DONALD EUGENE REDMOND

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Determination of fetal age by ultrasonography in St. Kitts green monkeys
    D Eugene Redmond
    St Kitts Biomedical Research Foundation, St Kitts, West Indies
    Am J Primatol 74:433-41. 2012
  2. ncbi Cellular repair in the parkinsonian nonhuman primate brain
    DONALD EUGENE REDMOND
    Department of Psychiatry and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Rejuvenation Res 13:188-94. 2010
  3. ncbi Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF
    D E Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 515:31-40. 2009
  4. ncbi Spatiotemporal patterns of gene expression during fetal monkey brain development
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Brain Res Dev Brain Res 146:99-106. 2003
  5. ncbi Cellular replacement therapy for Parkinson's disease--where we are today?
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, USA
    Neuroscientist 8:457-88. 2002
  6. ncbi Development of A9/A10 dopamine neurons during the second and third trimesters in the African green monkey
    Bret A Morrow
    Neuropsychopharmacology Research Unit, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CN 06511, USA
    J Comp Neurol 488:215-23. 2005
  7. ncbi Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestation
    Bret A Morrow
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
    Exp Neurol 204:802-7. 2007
  8. ncbi Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine
    John D Elsworth
    Neuropsychopharmacology Research Unit, Departments of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 33:491-6. 2008
  9. ncbi Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease
    Tamas L Horvath
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Endocrinology 144:2757-60. 2003
  10. ncbi Gonadal hormones are responsible for maintaining the integrity of spine synapses in the CA1 hippocampal subfield of female nonhuman primates
    Csaba Leranth
    Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Comp Neurol 447:34-42. 2002

Research Grants

  1. HUMAN NEURAL STEM CELLS IN PRIMATE PARKINSON'S MODEL
    DONALD REDMOND; Fiscal Year: 2004
  2. GDNF Delivery to MPTP Monkeys by EIAV lentivirus and AAV
    DONALD REDMOND; Fiscal Year: 2007
  3. Improving neural graft function in parkinsonian monkeys.
    DONALD REDMOND; Fiscal Year: 2007

Detail Information

Publications17

  1. ncbi Determination of fetal age by ultrasonography in St. Kitts green monkeys
    D Eugene Redmond
    St Kitts Biomedical Research Foundation, St Kitts, West Indies
    Am J Primatol 74:433-41. 2012
    ..These data will improve the estimates of fetal ages in previously published studies of St. Kitts green monkeys and provide more precise estimates of fetal age in studies of fetal development, genomics, and reproductive toxicology...
  2. ncbi Cellular repair in the parkinsonian nonhuman primate brain
    DONALD EUGENE REDMOND
    Department of Psychiatry and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Rejuvenation Res 13:188-94. 2010
    ..Studies to determine the optimum stage of differentiation from embryonic stem cells and to derive useful cells from somatic cell sources are in progress...
  3. ncbi Embryonic substantia nigra grafts in the mesencephalon send neurites to the host striatum in non-human primate after overexpression of GDNF
    D E Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Comp Neurol 515:31-40. 2009
    ....
  4. ncbi Spatiotemporal patterns of gene expression during fetal monkey brain development
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Brain Res Dev Brain Res 146:99-106. 2003
    ..These results may lead to new understanding of brain development and new strategies for treating and repairing disorders of brain function...
  5. ncbi Cellular replacement therapy for Parkinson's disease--where we are today?
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, USA
    Neuroscientist 8:457-88. 2002
    ..New sources of replacement cells and stem cells may provide additional advantages for the future. Full recovery from parkinsonism appears not only to be possible, but a reliable cell replacement treatment may finally be near...
  6. ncbi Development of A9/A10 dopamine neurons during the second and third trimesters in the African green monkey
    Bret A Morrow
    Neuropsychopharmacology Research Unit, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, New Haven, CN 06511, USA
    J Comp Neurol 488:215-23. 2005
    ..These data have relevance to transplantation studies that employ fetal dopaminergic grafts, and to disorders hypothesized to result from damage to developing midbrain dopamine neurons...
  7. ncbi Apoptotic natural cell death in developing primate dopamine midbrain neurons occurs during a restricted period in the second trimester of gestation
    Bret A Morrow
    Department of Psychiatry, Yale University School of Medicine, 300 George Street, New Haven, CT 06511, USA
    Exp Neurol 204:802-7. 2007
    ..Thus, marked apoptotic NCD occurs in the primate midbrain dopamine system half-way through gestation, and appears to be associated with the rapid developmental increase in striatal dopamine innervation...
  8. ncbi Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine
    John D Elsworth
    Neuropsychopharmacology Research Unit, Departments of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 33:491-6. 2008
    ..Thus, the present data support the hypothesis that the therapeutic effects of clozapine in this primate model and perhaps in schizophrenia may be related at least in part to the restoration of DA tone in the prefrontal cortex...
  9. ncbi Coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss in a primate model of Parkinson's disease
    Tamas L Horvath
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Endocrinology 144:2757-60. 2003
    ..Here we report that short-term oral administration of coenzyme Q induces nigral mitochondrial uncoupling and prevents dopamine cell loss after 1-methyl-4-phenyl-1,2,5,6 tetrahydropyridine administration in monkeys...
  10. ncbi Gonadal hormones are responsible for maintaining the integrity of spine synapses in the CA1 hippocampal subfield of female nonhuman primates
    Csaba Leranth
    Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Comp Neurol 447:34-42. 2002
    ..Because the hippocampus is involved in specific mnemonic functions, this observation highlights the importance of hormone replacement therapy in postmenopausal conditions...
  11. ncbi Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells
    D Eugene Redmond
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 104:12175-80. 2007
    ..We propose that multiple modes of reciprocal interaction between exogenous hNSCs and the pathological host milieu underlie the functional improvement observed in this model of PD...
  12. ncbi Neural stem cells implanted into MPTP-treated monkeys increase the size of endogenous tyrosine hydroxylase-positive cells found in the striatum: a return to control measures
    Kimberly B Bjugstad
    Department of Psychiatry, University of Colorado Health Sciences Center, Denver, CO, USA
    Cell Transplant 14:183-92. 2005
    ..We conclude that after MPTP treatment in the primate, hNSC prevent the MPTP-induced upregulation of TH+ cells in the caudate and putamen, indicating that hNSC may be beneficial to maintaining a normal striatal environment...
  13. ncbi Comparative transduction efficiency of AAV vector serotypes 1-6 in the substantia nigra and striatum of the primate brain
    Eleni A Markakis
    Section of Comparative Medicine, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Mol Ther 18:588-93. 2010
    ..These results suggest that AAV5 is a more effective vector than AAV2 at delivering potentially therapeutic transgenes to the nigrostriatal system of the primate brain...
  14. ncbi Know thyself: autologous cell transplantation strategies for brain repair
    Eleni A Markakis
    Department of Psychiatry, Yale University School of Medicine, 300 George Street Suite 8107, New Haven, CT 06510, USA
    Exp Neurol 196:6-8. 2005
  15. ncbi Human neural stem cells migrate along the nigrostriatal pathway in a primate model of Parkinson's disease
    Kimberly B Bjugstad
    Department of Pediatrics, Program in Neuroscience, University of Colorado Health Sciences Center, Denver, CO 80045, USA
    Exp Neurol 211:362-9. 2008
    ..The property of neural stem cells to align themselves along a neural pathway rendered dysfunctional by a given disease is potentially a valuable clinical tool...
  16. ncbi Embryonic ventral mesencephalic grafts to the substantia nigra of MPTP-treated monkeys: feasibility relevant to multiple-target grafting as a therapy for Parkinson's disease
    Timothy J Collier
    Department of Neurological Sciences, Research Center for Brain Repair, Rush Presbyterian St Luke s Medical Center, Chicago, Illinois 60612, USA
    J Comp Neurol 442:320-30. 2002
    ..These results encourage the further development of multiple-target grafting strategies as a means of restoring modulation of anatomically widespread basal ganglia structures relevant to treatment of Parkinson's disease...
  17. ncbi Safety of direct administration of AAV2(CU)hCLN2, a candidate treatment for the central nervous system manifestations of late infantile neuronal ceroid lipofuscinosis, to the brain of rats and nonhuman primates
    Neil R Hackett
    Belfer Gene Therapy Core Facility, Weill Medical College of Cornell University, New York, NY 10021, USA
    Hum Gene Ther 16:1484-503. 2005
    ..Together with the long-term gene expression after gene transfer, these findings supported the initiation of clinical trials to assess the safety of AAV2(CU)hCLN2 administration to individuals with LINCL...

Research Grants7

  1. HUMAN NEURAL STEM CELLS IN PRIMATE PARKINSON'S MODEL
    DONALD REDMOND; Fiscal Year: 2004
    ..The results will also advance understanding of useful methods for studying and treating a broad range of neurodegenerative, genetic, and traumatic conditions of the nervous system. ..
  2. GDNF Delivery to MPTP Monkeys by EIAV lentivirus and AAV
    DONALD REDMOND; Fiscal Year: 2007
    ..These studies aim to provide the necessary data to initiate successful clinical trials in Parkinson's patients at the earliest possible time. ..
  3. Improving neural graft function in parkinsonian monkeys.
    DONALD REDMOND; Fiscal Year: 2007
    ..abstract_text> ..