Seth Rakoff-Nahoum

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    Seth Rakoff-Nahoum
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 118:229-41. 2004
  2. ncbi Why cancer and inflammation?
    Seth Rakoff-Nahoum
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Yale J Biol Med 79:123-30. 2006
  3. ncbi Toll-like receptors and cancer
    Seth Rakoff-Nahoum
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Cancer 9:57-63. 2009
  4. ncbi Innate immune recognition of the indigenous microbial flora
    S Rakoff-Nahoum
    Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA
    Mucosal Immunol 1:S10-4. 2008
  5. ncbi Role of toll-like receptors in spontaneous commensal-dependent colitis
    Seth Rakoff-Nahoum
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Immunity 25:319-29. 2006
  6. ncbi Prostaglandin-secreting cells: a portable first aid kit for tissue repair
    Seth Rakoff Nahoum
    Howard Hughes Medical Institute HHMI and Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06405, USA
    J Clin Invest 117:83-6. 2007
  7. ncbi Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    Seth Rakoff-Nahoum
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 317:124-7. 2007

Collaborators

Detail Information

Publications7

  1. ncbi Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis
    Seth Rakoff-Nahoum
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell 118:229-41. 2004
    ..These findings reveal a novel function of TLRs-control of intestinal epithelial homeostasis and protection from injury-and provide a new perspective on the evolution of host-microbial interactions...
  2. ncbi Why cancer and inflammation?
    Seth Rakoff-Nahoum
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Yale J Biol Med 79:123-30. 2006
    ....
  3. ncbi Toll-like receptors and cancer
    Seth Rakoff-Nahoum
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Cancer 9:57-63. 2009
    ..The development of cancer has been associated with microbial infection, injury, inflammation and tissue repair. Here we discuss how the function of TLRs may relate to these processes in the context of carcinogenesis...
  4. ncbi Innate immune recognition of the indigenous microbial flora
    S Rakoff-Nahoum
    Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA
    Mucosal Immunol 1:S10-4. 2008
    ..In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of tissue injury and repair, spontaneous colitis, and postnatal development...
  5. ncbi Role of toll-like receptors in spontaneous commensal-dependent colitis
    Seth Rakoff-Nahoum
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Immunity 25:319-29. 2006
    ..In contrast, Il2(-/-) mice developed intestinal inflammation in the absence of TLR signaling pathways. These results demonstrate a differential role of innate immune recognition by TLRs in the development of commensal-dependent colitis...
  6. ncbi Prostaglandin-secreting cells: a portable first aid kit for tissue repair
    Seth Rakoff Nahoum
    Howard Hughes Medical Institute HHMI and Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06405, USA
    J Clin Invest 117:83-6. 2007
    ....
  7. ncbi Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88
    Seth Rakoff-Nahoum
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 317:124-7. 2007
    ..This study thus reveals the important role of an innate immune signaling pathway in intestinal tumorigenesis...