George Richerson

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Midbrain serotonergic neurons are central pH chemoreceptors
    Christopher A Severson
    Department of Neurology, 333 Cedar Street, Yale University, New Haven, Connecticut 06510, USA
    Nat Neurosci 6:1139-40. 2003
  2. ncbi request reprint Chemosensitivity of non-respiratory rat CNS neurons in tissue culture
    W Wang
    Department of Neurology, West Haven, CT, USA
    Brain Res 860:119-29. 2000
  3. ncbi request reprint Chemosensitivity of serotonergic neurons in the rostral ventral medulla
    G B Richerson
    Department of Neurology, Yale University School of Medicine, 15 York St, PO Box 208018, New Haven, CT 06520 8018, USA
    Respir Physiol 129:175-89. 2001
  4. ncbi request reprint Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore
    George B Richerson
    Department of Neurology, Yale University School of Medicine, New Haven 06520, USA
    J Neurophysiol 90:1363-74. 2003
  5. ncbi request reprint Homing in on the specific phenotype(s) of central respiratory chemoreceptors
    G B Richerson
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Exp Physiol 90:259-66; discussion 266-9. 2005
  6. doi request reprint Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons
    Matthew R Hodges
    Department of Neurology, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 28:2495-505. 2008
  7. pmc Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1
    Yuanming Wu
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 56:851-65. 2007
  8. ncbi request reprint Changes in glucose do not alter baseline firing rate or chemosensitivity of serotonin neurons cultured from the medullary raphé
    Wengang Wang
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Respir Physiol Neurobiol 157:235-41. 2007
  9. ncbi request reprint The transmembrane sodium gradient influences ambient GABA concentration by altering the equilibrium of GABA transporters
    Yuanming Wu
    Department of Neurology, LCI 712B, Yale University School of Medicine, 15 York St, PO 208018, New Haven, CT 06520 8018, USA
    J Neurophysiol 96:2425-36. 2006
  10. ncbi request reprint Mechanism of increased open probability by a mutation of the BK channel
    Ana Diez-Sampedro
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    J Neurophysiol 96:1507-16. 2006

Collaborators

Detail Information

Publications18

  1. ncbi request reprint Midbrain serotonergic neurons are central pH chemoreceptors
    Christopher A Severson
    Department of Neurology, 333 Cedar Street, Yale University, New Haven, Connecticut 06510, USA
    Nat Neurosci 6:1139-40. 2003
    ..We propose that midbrain raphé neurons are sensors of blood CO2 that maintain pH homeostasis by inducing arousal, anxiety and changes in cerebrovascular tone in response to respiratory acidosis...
  2. ncbi request reprint Chemosensitivity of non-respiratory rat CNS neurons in tissue culture
    W Wang
    Department of Neurology, West Haven, CT, USA
    Brain Res 860:119-29. 2000
    ..Chemosensitivity is not an all-or-none neuronal property, and the degree of chemosensitivity may be relevant to the role neurons play in sensing pH in vivo...
  3. ncbi request reprint Chemosensitivity of serotonergic neurons in the rostral ventral medulla
    G B Richerson
    Department of Neurology, Yale University School of Medicine, 15 York St, PO Box 208018, New Haven, CT 06520 8018, USA
    Respir Physiol 129:175-89. 2001
    ..The cellular properties of serotonergic raphé neurons suggest that they play a role in the CNS response to hypercapnia, and that they may contribute to interactions between the sleep/wake cycle and respiratory control...
  4. ncbi request reprint Dynamic equilibrium of neurotransmitter transporters: not just for reuptake anymore
    George B Richerson
    Department of Neurology, Yale University School of Medicine, New Haven 06520, USA
    J Neurophysiol 90:1363-74. 2003
    ..We propose that the GABA transporter plays a dynamic role in control of brain excitability by modulating the level of tonic inhibition in response to neuronal activity...
  5. ncbi request reprint Homing in on the specific phenotype(s) of central respiratory chemoreceptors
    G B Richerson
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Exp Physiol 90:259-66; discussion 266-9. 2005
    ..Future work will need to focus on which of the candidates are indeed chemoreceptors, what percentage of the overall response each one contributes, and how this percentage varies under different conditions...
  6. doi request reprint Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons
    Matthew R Hodges
    Department of Neurology, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 28:2495-505. 2008
    ..We conclude that the proper function of the 5-HT system is particularly important under conditions of environmental stress and contributes significantly to the hypercapnic ventilatory response and thermoregulatory cold defense...
  7. pmc Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1
    Yuanming Wu
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 56:851-65. 2007
    ..We conclude that GAT-1 regulates tonic inhibition by clamping ambient [GABA] at a level high enough to activate high-affinity GABA(A) receptors and that transporter-mediated GABA release can contribute to phasic inhibition...
  8. ncbi request reprint Changes in glucose do not alter baseline firing rate or chemosensitivity of serotonin neurons cultured from the medullary raphé
    Wengang Wang
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    Respir Physiol Neurobiol 157:235-41. 2007
    ..Although it is possible that these results were influenced by the use of tissue culture, they do not provide support for intrinsic glucose sensitivity of pH-sensitive serotonin neurons of the medullary raphé...
  9. ncbi request reprint The transmembrane sodium gradient influences ambient GABA concentration by altering the equilibrium of GABA transporters
    Yuanming Wu
    Department of Neurology, LCI 712B, Yale University School of Medicine, 15 York St, PO 208018, New Haven, CT 06520 8018, USA
    J Neurophysiol 96:2425-36. 2006
    ..The source of GABA release may be conceptually less important in determining the amount of tonic inhibition than the factors that control the equilibrium of GABA transporters...
  10. ncbi request reprint Mechanism of increased open probability by a mutation of the BK channel
    Ana Diez-Sampedro
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520 8018, USA
    J Neurophysiol 96:1507-16. 2006
    ..The resulting enhancement of BK channel function leads to an increase in brain excitability, possibly due to more rapid repolarization of action potentials...
  11. pmc GFP-expressing locus ceruleus neurons from Prp57 transgenic mice exhibit CO2/H+ responses in primary cell culture
    Sheree M Johnson
    Department of Physiology and Biophysics, Howard University College of Medicine, 520 W Street Northwest, Washington, DC 20059, USA
    J Appl Physiol 105:1301-11. 2008
    ..Prp57 transgenic mice will serve as a valuable model to delineate mechanisms involved in CO(2)/H(+) responsiveness in catecholaminergic neurons...
  12. pmc Effect of extracellular acid-base disturbances on the intracellular pH of neurones cultured from rat medullary raphe or hippocampus
    Patrice Bouyer
    Department of Cellular and Molecular Physiology, SHM B 133, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Physiol 559:85-101. 2004
    ..Moreover, regardless of whether neurones were cultured from the chemosensitive or the non-chemosensitive region, pH(i) did not recover during any of the acid-base stresses...
  13. ncbi request reprint Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis
    George B Richerson
    Department of Neurology, Yale University School of Medicine, New Haven, and the Veteran s Affairs Medical Center, West Haven, Connecticut, USA
    Nat Rev Neurosci 5:449-61. 2004
  14. ncbi request reprint Vigabatrin induces tonic inhibition via GABA transporter reversal without increasing vesicular GABA release
    Yuanming Wu
    Departments of Neurology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurophysiol 89:2021-34. 2003
    ..We propose that fast GABAergic neurotransmission and tonic inhibition can be independently modified and play complementary roles in control of neuronal excitability...
  15. pmc Quantification of the response of rat medullary raphe neurones to independent changes in pH(o) and P(CO2)
    Wengang Wang
    Departments of Neurology and Cellular and Molecular Physiology, Yale University, New Haven, CT 06510, USA
    J Physiol 540:951-70. 2002
    ..The results suggest that a change in intracellular pH (pH(i)) may be the primary stimulus for chemosensitivity in these putative central respiratory chemoreceptor neurones...
  16. ncbi request reprint Calcium-sensitive potassium channelopathy in human epilepsy and paroxysmal movement disorder
    Wei Du
    Center for Molecular Genetics, Department of Molecular Cardiology, Lerner Research Institute, Cleveland, Ohio 44115, USA
    Nat Genet 37:733-8. 2005
    ....
  17. ncbi request reprint Learning to take a deep breath--with BDNF
    George B Richerson
    Nat Med 10:25-6. 2004
  18. ncbi request reprint Role of the GABA transporter in epilepsy
    George B Richerson
    Department of Neurology, Yale University, Veterans Affairs Medical Center, New Haven, Connecticut, USA
    Adv Exp Med Biol 548:76-91. 2004
    ..Further defining this role may lead to a better understanding of the mechanisms of epilepsy and new avenues for treatment...

Research Grants20

  1. Nonvesicular GABA release via GABA transporter reversal
    George Richerson; Fiscal Year: 2005
    ..A complete description of GABA transporter function should help define the pathophysiology of epilepsy, and lead to a better understanding of how and when the new anticonvulsants should be used. ..
  2. MECHANISMS AND LOCALIZATION OF CO2 SENSITIVE CNS NEURONS
    George Richerson; Fiscal Year: 2005
    ..Understanding the basic mechanisms involved in modulation of neuronal activity by CO2, and the mechanisms by which breathing is affected by sleep, may help provide successful treatment for these diseases. ..
  3. Developmental defects in serotonin neurons and the response to O2 and CO2
    George Richerson; Fiscal Year: 2007
    ..This may provide a specific neurobiological mechanism for the association between SIDS and defects in the serotonin system. ..
  4. Non-vesicular GABA release via GABA transporter reversal
    George Richerson; Fiscal Year: 2009
    ..The anticipated results may lead to new treatments for neurological disease aimed at enhancing nonvesicular GABA release and targeting the newly discovered form of tonic inhibition. ..
  5. MECHANISMS AND LOCALIZATION OF CO2 SENSITIVE CNS NEURONS
    George Richerson; Fiscal Year: 2001
    ..Disturbances of breathing are common in human diseases. Understanding the basic mechanisms involved in modulation of neuronal activity by CO2 and pH may help provide successful treatment for these diseases. ..
  6. Developmental defects in serotonin neurons and the response to O2 and CO2
    George Richerson; Fiscal Year: 2009
    ..This may provide a specific neurobiological mechanism for the association between SIDS and defects in the serotonin system. ..