C A Redlich

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: genetic control of TH2-induced lung inflammation
    Christina A Herrick
    Departments of Dermatology, Immunobiology, and Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Allergy Clin Immunol 111:1087-94. 2003
  2. ncbi request reprint Human gamma/delta T-cell lines derived from airway biopsies
    A V Wisnewski
    Pulmonary and Critical Care Section, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Am J Respir Cell Mol Biol 24:332-8. 2001
  3. ncbi request reprint An FTIR investigation of isocyanate skin absorption using in vitro guinea pig skin
    Dhimiter Bello
    Harvard School of Public Health, Exposure, Epidemiology and Risk Program, Landmark Center, West 404F, 401 Park Drive, Boston, MA 02215, USA
    J Environ Monit 8:523-9. 2006
  4. pmc Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses
    Adam V Wisnewski
    Department of Internal Medicine Yale University School of Medicine 300 Cedar Street New Haven, CT 06510, USA
    J Occup Med Toxicol 6:6. 2011
  5. ncbi request reprint Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels
    C A Redlich
    Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cancer Epidemiol Biomarkers Prev 7:211-4. 1998
  6. ncbi request reprint Diisocyanate-exposed auto body shop workers: a one-year follow-up
    C A Redlich
    Yale Occupational and Environmental Medicine Program, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Ind Med 42:511-8. 2002
  7. ncbi request reprint Subclinical immunologic and physiologic responses in hexamethylene diisocyanate-exposed auto body shop workers
    C A Redlich
    Yale Occupational and Environmental Medicine Program, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Am J Ind Med 39:587-97. 2001
  8. doi request reprint Lung/skin connections in occupational lung disease
    Carrie A Redlich
    Occupational and Environmental Medicine and Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Allergy Clin Immunol 8:115-9. 2008
  9. pmc Skin exposure and asthma: is there a connection?
    Carrie A Redlich
    M P H, YOEMP, 135 College Street, 3rd Floor, New Haven, CT 06510, USA
    Proc Am Thorac Soc 7:134-7. 2010
  10. ncbi request reprint Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET)
    C A Redlich
    Yale University School of Medicine, Department of Medicine, New Haven, CT 06510, USA
    Atherosclerosis 145:425-32. 1999

Research Grants

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Differential roles for CD4 and CD8 T cells after diisocyanate sensitization: genetic control of TH2-induced lung inflammation
    Christina A Herrick
    Departments of Dermatology, Immunobiology, and Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    J Allergy Clin Immunol 111:1087-94. 2003
    ....
  2. ncbi request reprint Human gamma/delta T-cell lines derived from airway biopsies
    A V Wisnewski
    Pulmonary and Critical Care Section, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Am J Respir Cell Mol Biol 24:332-8. 2001
    ..The data suggest that gamma/delta T cells may be functionally enriched in human airways relative to peripheral blood...
  3. ncbi request reprint An FTIR investigation of isocyanate skin absorption using in vitro guinea pig skin
    Dhimiter Bello
    Harvard School of Public Health, Exposure, Epidemiology and Risk Program, Landmark Center, West 404F, 401 Park Drive, Boston, MA 02215, USA
    J Environ Monit 8:523-9. 2006
    ..The significance of these findings and their implications for dermal exposure sampling and isocyanate skin decontamination are discussed...
  4. pmc Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses
    Adam V Wisnewski
    Department of Internal Medicine Yale University School of Medicine 300 Cedar Street New Haven, CT 06510, USA
    J Occup Med Toxicol 6:6. 2011
    ..abstract:..
  5. ncbi request reprint Effect of supplementation with beta-carotene and vitamin A on lung nutrient levels
    C A Redlich
    Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Cancer Epidemiol Biomarkers Prev 7:211-4. 1998
    ....
  6. ncbi request reprint Diisocyanate-exposed auto body shop workers: a one-year follow-up
    C A Redlich
    Yale Occupational and Environmental Medicine Program, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Ind Med 42:511-8. 2002
    ..Auto body shops, a common hexamethylene diisocyanate (HDI) exposure setting, are difficult to study due to their small size and episodic exposures...
  7. ncbi request reprint Subclinical immunologic and physiologic responses in hexamethylene diisocyanate-exposed auto body shop workers
    C A Redlich
    Yale Occupational and Environmental Medicine Program, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Am J Ind Med 39:587-97. 2001
    ..Auto body shops, one of the most common hexamethylene diisocyanate (HDI) exposure settings, are particularly difficult to study due to their small size and episodic exposures. Surveillance studies of such workers are limited...
  8. doi request reprint Lung/skin connections in occupational lung disease
    Carrie A Redlich
    Occupational and Environmental Medicine and Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Curr Opin Allergy Clin Immunol 8:115-9. 2008
    ..Recent studies, however, suggest that the skin may also be an important route of exposure and site of sensitization. This article highlights key findings, focusing on isocyanate asthma and chronic beryllium disease...
  9. pmc Skin exposure and asthma: is there a connection?
    Carrie A Redlich
    M P H, YOEMP, 135 College Street, 3rd Floor, New Haven, CT 06510, USA
    Proc Am Thorac Soc 7:134-7. 2010
    ..Skin exposure methodologies are being developed to incorporate skin exposure assessment into epidemiology studies investigating asthma risk factors...
  10. ncbi request reprint Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET)
    C A Redlich
    Yale University School of Medicine, Department of Medicine, New Haven, CT 06510, USA
    Atherosclerosis 145:425-32. 1999
    ....
  11. ncbi request reprint Effect of long-term beta-carotene and vitamin A on serum cholesterol and triglyceride levels among participants in the Carotene and Retinol Efficacy Trial (CARET)
    C A Redlich
    Yale University School of Medicine, Department of Medicine, New Haven, CT 06510, USA
    Atherosclerosis 143:427-34. 1999
    ....
  12. ncbi request reprint Mouse models of diisocyanate asthma
    Carrie A Redlich
    Occupational Medical Program and Section of Pulmonary and Critical Care Medicine, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    Am J Respir Cell Mol Biol 27:385-90. 2002
  13. ncbi request reprint Identification of human lung and skin proteins conjugated with hexamethylene diisocyanate in vitro and in vivo
    A V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Respir Crit Care Med 162:2330-6. 2000
    ..The data from this study identify keratin and other proteins as potential "carriers" for diisocyanates in vivo, and suggest that HDI conjugation of these proteins may play a role in the pathogenesis of diisocyanate-induced asthma...
  14. ncbi request reprint Qualitative assessment of isocyanate skin exposure in auto body shops: a pilot study
    Y Liu
    Occupational and Environmental Medicine Program, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510 2283, USA
    Am J Ind Med 37:265-74. 2000
    ..This study provides initial data on hexamethylene diisocyanate skin exposure in three auto body shops...
  15. ncbi request reprint Changes in cholesterol and triglyceride concentrations in the Vanguard population of the Carotene and Retinol Efficacy Trial (CARET)
    B Cartmel
    Department of Epidemiology and Public Health and the Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA
    Eur J Clin Nutr 59:1173-80. 2005
    ..26 (95% confidence interval (CI) 0.99-1.61)) in the group assigned to a combination of 30 mg beta-carotene and 25 000 IU retinyl palmitate (vitamin A) daily. The basis for increased cardiovascular mortality is unexplained...
  16. ncbi request reprint Dietary vitamin A and prevalence of bronchial metaplasia in asbestos-exposed workers
    S T Mayne
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Am J Clin Nutr 68:630-5. 1998
    ..86; 95% CI: 1.09, 7.69). These results suggest that a higher (ie, above the median) intake of vitamin A from foods decreases the risk of bronchial metaplasia in workers occupationally exposed to asbestos...
  17. ncbi request reprint Skin exposure to aliphatic polyisocyanates in the auto body repair and refinishing industry: a qualitative assessment
    Youcheng Liu
    Occupational and Environmental Medicine Program, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Ann Occup Hyg 51:429-39. 2007
    ....
  18. ncbi request reprint Recent developments in diisocyanate asthma
    A V Wisnewski
    Occupational and Environmental Medicine Pulmonary and Critical Care Section, Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut 06520, USA
    Curr Opin Allergy Clin Immunol 1:169-75. 2001
    ..A better understanding of the pathogenesis of diisocyanate asthma should facilitate the development of better diagnostic tests and strategies for disease surveillance and intervention...
  19. pmc Human innate immune responses to hexamethylene diisocyanate (HDI) and HDI-albumin conjugates
    A V Wisnewski
    Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    Clin Exp Allergy 38:957-67. 2008
    ..Isocyanates, a leading cause of occupational asthma, are known to induce adaptive immune responses; however, innate immune responses, which generally precede and regulate adaptive immunity, remain largely uncharacterized...
  20. ncbi request reprint Glutathione protects human airway proteins and epithelial cells from isocyanates
    A V Wisnewski
    Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06510, USA
    Clin Exp Allergy 35:352-7. 2005
    ..However, the ability of GSH to modulate key chemical reactions, thought to be central to the development of human isocyanate allergy, has not been directly analyzed under biologic exposure conditions...
  21. pmc Antigenic changes in human albumin caused by reactivity with the occupational allergen diphenylmethane diisocyanate
    Adam V Wisnewski
    Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520, USA
    Anal Biochem 400:251-8. 2010
    ..The study also describes new applications of contemporary proteomic methodology for characterizing and standardizing MDI-albumin conjugates destined for use in clinical research...
  22. ncbi request reprint Isocyanate exposures in autobody shop work: the SPRAY study
    Judy Sparer
    Yale Occupational and Environmental Medicine Program, Yale School of Medicine, New Haven, CT 06510, USA
    J Occup Environ Hyg 1:570-81. 2004
    ..Despite improvements in autobody shop materials, practices, and controls, there are still opportunities for substantial exposures to isocyanates...
  23. ncbi request reprint Respiratory protection from isocyanate exposure in the autobody repair and refinishing industry
    Youcheng Liu
    Occupational and Environmental Medicine Program, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Occup Environ Hyg 3:234-49. 2006
    ....
  24. pmc Effects of hexamethylene diisocyanate exposure on human airway epithelial cells: in vitro cellular and molecular studies
    Adam V Wisnewski
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Environ Health Perspect 110:901-7. 2002
    ..Together, the data describe a novel approach for investigating the effects of HDI binding and uptake by human airway epithelial cells and begin to identify genes that may be involved in the acute response to exposure...
  25. ncbi request reprint Short-term outcomes in older intensive care unit patients with dementia
    Margaret A Pisani
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8057, USA
    Crit Care Med 33:1371-6. 2005
    ..To determine the impact of dementia on the outcomes of intensive care unit (ICU) care and use of ICU interventions among older patients...
  26. ncbi request reprint Predictors of lung cancer among asbestos-exposed men in the {beta}-carotene and retinol efficacy trial
    Mark R Cullen
    Occupational and Environmental Medicine Program and the Cancer Center, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Epidemiol 161:260-70. 2005
    ..Residual confounding by subclinical asbestosis, exposure to unmeasured lung carcinogens, or differences in smoking are unlikely to explain these observations better than a carcinogenic effect of asbestos per se...
  27. ncbi request reprint Urinary hexane diamine to assess respiratory exposure to hexamethylene diisocyanate aerosol: a human inhalation study
    Youcheng Liu
    Occupational and Environmental Medicine Program, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510 2283, USA
    Int J Occup Environ Health 10:262-71. 2004
    ..1, respectively, at 4, 9, and 18 hours post exposure. Considerable individual variability was found. Urinary HDA can assess acute respiratory exposure to HDI aerosol, but may have limited use as a biomarker of exposure in the workplace...
  28. ncbi request reprint Isocyanate vapor-induced antigenicity of human albumin
    Adam V Wisnewski
    Department of Internal Medicine, Yale School of Medicine, 333 Cedar Street, LCI 105, New Haven, CT 06520, USA
    J Allergy Clin Immunol 113:1178-84. 2004
    ..The bioreactivity of isocyanate, a leading cause of occupational asthma, has led to uncertainty regarding the chemical's antigenicity and mechanisms that elicit immunopathology...
  29. ncbi request reprint Screening for preexisting cognitive impairment in older intensive care unit patients: use of proxy assessment
    Margaret A Pisani
    Department of Internal Medicine, Yale University School ofMedicine, New Haven, Connecticut 06520, USA
    J Am Geriatr Soc 51:689-93. 2003
    ..To determine the prevalence of preexisting cognitive impairment (CI) in patients admitted to the medical intensive care unit (ICU) and compare two different proxy measures of preexisting CI in ICU patients...
  30. pmc Surveillance for isocyanate asthma: a model based cost effectiveness analysis
    D M Wild
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Occup Environ Med 62:743-9. 2005
    ....
  31. pmc Serum hepatic biochemical activity in two populations of workers exposed to styrene
    C A Brodkin
    Department of Medicine, University of Washington, Seattle, WA, USA
    Occup Environ Med 58:95-102. 2001
    ....
  32. ncbi request reprint A novel mouse model of diisocyanate-induced asthma showing allergic-type inflammation in the lung after inhaled antigen challenge
    Christina A Herrick
    Departments of Dermatology, Immunobiology, and Internal Medicine, Yale University School of Medicine, New Haven, Conn 06520 8059, USA
    J Allergy Clin Immunol 109:873-8. 2002
    ..In contrast to mouse models of atopic asthma, previous mouse models of diisocyanate-induced asthma have failed to show lung inflammation with characteristics of human disease...
  33. ncbi request reprint Evidence for excess colorectal cancer incidence among asbestos-exposed men in the Beta-Carotene and Retinol Efficacy Trial
    Oluremi A Aliyu
    Cancer Center, Yale University School of Medicine, New Haven, CT, USA
    Am J Epidemiol 162:868-78. 2005
    ..Nonetheless, these data suggest that colorectal cancer risk is elevated among men occupationally exposed to asbestos, especially those with evidence of nonmalignant asbestos-associated radiographic changes...
  34. ncbi request reprint Human gamma/delta T-cell proliferation and IFN-gamma production induced by hexamethylene diisocyanate
    Adam V Wisnewski
    Department of Internal Medicine, Immunobiology and Dermatology, Yale School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Allergy Clin Immunol 112:538-46. 2003
    ..The human immune response to isocyanate, a leading cause of occupational asthma, remains incompletely characterized, including the cell types involved and the form of the chemical that acts as an antigen...
  35. ncbi request reprint Diisocyanate asthma: clinical aspects and immunopathogenesis
    Carrie A Redlich
    Occupational and Environmental Medicine Program, Yale University, New Haven, CT, USA
    Int Immunopharmacol 2:213-24. 2002
    ..It is anticipated that greater understanding of the immunopathogenesis of diisocyanate asthma, including the initial cell/diisocyanate reactions, should lead to clinically useful markers of exposure and early disease...
  36. pmc Priorities for development of research methods in occupational cancer
    Elizabeth M Ward
    National Institute for Occupational Safety and Health, Cincinnati, Ohio 45226, USA
    Environ Health Perspect 111:1-12. 2003
    ..Progress in occupational cancer will require interdisciplinary research involving epidemiologists, industrial hygienists, toxicologists, and molecular biologists...
  37. doi request reprint Comparison of task-based exposure metrics for an epidemiologic study of isocyanate inhalation exposures among autobody shop workers
    Susan R Woskie
    Department of Work Environment, University of Massachusetts at Lowell, Lowell, Massachusetts 01854, USA susan
    J Occup Environ Hyg 5:588-98. 2008
    ..K. Health and Safety Executive occupational exposure limit (OEL) for total NCO of 20 microg/m(3). When respirator use was incorporated, all personal daily exposures were below the U.K. OEL...
  38. doi request reprint Skin exposure to aliphatic polyisocyanates in the auto body repair and refinishing industry: II. A quantitative assessment
    Dhimiter Bello
    Department of Work Environment, School of Health and Environment, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USA
    Ann Occup Hyg 52:117-24. 2008
    ..Skin exposure to isocyanates, in addition to respiratory exposures, may contribute to sensitization and asthma. Quantitative skin exposure data are scarce and quantitative methods limited...
  39. pmc Cost-effectiveness of various diagnostic approaches for occupational asthma
    Wendy A Kennedy
    Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada
    Can Respir J 14:276-80. 2007
    ..Diagnosis of occupational asthma (OA) by specific inhalation challenge (SIC) can be costly and is not always available. The use of sputum testing to avoid this in some patients may be a more cost-effective alternative...
  40. ncbi request reprint Slow curing of aliphatic polyisocyanate paints in automotive refinishing: a potential source for skin exposure
    Dhimiter Bello
    Department of Work Environment, University of Massachusetts Lowell, Lowell, Massachusetts 01854, USA
    J Occup Environ Hyg 4:406-11. 2007
    ..Unbound isocyanates may remain on the surface of painted car parts for prolonged periods (days to weeks) after dried. Such surfaces are an under-recognized potential source of skin exposure to autobody workers...
  41. pmc Skin exposure to isocyanates: reasons for concern
    Dhimiter Bello
    Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Boston, Massachusetts 01854, USA
    Environ Health Perspect 115:328-35. 2007
    ..In this review we evaluate the potential role of skin exposure in the development of isocyanate asthma...
  42. ncbi request reprint Biophysical determinants of toluene diisocyanate antigenicity associated with exposure and asthma
    Young Min Ye
    Department of Allergy and Rheumatology, Ajou University School of Medicine, Suwon, Korea
    J Allergy Clin Immunol 118:885-91. 2006
    ..Structural elucidation of TDI-albumin conjugates is crucial to understanding the human immune response to TDI exposure...
  43. ncbi request reprint Truncating the dose range for methacholine challenge tests: three occupational studies
    Ilir Agalliu
    Department of Work Environment, University of Massachusetts, Lowell, MA 01854, USA
    J Occup Environ Med 45:841-7. 2003
    ..Furthermore, to ensure validity, neither slope nor PC(20) should be extrapolated beyond data...
  44. ncbi request reprint Polyisocyanates in occupational environments: a critical review of exposure limits and metrics
    Dhimiter Bello
    University of Massachusetts Lowell, Work Environment Department, KI 200, One University Avenue, Lowell, MA 01854, USA
    Am J Ind Med 46:480-91. 2004
    ..However, with multiple different measurement metrics in use, comparison of isocyanate exposure data between studies and development of occupational exposure limits (OELs) for polyisocyanates is difficult...
  45. doi request reprint Chronic beryllium disease: risk from low-level exposure
    Carrie A Redlich
    Am J Respir Crit Care Med 177:936-7. 2008
  46. doi request reprint Diagnosis and management of work-related asthma: American College Of Chest Physicians Consensus Statement
    Susan M Tarlo
    Toronto Western Hospital EW7 449, 399 Bathurst St, Toronto, ON, Canada M5T 2S8
    Chest 134:1S-41S. 2008
    ..The current Consensus Statement updates the previous one based on additional research that has been published since then, including findings relevant to preventive measures and work-exacerbated asthma (WEA)...
  47. ncbi request reprint A laboratory investigation of the effectiveness of various skin and surface decontaminants for aliphatic polyisocyanates
    Dhimiter Bello
    University of Massachusetts Lowell, Work Environment Department, KI 200, One University Ave, Lowell, MA 01854, USA
    J Environ Monit 7:716-21. 2005
    ..In vitro testing using animal skins and in vivo testing with field workers are being conducted to further assess the efficiency and identify related determinants...

Research Grants7

  1. HEALTH AND SOCIOECONOMIC CONSEQUENCES OF NSBRI
    Carrie Redlich; Fiscal Year: 2001
    ..This information is critical for the development of interventions to prevent and/or ameliorate the adverse consequences of NSBRI. ..
  2. HEALTH AND SOCIOECONOMIC CONSEQUENCES OF NSBRI
    Carrie Redlich; Fiscal Year: 2002
    ..This information is critical for the development of interventions to prevent and/or ameliorate the adverse consequences of NSBRI. ..
  3. HEALTH AND SOCIOECONOMIC CONSEQUENCES OF NSBRI
    Carrie Redlich; Fiscal Year: 2003
    ..This information is critical for the development of interventions to prevent and/or ameliorate the adverse consequences of NSBRI. ..
  4. Program for Patient-Oriented Environment Health Research and Training
    Carrie Redlich; Fiscal Year: 2007
    ..Importantly, this new project will also serve to advance Dr. Redlich's research skills in new areas and provide a unique opportunity to mentor junior. ..
  5. Isocyanate Skin and Air Exposure: Assessment and Control
    Carrie Redlich; Fiscal Year: 2009
    ..The findings should be relevant to the millions of workers who produce and use polyurethane products. ..
  6. Isocyanate Skin and Air Exposure: Assessment and Control
    Carrie A Redlich; Fiscal Year: 2010
    ..The findings should be relevant to the millions of workers who produce and use polyurethane products. ..