. pmc Ovarian cancer risk is associated with a common variant in the promoter sequence of the mismatch repair gene MLH1
    Ian Harley
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Toronto, ON, Canada
    Gynecol Oncol 109:384-7. 2008
    ..We sought to establish whether or not this polymorphic variant also predisposes to ovarian cancer...
  16. ncbi request reprint Alcohol dehydrogenase 3 and risk of esophageal and gastric adenocarcinomas
    Mary Beth Terry
    Mailman School of Public Health, Department of Epidemiology, Columbia University, 722 West 168th Street, Room 724A, New York, NY 10032, USA
    Cancer Causes Control 18:1039-46. 2007
    ..The alcohol dehydrogenase gene has several polymorphisms which may lead to faster conversion of ethanol to acetaldehyde, which may increase cancer risk...
  17. ncbi request reprint A functional polymorphism of toll-like receptor 4 gene increases risk of gastric carcinoma and its precursors
    Georgina L Hold
    Department of Medicine and Therapeutics, Aberdeen University, Aberdeen, Scotland
    Gastroenterology 132:905-12. 2007
    ..The TLR4+896A>G polymorphism linked with impaired reactivity to bacterial lipopolysaccharide may play a role in gastric carcinogenesis...
  18. ncbi request reprint Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study
    John R McLaughlin
    Samuel Lunenfeld Research Institute, Toronto, ON, Canada
    Lancet Oncol 8:26-34. 2007
    ..We aimed to assess the effect of these three risk factors, and of tubal ligation, on the risk of ovarian cancer in women who carry a mutation in the BRCA1 or BRCA2 genes...
  19. ncbi request reprint Population attributable risks of esophageal and gastric cancers
    Lawrence S Engel
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA
    J Natl Cancer Inst 95:1404-13. 2003
    ..Herein, we estimate the population attributable risks (PARs) for various risk factors observed in a multicenter population-based case-control study...
  20. ncbi request reprint Re: On the use of familial aggregation in population-based case probands for calculating penetrance
    Harvey A Risch
    J Natl Cancer Inst 95:73-4; author reply 77-8. 2003
  21. ncbi request reprint Increased risk of noncardia gastric cancer associated with proinflammatory cytokine gene polymorphisms
    Emad M El-Omar
    Department of Medicine and Therapeutics, Aberdeen University, Foresterhill, Scotland
    Gastroenterology 124:1193-201. 2003
    ..The aim of this study was to evaluate the role of proinflammatory cytokine gene polymorphisms in gastric and esophageal cancers defined by anatomic subsite...
  22. ncbi request reprint Re: Cancer risks in BRCA1 carriers: time for the next generation of studies
    Harvey A Risch
    J Natl Cancer Inst 95:758. 2003
  23. ncbi request reprint Demographic and lifestyle predictors of survival in patients with esophageal or gastric cancers
    Katrina F Trivers
    Department of Epidemiology, University of North Carolina at Chapel Hill, CB 7435, Chapel Hill, North Carolina 27599 7435, USA
    Clin Gastroenterol Hepatol 3:225-30. 2005
    ..Risk factors for subtypes of esophageal and gastric cancer recently have been identified, but their effect on survival is unknown...
  24. ncbi request reprint Re: Are women more susceptible to lung cancer?
    Harvey A Risch
    J Natl Cancer Inst 96:1560; author reply 1560-1. 2004
  25. ncbi request reprint Nonsteroidal anti-inflammatory drug use associated with reduced incidence of adenocarcinomas of the esophagus and gastric cardia that overexpress cyclin D1: a population-based study
    Marilie D Gammon
    University of North Carolina, School of Public Health, Department of Epidemiology, Chapel Hill, North Carolina, USA
    Cancer Epidemiol Biomarkers Prev 13:34-9. 2004
    ..These data suggest that the reduction in risk associated with NSAID use may be restricted to those esophageal and gastric cardia adenocarcinomas that overexpress cyclin D1...
  26. ncbi request reprint Changing incidence of thyroid cancer
    Yawei Zhang
    JAMA 296:1350; author reply 1350. 2006
  27. ncbi request reprint Infertility, fertility drugs, and ovarian cancer: a pooled analysis of case-control studies
    Roberta B Ness
    University of Pittsburgh School of Public Health, Pittsburgh, PA 15261, USA
    Am J Epidemiol 155:217-24. 2002
    ..10, 2.71) and unknown cause of infertility (OR = 1.19, 95% CI: 1.00, 1.40) increased cancer risk. These data suggest a role for specific biologic causes of infertility, but not for fertility drugs in overall risk for ovarian cancer...
  28. ncbi request reprint Hormone replacement therapy and the risk of ovarian cancer
    Harvey A Risch
    Gynecol Oncol 86:115-7. 2002

Research Grants19

  1. Case-Control Study of Pancreas Cancer Etiologic Factors
    Harvey Risch; Fiscal Year: 2007
    ..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. ..
  2. Case Control Study of Pancreas Cancer in Shanghai, China
    Harvey Risch; Fiscal Year: 2007
    ..In addition to reduction of cigarette smoking, Helicobacter and dietary factors are modifiable and could be involved in a program to reduce risk of pancreas cancer. ..
  3. Case-Control Study of Pancreas Cancer Etiologic Factors
    Harvey Risch; Fiscal Year: 2006
    ..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. ..
  4. Case-Control Study of Pancreas Cancer Etiologic Factors
    Harvey Risch; Fiscal Year: 2005
    ..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. ..
  5. Case-Control Study of Pancreas Cancer Etiologic Factors
    Harvey Risch; Fiscal Year: 2004
    ..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. ..
  6. Case-Control Study of Pancreas Cancer Etiologic Factors
    Harvey Risch; Fiscal Year: 2003
    ..The factors to be examined here have received little attention with respect to pancreas cancer, and the proposed study will evaluate them systematically in a vigorous, large-scale and integrated project. ..
  7. CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGY
    Harvey Risch; Fiscal Year: 2002
    ....
  8. DNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDY
    Harvey Risch; Fiscal Year: 2002
    ..abstract_text> ..
  9. CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGY
    Harvey Risch; Fiscal Year: 2001
    ....
  10. DNA POLYMORPHISMS IN OVARIAN CANCER--CASE CONTROL STUDY
    Harvey Risch; Fiscal Year: 2001
    ..abstract_text> ..
  11. CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGY
    Harvey Risch; Fiscal Year: 2000
    ....
  12. CASE CONTROL STUDY OF OVARIAN CANCER HORMONAL ETIOLOGY
    Harvey Risch; Fiscal Year: 1999
    ....
  13. Case Control Study of Pancreas Cancer in Shanghai, China
    Harvey A Risch; Fiscal Year: 2010
    ..In addition to reduction of cigarette smoking, Helicobacter and dietary factors are modifiable and could be involved in a program to reduce risk of pancreas cancer. ..