James Poling

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Six-month trial of bupropion with contingency management for cocaine dependence in a methadone-maintained population
    James Poling
    Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 63:219-28. 2006
  2. ncbi request reprint Treatment outcome predictors for cocaine dependence
    James Poling
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System West Haven, CT 06516, USA
    Am J Drug Alcohol Abuse 33:191-206. 2007
  3. ncbi request reprint Clinical efficacy of citalopram alone or augmented with bupropion in methadone-stabilized patients
    James Poling
    Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Addict 16:187-94. 2007
  4. pmc The safety and efficacy of varenicline in cocaine using smokers maintained on methadone: a pilot study
    James Poling
    Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Am J Addict 19:401-8. 2010
  5. ncbi request reprint Naltrexone and disulfiram in patients with alcohol dependence and current depression
    Ismene Petrakis
    Department of Psychiatry, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    J Clin Psychopharmacol 27:160-5. 2007
  6. pmc Preliminary study of buprenorphine and bupropion for opioid-dependent smokers
    Marc E Mooney
    Department of Psychiatry, Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55414, USA
    Am J Addict 17:287-92. 2008
  7. pmc 5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder
    Kara Douglas
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, USA
    Psychiatr Genet 21:240-8. 2011
  8. pmc A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia
    Tetyana Zayats
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    PLoS ONE 8:e49368. 2013
  9. ncbi request reprint Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder
    Ismene L Petrakis
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 60:777-83. 2006
  10. pmc Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10
    Joel Gelernter
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA
    Biol Psychiatry 65:111-5. 2009

Research Grants

Detail Information

Publications45

  1. ncbi request reprint Six-month trial of bupropion with contingency management for cocaine dependence in a methadone-maintained population
    James Poling
    Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 63:219-28. 2006
    ..No effective pharmacotherapies exist for cocaine dependence, although contingency management (CM) has demonstrated efficacy...
  2. ncbi request reprint Treatment outcome predictors for cocaine dependence
    James Poling
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System West Haven, CT 06516, USA
    Am J Drug Alcohol Abuse 33:191-206. 2007
    ..Initial promising findings with genetic polymorphism, brain activation, and stress response have also been found and need to be replicated in future studies...
  3. ncbi request reprint Clinical efficacy of citalopram alone or augmented with bupropion in methadone-stabilized patients
    James Poling
    Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Addict 16:187-94. 2007
    ..The results indicate that neither citalopram nor citalopram augmented with bupropion were more effective than placebo in the treatment of opioid abuse...
  4. pmc The safety and efficacy of varenicline in cocaine using smokers maintained on methadone: a pilot study
    James Poling
    Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Am J Addict 19:401-8. 2010
    ..These preliminary findings may point to potential therapeutic value of varenicline for smoking cessation in cocaine users maintained on methadone...
  5. ncbi request reprint Naltrexone and disulfiram in patients with alcohol dependence and current depression
    Ismene Petrakis
    Department of Psychiatry, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    J Clin Psychopharmacol 27:160-5. 2007
    ..In particular, the effect of these medications on alcohol use outcomes and on specific psychiatric symptoms is still unknown in patients with the most common co-occurring disorder, major depression...
  6. pmc Preliminary study of buprenorphine and bupropion for opioid-dependent smokers
    Marc E Mooney
    Department of Psychiatry, Transdisciplinary Tobacco Use Research Center, University of Minnesota, Minneapolis, Minnesota 55414, USA
    Am J Addict 17:287-92. 2008
    ..These preliminary findings do not support the efficacy of BUPRO, in combination with BUPRE, for the concurrent treatment of opioid and tobacco addiction...
  7. pmc 5-HTTLPR as a potential moderator of the effects of adverse childhood experiences on risk of antisocial personality disorder
    Kara Douglas
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, USA
    Psychiatr Genet 21:240-8. 2011
    ..Childhood abuse is an important predictor of ASPD. We examined 5-HTTLPR genotype and adverse childhood events (ACEs) as risk factors for ASPD in a SD sample...
  8. pmc A complex interplay between personality domains, marital status and a variant in CHRNA5 on the risks of cocaine, nicotine dependences and cocaine-induced paranoia
    Tetyana Zayats
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    PLoS ONE 8:e49368. 2013
    ..This study examined if environment (marriage) or genetics (a single SNP, CHRNA5*rs16969968) would moderate the correlation of personality with CD, ND and cocaine-induced paranoia (CIP) in African and European Americans (AAs, EAs)...
  9. ncbi request reprint Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder
    Ismene L Petrakis
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 60:777-83. 2006
    ....
  10. pmc Dense genomewide linkage scan for alcohol dependence in African Americans: significant linkage on chromosome 10
    Joel Gelernter
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, CT, USA
    Biol Psychiatry 65:111-5. 2009
    ..Risk loci in several populations have been identified with genetic linkage analysis. To date, there has been no published linkage study of AD focused on African Americans (AAs)...
  11. ncbi request reprint Genomewide linkage scan for nicotine dependence: identification of a chromosome 5 risk locus
    Joel Gelernter
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 61:119-26. 2007
    ..Nicotine dependence (ND) is costly to societies worldwide, moderately heritable, and genetically complex. Risk loci can be identified with genetic linkage analysis independent of prior physiological hypotheses...
  12. pmc Interaction between two independent CNR1 variants increases risk for cocaine dependence in European Americans: a replication study in family-based sample and population-based sample
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1504-13. 2009
    ..019). We conclude that two independent CNR1 variants have significant interaction effects on risk for CD in EAs; they may also have effects on risk for CD in AAs...
  13. pmc Genomewide linkage scan for opioid dependence and related traits
    Joel Gelernter
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Am J Hum Genet 78:759-69. 2006
    ..These results are an initial step in identifying genes for opioid dependence on the basis of a genomewide investigation (i.e., a study not conditioned on prior physiological candidate-gene hypotheses)...
  14. pmc Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 35:1684-92. 2010
    ..This study provides further evidence of a gene x environment effect of FKBP5 and childhood abuse on the risk for PTSD in AAs. Further study is required in other populations...
  15. ncbi request reprint Prediction of treatment outcome by baseline urine cocaine results and self-reported cocaine use for cocaine and opioid dependence
    Mehmet Sofuoglu
    Department of Psychiatry and VA Connecticut Healthcare System, School of Medicine, Yale University, West Haven, Connecticut 06516, USA
    Am J Drug Alcohol Abuse 29:713-27. 2003
    ..These results suggest that baseline cocaine urine results should be considered as stratifying variables in clinical trials for cocaine dependence...
  16. ncbi request reprint Desipramine treatment for cocaine dependence in buprenorphine- or methadone-treated patients: baseline urine results as predictor of response
    Thomas Kosten
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Addict 14:8-17. 2005
    ..The CU+ patients showed a treatment effect of DMI. This DMI effect was significant in patients maintained on BUP but not on Meth...
  17. pmc Interactive effect of stressful life events and the serotonin transporter 5-HTTLPR genotype on posttraumatic stress disorder diagnosis in 2 independent populations
    Pingxing Xie
    Department of Genetics, Yale University School of Medicine, New Haven, CT, USA
    Arch Gen Psychiatry 66:1201-9. 2009
    ..Previous studies generally focused on its effect on depressive symptoms; little is known about its moderation of the development of posttraumatic stress disorder (PTSD)...
  18. ncbi request reprint Desipramine and contingency management for cocaine and opiate dependence in buprenorphine maintained patients
    Thomas Kosten
    Department of Psychiatry, Yale University School of Medicine, VA New England MIRECC, VA Caonnecticut Healthcare System, 950 Campbell Avenue, Bldg 35, West Haven, CT 06516, USA
    Drug Alcohol Depend 70:315-25. 2003
    ..DMI and CM had independent and additive effects in facilitating cocaine-free urines in buprenorphine maintained patients. The antidepressant appeared to enhance responsiveness to CM reinforcement...
  19. pmc ADH1A variation predisposes to personality traits and substance dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 153:376-86. 2010
    ..008 <or= P <or= 0.060). The present study demonstrates that the ADH1A variation may contribute to the genetic component of variation in personality traits and SD...
  20. pmc Adverse childhood events as risk factors for substance dependence: partial mediation by mood and anxiety disorders
    Kara R Douglas
    Department of Psychiatry, University of Connecticut School of Medicine, Farmington, CT 06030 2103, USA
    Addict Behav 35:7-13. 2010
    ..Adverse childhood events (ACEs) are associated with negative health outcomes. We examined ACEs as risk factors for substance dependence (SD) and the mediating effects of mood and anxiety disorders on the relations between ACEs and SD risk...
  21. ncbi request reprint Efficacy of dose and contingency management procedures in LAAM-maintained cocaine-dependent patients
    Alison Oliveto
    Department of Psychiatry, Yale School of Medicine and the VA CT Healthcare System, West Haven, CT, USA
    Drug Alcohol Depend 79:157-65. 2005
    ..These results suggest that an efficacious maintenance dose is necessary for contingencies to be effective in facilitating both opioid and cocaine abstinence...
  22. ncbi request reprint Cocaine withdrawal symptoms predict medication response in cocaine users
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Am J Drug Alcohol Abuse 32:617-27. 2006
    ..This hypothesis needs to be tested in prospective clinical trials...
  23. pmc Cognitive flexibility is associated with KIBRA variant and modulated by recent tobacco use
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 34:2508-16. 2009
    ..We conclude that variation in KIBRA influences cognitive flexibility in a population-specific way, and that current smoking status moderates this effect...
  24. ncbi request reprint Progesterone effects on cocaine use in male cocaine users maintained on methadone: a randomized, double-blind, pilot study
    Mehmet Sofuoglu
    Department of Psychiatry, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, Connecticut, USA
    Exp Clin Psychopharmacol 15:453-60. 2007
    ..60 vs. 0.73; U=4837, p<.04). These preliminary findings do not support the efficacy of progesterone in male cocaine users. The efficacy of progesterone in female cocaine users remains to be determined in future studies...
  25. pmc The safety of modafinil in combination with oral ∆9-tetrahydrocannabinol in humans
    Dawn E Sugarman
    Yale University School of Medicine, Department of Psychiatry, 300 George St, New Haven, CT 06511, USA
    Pharmacol Biochem Behav 98:94-100. 2011
    ..These findings support the safety of modafinil in combination with THC. The effects of modafinil in combination with a range of doses of THC need to be determined in future studies...
  26. pmc Atomoxetine attenuates dextroamphetamine effects in humans
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Drug Alcohol Abuse 35:412-6. 2009
    ..Although preclinical studies support the contribution of the noradrenergic system activation in mediating the acute effects of amphetamines, these findings have not been followed up in clinical studies...
  27. ncbi request reprint Effects of topiramate in combination with intravenous nicotine in overnight abstinent smokers
    Mehmet Sofuoglu
    Department of Psychiatry, VA Connecticut Healthcare System, School of Medicine, Yale University, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 184:645-51. 2006
    ..While a recent clinical study has demonstrated the potential utility of topiramate for smoking cessation in alcohol-dependent smokers, the effects of topiramate on tobacco addiction have not been systematically examined in humans...
  28. ncbi request reprint Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Psychopharmacology (Berl) 172:291-7. 2004
    ..The purpose of this study was to evaluate the efficacy of naltrexone in alcohol-abusing schizophrenic patients...
  29. pmc Variation in the nicotinic acetylcholine receptor gene cluster CHRNA5-CHRNA3-CHRNB4 and its interaction with recent tobacco use influence cognitive flexibility
    Huiping Zhang
    Division of Human Genetics, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Neuropsychopharmacology 35:2211-24. 2010
    ..These findings could account in part for differences in ND risk associated with these variants in AAs and EAs...
  30. pmc Effect of PTSD diagnosis and contingency management procedures on cocaine use in dually cocaine- and opioid-dependent individuals maintained on LAAM: a retrospective analysis
    Michael J Mancino
    Department of Psychiatry, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA
    Am J Addict 19:169-77. 2010
    ..This suggests that CM may help improve the potentially worse outcomes in opioid- and cocaine-dependent individuals with PTSD compared to those without PTSD. (Am J Addict 2010;00:1-9)...
  31. pmc Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial
    Bridget A Martell
    Department of Medicine, Yale University School of Medicine, New Haven, CT, USA
    Arch Gen Psychiatry 66:1116-23. 2009
    ..Cocaine dependence, which affects 2.5 million Americans annually, has no US Food and Drug Administration-approved pharmacotherapy...
  32. pmc Disulfiram enhances subjective effects of dextroamphetamine in humans
    Mehmet Sofuoglu
    Yale University, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, United States
    Pharmacol Biochem Behav 90:394-8. 2008
    ..How these enhanced subjective amphetamine responses affect cocaine use behavior remains to be determined in future clinical trials...
  33. pmc Galantamine improves sustained attention in chronic cocaine users
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Avenue, Bldg 36 116A4, West Haven, CT 06516, USA
    Exp Clin Psychopharmacol 19:11-9. 2011
    ..g., sustained attention) in abstinent cocaine users. The potential efficacy of galantamine as a treatment for cocaine abuse needs to be further evaluated in clinical trials...
  34. pmc D-Cycloserine attenuates reactivity to smoking cues in nicotine dependent smokers: a pilot investigation
    Elizabeth J Santa Ana
    VA Connecticut Healthcare System, Department of Psychiatry, Division of Substance Abuse, West Haven, CT 06516, USA
    Drug Alcohol Depend 104:220-7. 2009
    ..These findings provide promising support for DCS combined with cue exposure therapy in attenuating conditioned reactivity to smoking cues...
  35. ncbi request reprint Isradipine and dextromethorphan in methadone-maintained humans under a naloxone discrimination procedure
    Alison Oliveto
    CT and VA Connecticut Healthcare System, Yale University, New Haven, 950 Campbell Avenue, Psychiatry 116A 4, Building 36, West Haven, CT 06516, USA
    Eur J Pharmacol 491:157-68. 2004
    ..These results suggest that isradipine attenuates and dextromethorphan enhances some of the behavioral effects of naloxone in opioid-dependent humans...
  36. ncbi request reprint Tiagabine affects the subjective responses to cocaine in humans
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry and VA Connecticut Healthcare System, West Haven, CT, USA
    Pharmacol Biochem Behav 82:569-73. 2005
    ..GABA medications, including tiagabine, are currently being evaluated in controlled clinical trials for the treatment of cocaine dependence...
  37. pmc Sertraline delays relapse in recently abstinent cocaine-dependent patients with depressive symptoms
    Alison Oliveto
    University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA
    Addiction 107:131-41. 2012
    ..Whether the selective serotonin re-uptake inhibitor sertraline at 200 mg/day delays relapse in recently abstinent cocaine-dependent individuals...
  38. ncbi request reprint D-cycloserine-Naloxone interactions in opioid-dependent humans under a novel-response naloxone discrimination procedure
    Alison Oliveto
    Department of Psychiatry, Yale School of Medicine and Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut 06516, USA
    Exp Clin Psychopharmacol 11:237-46. 2003
    ..Naloxone attenuated D-cycloserine-induced increases in systolic blood pressure. These results suggest that D-cycloserine at doses up to 500 mg/70 kg may have some limited usefulness in relieving symptoms of opioid withdrawal...
  39. ncbi request reprint Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut 06516, USA
    Biol Psychiatry 57:1128-37. 2005
    ..Disulfiram and naltrexone are approved by the Food and Drug Administration (FDA) for the treatment of alcoholism, but these agents have not been rigorously evaluated in dually diagnosed individuals...
  40. ncbi request reprint Vaccine pharmacotherapy for the treatment of cocaine dependence
    Bridget A Martell
    Section of General Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 58:158-64. 2005
    ..Cocaine abuse has no established pharmacotherapy, but active immunotherapy with a cocaine vaccine shows promise as a therapeutic intervention...
  41. ncbi request reprint Effects of reducing contingency management values on heroin and cocaine use for buprenorphine- and desipramine-treated patients
    Thomas Kosten
    Department of Psychiatry, Yale University School of Medicine, VA New England MIRECC, West Haven, CT 06516, USA
    Addiction 98:665-71. 2003
    ..The 'escalating CM' was eliminated during months 4-6 to assess any reduction in drug-free urines...
  42. ncbi request reprint Genomewide linkage scan for cocaine dependence and related traits: significant linkages for a cocaine-related trait and cocaine-induced paranoia
    Joel Gelernter
    Yale University School of Medicine, Department of Psychiatry, Division of Human Genetics and VA CT Healthcare Center, West Haven, CT 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 136:45-52. 2005
    ..35 for membership in the "Moderate Cocaine and Opioid Abuse" cluster on chromosome 18. These results provide a basis for the identification of specific genes contributing to risk for these traits...
  43. pmc The effect of cannabis compared with alcohol on driving
    R Andrew Sewell
    VA Connecticut Healthcare Yale University School of Medicine, West Haven, Connecticut, USA
    Am J Addict 18:185-93. 2009
    ..Future research should focus on resolving contradictions posed by previous studies, and patients who smoke cannabis should be counseled to wait several hours before driving, and avoid combining the two drugs...
  44. ncbi request reprint The effect of individual cocaine withdrawal symptoms on outcomes in cocaine users
    Mehmet Sofuoglu
    Yale University, School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Ave, Bldg 36 116A4, West Haven, CT 06516, USA
    Addict Behav 30:1125-34. 2005
    ..Our findings support two dimensions in cocaine withdrawal symptoms with differential effects on cocaine dependence outcomes...
  45. pmc Substance dependence low-density whole genome association study in two distinct American populations
    Yi Yu
    Department of Medicine Genetics Program, Boston University Schools of Medicine and Public Health, Boston, MA, USA
    Hum Genet 123:495-506. 2008
    ..Our study provides an initial substance dependence trait-specific blueprint of associated regions for future candidate gene studies...

Research Grants3

  1. Pharmacotherapy & CM for Opioid and Cocaine Dependence
    James Poling; Fiscal Year: 2007
    ..4) To investigate the role of modafinil-related improvements in memory, attention, impulse control and fatigue in mediating cocaine abstinence and treatment retention. ..
  2. Pharmacotherapy & CM for Opioid and Cocaine Dependence
    James Poling; Fiscal Year: 2010
    ..4) To investigate the role of modafinil-related improvements in memory, attention, impulse control and fatigue in mediating cocaine abstinence and treatment retention. ..