Research Topics
Species | Ken PughSummaryAffiliation: Yale University Country: USA Publications
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Publications
The relationship between phonological and auditory processing and brain organization in beginning readersKenneth R Pugh
Haskins Laboratories, New Haven, CT, United States Yale University, School of Medicine, Department of Diagnostic Radiology, United States University of Connecticut, Department of Psychology, United States Electronic address
Brain Lang 125:173-83. 2013..Implications for brain-based models of literacy acquisition are discussed...
Effects of stimulus difficulty and repetition on printed word identification: an fMRI comparison of nonimpaired and reading-disabled adolescent cohortsKenneth R Pugh
Haskins Laboratories, New Haven, CT 06511, USA
J Cogn Neurosci 20:1146-60. 2008..For RD readers, facilitative factors resulted in increased activation in these same reading-related sites, suggesting that the LH reading circuitry in adolescent RD is poorly trained but not wholly disrupted...
A neurocognitive overview of reading acquisition and dyslexia across languagesKen Pugh
Department of Pediatrics, Yale School of Medicine and Haskins Laboratories, New Haven, CT 06511, USA
Dev Sci 9:448-50; discussion 451-3. 2006- Predicting reading performance from neuroimaging profiles: the cerebral basis of phonological effects in printed word identificationK R Pugh
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510 8064, USA
J Exp Psychol Hum Percept Perform 23:299-318. 1997.... - Nicotine effects on brain function and functional connectivity in schizophreniaLeslie K Jacobsen
Department of Psychiatry, Yale University School of Medicine, 100 York Street #28, West Haven, CT 06511, USA
Biol Psychiatry 55:850-8. 2004..CONCLUSIONS: In tasks that tax working memory and selective attention, nicotine may improve performance in schizophrenia patients by enhancing activation of and functional connectivity between brain regions that mediate task performance... - Functional connectivity to a right hemisphere language center in prematurely born adolescentsEliza H Myers
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
Neuroimage 51:1445-52. 2010..439, p=0.019). Preterm adolescents engage a dorsal right hemisphere region for language at age 16years. Those with the greatest cognitive deficits demonstrate increasing reliance on this alternate pathway... - Reading differences and brain: cortical integration of speech and print in sentence processing varies with reader skillDonald Shankweiler
Haskins Laboratories, Department of Psychology, University of Connecticut, New Haven, CT 06511, USA
Dev Neuropsychol 33:745-75. 2008..The findings provide new evidence of the role of the inferior frontal region in supporting supramodal systems of linguistic representation... - Behavioral and neurobiological effects of printed word repetition in lexical decision and namingLeonard Katz
Haskins Laboratories, New Haven, CT, USA
Neuropsychologia 43:2068-83. 2005.... - Alterations in functional connectivity for language in prematurely born adolescentsRobin J Schafer
Department of Diagnostic Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, PO Box 208043, New Haven, CT 06520, USA
Brain 132:661-70. 2009..Plasticity in network connections may provide the substrate for improving language skills in the prematurely born... - Impact of smoking abstinence on working memory neurocircuitry in adolescent daily tobacco smokersLeslie K Jacobsen
Department of Psychiatry, Yale University School of Medicine, 2 Church Street South, Suite 207, New Haven, CT 06519, USA
Psychopharmacology (Berl) 193:557-66. 2007..Work in rodents has shown that exposure to nicotine during adolescence leads to nicotine withdrawal emergent alterations in cortical and subcortical dopamine neurotransmission... - Phonological awareness predicts activation patterns for print and speechStephen J Frost
Haskins Laboratories, 300 George Street, New Haven, CT 06511, USA
Ann Dyslexia 59:78-97. 2009.... - An fMRI study of multimodal semantic and phonological processing in reading disabled adolescentsNicole Landi
Child Study Center, Yale University School of Medicine, 230 S Frontage, New Haven, CT 06520, USA
Ann Dyslexia 60:102-21. 2010..These findings indicate a neurobiological marker in RD that is independent of task, modality, or performance. These findings are discussed in the context of current neurobiological models of RD... - Unification of sentence processing via ear and eye: an fMRI studyDavid Braze
Haskins Laboratories, 300 George Street, New Haven, Connecticut 06511, USA
Cortex 47:416-31. 2011..Voxel-by-voxel exploration over the whole brain based on a cosine similarity measure of common function confirmed the specificity of supramodal zones... - Early and late talkers: school-age language, literacy and neurolinguistic differencesJonathan L Preston
Haskins Laboratories, 300 George St, Suite 900, New Haven, CT 06511, USA
Brain 133:2185-95. 2010.... - Gender-specific effects of prenatal and adolescent exposure to tobacco smoke on auditory and visual attentionLeslie K Jacobsen
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Neuropsychopharmacology 32:2453-64. 2007.... - Functional correlates of verbal memory deficits emerging during nicotine withdrawal in abstinent adolescent cannabis usersLeslie K Jacobsen
Department of Psychiatry, Yale University School of Medicine, Connecticut 06519, USA
Biol Psychiatry 61:31-40. 2007..Human studies have shown that both cannabis and tobacco exert effects on cognitive function; however, little is known about possible interacting effects of these drugs on brain function and cognition during adolescent development... - C957T polymorphism of the dopamine D2 receptor gene modulates the effect of nicotine on working memory performance and cortical processing efficiencyLeslie K Jacobsen
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Psychopharmacology (Berl) 188:530-40. 2006.... - Sentence complexity and input modality effects in sentence comprehension: an fMRI studyR Todd Constable
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520 8042, USA
Neuroimage 22:11-21. 2004..These sites showing modulation of activity as a function of sentence type, independent of input mode, arguably form the core of a cortical system essential to sentence parsing... - Impact of cannabis use on brain function in adolescentsLeslie K Jacobsen
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Ann N Y Acad Sci 1021:384-90. 2004..This paper reports results of a pilot study using fMRI and a working memory task to compare brain function of adolescent cannabis users to that of two control groups, one matched for tobacco use and the other for nonsmokers... - The neurobiology of adaptive learning in reading: a contrast of different training conditionsRebecca Sandak
Haskins Laboratories, New Haven, Connecticut 06511 6695, USA
Cogn Affect Behav Neurosci 4:67-88. 2004..The findings indicate that the putative ventral visual word form area is sensitive to the phonological structure of words, with phonologically analytic processing contributing to the specialization of this region... - Effects of smoking and smoking abstinence on cognition in adolescent tobacco smokersLeslie K Jacobsen
Department of Psychiatry, Yale University School of Medicine, 100 York Street 2B, New Haven, CT 06511, USA
Biol Psychiatry 57:56-66. 2005..We tested for evidence of acute and chronic effects of tobacco smoking on cognition in adolescents who smoked tobacco daily and were compared with adolescent nonsmokers... - A functional magnetic resonance imaging study of the tradeoff between semantics and phonology in reading aloudStephen J Frost
Haskins Laboratories, Yale University School of Medicine, New Haven, Connecticut, USA
Neuroreport 16:621-4. 2005.... - Visuospatial memory deficits emerging during nicotine withdrawal in adolescents with prenatal exposure to active maternal smokingLeslie K Jacobsen
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Neuropsychopharmacology 31:1550-61. 2006.... - Preliminary evidence of hippocampal dysfunction in adolescent MDMA ("ecstasy") users: possible relationship to neurotoxic effectsLeslie K Jacobsen
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06511, USA
Psychopharmacology (Berl) 173:383-90. 2004..Although cognitive deficits among adult MDMA users are well documented, little is known of the cognitive and brain functional sequelae of MDMA use during adolescence... - Development of left occipitotemporal systems for skilled reading in children after a phonologically- based interventionBennett A Shaywitz
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510-8064, USA
Biol Psychiatry 55:926-33. 2004.... - Neural systems for compensation and persistence: young adult outcome of childhood reading disabilitySally E Shaywitz
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510-8064, USA
Biol Psychiatry 54:25-33. 2003..CONCLUSIONS: These findings of divergent neural outcomes as young adults are both new and unexpected and suggest a neural basis for reading outcomes of compensation and persistence in adults with childhood dyslexia... - Disruption of posterior brain systems for reading in children with developmental dyslexiaBennett A Shaywitz
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06510-8064, USA
Biol Psychiatry 52:101-10. 2002..The locus of the disruption places childhood dyslexia within the same neurobiological framework as dyslexia, and acquired alexia, occurring in adults...
Research Grants
- COGNITIVE & NEUROBIOL MECHANISMS IN READING DISABILITYKenneth Pugh; Fiscal Year: 2005....
- Neurobiological Foundations of reading (dis)abilityKenneth Pugh; Fiscal Year: 2009....
- Neurobiological Foundations of reading (dis)abilityKenneth R Pugh; Fiscal Year: 2010....