JORDAN POBER

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis
    Yajaira Suarez
    Department of Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, Amistad Research Building, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 105:14082-7. 2008
  2. pmc Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection
    Deepak A Rao
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 205:3145-58. 2008
  3. pmc Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation
    Julie Devalliere
    2Department of Immunobiology, PO Box 208089, New Haven, CT 06520 8089, USA
    FASEB J 28:908-22. 2014
  4. pmc Participation of blood vessel cells in human adaptive immune responses
    Jordan S Pober
    Yale University School of Medicine, PO Box 208089, 10 Amistad Street, Rm 401, New Haven, CT 06520 8089, USA
    Trends Immunol 33:49-57. 2012
  5. pmc Endothelial cells present antigens in vivo
    Annette L Rothermel
    Department of Pathology, Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    BMC Immunol 5:5. 2004
  6. ncbi request reprint Human endothelial cell presentation of antigen and the homing of memory/effector T cells to skin
    J S Pober
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Ann N Y Acad Sci 941:12-25. 2001
  7. doi request reprint Mechanisms of endothelial dysfunction, injury, and death
    Jordan S Pober
    Departments of Immunobiology and Dermatology, Yale University School of Medicine, New Haven, CT 06520 8089, USA
    Annu Rev Pathol 4:71-95. 2009
  8. ncbi request reprint Evolving functions of endothelial cells in inflammation
    Jordan S Pober
    Interdepartmental Program in Vascular Biology and Therapeutics, Amistad Research Building, Yale University School of Medicine, 10 Amistad Street, New Haven, Connecticut 06509, USA
    Nat Rev Immunol 7:803-15. 2007
  9. pmc Endothelial activation: intracellular signaling pathways
    Jordan S Pober
    Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06510, USA
    Arthritis Res 4:S109-16. 2002
  10. ncbi request reprint Obstacles facing translational research in academic medical centers
    J S Pober
    Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut 06536 0812, USA
    FASEB J 15:2303-13. 2001

Collaborators

Detail Information

Publications87

  1. pmc Dicer-dependent endothelial microRNAs are necessary for postnatal angiogenesis
    Yajaira Suarez
    Department of Immunobiology, Vascular Biology and Therapeutics Program, Yale University School of Medicine, Amistad Research Building, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 105:14082-7. 2008
    ..Thus, endothelial miRNAs regulate postnatal angiogenesis and VEGF induces the expression of miRNAs implicated in the regulation of an integrated angiogenic response...
  2. pmc Interleukin (IL)-1 promotes allogeneic T cell intimal infiltration and IL-17 production in a model of human artery rejection
    Deepak A Rao
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    J Exp Med 205:3145-58. 2008
    ....
  3. pmc Sustained delivery of proangiogenic microRNA-132 by nanoparticle transfection improves endothelial cell transplantation
    Julie Devalliere
    2Department of Immunobiology, PO Box 208089, New Haven, CT 06520 8089, USA
    FASEB J 28:908-22. 2014
    ..These data suggest that sustained delivery of miR-132 encapsulated in a targeted biodegradable polymer NP is a safe and efficient strategy to improve EC transplantation and vascularization...
  4. pmc Participation of blood vessel cells in human adaptive immune responses
    Jordan S Pober
    Yale University School of Medicine, PO Box 208089, 10 Amistad Street, Rm 401, New Haven, CT 06520 8089, USA
    Trends Immunol 33:49-57. 2012
    ..In this review, we compare and contrast what is known about the nature of these interactions in humans...
  5. pmc Endothelial cells present antigens in vivo
    Annette L Rothermel
    Department of Pathology, Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    BMC Immunol 5:5. 2004
    ..coli beta-galactosidase (beta-gal) in two lines of transgenic mice that express beta-gal exclusively in their EC. TIE2-lacZ mice express beta-gal in all EC and VWF-lacZ mice express beta-gal in heart and brain microvascular EC...
  6. ncbi request reprint Human endothelial cell presentation of antigen and the homing of memory/effector T cells to skin
    J S Pober
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Ann N Y Acad Sci 941:12-25. 2001
    ..New models involving transplantation of normal and genetically modified human dermal ECs into immunodeficient mice may be used to further explore these properties...
  7. doi request reprint Mechanisms of endothelial dysfunction, injury, and death
    Jordan S Pober
    Departments of Immunobiology and Dermatology, Yale University School of Medicine, New Haven, CT 06520 8089, USA
    Annu Rev Pathol 4:71-95. 2009
    ..The biochemical pathways activated by these injurious stimuli are described herein and will serve as a basis for future development of endothelial protective therapies...
  8. ncbi request reprint Evolving functions of endothelial cells in inflammation
    Jordan S Pober
    Interdepartmental Program in Vascular Biology and Therapeutics, Amistad Research Building, Yale University School of Medicine, 10 Amistad Street, New Haven, Connecticut 06509, USA
    Nat Rev Immunol 7:803-15. 2007
    ..This Review describes the functions performed by endothelial cells at each stage of the inflammatory process, emphasizing the principal mediators and signalling pathways involved and the therapeutic implications...
  9. pmc Endothelial activation: intracellular signaling pathways
    Jordan S Pober
    Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06510, USA
    Arthritis Res 4:S109-16. 2002
    ..I focus on the biochemistry and cell biology of signal transduction in TNF-treated endothelial cells that lead to the expression of adhesion molecules...
  10. ncbi request reprint Obstacles facing translational research in academic medical centers
    J S Pober
    Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, Connecticut 06536 0812, USA
    FASEB J 15:2303-13. 2001
    ..We offer several suggestions to reduce these impediments...
  11. pmc Reperfusion injury intensifies the adaptive human T cell alloresponse in a human-mouse chimeric artery model
    Tai Yi
    Department of Immunobiology, Yale University School of Medicine, 10 Amistad St, New Haven, CT 06520 8089, USA
    Arterioscler Thromb Vasc Biol 32:353-60. 2012
    ..Perioperative nonimmune injuries to an allograft can decrease graft survival. We have developed a model for studying this process using human materials...
  12. ncbi request reprint Immunobiology of human vascular endothelium
    J S Pober
    Yale University School of Medicine, Boyer Center for Molecular Medicine, New Haven, CT 06520, USA
    Immunol Res 19:225-32. 1999
    ..g., in allograft rejection. These three hypotheses are explored through in vitro experiments, through analyses of human tissue specimens, and through in vivo studies employing novel human-mouse chimeric animals...
  13. pmc Human T-cell-mediated destruction of allogeneic dermal microvessels in a severe combined immunodeficient mouse
    A G Murray
    Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510
    Proc Natl Acad Sci U S A 91:9146-50. 1994
    ..This small animal model may permit evaluation of potential therapeutic reagents that inhibit human T-cell-mediated injury...
  14. ncbi request reprint Human T cells infiltrate and injure pig coronary artery grafts with activated but not quiescent endothelium in immunodeficient mouse hosts
    D A Tereb
    Section of Cardiothoracic Surgery, Yale University School of Medicine, 121 FMB, 333 Cedar Street, New Haven, CT 06510, USA
    Transplantation 71:1622-30. 2001
    ..Activation of pig coronary artery endothelial cells by human tumor necrosis factor, but not porcine interferon-gamma, elicits cellular xenoresponses...
  15. ncbi request reprint Mechanism of sustained E-selectin expression in cultured human dermal microvascular endothelial cells
    M S Kluger
    Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536 0812, USA
    J Immunol 158:887-96. 1997
    ..We conclude that HDMEC sustain higher levels of expression at 24 h by slower internalization and degradation of E-selectin protein and that this may be a general property of microvascular EC...
  16. ncbi request reprint Human vascular endothelial cells stimulate a lower frequency of alloreactive CD8+ pre-CTL and induce less clonal expansion than matching B lymphoblastoid cells: development of a novel limiting dilution analysis method based on CFSE labeling of lymphocytes
    T J Dengler
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 166:3846-54. 2001
    ....
  17. ncbi request reprint Interferon-gamma elicits arteriosclerosis in the absence of leukocytes
    G Tellides
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, and the Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nature 403:207-11. 2000
    ....
  18. pmc In vivo formation of complex microvessels lined by human endothelial cells in an immunodeficient mouse
    J S Schechner
    Interdepartmental Program in Vascular Biology and Transplantation, Department of Dermatology, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 97:9191-6. 2000
    ..Incorporation of such human endothelial-lined microvessels into engineered synthetic skin may improve graft viability, especially in recipients with impaired angiogenesis...
  19. ncbi request reprint Porcine endothelial CD86 is a major costimulator of xenogeneic human T cells: cloning, sequencing, and functional expression in human endothelial cells
    S E Maher
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 157:3838-44. 1996
    ..Costimulation of human T cells by pCD86 in both systems is as effective as costimulation by human CD80 or CD86, and can be blocked by human CTLA4Ig. We conclude that pCD86 contributes to the strong xenoreactivity of porcine endothelium...
  20. pmc CD40 on human endothelial cells: inducibility by cytokines and functional regulation of adhesion molecule expression
    K Karmann
    Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 92:4342-6. 1995
    ..CD40 may be detected immunocytochemically on human microvascular EC in normal skin. We conclude that endothelial CD40 may play a role as a signaling receptor in the development of T-cell-mediated inflammatory reactions...
  21. ncbi request reprint Selective inhibition of NF-kappaB activation by a peptide that blocks the interaction of NEMO with the IkappaB kinase complex
    M J May
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 289:1550-4. 2000
    ..The NBD provides a target for the development of drugs that would block proinflammatory activation of the IKK complex without inhibiting basal NF-kappaB activity...
  22. pmc Suppression of vascular endothelial growth factor-mediated endothelial cell protection by survivin targeting
    M Mesri
    Department of Pathology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Am J Pathol 158:1757-65. 2001
    ....
  23. pmc Initial evaluation of the use of USPIO cell labeling and noninvasive MR monitoring of human tissue-engineered vascular grafts in vivo
    G N Nelson
    Yale University School of Medicine, Interdepartmental Program in Vascular Biology and Therapeutics, Amistad Research Bldg, 10 Amistad St, Rm 301B, P O Box 208089, New Haven, CT 06520, USA
    FASEB J 22:3888-95. 2008
    ..This study demonstrates the feasibility of applying noninvasive imaging techniques for evaluation of in vivo TEVG performance...
  24. pmc Human placental pericytes poorly stimulate and actively regulate allogeneic CD4 T cell responses
    Cheryl L Maier
    Yale University School of Medicine, New Haven, CT 06520, USA
    Arterioscler Thromb Vasc Biol 31:183-9. 2011
    ..Here, we investigate how human T cells interact with PC...
  25. ncbi request reprint Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors
    X Feng
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
    J Biol Chem 276:8341-9. 2001
    ..These findings suggest that intracellular distribution of activated TNF receptors may be regulated by caveolin-1 via its interaction with TRAF2...
  26. ncbi request reprint IL-11 activates human endothelial cells to resist immune-mediated injury
    K Mahboubi
    Molecular Cardiobiology Program, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 164:3837-46. 2000
    ..Our results indicate that low (i.e., STAT3- and MAPK-activating) concentrations of IL-11 confer resistance to immune-mediated injury in cultured HUVECs without inhibiting proinflammatory responses...
  27. ncbi request reprint A phosphatidylinositol 3-kinase/Akt pathway, activated by tumor necrosis factor or interleukin-1, inhibits apoptosis but does not activate NFkappaB in human endothelial cells
    L A Madge
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    J Biol Chem 275:15458-65. 2000
    ..Moreover, the PI 3-kinase/Akt pathway does not play a major role in the pro-inflammatory responses of EC to TNF or IL-1...
  28. ncbi request reprint Interleukin-11 up-regulates survivin expression in endothelial cells through a signal transducer and activator of transcription-3 pathway
    K Mahboubi
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    Lab Invest 81:327-34. 2001
    ..We conclude that IL-11 induces expression of survivin, an antiapoptotic protein, in vitro and in vivo, and identify STAT3 as a critical mediator of this response...
  29. ncbi request reprint TNF signaling in vascular endothelial cells
    L A Madge
    Department of Pathology and the Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Exp Mol Pathol 70:317-25. 2001
    ..In this review the authors will summarize the state of the field, emphasizing studies in cultured human EC...
  30. pmc Antigen presentation by human microvascular endothelial cells triggers ICAM-1-dependent transendothelial protrusion by, and fractalkine-dependent transendothelial migration of, effector memory CD4+ T cells
    Thomas D Manes
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 180:8386-92. 2008
    ..These in vitro observations suggest that presentation of Ag by human microvascular endothelial cells to circulating CD4(+) effector memory T cells may function to initiate recall responses in peripheral tissues...
  31. ncbi request reprint Interferon-gamma induces human vascular smooth muscle cell proliferation and intimal expansion by phosphatidylinositol 3-kinase dependent mammalian target of rapamycin raptor complex 1 activation
    Yinong Wang
    Interdepartmental Program in Vascular Biology and Transplantation, Department of Surgery, Yale University School of Medicine, New Haven, Conn, USA
    Circ Res 101:560-9. 2007
    ....
  32. ncbi request reprint Alloimmune-mediated vascular remodeling of human coronary artery grafts in immunodeficient mouse recipients is independent of preexisting atherosclerosis
    Yinong Wang
    Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, CT, USA
    Transplantation 83:1501-5. 2007
    ..Our results support the concept of extending the criteria for organ donors to include modest coronary atherosclerosis...
  33. ncbi request reprint Interferon-gamma axis in graft arteriosclerosis
    George Tellides
    Interdepartmental Program in Vascular Biology and Transplantation, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA
    Circ Res 100:622-32. 2007
    ..These observations lead us to suggest that new therapies for graft arteriosclerosis should be optimized which focus on reducing IFN-gamma synthesis or actions...
  34. ncbi request reprint TCR signaling antagonizes rapid IP-10-mediated transendothelial migration of effector memory CD4+ T cells
    Thomas D Manes
    Department of Pathology, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue, New Haven, CT 06520, USA
    J Immunol 178:3237-43. 2007
    ....
  35. ncbi request reprint Immunomodulatory properties of FK734, a humanized anti-CD28 monoclonal antibody with agonistic and antagonistic activities
    Stephen L Shiao
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Transplantation 83:304-13. 2007
    ..We describe immunomodulatory effects of FK734, a humanized version of a mouse anti-human CD28 mAb (clone TN228), in vitro and in a chimeric human-mouse model of allograft rejection...
  36. ncbi request reprint Increased ICAM-1 expression causes endothelial cell leakiness, cytoskeletal reorganization and junctional alterations
    Paul R Clark
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA
    J Invest Dermatol 127:762-74. 2007
    ..Induction of ICAM-1 may contribute to but does not fully account for TNF-induced vascular leak and EC shape change...
  37. ncbi request reprint An inflammatory pathway of IFN-gamma production in coronary atherosclerosis
    Hooman Ranjbaran
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 178:592-604. 2007
    ..In conclusion, circulating IL-12 may provide a mechanistic link between inflammation and Th1-type cytokine production in coronary atherosclerosis...
  38. ncbi request reprint Cutting Edge: Internalization of transduced E-selectin by cultured human endothelial cells: comparison of dermal microvascular and umbilical vein cells and identification of a phosphoserine-type di-leucine motif
    Martin S Kluger
    Interdepartmental Program in Vascular Biology and Transplantation, Department of Dermatology, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA
    J Immunol 168:2091-5. 2002
    ..Control of E-selectin surface expression appears to be phosphoserine dependent, since alanine but not aspartic acid substitution for S581 slows E-selectin internalization...
  39. ncbi request reprint Endothelial cell-T lymphocyte interactions: IP[corrected]-10 stimulates rapid transendothelial migration of human effort but not central memory CD4+ T cells. Requirements for shear stress and adhesion molecules
    Thomas D Manes
    Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, CT, USA
    Transplantation 82:S9-14. 2006
    ..TNF treatment of ECs may be effectively replaced by transduction of vascular cell adhesion molecule-1 or intercellular adhesion molecule-1 but not E-selectin...
  40. ncbi request reprint Human effector memory CD4+ T cells directly recognize allogeneic endothelial cells in vitro and in vivo
    Stephen L Shiao
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:4397-404. 2007
    ..Consistent with EC activation of effector functions, human CD4+ T(EM) can mediate allogeneic EC injury in vivo...
  41. ncbi request reprint Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege
    Madison C Cuffy
    Interdepartmental Program in Vascular Biology and Transplantation, Department of Surgery, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 179:5246-54. 2007
    ....
  42. ncbi request reprint IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response
    Deepak A Rao
    Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510 USA
    J Immunol 179:6536-46. 2007
    ..Our results suggest that IL-1, released by injured EC or by HMGB1-stimulated monocytes, is a key link between injury and enhanced alloimmunity, offering a new therapeutic target for preventing late graft failure...
  43. ncbi request reprint Activation of signal transducer and activator of transcription 1 (STAT1) is not sufficient for the induction of STAT1-dependent genes in endothelial cells. Comparison of interferon-gamma and oncostatin M
    Keyvan Mahboubi
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 277:8012-21. 2002
    ..However, signals provided by IFN gamma other than STAT1 activation cannot be provided in trans to complement the response to OnM...
  44. pmc IFN-alpha induces transcription of hypoxia-inducible factor-1alpha to inhibit proliferation of human endothelial cells
    Scott A Gerber
    Department of Immunobiology, Interdepartmental Program in Vascular Biology and Therapeutics, School of Medicine, Yale University, New Haven, CT 06509 8089, USA
    J Immunol 181:1052-62. 2008
    ..We conclude that IFN-alpha induces the transcription of HIF-1alpha in human endothelial cells though a JAK-ISGF3 pathway under normoxic conditions, and that this response contributes to the antiproliferative activity of this cytokine...
  45. ncbi request reprint Antiapoptotic activities of bcl-2 correlate with vascular maturation and transcriptional modulation of human endothelial cells
    David R Enis
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
    Endothelium 15:59-71. 2008
    ..Bcl-2-regulated transcription in ECs may contribute to vascular maturation, and support design of tissue engineering strategies using EC...
  46. pmc Human endothelial cells enhance human immunodeficiency virus type 1 replication in CD4+ T cells in a Nef-dependent manner in vitro and in vivo
    Jaehyuk Choi
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 79:264-76. 2005
    ....
  47. pmc Engineering of multifunctional gels integrating highly efficient growth factor delivery with endothelial cell transplantation
    Steven M Jay
    Yale University, Department of Biomedical Engineering, 55 Prospect St, New Haven, CT 06511, USA
    FASEB J 22:2949-56. 2008
    ....
  48. pmc Regulation of arterial-venous differences in tumor necrosis factor responsiveness of endothelial cells by anatomic context
    Meng Liu
    Yale University School of Medicine, 10 Amistad Street, New Haven, CT 06509, USA
    Am J Pathol 172:1088-99. 2008
    ..Flow-induced expression of KLF2 contributes to the in situ responses of HUAECs but not of HUVECs...
  49. doi request reprint Interferon-gamma induces X-linked inhibitor of apoptosis-associated factor-1 and Noxa expression and potentiates human vascular smooth muscle cell apoptosis by STAT3 activation
    Yalai Bai
    Interdepartmental Program in Vascular Biology and Transplantation and the Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 283:6832-42. 2008
    ..The data suggest STAT1-independent signaling by IFN-gamma via STAT3 that promotes the death of human VSMCs...
  50. pmc Small-diameter biodegradable scaffolds for functional vascular tissue engineering in the mouse model
    Jason D Roh
    Yale University School of Medicine, Interdepartmental Program in Vascular Biology and Therapeutics, New Haven, CT 06510, USA
    Biomaterials 29:1454-63. 2008
    ..These results present the ability to create sub-1mm ID biodegradable tubular scaffolds that are functional as vascular grafts, and provide an experimental approach for the study of vascular tissue engineering using mouse models...
  51. pmc Knockdown of TNFR1 by the sense strand of an ICAM-1 siRNA: dissection of an off-target effect
    Paul R Clark
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06510, USA
    Nucleic Acids Res 36:1081-97. 2008
    ....
  52. ncbi request reprint Vascularization and engraftment of a human skin substitute using circulating progenitor cell-derived endothelial cells
    Benjamin R Shepherd
    Department of Pathology, Yale University School of Medicine, 295 Congress Ave, Boyer Center for Molecular Medicine Rm 454, New Haven, Connecticut 06510, USA
    FASEB J 20:1739-41. 2006
    ..We conclude that EC differentiated from circulating progenitors can be utilized to vascularize human skin substitutes even in the setting of compromised host angiogenesis/vasculogenesis...
  53. ncbi request reprint Development of a model system for preliminary evaluation of tissue-engineered vascular conduits
    Amit Goyal
    Department of Surgery, Yale University, New Haven, CT 06520, USA
    J Pediatr Surg 41:787-91. 2006
    ....
  54. ncbi request reprint Histamine antagonizes tumor necrosis factor (TNF) signaling by stimulating TNF receptor shedding from the cell surface and Golgi storage pool
    Jun Wang
    Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Box 157, Hills Road, Cambridge CB2 2QQ, United Kingdom
    J Biol Chem 278:21751-60. 2003
    ..These results both clarify relationships among TNFR1 populations and reveal a novel anti-inflammatory activity of histamine...
  55. ncbi request reprint Effects of antisense oligonucleotide-mediated depletion of tumor necrosis factor (TNF) receptor 1-associated death domain protein on TNF-induced gene expression
    Andrew M Siwkowski
    Isis Pharmaceuticals, Inc, 2292 Faraday Avenue, Carlsbad, CA 92008, USA
    Mol Pharmacol 66:572-9. 2004
    ..These results indicate usage of antisense inhibitors of TRADD expression for modulating diseases associated with TRADD-dependent signal transduction pathways...
  56. ncbi request reprint Bcl-2 transduction protects human endothelial cell synthetic microvessel grafts from allogeneic T cells in vivo
    Lian Zheng
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 173:3020-6. 2004
    ..Using this model, we demonstrate that transduced Bcl-2 protein in the engrafted EC effectively prevents injury even as it enhances T cell graft infiltration and replication...
  57. ncbi request reprint Interferon alpha but not interleukin 12 activates STAT4 signaling in human vascular endothelial cells
    Nicholas Torpey
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 279:26789-96. 2004
    ..These observations reveal that there is a STAT4 response of EC, activated by IFNalpha but not IL12, and that it may modulate the pro-inflammatory behavior of EC...
  58. ncbi request reprint T lymphocyte-endothelial cell interactions
    Jaehyuk Choi
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 0812, USA
    Annu Rev Immunol 22:683-709. 2004
    ..T cell interactions with vascular EC are thus bidirectional and link the immune and circulatory systems...
  59. pmc Early delayed-type hypersensitivity eosinophil infiltrates depend on T helper 2 cytokines and interferon-gamma via CXCR3 chemokines
    Moe Akahira-Azuma
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 0813, USA
    Immunology 111:306-17. 2004
    ..These results suggest that both a Th2-like (IL-5, IL-4 and STAT-6) and a Th1-like (IFN-gamma, IP-10, CXCR3) pathway contribute to eosinophil recruitment in early delayed-type hypersensitivity...
  60. ncbi request reprint Immunopathology of human T cell responses to skin, artery and endothelial cell grafts in the human peripheral blood lymphocyte/severe combined immunodeficient mouse
    Jordan S Pober
    Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, Boyer Center for Molecular Medicine, 295 Congress Avenue Room 454, New Haven, CT 06510, USA
    Springer Semin Immunopathol 25:167-80. 2003
    ..We also describe our more limited experience using porcine skin and artery transplantation to study human T cells responses to pig endothelium...
  61. ncbi request reprint IL-11 protects human microvascular endothelium from alloinjury in vivo by induction of survivin expression
    Nancy C Kirkiles-Smith
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine and Department of Pathology, Yale University School of Medicine, New Haven CT 06510, USA
    J Immunol 172:1391-6. 2004
    ..We conclude that in this human transplant model, IL-11 exerts a cytoprotective rather than anti-inflammatory or immunomodulatory effect mediated through induction of survivin...
  62. ncbi request reprint Interferon-gamma plays a nonredundant role in mediating T cell-dependent outward vascular remodeling of allogeneic human coronary arteries
    Yinong Wang
    Interdepartmental Program in Vascular Biology and Transplantation, and the Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    FASEB J 18:606-8. 2004
    ..The nonredundant role of IFN-gamma in T-cell-dependent remodeling of human coronary arteries demonstrated here presents a new therapeutic target for preservation of vessel lumen in arteriosclerosis...
  63. ncbi request reprint Engraftment of a vascularized human skin equivalent
    Jeffrey S Schechner
    Department of Dermatology, Yale University School of Medicine, P O Box 208059, New Haven, CT 06520 8059, USA
    FASEB J 17:2250-6. 2003
    ..Successful transplantation of such vascularized human skin equivalents should enhance clinical utility, especially in recipients with impaired angiogenesis...
  64. pmc T cell-mediated vascular dysfunction of human allografts results from IFN-gamma dysregulation of NO synthase
    Kian Peng Koh
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Clin Invest 114:846-56. 2004
    ..We conclude that IFN-gamma is a central mediator of vascular dysfunction and, through dysregulation of NOS expression, links early dysfunction with late arteriosclerosis...
  65. pmc Airway hyper-reactivity mediated by B-1 cell immunoglobulin M antibody generating complement C5a at 1 day post-immunization in a murine hapten model of non-atopic asthma
    Ivana Kawikova
    Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Immunology 113:234-45. 2004
    ....
  66. ncbi request reprint TRAIL induces apoptosis and inflammatory gene expression in human endothelial cells
    Jie Hui Li
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 171:1526-33. 2003
    ..These data suggest that TRAIL is an inducer of tissue injury in humans, an outcome that may influence antitumor therapy with TRAIL...
  67. ncbi request reprint Memory T cells and their costimulators in human allograft injury
    Stephen L Shiao
    Section of Immunobiology, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 175:4886-96. 2005
    ..These data demonstrate that human memory T cells respond to microvascular endothelial cells and can injure allografts in vivo without priming. Furthermore, several recently described costimulators contribute to these processes...
  68. ncbi request reprint Inhibition of phosphatidylinositol 3-kinase sensitizes vascular endothelial cells to cytokine-initiated cathepsin-dependent apoptosis
    Lisa A Madge
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 278:21295-306. 2003
    ..These results suggest that inhibition of PI3K allows cytokines to activate a cathepsin-dependent, mitochondrial death pathway in which caspase activation is secondary, is not inhibited by c-FLIP, and is not essential for cell death...
  69. ncbi request reprint Heparin displaces interferon-gamma-inducible chemokines (IP-10, I-TAC, and Mig) sequestered in the vasculature and inhibits the transendothelial migration and arterial recruitment of T cells
    Hooman Ranjbaran
    Department of Surgery, Yale University School of Medicine, New Haven, Conn, USA
    Circulation 114:1293-300. 2006
    ....
  70. ncbi request reprint The cathepsin B death pathway contributes to TNF plus IFN-gamma-mediated human endothelial injury
    Jie Hui Li
    Department of Pathology and Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    J Immunol 175:1858-66. 2005
    ..These observations suggest that the Cat B death pathway is cell type-specific and may contribute to cytokine-mediated human tissue injury and to the embryonic lethality of FADD gene disruption in mice...
  71. ncbi request reprint Recruitment of CXCR3+ and CCR5+ T cells and production of interferon-gamma-inducible chemokines in rejecting human arteries
    William R Burns
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Department of Surgery, Yale University School of Medicine, New Haven, CT, USA
    Am J Transplant 5:1226-36. 2005
    ..These data explain the recruitment of IFN-gamma-secreting T cells to the vessel wall, and reinforce the suggestion that the arterial media may be a site of immunological privilege...
  72. pmc Endothelial cells require STAT3 for protection against endotoxin-induced inflammation
    Arihiro Kano
    Dept of Pathology, Yale University School of Medicine, P O Box 208023, New Haven, CT 06520, USA
    J Exp Med 198:1517-25. 2003
    ..These data define STAT3 signaling within endothelia as a critical antiinflammatory mediator and provide new insight to the protective function of ECs in inflammation...
  73. pmc Induction, differentiation, and remodeling of blood vessels after transplantation of Bcl-2-transduced endothelial cells
    David R Enis
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, and Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 102:425-30. 2005
    ..Our results support the utility of differentiated EC transplantation to treat tissue ischemia...
  74. pmc Interferon-gamma augments CD95(APO-1/Fas) and pro-caspase-8 expression and sensitizes human vascular endothelial cells to CD95-mediated apoptosis
    Jie Hui Li
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Am J Pathol 161:1485-95. 2002
    ..We conclude that IFN-gamma induces sensitivity of endothelium to CD95L-mediated apoptosis, and that this response may result from increased expression of CD95 and/or pro-caspase-8...
  75. pmc Endothelial cells promote human immunodeficiency virus replication in nondividing memory T cells via Nef-, Vpr-, and T-cell receptor-dependent activation of NFAT
    Jaehyuk Choi
    Section of Immunology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Virol 79:11194-204. 2005
    ....
  76. pmc Expression of silencer of death domains and death-receptor-3 in normal human kidney and in rejecting renal transplants
    Rafia S Al-Lamki
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge, United Kingdom
    Am J Pathol 163:401-11. 2003
    ..These data confirm that TNF receptor family members are expressed in a regulated manner during renal transplant rejection, and identify DR3 as a potential inducible mediator of tubular inflammation and injury...
  77. ncbi request reprint Interleukin-11 and interleukin-6 protect cultured human endothelial cells from H2O2-induced cell death
    Aaron B Waxman
    Pulmonary Critical Care Unit, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Bulfinch 148 Boston, MA 02114
    Am J Respir Cell Mol Biol 29:513-22. 2003
    ..They also demonstrate that this protection is mediated, at least in part, by a STAT3 and MEK-1-dependent specific signal transduction pathway(s)...
  78. ncbi request reprint Desensitization of signaling by oncostatin M in human vascular cells involves cytoplasmic Tyr residue 759 in gp130 but is not mediated by either Src homology 2 domain-containing tyrosine phosphatase 2 or suppressor of cytokine signaling 3
    Keyvan Mahboubi
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 278:25014-23. 2003
    ....
  79. pmc TL1A both promotes and protects from renal inflammation and injury
    Rafia S Al-Lamki
    Department of Medicine, University of Cambridge, Addenbrooke s Hospital, Cambridge CB2 2QQ, UK
    J Am Soc Nephrol 19:953-60. 2008
    ....
  80. ncbi request reprint Alloimmunity to human endothelial cells derived from cord blood progenitors
    Yajaira Suarez
    Department of Immunobiology, Interdepartmental Program in Vascular Biology and Therapeutics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 179:7488-96. 2007
    ..These findings have significant implications for the use of cord blood EPCs in regenerative medicine or tissue engineering...
  81. ncbi request reprint Porcine endothelial cells, unlike human endothelial cells, can be killed by human CTL via Fas ligand and cannot be protected by Bcl-2
    Lian Zheng
    Section of Immunobiology and Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, New Haven, CT 06520 8011, USA
    J Immunol 169:6850-5. 2002
    ..These data reveal differences in the susceptibility of human and porcine targets to huCTL...
  82. ncbi request reprint Endothelial injury mediated by cytotoxic T lymphocytes and loss of microvessels in chronic graft versus host disease
    Barbara C Biedermann
    Department of Medicine, University Hospital Bruderholz, Bruderholz, Switzerland
    Lancet 359:2078-83. 2002
    ..Vascular injury has been seen in patients with acute graft versus host disease (GVHD) in the skin. We aimed to see whether vascular injury mediated by cytotoxic T lymphocytes and microvessel loss arises in patients with chronic GVHD...
  83. ncbi request reprint RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation
    Haifeng Zhang
    Interdepartmental Program in Vascular Biology and Transplantation, Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 282:14788-96. 2007
    ..Our results demonstrate that RIP1-mediated AIP1 phosphorylation at the 14-3-3-binding site Ser-604 is essential for TNF-induced TRAF2-RIP1-AIP1-ASK1 complex formation and for the activation of ASK1-JNK/p38 apoptotic signaling...
  84. ncbi request reprint Dicer dependent microRNAs regulate gene expression and functions in human endothelial cells
    Yajaira Suarez
    Department of Pathology, Yale University School of Medicine, New Haven, Conn 06536, USA
    Circ Res 100:1164-73. 2007
    ..Collectively, these results indicate that maintenance and regulation of endogenous miRNA levels via Dicer mediated processing is critical for EC gene expression and functions in vitro...
  85. pmc Caveolae participate in tumor necrosis factor receptor 1 signaling and internalization in a human endothelial cell line
    Alessio D'Alessio
    Interdepartmental Program in Vascular Biology and Transplantation, Boyer Center for Molecular Medicine, Yale University School of Medicine, 295 Congress Ave, New Haven, CT 06536 0812, USA
    Am J Pathol 166:1273-82. 2005
    ....
  86. ncbi request reprint Immune accessory functions of human endothelial cells are modulated by overexpression of B7-H1 (PDL1)
    Adriana J LaGier
    Evelyn F and William L McKnight Vision Research Center, Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA
    Hum Immunol 67:568-78. 2006
    ..B7H1-EC were less able to stimulate allogeneic proliferation of CD4+ memory T cells than control EC. These data suggest that B7-H1 overexpression may be a useful approach for reducing allogeneic CD4+ memory T-cell responses to EC...
  87. ncbi request reprint Human allograft arterial injury is ameliorated by sirolimus and cyclosporine and correlates with suppression of interferon-gamma
    Tai Yi
    Department of Surgery, Section of Organ Transplantation and Immunology, Yale University School of Medicine, New Haven, CT 06510, USA
    Transplantation 81:559-66. 2006
    ..This study evaluated whether sirolimus (SRL), with cyclosporine A (CsA) or alone, affects TA, and examined possible mechanisms of action...

Research Grants38

  1. PROTEINS OF THE ENDOTHELIAL CELL SURFACE
    JORDAN POBER; Fiscal Year: 1991
    ..Finally, the availability of such reagents and data may suggest new avenues for therapeutic intervention aimed at blocking harmful immune inflammatory episodes through modulation of endothelial cell responses...
  2. PROTEINS OF THE ENDOTHELIAL CELL SURFACE
    JORDAN POBER; Fiscal Year: 2004
    ..HUVEC. Insights from these experiments may lead to more nuanced strategies to control inflammation. ..
  3. ENDOTHELIAL MODIFICATIONS THAT REDUCE T CELL ACTIVATION
    JORDAN POBER; Fiscal Year: 1999
    ....
  4. HUMAN CTL-MEDIATED INJURY OF GRAFT ENDOTHELIAL CELLS
    JORDAN POBER; Fiscal Year: 2005
    ..These data will provide a rational basis for developing new, complementary strategies to further reduce the incidence and consequences of allograft rejection. ..
  5. Alloimmunity to Progenitor Cell-Derived Human Vascular Cells
    JORDAN POBER; Fiscal Year: 2006
    ..abstract_text> ..
  6. PROTEINS OF THE ENDOTHELIAL CELL SURFACE
    JORDAN POBER; Fiscal Year: 2006
    ..HUVEC. Insights from these experiments may lead to more nuanced strategies to control inflammation. ..
  7. HUMAN CTL-MEDIATED INJURY OF GRAFT ENDOTHELIAL CELLS
    JORDAN POBER; Fiscal Year: 2006
    ..These data will provide a rational basis for developing new, complementary strategies to further reduce the incidence and consequences of allograft rejection. ..
  8. Alloimmunity to Progenitor Cell-Derived Human Vascular Cells
    JORDAN POBER; Fiscal Year: 2007
    ..abstract_text> ..
  9. HUMAN CTL-MEDIATED INJURY OF GRAFT ENDOTHELIAL CELLS
    JORDAN POBER; Fiscal Year: 2007
    ..These data will provide a rational basis for developing new, complementary strategies to further reduce the incidence and consequences of allograft rejection. ..
  10. Alloimmunity to Progenitor Cell-Derived Human Vascular Cells
    JORDAN POBER; Fiscal Year: 2009
    ..abstract_text> ..
  11. PROTEINS OF THE ENDOTHELIAL CELL SURFACE
    JORDAN POBER; Fiscal Year: 2009
    ....
  12. HUMAN CTL-MEDIATED INJURY OF GRAFT ENDOTHELIAL CELLS
    JORDAN POBER; Fiscal Year: 2009
    ..These data will provide a rational basis for developing new, complementary strategies to further reduce the incidence and consequences of allograft rejection. ..
  13. Alloimmunity to Progenitor Cell-Derived Human Vascular Cells
    Jordan S Pober; Fiscal Year: 2010
    ..abstract_text> ..
  14. PROTEINS OF THE ENDOTHELIAL CELL SURFACE
    Jordan S Pober; Fiscal Year: 2010
    ....
  15. PROTEINS OF THE ENDOTHELIAL CELL SURFACE
    JORDAN POBER; Fiscal Year: 2005
    ..HUVEC. Insights from these experiments may lead to more nuanced strategies to control inflammation. ..
  16. ENDOTHELIAL MODIFICATIONS THAT REDUCE T CELL ACTIVATION
    JORDAN POBER; Fiscal Year: 2005
    ..g., in atherosclerosis and receptors and acute coronary syndromes. ..
  17. PROTEINS OF THE ENDOTHELIAL CELL SURFACE
    JORDAN POBER; Fiscal Year: 1992
    ..The information generated by this proposal may open new therapeutic avenues to control inflammation by allowing pharmacological manipulation of EC adhesion molecule expression in vivo...
  18. ENDOTHELIAL MODIFICATIONS THAT REDUCE T CELL ACTIVATION
    JORDAN POBER; Fiscal Year: 2000
    ....
  19. ENDOTHELIAL MODIFICATIONS THAT REDUCE T CELL ACTIVATION
    JORDAN POBER; Fiscal Year: 2001
    ..g., in atherosclerosis and receptors and acute coronary syndromes. ..
  20. HUMAN CTL-MEDIATED INJURY OF GRAFT ENDOTHELIAL CELLS
    JORDAN POBER; Fiscal Year: 2001
    ..The results of these studies will advance knowledge about EC-CTL interactions in transplantation and provide a basis for novel immunomodulatory or gene-based therapies to improve graft outcome. ..
  21. HUMAN CTL-MEDIATED INJURY OF GRAFT ENDOTHELIAL CELLS
    JORDAN POBER; Fiscal Year: 2002
    ..The results of these studies will advance knowledge about EC-CTL interactions in transplantation and provide a basis for novel immunomodulatory or gene-based therapies to improve graft outcome. ..
  22. ENDOTHELIAL MODIFICATIONS THAT REDUCE T CELL ACTIVATION
    JORDAN POBER; Fiscal Year: 2002
    ..g., in atherosclerosis and receptors and acute coronary syndromes. ..
  23. PROTEINS OF THE ENDOTHELIAL CELL SURFACE
    JORDAN POBER; Fiscal Year: 2002
    ..HUVEC. Insights from these experiments may lead to more nuanced strategies to control inflammation. ..
  24. PROTEINS OF THE ENDOTHELIAL CELL SURFACE
    JORDAN POBER; Fiscal Year: 2003
    ..HUVEC. Insights from these experiments may lead to more nuanced strategies to control inflammation. ..
  25. HUMAN CTL-MEDIATED INJURY OF GRAFT ENDOTHELIAL CELLS
    JORDAN POBER; Fiscal Year: 2003
    ..The results of these studies will advance knowledge about EC-CTL interactions in transplantation and provide a basis for novel immunomodulatory or gene-based therapies to improve graft outcome. ..
  26. ENDOTHELIAL MODIFICATIONS THAT REDUCE T CELL ACTIVATION
    JORDAN POBER; Fiscal Year: 2003
    ..g., in atherosclerosis and receptors and acute coronary syndromes. ..
  27. HUMAN CTL-MEDIATED INJURY OF GRAFT ENDOTHELIAL CELLS
    JORDAN POBER; Fiscal Year: 2004
    ..The results of these studies will advance knowledge about EC-CTL interactions in transplantation and provide a basis for novel immunomodulatory or gene-based therapies to improve graft outcome. ..
  28. ENDOTHELIAL MODIFICATIONS THAT REDUCE T CELL ACTIVATION
    JORDAN POBER; Fiscal Year: 2004
    ..g., in atherosclerosis and receptors and acute coronary syndromes. ..
  29. Presentation of Alloantigen by Human Vascular Cells
    Jordan S Pober; Fiscal Year: 2011
    ..This project will further characterize such interactions between human cells and, if successful, will suggest new approaches to reduce organ graft rejection. ..