P Rakic

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Gap junctions/hemichannels modulate interkinetic nuclear migration in the forebrain precursors
    Xiuxin Liu
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 30:4197-209. 2010
  2. ncbi request reprint Serotonin modulates the response of embryonic thalamocortical axons to netrin-1
    Alexandre Bonnin
    Department of Pharmacology, Vanderbilt University, 465 21st Ave South, Nashville, Tennessee 37232, USA
    Nat Neurosci 10:588-97. 2007
  3. ncbi request reprint Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia
    Kevin A Burns
    Divisions of Developmental Biology and Pediatric Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Cereb Cortex 17:2585-92. 2007
  4. pmc MEKK4 signaling regulates filamin expression and neuronal migration
    Matthew R Sarkisian
    Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Neuron 52:789-801. 2006
  5. ncbi request reprint Internalization of D2 dopamine receptors is clathrin-dependent and select to dendro-axonic appositions in primate prefrontal cortex
    Constantinos D Paspalas
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Eur J Neurosci 24:1395-403. 2006
  6. pmc Microarray analysis of microRNA expression in the developing mammalian brain
    Eric A Miska
    Howard Hughes Medical Institute, Department of Biology and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Biol 5:R68. 2004
  7. ncbi request reprint Adult neurogenesis in mammals: an identity crisis
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 22:614-8. 2002
  8. ncbi request reprint Evolving concepts of cortical radial and areal specification
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, P O Box 208001, New Haven, CT 06520 8001, USA
    Prog Brain Res 136:265-80. 2002
  9. ncbi request reprint Neurogenesis in adult primates
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Prog Brain Res 138:3-14. 2002
  10. ncbi request reprint Elusive radial glial cells: historical and evolutionary perspective
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, SHM, C 303, New Haven, CT 06510, USA
    Glia 43:19-32. 2003

Research Grants

  1. PRENATAL DEVELOPMENT OF THE VISUAL SYSTEM
    Pasko Rakic; Fiscal Year: 1990
  2. Origin of Cortical Species-specific Distinctions
    Pasko Rakic; Fiscal Year: 2010
  3. PRENATAL DEVELOPMENT OF THE VISUAL SYSTEM
    Pasko Rakic; Fiscal Year: 2001
  4. STRESS ACTIVATED PROTEIN KINASE IN NEURONAL APOPTOSIS
    Pasko Rakic; Fiscal Year: 2003
  5. MICROARCHITECTURE OF COGNITION
    Pasko Rakic; Fiscal Year: 2004
  6. NEUROGENETIC PROCESSES IN THE FETAL BRAIN
    Pasko Rakic; Fiscal Year: 2010
  7. Origin of Cortical Species-specific Distinctions
    Pasko Rakic; Fiscal Year: 2009
  8. NEUROGENETIC PROCESSES IN THE FETAL BRAIN
    Pasko Rakic; Fiscal Year: 2004
  9. Notch Signaling in the Adult, Aging and Diseased Brain
    Pasko Rakic; Fiscal Year: 2005
  10. NEUROGENETIC PROCESSES IN THE FETAL BRAIN
    Pasko Rakic; Fiscal Year: 2003

Collaborators

Detail Information

Publications72

  1. pmc Gap junctions/hemichannels modulate interkinetic nuclear migration in the forebrain precursors
    Xiuxin Liu
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 30:4197-209. 2010
    ..Our findings indicate that functional interference with gap junctions/hemichannels during embryonic development may lead to abnormal corticogenesis and dysfunction of the cerebral cortex in adult organisms...
  2. ncbi request reprint Serotonin modulates the response of embryonic thalamocortical axons to netrin-1
    Alexandre Bonnin
    Department of Pharmacology, Vanderbilt University, 465 21st Ave South, Nashville, Tennessee 37232, USA
    Nat Neurosci 10:588-97. 2007
    ..These data demonstrate that serotonergic signaling has a previously unrecognized role in the modulation of axonal responsiveness to a classic guidance cue...
  3. ncbi request reprint Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia
    Kevin A Burns
    Divisions of Developmental Biology and Pediatric Neurology, Cincinnati Children s Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Cereb Cortex 17:2585-92. 2007
    ..These results suggest that the nestin-CreER system is a useful tool for detecting embryonic and adult neurogensis. They also confirm the existence of nonproliferative DNA synthesis by old neurons after experimental brain injury...
  4. pmc MEKK4 signaling regulates filamin expression and neuronal migration
    Matthew R Sarkisian
    Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Neuron 52:789-801. 2006
    ..Collectively, our results demonstrate a link between MEKK4 and Fln-A that impacts neuronal migration initiation and provides insight into the pathogenesis of human PVH...
  5. ncbi request reprint Internalization of D2 dopamine receptors is clathrin-dependent and select to dendro-axonic appositions in primate prefrontal cortex
    Constantinos D Paspalas
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Eur J Neurosci 24:1395-403. 2006
    ....
  6. pmc Microarray analysis of microRNA expression in the developing mammalian brain
    Eric A Miska
    Howard Hughes Medical Institute, Department of Biology and McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genome Biol 5:R68. 2004
    ..In invertebrates microRNAs have been implicated as regulators of developmental timing, neuronal differentiation, cell proliferation, programmed cell death and fat metabolism. Little is known about the roles of microRNAs in mammals...
  7. ncbi request reprint Adult neurogenesis in mammals: an identity crisis
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 22:614-8. 2002
  8. ncbi request reprint Evolving concepts of cortical radial and areal specification
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, P O Box 208001, New Haven, CT 06520 8001, USA
    Prog Brain Res 136:265-80. 2002
    ....
  9. ncbi request reprint Neurogenesis in adult primates
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Prog Brain Res 138:3-14. 2002
  10. ncbi request reprint Elusive radial glial cells: historical and evolutionary perspective
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, SHM, C 303, New Haven, CT 06510, USA
    Glia 43:19-32. 2003
    ..The multiple functions of radial glial cells and their species-specific adaptations indicate a pivotal role in evolution, development, and pathology of the cerebral neocortex...
  11. pmc Confusing cortical columns
    Pasko Rakic
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 105:12099-100. 2008
  12. pmc The radial edifice of cortical architecture: from neuronal silhouettes to genetic engineering
    Pasko Rakic
    Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Brain Res Rev 55:204-19. 2007
    ..The findings obtained from different levels of analyses sustain the radial unit hypothesis as a useful framework for understanding the mechanisms of cortical development and its evolution as an organ of thought...
  13. ncbi request reprint Neuroscience. No more cortical neurons for you
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520 8001, USA
    Science 313:928-9. 2006
  14. ncbi request reprint A century of progress in corticoneurogenesis: from silver impregnation to genetic engineering
    Pasko Rakic
    Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine New Haven, CT 06511, USA
    Cereb Cortex 16:i3-17. 2006
    ....
  15. ncbi request reprint Neuroscience. Genetic control of cortical convolutions
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 303:1983-4. 2004
  16. ncbi request reprint Neurogenesis in adult primate neocortex: an evaluation of the evidence
    Pasko Rakic
    Pasko Rakic is at the Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Rev Neurosci 3:65-71. 2002
    ..Here, I review the available evidence, and question the scientific basis of this claim...
  17. pmc Decision by division: making cortical maps
    Pasko Rakic
    Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Trends Neurosci 32:291-301. 2009
    ..We examine the history and evidence behind the concept of early specification of neurons and provide the latest compendium of genes and signaling molecules involved in neuronal fate determination and specification...
  18. ncbi request reprint Organotypic slice cultures for analysis of proliferation, cell death, and migration in the embryonic neocortex
    T F Haydar
    Section of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Brain Res Brain Res Protoc 4:425-37. 1999
    ....
  19. ncbi request reprint Role of GGF/neuregulin signaling in interactions between migrating neurons and radial glia in the developing cerebral cortex
    E S Anton
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510 8001, USA
    Development 124:3501-10. 1997
    ....
  20. ncbi request reprint Origin of GABAergic neurons in the human neocortex
    Kresimir Letinic
    Yale University School of Medicine, Section of Neurobiology, New Haven, Connecticut 06510, USA
    Nature 417:645-9. 2002
    ....
  21. ncbi request reprint Developmental and evolutionary adaptations of cortical radial glia
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cereb Cortex 13:541-9. 2003
    ....
  22. pmc Interaction between Reelin and Notch signaling regulates neuronal migration in the cerebral cortex
    Kazue Hashimoto-Torii
    Department of Neurobiology, Yale Medical School, New Haven, CT 06510, USA
    Neuron 60:273-84. 2008
    ..Finally, our in vitro biochemical studies show that Reelin signaling inhibits Notch ICD degradation via Dab1. Together, our results indicate that neuronal migration in the developing cerebral cortex requires a Reelin-Notch interaction...
  23. ncbi request reprint Cell proliferation without neurogenesis in adult primate neocortex
    D R Kornack
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 294:2127-30. 2001
    ..Thus, our results do not substantiate the claim of neurogenesis in normal adult primate neocortex...
  24. ncbi request reprint The role of cell death in regulating the size and shape of the mammalian forebrain
    T F Haydar
    Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cereb Cortex 9:621-6. 1999
    ..Thus, the precise coordination of different apoptotic signaling pathways during early stages of neurogenesis is crucial for regulation of the proper cortical size and shape...
  25. pmc Changes in cell-cycle kinetics during the development and evolution of primate neocortex
    D R Kornack
    Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 95:1242-6. 1998
    ..These findings suggest that evolutionary modification of the duration and number of progenitor cell divisions contributed to both the expansion and laminar elaboration of the primate neocortex...
  26. ncbi request reprint Numb and Numbl are required for maintenance of cadherin-based adhesion and polarity of neural progenitors
    Mladen Roko Rasin
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nat Neurosci 10:819-27. 2007
    ..Thus, by regulating RGC adhesion and polarity, Numb and Numbl are required for the tissue architecture of neurogenic niches and the cerebral cortex...
  27. pmc Primary cilia regulate hippocampal neurogenesis by mediating sonic hedgehog signaling
    Joshua J Breunig
    Department of Neurobiology and Kavli Institute of Neuroscience, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 105:13127-32. 2008
    ..Our data suggest these organelles are cellular "antennae" critically required to modulate ALNP behavior...
  28. pmc The role of ATP signaling in the migration of intermediate neuronal progenitors to the neocortical subventricular zone
    Xiuxin Liu
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 105:11802-7. 2008
    ..Interference of ATP signaling or abnormal Ca(2+) fluctuations in INPs may play a significant role in variety of genetic or acquired cortical malformations...
  29. ncbi request reprint Early emergence of photoreceptor mosaicism in the primate retina revealed by a novel cone-specific monoclonal antibody
    K C Wikler
    Section of Neurobiology, Yale School of Medicine, New Haven, Connecticut 06510, USA
    J Comp Neurol 377:500-8. 1997
    ..These results suggest that the periodic spacing of cones in the primate retina emerges autonomously within the photoreceptor layer, prior to the formation of synaptic connections within the retina or with the brain...
  30. pmc Evolution of the neocortex: a perspective from developmental biology
    Pasko Rakic
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Neurosci 10:724-35. 2009
    ....
  31. pmc Integration of neuronal clones in the radial cortical columns by EphA and ephrin-A signalling
    Masaaki Torii
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 461:524-8. 2009
    ....
  32. ncbi request reprint Genetic determinants of neuronal migration in the cerebral cortex
    Pasko Rakic
    Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA
    Novartis Found Symp 288:45-53; discussion 53-8, 96-8. 2007
    ....
  33. ncbi request reprint Independent parcellation of the embryonic visual cortex and thalamus revealed by combinatorial Eph/ephrin gene expression
    N Sestan
    Section of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Curr Biol 11:39-43. 2001
    ....
  34. ncbi request reprint Distinct functions of alpha3 and alpha(v) integrin receptors in neuronal migration and laminar organization of the cerebral cortex
    E S Anton
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510 8001, USA
    Neuron 22:277-89. 1999
    ..These results suggest that alpha3beta1 and alpha(v) integrins regulate distinct aspects of neuronal migration and neuron-glial interactions during corticogenesis...
  35. ncbi request reprint Telencephalic origin of human thalamic GABAergic neurons
    K Letinic
    Yale University School of Medicine, Section of Neurobiology, New Haven, Connecticut 06510, USA
    Nat Neurosci 4:931-6. 2001
    ....
  36. ncbi request reprint Vive la difference!
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Neuron 47:323-5. 2005
    ....
  37. pmc Notch regulates cell fate and dendrite morphology of newborn neurons in the postnatal dentate gyrus
    Joshua J Breunig
    Department of Neurobiology, Kavli Institute for Neuroscience, and Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 104:20558-63. 2007
    ..These results provide evidence for the expansive prevalence of Notch signaling in hippocampal morphogenesis and plasticity, suggesting that Notch1 could be a target of diverse traumatic and environmental modulators of adult neurogenesis...
  38. ncbi request reprint The Jnk1 and Jnk2 protein kinases are required for regional specific apoptosis during early brain development
    C Y Kuan
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Neuron 22:667-76. 1999
    ..In contrast, increased apoptosis and caspase activation were found in the mutant forebrain, leading to precocious degeneration. These results suggest that Jnk1 and Jnk2 regulate region-specific apoptosis during early brain development...
  39. ncbi request reprint Cortical development: view from neurological mutants two decades later
    P Rakic
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Neuron 14:1101-4. 1995
  40. ncbi request reprint Early serotonergic projections to Cajal-Retzius cells: relevance for cortical development
    Skirmantas Janusonis
    Yale University School of Medicine, Department of Neurobiology, New Haven, Connecticut 06520 8001, USA
    J Neurosci 24:1652-9. 2004
    ....
  41. pmc Prenatal exposure to ultrasound waves impacts neuronal migration in mice
    Eugenius S B C Ang
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale Medical School, Sterling Hall of Medicine, Room C 318, 333 Cedar Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 103:12903-10. 2006
    ..These results call for a further investigation in larger and slower-developing brains of non-human primates and continued scrutiny of unnecessarily long prenatal ultrasound exposure...
  42. ncbi request reprint Direct and indirect effects of fetal irradiation on cortical gray and white matter volume in the macaque
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, PO Box 208001, New Haven, CT 06520 8001, USA
    Biol Psychiatry 57:83-90. 2005
    ..Exposure of nonhuman primates to x-irradiation in early gestation has previously been shown to decrease thalamic volume and neuronal number. Here we examine whether early gestational irradiation also results in cortical volume reduction...
  43. doi request reprint Neuroanatomy of the FGF system
    Martin H Dominguez
    Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Comp Neurol 509:141-3. 2008
  44. ncbi request reprint Phosphatidylserine receptor is required for clearance of apoptotic cells
    Ming O Li
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 302:1560-3. 2003
    ..These data demonstrate a critical role for PSR in early stages of mammalian organogenesis and suggest that this receptor may be involved in respiratory distress syndromes and congenital brain malformations...
  45. pmc Novel neuronal phenotypes from neural progenitor cells
    Eleni A Markakis
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 24:2886-97. 2004
    ....
  46. doi request reprint Trouble making the first move: interpreting arrested neuronal migration in the cerebral cortex
    Matthew R Sarkisian
    Department of Neurobiology and Kavli Institute of Neuroscience, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Neurosci 31:54-61. 2008
    ..Elucidating the basic functions of FLNa and associated molecules is crucial for understanding the causes of PH and for developing prevention for at-risk patients...
  47. ncbi request reprint Four-dimensional migratory coordinates of GABAergic interneurons in the developing mouse cortex
    Eugenius S B C Ang
    Department of Neurobiology, Yale Medical School, New Haven, Connecticut 06510, USA
    J Neurosci 23:5805-15. 2003
    ..This approach opens a new avenue for study of normal and abnormal neuronal migration in their native environment and indicate that interneurons have specific programs for their areal and laminar deployment...
  48. ncbi request reprint Peptidergic innervation and the nicotinic acetylcholine receptor in the primate basal nucleus
    B Csillik
    Section of Neurobiology, Yale University Medical School, New Haven, CT, USA
    Eur J Neurosci 10:573-85. 1998
    ..Our results suggest that presynaptic nAChR-s are involved in the regulation of acetylcholine release from a feed-forward amplification mechanism of cholinergic principal cells of BNM...
  49. ncbi request reprint Everything that glitters isn't gold: a critical review of postnatal neural precursor analyses
    Joshua J Breunig
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cell Stem Cell 1:612-27. 2007
    ..A multipronged approach will enhance the overall rigor of research on stem cell biology and related fields by allowing increased replication of findings between groups and across systems...
  50. ncbi request reprint Ontogeny of brain and blood serotonin levels in 5-HT receptor knockout mice: potential relevance to the neurobiology of autism
    Skirmantas Janusonis
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurochem 99:1019-31. 2006
    ..The results are discussed in relation to the possible role of 5-HT in the ontogeny of autism...
  51. pmc Mitotic spindle rotation and mode of cell division in the developing telencephalon
    Tarik F Haydar
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 100:2890-5. 2003
    ....
  52. pmc Selective reduction of neuron number and volume of the mediodorsal nucleus of the thalamus in macaques following irradiation at early gestational ages
    Lynn D Selemon
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8001, USA
    J Comp Neurol 515:454-64. 2009
    ..Comp. Neurol. 176:23-52). The early gestationally irradiated macaque is discussed as a potentially useful model for studying the neurodevelopmental pathogenesis of schizophrenia...
  53. ncbi request reprint Translocation of synaptically connected interneurons across the dentate gyrus of the early postnatal rat hippocampus
    Yury M Morozov
    Department of Neurobiology, Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Neurosci 26:5017-27. 2006
    ..The migration of synaptically interconnected neurons that may occur in response to local functional demand represents a novel mode of cell movement and form of neuroplasticity...
  54. pmc Exocyst is involved in polarized cell migration and cerebral cortical development
    Kresimir Letinic
    Department of Neurobiology and Kavli Institute for Neuroscience, 333 Cedar Street, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 106:11342-7. 2009
    ..Thus, our study supports the notion that polarized membrane traffic regulated by the exocyst is an essential component of cell migration and that its deficit may lead to cortical abnormalities involving cortical neuronal malpositioning...
  55. ncbi request reprint Processing of the notch ligand delta by the metalloprotease Kuzbanian
    H Qi
    Howard Hughes Medical Institute, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06536 0812, USA
    Science 283:91-4. 1999
    ..The ADAM disintegrin metalloprotease Kuzbanian is required for this processing event. These observations raise the possibility that Notch signaling in vivo is modulated by soluble forms of the Notch ligands...
  56. ncbi request reprint Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene
    D D Yang
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 389:865-70. 1997
    ..These data indicate that the observed neuroprotection is due to the extinction of a Jnk3-mediated signalling pathway, which is an important component in the pathogenesis of glutamate neurotoxicity...
  57. ncbi request reprint Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice
    K Kuida
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 384:368-72. 1996
    ..Thus CPP32 is shown to play a critical role during morphogenetic cell death in the mammalian brain...
  58. ncbi request reprint Craniofacial dysmorphogenesis in fetally irradiated nonhuman primates: implications for the neurodevelopmental hypothesis of schizophrenia
    Douglas L Gelowitz
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Biol Psychiatry 52:716-20. 2002
    ..This study investigates whether craniofacial dysmorphology and thalamic neuron loss might be associated manifestations of a disruption in embryonic development...
  59. pmc Origin, early commitment, migratory routes, and destination of cannabinoid type 1 receptor-containing interneurons
    Yury M Morozov
    Department of Neurobiology, Yale University School of Medicine and Kavli Institute for Neuroscience, New Haven, CT 06510, USA
    Cereb Cortex 19:i78-89. 2009
    ..Thus, the specific subclasses of CB(1)+ inhibitory interneurons, similar to the projection neurons, are determined at the time and place of last cell division and follow their own complex migratory pattern to the final positions...
  60. ncbi request reprint Forward to the special issue on the prefrontal cortex and working memory: in memory of Patricia S. Goldman-Rakic
    Pasko Rakic
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Cereb Cortex 17:i1-3. 2007
  61. pmc Molecular and morphological heterogeneity of neural precursors in the mouse neocortical proliferative zones
    Jonathan S Gal
    Center for Neuroscience Research, Children s Research Institute, Children s National Medical Center, Washington, DC 20010, USA
    J Neurosci 26:1045-56. 2006
    ....
  62. ncbi request reprint The first neurons of the human cerebral cortex
    Irina Bystron
    Department of Physiology, Anatomy and Genetics, University of Oxford, Parks Road, Oxford, Oxfordshire OX13PT, UK
    Nat Neurosci 9:880-6. 2006
    ..These neurons, described here for the first time, precede all other known cell types of the developing cortex...
  63. pmc Hypoxia-ischemia induces DNA synthesis without cell proliferation in dying neurons in adult rodent brain
    Chia Yi Kuan
    Department of Pediatrics, Children s Hospital Medical Center, Cincinnati, Ohio 45229, USA
    J Neurosci 24:10763-72. 2004
    ..Manipulating the aberrant apoptosis-associated DNA synthesis that occurs with hypoxia-ischemia and perhaps neurodegenerative diseases could promote neuronal survival and neurogenesis...
  64. ncbi request reprint SPARC-like 1 regulates the terminal phase of radial glia-guided migration in the cerebral cortex
    Vik Gongidi
    UNC Neuroscience Center, Department of Cell and Molecular Physiology, The University of North Carolina School of Medicine, Chapel Hill, 27599, USA
    Neuron 41:57-69. 2004
    ..Together, these data suggest that antiadhesive signaling via SPARC-like 1 on radial glial cell surfaces may enable neurons to recognize the end of migration in the developing cerebral cortex...
  65. ncbi request reprint Hardwiring the brain: endocannabinoids shape neuronal connectivity
    Paul Berghuis
    Division of Molecular Neurobiology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, S 17177 Stockholm, Sweden
    Science 316:1212-6. 2007
    ....
  66. doi request reprint Development of the human cerebral cortex: Boulder Committee revisited
    Irina Bystron
    Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford, OX1 3PT, UK
    Nat Rev Neurosci 9:110-22. 2008
    ..We review current data on the development of the human cerebral cortex and update the classical model of how the structure that makes us human is formed...
  67. pmc A critical role of neural-specific JNK3 for ischemic apoptosis
    Chia Yi Kuan
    Department of Pediatrics, Division of Developmental Biology, Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Proc Natl Acad Sci U S A 100:15184-9. 2003
    ..The downstream mechanism of JNK3-mediated apoptosis may include the induction of Bim and Fas and the mitochondrial release of cytochrome c. These results suggest that JNK3 is a potential target for neuroprotection therapies in stroke...
  68. ncbi request reprint Neuroscience: immigration denied
    Pasko Rakic
    Nature 427:685-6. 2004
  69. ncbi request reprint Less is more: progenitor death and cortical size
    Pasko Rakic
    Nat Neurosci 8:981-2. 2005
  70. pmc Requirement of JIP scaffold proteins for NMDA-mediated signal transduction
    Norman J Kennedy
    Howard Hughes Medical Institute and Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, USA
    Genes Dev 21:2336-46. 2007
    ..JIP complexes interact with the SH2 domain of cFyn and may therefore promote tyrosine phosphorylation and activity of the NMDA receptor. We conclude that JIP scaffold proteins are critically required for normal NMDA receptor function...

Research Grants65

  1. PRENATAL DEVELOPMENT OF THE VISUAL SYSTEM
    Pasko Rakic; Fiscal Year: 1990
    ....
  2. Origin of Cortical Species-specific Distinctions
    Pasko Rakic; Fiscal Year: 2010
    ....
  3. PRENATAL DEVELOPMENT OF THE VISUAL SYSTEM
    Pasko Rakic; Fiscal Year: 2001
    ..The aim of these studies is the elucidation of the timing, sequence and mechanisms that govern both normal and altered development of vision in primates as a basis for the understanding of normal and abnormal vision in humans. ..
  4. STRESS ACTIVATED PROTEIN KINASE IN NEURONAL APOPTOSIS
    Pasko Rakic; Fiscal Year: 2003
    ..abstract_text> ..
  5. MICROARCHITECTURE OF COGNITION
    Pasko Rakic; Fiscal Year: 2004
    ..abstract_text> ..
  6. NEUROGENETIC PROCESSES IN THE FETAL BRAIN
    Pasko Rakic; Fiscal Year: 2010
    ..Thus, we propose to continue our investigation of cellular and molecular mechanisms of normal and abnormal cortical neurogenesis to obtain new insight into the causes of these disorders that may lead to their prevention or therapy. ..
  7. Origin of Cortical Species-specific Distinctions
    Pasko Rakic; Fiscal Year: 2009
    ....
  8. NEUROGENETIC PROCESSES IN THE FETAL BRAIN
    Pasko Rakic; Fiscal Year: 2004
    ....
  9. Notch Signaling in the Adult, Aging and Diseased Brain
    Pasko Rakic; Fiscal Year: 2005
    ..abstract_text> ..
  10. NEUROGENETIC PROCESSES IN THE FETAL BRAIN
    Pasko Rakic; Fiscal Year: 2003
    ....
  11. PRENATAL DEVELOPMENT OF THE VISUAL SYSTEM
    Pasko Rakic; Fiscal Year: 1993
    ..The underlying strategy is to discern how developmental events are orchestrated between the periphery and brain centers and to elucidate their involvement in congenital and acquired defects of vision...
  12. NEUROGENETIC PROCESSES IN THE FETAL BRAIN
    Pasko Rakic; Fiscal Year: 1980
    ..Pathological development and neuronal plasticity in the auditory system, pyramidal and cortico-ponto-cerebellar system and 3. Correlation of "critical periods" in the developing monkey and human brain...
  13. PRENATAL DEVELOPMENT OF THE PRIMATE VISUAL SYSTEM
    Pasko Rakic; Fiscal Year: 1980
    ....
  14. NEUROGENETIC PROCESSES IN THE FETAL BRAIN
    Pasko Rakic; Fiscal Year: 1990
    ....
  15. NEUROGENETIC PROCESSES IN THE FETAL BRAIN
    Pasko Rakic; Fiscal Year: 2007
    ....
  16. PRENATAL DEVELOPMENT OF THE VISUAL SYSTEM
    Pasko Rakic; Fiscal Year: 2006
    ....