VALERIE J REINKE

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB)
    Woo Chi
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Development 133:3147-57. 2006
  2. pmc Expression profiling of MAP kinase-mediated meiotic progression in Caenorhabditis elegans
    Stefanie W Leacock
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Genet 2:e174. 2006
  3. pmc Comparison and calibration of transcriptome data from RNA-Seq and tiling arrays
    Ashish Agarwal
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    BMC Genomics 11:383. 2010
  4. ncbi request reprint Developmental genomic approaches in model organisms
    Valerie Reinke
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Genomics Hum Genet 3:153-78. 2002
  5. pmc Germline expression influences operon organization in the Caenorhabditis elegans genome
    Valerie Reinke
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Genetics 181:1219-28. 2009
  6. doi request reprint Gene regulation: a tale of germline mRNA tails
    Valerie Reinke
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Curr Biol 18:R915-6. 2008
  7. ncbi request reprint Genome-wide germline-enriched and sex-biased expression profiles in Caenorhabditis elegans
    Valerie Reinke
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Development 131:311-23. 2004
  8. ncbi request reprint Functional exploration of the C. elegans genome using DNA microarrays
    Valerie Reinke
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Genet 32:541-6. 2002
  9. ncbi request reprint Genome-wide analysis of sex-enriched gene expression during C. elegans larval development
    Kara Thoemke
    Department of Genetics, Cell Biology, and Development, and Developmental Biology Center, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 284:500-8. 2005
  10. pmc DPL-1 (DP) acts in the germ line to coordinate ovulation and fertilization in C. elegans
    Woo Chi
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
    Mech Dev 126:406-16. 2009

Research Grants

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Promotion of oogenesis and embryogenesis in the C. elegans gonad by EFL-1/DPL-1 (E2F) does not require LIN-35 (pRB)
    Woo Chi
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Development 133:3147-57. 2006
    ..Thus, in vivo, C. elegans E2F directly promotes oogenesis and embryogenesis through the activation of a tissue-specific transcriptional program that does not require LIN-35...
  2. pmc Expression profiling of MAP kinase-mediated meiotic progression in Caenorhabditis elegans
    Stefanie W Leacock
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Genet 2:e174. 2006
    ..This study highlights the utility of applying global gene expression methods to investigate genes downstream of commonly used signaling pathways in vivo...
  3. pmc Comparison and calibration of transcriptome data from RNA-Seq and tiling arrays
    Ashish Agarwal
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    BMC Genomics 11:383. 2010
    ..Understanding the relative merits of these technologies will help researchers select the appropriate technology for their needs...
  4. ncbi request reprint Developmental genomic approaches in model organisms
    Valerie Reinke
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Annu Rev Genomics Hum Genet 3:153-78. 2002
    ....
  5. pmc Germline expression influences operon organization in the Caenorhabditis elegans genome
    Valerie Reinke
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Genetics 181:1219-28. 2009
    ..These analyses demonstrate that mechanisms governing germline gene expression influence operon origination and/or maintenance. Thus, gene expression in a specific tissue can have profound effects on the evolution of genome organization...
  6. doi request reprint Gene regulation: a tale of germline mRNA tails
    Valerie Reinke
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Curr Biol 18:R915-6. 2008
    ..In Caenorhabditis elegans, the spatial and temporal expression of germline genes is controlled post-transcriptionally via the 3' UTR rather than transcriptionally via the promoter...
  7. ncbi request reprint Genome-wide germline-enriched and sex-biased expression profiles in Caenorhabditis elegans
    Valerie Reinke
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Development 131:311-23. 2004
    ..Comparison with data from large-scale RNAi screens demonstrates that genes expressed in the oogenic germline display visible phenotypes more frequently than expected...
  8. ncbi request reprint Functional exploration of the C. elegans genome using DNA microarrays
    Valerie Reinke
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Genet 32:541-6. 2002
    ..elegans development...
  9. ncbi request reprint Genome-wide analysis of sex-enriched gene expression during C. elegans larval development
    Kara Thoemke
    Department of Genetics, Cell Biology, and Development, and Developmental Biology Center, University of Minnesota, Minneapolis, MN 55455, USA
    Dev Biol 284:500-8. 2005
    ..These results suggest that TRA-1 controls sexual dimorphism through a small number of intermediary regulators rather than by acting directly on the full constellation of genes involved in sex-specific differentiation...
  10. pmc DPL-1 (DP) acts in the germ line to coordinate ovulation and fertilization in C. elegans
    Woo Chi
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
    Mech Dev 126:406-16. 2009
    ..We propose that DPL-1 acts with EFL-1 in developing oocytes to directly regulate a transcriptional program that couples the critical events of ovulation and fertilization...
  11. pmc Genome-wide analysis of germ cell proliferation in C.elegans identifies VRK-1 as a key regulator of CEP-1/p53
    Katherine Waters
    Yale University School of Medicine, New Haven, CT 06520, USA
    Dev Biol 344:1011-25. 2010
    ..This finding reveals a previously unsuspected mechanism for negative regulation of p53 activity in germ cells to control proliferation...
  12. pmc MEG-1 and MEG-2 are embryo-specific P-granule components required for germline development in Caenorhabditis elegans
    Stefanie W Leacock
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Genetics 178:295-306. 2008
    ....
  13. pmc A C. elegans Piwi, PRG-1, regulates 21U-RNAs during spermatogenesis
    Guilin Wang
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
    Curr Biol 18:861-7. 2008
    ..C. elegans contains a large set of Argonaute/Piwi-related proteins, including two closely related to piwi called prg-1 and prg-2. The function of prg-1 and prg-2 and whether piRNAs exist in C. elegans is unknown...
  14. pmc The candidate MAP kinase phosphorylation substrate DPL-1 (DP) promotes expression of the MAP kinase phosphatase LIP-1 in C. elegans germ cells
    Baiqing Lin
    Department of Genetics, School of Medicine, Yale University, New Haven, CT 06520, USA
    Dev Biol 316:50-61. 2008
    ..elegans germ cell development. These two highly conserved pathways with major regulatory roles in proliferation and differentiation likely have multiple mechanisms for cross-talk during development across many species...
  15. pmc C. elegans nucleostemin is required for larval growth and germline stem cell division
    Michelle M Kudron
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Genet 4:e1000181. 2008
    ..Our data support a role for C. elegans nucleostemin in cell growth and proliferation by promoting ribosome biogenesis...

Research Grants5

  1. MAP kinase signal specificity in the C. elegans germline
    Valerie Reinke; Fiscal Year: 2007
    ..Together these experiments should build toward a comprehensive understanding of the mechanisms used to produce a specific cell fate in response to a generally used signaling pathway. ..