DONALD EUGENE REDMOND
Affiliation: Yale University
- Determination of fetal age by ultrasonography in St. Kitts green monkeysD Eugene Redmond
St Kitts Biomedical Research Foundation, St Kitts, West Indies
Am J Primatol 74:433-41. 2012..These data will improve the estimates of fetal ages in previously published studies of St. Kitts green monkeys and provide more precise estimates of fetal age in studies of fetal development, genomics, and reproductive toxicology...
- Cellular repair in the parkinsonian nonhuman primate brainDONALD EUGENE REDMOND
Department of Psychiatry and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06511, USA
Rejuvenation Res 13:188-94. 2010..Studies to determine the optimum stage of differentiation from embryonic stem cells and to derive useful cells from somatic cell sources are in progress...
- Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNFD E Redmond
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Comp Neurol 515:31-40. 2009....
- Spatiotemporal patterns of gene expression during fetal monkey brain developmentD Eugene Redmond
Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Brain Res Dev Brain Res 146:99-106. 2003..These results may lead to new understanding of brain development and new strategies for treating and repairing disorders of brain function...
- Cellular replacement therapy for Parkinson's disease--where we are today?D Eugene Redmond
Department of Psychiatry, Yale University School of Medicine, USA
Neuroscientist 8:457-88. 2002..New sources of replacement cells and stem cells may provide additional advantages for the future. Full recovery from parkinsonism appears not only to be possible, but a reliable cell replacement treatment may finally be near...
- Development of A9/A10 dopamine neurons during the second and third trimesters in the African green monkeyBret A Morrow
Neuropsychopharmacology Research Unit, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CN 06511, USA
J Comp Neurol 488:215-23. 2005..These data have relevance to transplantation studies that employ fetal dopaminergic grafts, and to disorders hypothesized to result from damage to developing midbrain dopamine neurons...
- Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestationBret A Morrow
Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
Exp Neurol 204:802-7. 2007..Thus, marked apoptotic NCD occurs in the primate midbrain dopamine system half-way through gestation, and appears to be associated with the rapid developmental increase in striatal dopamine innervation...
- Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidineJohn D Elsworth
Neuropsychopharmacology Research Unit, Departments of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
Neuropsychopharmacology 33:491-6. 2008..Thus, the present data support the hypothesis that the therapeutic effects of clozapine in this primate model and perhaps in schizophrenia may be related at least in part to the restoration of DA tone in the prefrontal cortex...
- Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's diseaseTamas L Horvath
Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
Endocrinology 144:2757-60. 2003..Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys...
- Gonadal hormones are responsible for maintaining the integrity of spine synapses in the CA1 hippocampal subfield of female nonhuman primatesCsaba Leranth
Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, Connecticut 06520 8063, USA
J Comp Neurol 447:34-42. 2002..Because the hippocampus is involved in specific mnemonic functions, this observation highlights the importance of hormone replacement therapy in postmenopausal conditions...
- Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cellsD Eugene Redmond
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 104:12175-80. 2007..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD...
- Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measuresKimberly B Bjugstad
Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
Cell Transplant 14:183-92. 2005..We conclude that after MPTP treatment in the primate, hNSC prevent the MPTP-induced upregulation of TH+ cells in the caudate and putamen, indicating that hNSC may be beneficial to maintaining a normal striatal environment...
- Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brainEleni A Markakis
Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06511, USA
Mol Ther 18:588-93. 2010..These results suggest that AAV5 is a more effective vector than AAV2 at delivering potentially therapeutic transgenes to the nigrostriatal system of the primate brain...
- Know thyself: autologous cell transplantation strategies for brain repairEleni A Markakis
Department of Psychiatry, Yale University School of Medicine, 300 George Street Suite 8107, New Haven, CT 06510, USA
Exp Neurol 196:6-8. 2005
- Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's diseaseKimberly B Bjugstad
Department of Pediatrics, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80045, USA
Exp Neurol 211:362-9. 2008..The property of neural stem cells to align themselves along a neural pathway rendered dysfunctional by a given disease is potentially a valuable clinical tool...
- Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's diseaseTimothy J Collier
Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
J Comp Neurol 442:320-30. 2002..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease...
- Safety of direct administration of AAV2(CU)hCLN2, a candidate treatment for the central nervous system manifestations of late infantile neuronal ceroid lipofuscinosis, to the brain of rats and nonhuman primatesNeil R Hackett
Belfer Gene Therapy Core Facility, Weill Medical College of Cornell University, New York, NY 10021, USA
Hum Gene Ther 16:1484-503. 2005..Together with the long-term gene expression after gene transfer, these findings supported the initiation of clinical trials to assess the safety of AAV2(CU)hCLN2 administration to individuals with LINCL...
- HUMAN NEURAL STEM CELLS IN PRIMATE PARKINSON'S MODELDONALD REDMOND; Fiscal Year: 2004..The results will also advance understanding of useful methods for studying and treating a broad range of neurodegenerative, genetic, and traumatic conditions of the nervous system. ..
- Improving neural graft function in parkinsonian monkeys.DONALD REDMOND; Fiscal Year: 2007..abstract_text> ..
- GDNF Delivery to MPTP Monkeys by EIAV lentivirus and AAVDONALD REDMOND; Fiscal Year: 2008..These studies aim to provide the necessary data to initiate successful clinical trials in Parkinson's patients at the earliest possible time. ..