MARINA PICCIOTTO

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice
    Rebecca C Steiner
    Interdepartmental Neuroscience Program and Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Behav Brain Res 171:56-62. 2006
  2. pmc Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference
    Darlene H Brunzell
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1993-2001. 2009
  3. pmc Molecules and circuits involved in nicotine addiction: The many faces of smoking
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA Electronic address
    Neuropharmacology 76:545-53. 2014
  4. pmc Molecular mechanisms underlying behaviors related to nicotine addiction
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Cold Spring Harb Perspect Med 3:a012112. 2013
  5. pmc Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuron 76:116-29. 2012
  6. ncbi request reprint Use of knock-out mice to determine the molecular basis for the actions of nicotine
    M R Picciotto
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Nicotine Tob Res 1:S121-5; discussion S139-40. 1999
  7. ncbi request reprint Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Front Biosci 13:492-504. 2008
  8. doi request reprint Galanin and addiction
    M R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, Connecticut 06508, USA
    Cell Mol Life Sci 65:1872-9. 2008
  9. pmc It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Prog Neurobiol 84:329-42. 2008
  10. ncbi request reprint Galanin can attenuate opiate reinforcement and withdrawal
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    Neuropeptides 39:313-5. 2005

Research Grants

  1. Antidepressant effect of nicotinic receptor blockade
    Marina R Picciotto; Fiscal Year: 2010
  2. Galanin-opiate interactions
    Marina R Picciotto; Fiscal Year: 2010
  3. NICOTINE ADDICTION IN MICE LACKING THE NEURONAL NACHR
    MARINA PICCIOTTO; Fiscal Year: 2009
  4. Antidepressant effect of nicotinic receptor blockade
    MARINA PICCIOTTO; Fiscal Year: 2007
  5. Galanin-opiate interactions
    MARINA PICCIOTTO; Fiscal Year: 2006
  6. Anatomical basis for nicotine addiction
    Marina R Picciotto; Fiscal Year: 2010
  7. ROLE OF THE HIGH AFFINITY NICOTINE RECEPTOR IN ADDICTION
    MARINA PICCIOTTO; Fiscal Year: 2007
  8. Anatomical basis for nicotine addiction in mice
    MARINA PICCIOTTO; Fiscal Year: 2005

Detail Information

Publications70

  1. ncbi request reprint Cocaine self-administration and locomotor sensitization are not altered in CART knockout mice
    Rebecca C Steiner
    Interdepartmental Neuroscience Program and Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Behav Brain Res 171:56-62. 2006
    ..In conclusion, these data indicate that CART is not integral to the effects of psychostimulants in mice lacking CART throughout development, although it may play a regulatory role in the intact animal...
  2. pmc Nucleus accumbens CREB activity is necessary for nicotine conditioned place preference
    Darlene H Brunzell
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 34:1993-2001. 2009
    ..Taken together, these studies identify the NAc shell as a brain region where CREB activity is essential for nicotine CPP...
  3. pmc Molecules and circuits involved in nicotine addiction: The many faces of smoking
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA Electronic address
    Neuropharmacology 76:545-53. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  4. pmc Molecular mechanisms underlying behaviors related to nicotine addiction
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Cold Spring Harb Perspect Med 3:a012112. 2013
    ..Here we review recent insights into the behavioral actions of nicotine and the nAChRs subtypes involved, which likely contribute to the development of tobacco dependence in smokers...
  5. pmc Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuron 76:116-29. 2012
    ..The ability of acetylcholine to coordinate the response of neuronal networks in many brain areas makes cholinergic modulation an essential mechanism underlying complex behaviors...
  6. ncbi request reprint Use of knock-out mice to determine the molecular basis for the actions of nicotine
    M R Picciotto
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Nicotine Tob Res 1:S121-5; discussion S139-40. 1999
    ..Multidisciplinary approaches to nAChR function will be essential to answering these questions...
  7. ncbi request reprint Neuroprotection via nAChRs: the role of nAChRs in neurodegenerative disorders such as Alzheimer's and Parkinson's disease
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Front Biosci 13:492-504. 2008
    ..This review summarizes recent studies related to the mechanisms underlying nicotine-mediated neuroprotection, and addresses issues that are relevant to use of nicotine as a neuroprotective agent in vivo...
  8. doi request reprint Galanin and addiction
    M R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, Connecticut 06508, USA
    Cell Mol Life Sci 65:1872-9. 2008
    ..Further, galanin receptors might be potential targets for development of novel treatments for addiction...
  9. pmc It is not "either/or": activation and desensitization of nicotinic acetylcholine receptors both contribute to behaviors related to nicotine addiction and mood
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Prog Neurobiol 84:329-42. 2008
    ..We conclude that there are effects of nAChR activation and desensitization on drug reinforcement and affective behavior, and that both processes are important in the behavioral consequences of nicotine in tobacco smoking...
  10. ncbi request reprint Galanin can attenuate opiate reinforcement and withdrawal
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    Neuropeptides 39:313-5. 2005
    ..Further, genetic variation in the genes encoding galanin and its receptors could be associated with altered susceptibility to opiate dependence...
  11. ncbi request reprint Nicotine as a modulator of behavior: beyond the inverted U
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street 3rd Floor Research, New Haven, CT 06508, USA
    Trends Pharmacol Sci 24:493-9. 2003
    ....
  12. pmc Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence
    Christopher J Heath
    Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, CT 06508, USA
    Physiol Behav 101:764-9. 2010
    ....
  13. pmc The nicotinic acetylcholine receptor partial agonist varenicline increases the ataxic and sedative-hypnotic effects of acute ethanol administration in C57BL/6J mice
    Helen M Kamens
    Department of Psychiatry, Yale University, New Haven, CT 06508, USA
    Alcohol Clin Exp Res 34:2053-60. 2010
    ..Recently, the nicotinic acetylcholine receptor (nAChR) partial agonist varenicline has been shown to decrease ethanol consumption in both humans and animal models...
  14. ncbi request reprint Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications
    M R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    Pharmacol Ther 92:89-108. 2001
    ..Genetic manipulations in mice have also elucidated the role of nAChR subunits in various disease states, and suggest several avenues for drug development...
  15. ncbi request reprint Neuronal systems underlying behaviors related to nicotine addiction: neural circuits and molecular genetics
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 22:3338-41. 2002
    ..The use of multiple techniques by many laboratories provides optimism that the field is advancing toward elucidating the basic mechanisms of nicotine dependence...
  16. ncbi request reprint Galanin and addiction
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    EXS 102:195-208. 2010
    ..Further, galanin receptors might be potential targets for development of novel treatments for addiction...
  17. pmc Effects of galanin on monoaminergic systems and HPA axis: Potential mechanisms underlying the effects of galanin on addiction- and stress-related behaviors
    Marina R Picciotto
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, USA
    Brain Res 1314:206-18. 2010
    ..Understanding the mechanisms underlying galanin's effects on neuronal function in brain regions related to stress and addiction may be useful in developing novel therapeutics for the treatment of stress- and addiction-related disorders...
  18. ncbi request reprint Nicotinic receptors in aging and dementia
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, Connecticut 06508, USA
    J Neurobiol 53:641-55. 2002
    ..We will also present hypotheses that might address the mechanisms underlying the ability of nAChR function to protect against neurodegeneration or improve cognition, two potentially distinct actions of nicotine...
  19. pmc Voluntary oral nicotine intake in mice down-regulates GluR2 but does not modulate depression-like behaviors
    Patricia Vieyra-Reyes
    Yale University, Department of Psychiatry, 34 Park Street, New Haven, CT 06508, USA
    Neurosci Lett 434:18-22. 2008
    ..In addition, alterations in CREB and GluR1 levels are not sufficient to explain preference for nicotine in a 2-bottle choice paradigm...
  20. ncbi request reprint Characterization of GalR1, GalR2, and GalR3 immunoreactivity in catecholaminergic nuclei of the mouse brain
    Jessica J Hawes
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Comp Neurol 479:410-23. 2004
    ..Overall, GalR1, GalR2, and GalR3 are distributed widely throughout the brain, correlate with widespread galanin binding, and colocalize with tyrosine hydroxylase in catecholaminergic brain areas...
  21. ncbi request reprint Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior
    Sarah L King
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 23:3837-43. 2003
    ....
  22. ncbi request reprint In vivo nicotine treatment regulates mesocorticolimbic CREB and ERK signaling in C57Bl/6J mice
    Darlene H Brunzell
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurochem 84:1431-41. 2003
    ..Overall, these results support a role for ERK and CREB activity in neural plasticity associated with nicotine dependence...
  23. ncbi request reprint Neuroprotection by nicotine in mouse primary cortical cultures involves activation of calcineurin and L-type calcium channel inactivation
    Tanya R Stevens
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 23:10093-9. 2003
    ..We conclude that neuroprotective effects of nicotine in cortical neurons involve both beta2- and alpha7-containing nAChRs, activation of calcineurin, and decreased intracellular calcium via L-type channels...
  24. pmc The membrane cytoskeletal protein adducin is phosphorylated by protein kinase C in D1 neurons of the nucleus accumbens and dorsal striatum following cocaine administration
    Jeremie Lavaur
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurochem 111:1129-37. 2009
    ..These data indicate that adducin phosphorylation is a signaling event regulated by cocaine administration and further suggest that adducin may be involved in remodeling of the neuronal cytoskeleton in response to cocaine administration...
  25. ncbi request reprint Nicotine-induced phosphorylation of ERK in mouse primary cortical neurons: evidence for involvement of glutamatergic signaling and CaMKII
    Rebecca C Steiner
    Interdepartmental Neuroscience Program and Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurochem 103:666-78. 2007
    ....
  26. ncbi request reprint Deficiency in inhibitory cortical interneurons associates with hyperactivity in fibroblast growth factor receptor 1 mutant mice
    Karen Müller Smith
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    Biol Psychiatry 63:953-62. 2008
    ..Motor hyperactivity due to hyper-dopaminergic neurotransmission in the basal ganglia is well characterized; much less is known about the role of the neocortex in controlling motor behavior...
  27. ncbi request reprint Nestin promoter/enhancer directs transgene expression to precursors of adult generated periglomerular neurons
    Robert D Beech
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor, New Haven, CT 06508, USA
    J Comp Neurol 475:128-41. 2004
    ..The ability to express different transgenes within this subpopulation of neuronal precursors provides a powerful system to define the signals regulating the differentiation and survival of adult-generated neurons in the olfactory bulb...
  28. ncbi request reprint Prenatal and adolescent exposure to tobacco smoke modulates the development of white matter microstructure
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    J Neurosci 27:13491-8. 2007
    ....
  29. pmc Effects of galanin on cocaine-mediated conditioned place preference and ERK signaling in mice
    Roopashree Narasimhaiah
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 204:95-102. 2009
    ..Galanin has been shown to attenuate neurochemical, physiological, and behavioral signs of opiate and amphetamine reinforcement...
  30. pmc Varenicline reduces alcohol self-administration in heavy-drinking smokers
    Sherry A McKee
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 66:185-90. 2009
    ..Varenicline, a partial nicotinic agonist with high affinity for the alpha4beta2 nAChR receptor, reduced ethanol intake in rodents. We aimed to test whether varenicline would reduce alcohol consumption and alcohol craving in humans...
  31. ncbi request reprint Human tobacco smokers in early abstinence have higher levels of beta2* nicotinic acetylcholine receptors than nonsmokers
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06511, USA
    J Neurosci 26:8707-14. 2006
    ..Greater beta2*-nAChR availability during early abstinence may impact the ability of smokers to maintain abstinence...
  32. ncbi request reprint Smoking as a complex but critical covariate in neurobiological studies of posttraumatic stress disorders: a review
    Ann M Rasmusson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Psychopharmacol 20:693-707. 2006
    ....
  33. pmc Sex differences in anxiety-like behavior and locomotor activity following chronic nicotine exposure in mice
    Barbara J Caldarone
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    Neurosci Lett 439:187-91. 2008
    ..This shows that female mice have an anxiogenic-like response to chronic nicotine, but are less sensitive to nicotine's psychostimulant properties, which may be related to the increased relapse to smoking following abstinence in women...
  34. ncbi request reprint beta2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice
    Darlene H Brunzell
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 184:328-38. 2006
    ..Nicotine administration potentiates conditioned reinforcement in rats, an effect that persists for weeks after chronic exposure. Little is known regarding the nicotinic receptor subtypes that may mediate this effect...
  35. pmc Galanin protects against behavioral and neurochemical correlates of opiate reward
    Jessica J Hawes
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 33:1864-73. 2008
    ..These data suggest that galanin normally attenuates behavioral and neurochemical effects of opiates; thus, galanin agonists may represent a new class of therapeutic targets for opiate addiction...
  36. ncbi request reprint Alteration of hippocampal cell proliferation in mice lacking the beta 2 subunit of the neuronal nicotinic acetylcholine receptor
    Alexia Harrist
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Synapse 54:200-6. 2004
    ....
  37. doi request reprint Role of beta2-containing nicotinic acetylcholine receptors in auditory event-related potentials
    Noam D Rudnick
    Stanley Center for Experimental Therapeutics, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19312, USA
    Psychopharmacology (Berl) 202:745-51. 2009
    ..Less is known about the role of specific nicotinic acetylcholine receptor (nAChR) subtypes...
  38. pmc Genetics of nicotinic acetylcholine receptors: Relevance to nicotine addiction
    Yann S Mineur
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    Biochem Pharmacol 75:323-33. 2008
    ....
  39. ncbi request reprint Beta2-subunit-containing nicotinic acetylcholine receptors are critical for dopamine-dependent locomotor activation following repeated nicotine administration
    Sarah L King
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    Neuropharmacology 47:132-9. 2004
    ....
  40. pmc Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
    Alfonso Abizaid
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06519, USA
    J Clin Invest 116:3229-39. 2006
    ..Taken together, these data suggest that the mesolimbic reward circuitry is targeted by peripheral ghrelin to influence physiological mechanisms related to feeding...
  41. ncbi request reprint Galanin and galanin-like peptide modulate neurite outgrowth via protein kinase C-mediated activation of extracellular signal-related kinase
    Jessica J Hawes
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    Eur J Neurosci 23:2937-46. 2006
    ..This study identified a novel physiological role for galanin-induced ERK phosphorylation and identified ERK and protein kinase C as important signaling components in the galanin-mediated modulation of neurite outgrowth...
  42. pmc The neuropeptide galanin modulates behavioral and neurochemical signs of opiate withdrawal
    Venetia Zachariou
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 100:9028-33. 2003
    ..These studies suggest that galanin normally acts to counteract opiate withdrawal and that small molecule galanin agonists could be effective in diminishing the physical signs of withdrawal...
  43. ncbi request reprint Decreased synaptic vesicle recycling efficiency and cognitive deficits in amphiphysin 1 knockout mice
    Gilbert Di Paolo
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Neuron 33:789-804. 2002
    ..These defects correlate with increased mortality due to rare irreversible seizures and with major learning deficits, suggesting a critical role of amphiphysin for higher brain functions...
  44. pmc Knockout of striatal enriched protein tyrosine phosphatase in mice results in increased ERK1/2 phosphorylation
    Deepa V Venkitaramani
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Synapse 63:69-81. 2009
    ..These data demonstrate more conclusively the role of STEP in the regulation of ERK1/2 activity...
  45. pmc Regulation of synaptic efficacy in hypocretin/orexin-containing neurons by melanin concentrating hormone in the lateral hypothalamus
    Yan Rao
    Department of Obstetrics Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 28:9101-10. 2008
    ..These data from MCHR1 KO and WT mice demonstrate a novel interaction between these two systems, implying that MCH may exert a unique inhibitory influence on hypocretin/orexin signaling as a way to fine-tune the output of the LH...
  46. ncbi request reprint Reduction of cocaine place preference in mice lacking the protein phosphatase 1 inhibitors DARPP 32 or Inhibitor 1
    Venetia Zachariou
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Biol Psychiatry 51:612-20. 2002
    ..Protein phosphatase-1 (PP-1) is known to mediate some of the changes in neuronal signaling that occur following activation of the dopaminergic system...
  47. pmc Nicotine-induced plasticity during development: modulation of the cholinergic system and long-term consequences for circuits involved in attention and sensory processing
    Christopher J Heath
    Interdepartmental Neuroscience Program, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    Neuropharmacology 56:254-62. 2009
    ....
  48. ncbi request reprint Effect of nicotine and nicotinic receptors on anxiety and depression
    Marina R Picciotto
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Neuroreport 13:1097-106. 2002
    ....
  49. ncbi request reprint High-affinity nicotinic acetylcholine receptors are required for antidepressant effects of amitriptyline on behavior and hippocampal cell proliferation
    Barbara J Caldarone
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Biol Psychiatry 56:657-64. 2004
    ..A wide variety of antidepressants act as noncompetitive antagonists of nicotinic acetylcholine receptors (nAChRs), but the relationship between this antagonism and the therapeutic effects of antidepressants is unknown...
  50. pmc Impaired synaptic plasticity and learning in mice lacking beta-adducin, an actin-regulating protein
    Rebecca L Rabenstein
    Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 25:2138-45. 2005
    ..The current results indicate that beta-adducin may play an important role in the cellular mechanisms underlying activity-dependent synaptic plasticity associated with learning and memory...
  51. pmc GalR1, but not GalR2 or GalR3, levels are regulated by galanin signaling in the locus coeruleus through a cyclic AMP-dependent mechanism
    Jessica J Hawes
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurochem 93:1168-76. 2005
    ..These findings suggest that changes in levels of GalR1 may play an important role in modulating signaling events and neuroplasticity underlying physiological functions of the LC...
  52. ncbi request reprint Galanin attenuates cyclic AMP regulatory element-binding protein (CREB) phosphorylation induced by chronic morphine and naloxone challenge in Cath.a cells and primary striatal cultures
    Jessica J Hawes
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurochem 96:1160-8. 2006
    ..a cells. These data suggest that galanin receptors may serve as an additional potential therapeutic target for the treatment of opiate withdrawal...
  53. pmc Blockade of protein phosphatase 2B activity in the amygdala increases anxiety- and depression-like behaviors in mice
    Amine Bahi
    Division of Molecular Psychiatry, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 66:1139-46. 2009
    ..It is therefore important to determine whether chronic blockade of calcineurin might contribute to symptoms of anxiety and depression in these patients...
  54. ncbi request reprint Nicotine induces glutamate release from thalamocortical terminals in prefrontal cortex
    Evelyn K Lambe
    Departments of Psychiatry and Pharmacology, Yale School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 28:216-25. 2003
    ..These findings give new insight into the mechanism by which nicotine affects excitatory neurotransmission to the output neurons of the cerebral cortex in a pathway that is critical for cognitive function and reward expectation...
  55. ncbi request reprint Effect of cocaine self-administration on striatal PKA-regulated signaling in male and female rats
    Wendy J Lynch
    Division of Molecular Psychiatry and Center for Genes and Behavior, Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 191:263-71. 2007
    ..Chronic cocaine produces changes in the dopamine (DA)/D1/cAMP/protein kinase A (PKA)-regulated signaling pathway that may underlie the development of addiction...
  56. pmc Allelic variation of calsyntenin 2 (CLSTN2) modulates the impact of developmental tobacco smoke exposure on mnemonic processing in adolescents
    Leslie K Jacobsen
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06320, USA
    Biol Psychiatry 65:671-9. 2009
    ..The present study tested for evidence that genetic variation may contribute to individual differences in vulnerability to the effects of developmental exposure to tobacco smoke on memory and medial temporal lobe function in adolescents...
  57. ncbi request reprint Antidepressant-like effects of ceftriaxone in male C57BL/6J mice
    Yann S Mineur
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 61:250-2. 2007
    ..Recent evidence that beta-lactam antibiotic agents stimulate uptake of glutamate suggests that this class of compounds might possess antidepressant-like activity...
  58. ncbi request reprint Role of calcineurin in nicotine-mediated locomotor sensitization
    Nii A Addy
    Interdepartmental Neuroscience Program, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 27:8571-80. 2007
    ..Together, the data suggest that activation of calcineurin, particularly in the VTA, is a novel signaling event important for nicotine-mediated behavior and intracellular signaling...
  59. pmc Prolonged wakefulness induces experience-dependent synaptic plasticity in mouse hypocretin/orexin neurons
    Yan Rao
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 117:4022-33. 2007
    ..These results indicate that synaptic plasticity due to prolonged wakefulness occurs in circuits responsible for arousal and may contribute to changes in the brain and body of animals experiencing sleep loss...
  60. pmc Cytisine, a partial agonist of high-affinity nicotinic acetylcholine receptors, has antidepressant-like properties in male C57BL/6J mice
    Yann S Mineur
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, 3rd Floor Research, New Haven, CT 06508, USA
    Neuropharmacology 52:1256-62. 2007
    ..These studies also suggest that both antagonists and partial agonists of alpha4/beta2*nAChRs would be interesting targets for the development of novel antidepressant drugs...
  61. pmc Cytisine-based nicotinic partial agonists as novel antidepressant compounds
    Yann S Mineur
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06508, USA
    J Pharmacol Exp Ther 329:377-86. 2009
    ..These results suggest that novel nicotinic partial agonists may provide new possibilities for development of drugs to treat mood disorders...
  62. ncbi request reprint Inhibition of both alpha7* and beta2* nicotinic acetylcholine receptors is necessary to prevent development of sensitization to cocaine-elicited increases in extracellular dopamine levels in the ventral striatum
    Lara Zanetti
    Department of Biomedical Sciences, Section of Physiology University of Modena and Reggio Emilia, Via Campi 287, 41100 Modena, Italy
    Psychopharmacology (Berl) 187:181-8. 2006
    ..Several studies have suggested that nicotine treatment can modulate the behavioral and neurochemical responses to other psychostimulants, such as cocaine...
  63. ncbi request reprint Characterization of [(125) I]epibatidine binding and nicotinic agonist-mediated (86) Rb(+) efflux in interpeduncular nucleus and inferior colliculus of beta2 null mutant mice
    Michael J Marks
    Institute for Behavioral Genetics, University of Colorado, Boulder, Colorado, USA
    J Neurochem 81:1102-15. 2002
    ..Thus, beta2 null mutant mice express residual nicotinic activity with properties resembling those of alpha3beta4*-nAChR...
  64. ncbi request reprint The prototoxin lynx1 acts on nicotinic acetylcholine receptors to balance neuronal activity and survival in vivo
    Julie M Miwa
    The Laboratory of Molecular Biology, Howard Hughes Medical Institute, The Rockefeller University, New York, NY 10021, USA
    Neuron 51:587-600. 2006
    ..We conclude that lynx1 functions as an allosteric modulator of nAChR function in vivo, balancing neuronal activity and survival in the CNS...
  65. pmc Antidepressant-like effects of nicotine and transcranial magnetic stimulation in the olfactory bulbectomy rat model of depression
    Patricia Vieyra-Reyes
    Depto de Neurociencias Instituto de Fisiología Celular, Universidad Nacional Autonoma de Mexico, Circuito Interior, Ciudad Universitaria, CP 04510 Mexico, D F, Mexico
    Brain Res Bull 77:13-8. 2008
    ..In conclusion, our results support the idea that there are possible innate differences for depression susceptibility and that nicotine and TMS may be useful in the treatment of this syndrome...
  66. ncbi request reprint Nicotine withdrawal increases body weight, neuropeptide Y and Agouti-related protein expression in the hypothalamus and decreases uncoupling protein-3 expression in the brown adipose tissue in high-fat fed mice
    Alice Fornari
    Department of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia, Italy
    Neurosci Lett 411:72-6. 2007
    ....
  67. ncbi request reprint Differential effects of nicotinic antagonists perfused into the nucleus accumbens or the ventral tegmental area on cocaine-induced dopamine release in the nucleus accumbens of mice
    Lara Zanetti
    Department of Biomedical Sciences, Section of Physiology, University of Modena and Reggio Emilia, Via Campi 287, 41100, Modena, Italy
    Psychopharmacology (Berl) 190:189-99. 2007
    ..The mesolimbic dopamine (DA) system is considered a principal site for nicotine-cocaine interactions...
  68. ncbi request reprint Alpha 4 beta 2* nicotinic acetylcholine receptors modulate the effects of ethanol and nicotine on the acoustic startle response
    Jeremy C Owens
    Institute for Behavioral Genetics, University of Colorado, Boulder 80309 0447, USA
    Alcohol Clin Exp Res 27:1867-75. 2003
    ..Ethanol also alters the acoustic startle response. Thus, we evaluated the potential role of alpha4beta2 nAChRs in modulating ethanol's effects on acoustic startle...
  69. ncbi request reprint Guidelines on nicotine dose selection for in vivo research
    Shannon G Matta
    Department of Pharmacology, College of Medicine, University of Tennessee Health Science Center, 874 Union Avenue, Crowe 115, Memphis, TN 38163, USA
    Psychopharmacology (Berl) 190:269-319. 2007
    ..In many cases, such discrepancies could be attributed to the complex variables comprising species-specific in vivo responses to acute or chronic nicotine exposure...
  70. ncbi request reprint Identification and characterization of Aplysia adducin, an Aplysia cytoskeletal protein homologous to mammalian adducins: increased phosphorylation at a protein kinase C consensus site during long-term synaptic facilitation
    Lore M Gruenbaum
    Boehringer Ingelheim Pharmaceuticals, Ridgefield, Connecticut 06877, USA
    J Neurosci 23:2675-85. 2003
    ..Thus, ApADD is modulated specifically with later phases of LTF and provides an attractive candidate protein that contributes to structural changes accompanying long-lasting synaptic alteration...

Research Grants27

  1. Antidepressant effect of nicotinic receptor blockade
    Marina R Picciotto; Fiscal Year: 2010
    ..These studies should be an important step in identifying novel nicotinic agents that could have efficacy as antidepressants. ..
  2. Galanin-opiate interactions
    Marina R Picciotto; Fiscal Year: 2010
    ..In addition, genetic factors related to galanin signaling could be important determinants of whether individuals are susceptible to opiate addiction. ..
  3. NICOTINE ADDICTION IN MICE LACKING THE NEURONAL NACHR
    MARINA PICCIOTTO; Fiscal Year: 2009
    ..We propose that this mouse model may have implications for the development of psychiatric disorders in subjects exposed to nicotine in utero. ..
  4. Antidepressant effect of nicotinic receptor blockade
    MARINA PICCIOTTO; Fiscal Year: 2007
    ..These studies should be an important step in identifying novel nicotinic agents that could have efficacy as antidepressants. ..
  5. Galanin-opiate interactions
    MARINA PICCIOTTO; Fiscal Year: 2006
    ..The proposed studies will identify the pathways in the brain involved in galanin's actions on these processes. ..
  6. Anatomical basis for nicotine addiction
    Marina R Picciotto; Fiscal Year: 2010
    ..We propose that targeting the molecules that lead to long- lasting changes in the communication between nerve cells in the nucleus accumbens shell could lead to new therapies for smoking cessation. ..
  7. ROLE OF THE HIGH AFFINITY NICOTINE RECEPTOR IN ADDICTION
    MARINA PICCIOTTO; Fiscal Year: 2007
    ....
  8. Anatomical basis for nicotine addiction in mice
    MARINA PICCIOTTO; Fiscal Year: 2005
    ..In addition, these experiments will help identify the molecular mechanisms and signaling pathways involved in the switch from nicotine use to dependence. ..