Research Topics
Species | Christian M PettkerSummaryAffiliation: Yale University Country: USA Publications
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Publications
Impact of a comprehensive patient safety strategy on obstetric adverse eventsChristian M Pettker
Department of Obstetrics, Gynecology, and Reproductive Science, Yale University School of Medicine, New Haven, CT 06520 8063, USA
Am J Obstet Gynecol 200:492.e1-8. 2009..We implemented a comprehensive strategy to track and reduce adverse events...
Transcervical Foley catheter with and without oxytocin for cervical ripening: a randomized controlled trialChristian M Pettker
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
Obstet Gynecol 111:1320-6. 2008..To estimate whether adding oxytocin to transcervical Foley catheter preinduction cervical ripening improves induction success...
Standardization of intrapartum management and impact on adverse outcomesChristian M Pettker
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Yale New Haven Hospital, New Haven, Connecticut, USA
Clin Obstet Gynecol 54:8-15. 2011..Such measures can impact significantly perinatal outcomes and safety culture. Investigation of the impact of standardizing intrapartum management remains an important area of further study...
Value of placental microbial evaluation in diagnosing intra-amniotic infectionChristian M Pettker
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Obstet Gynecol 109:739-49. 2007..To evaluate the ability of microbiologic and pathologic examination of the placenta to accurately diagnose intraamniotic infection and inflammation...
Fetal heart rate monitoring patterns in women with amniotic fluid proteomic profiles indicative of inflammationCatalin S Buhimschi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
Am J Perinatol 25:359-72. 2008..An abnormal FHR-MP can thus raise the level of awareness that a fetus with EONS may be born, but it is not a useful clinical indicator of the need for antibiotic treatment of the neonate...
Using proteomic analysis of the human amniotic fluid to identify histologic chorioamnionitisIrina A Buhimschi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Obstet Gynecol 111:403-12. 2008..To estimate the relationship between histologic chorioamnionitis and four amniotic fluid proteomic biomarkers characteristic of inflammation (defensins 2 and 1, calgranulins C and A)...
Proteomic profiling of the amniotic fluid to detect inflammation, infection, and neonatal sepsisCatalin S Buhimschi
Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, Connecticut, United States of America
PLoS Med 4:e18. 2007..Proteomic analysis of amniotic fluid shows the presence of biomarkers characteristic of intrauterine inflammation. We sought to validate prospectively the clinical utility of one such proteomic profile, the Mass Restricted (MR) score...
Proteomics mapping of cord blood identifies haptoglobin "switch-on" pattern as biomarker of early-onset neonatal sepsis in preterm newbornsCatalin S Buhimschi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, Connecticut, United States of America
PLoS ONE 6:e26111. 2011..A prompt and accurate diagnosis of EONS is critical for improved neonatal outcomes. We sought to explore the cord blood proteome and identify biomarkers and functional protein networks characterizing EONS in preterm newborns...
Cord blood erythropoietin and interleukin-6 for prediction of intraventricular hemorrhage in the preterm neonateVineet Bhandari
Division of Perinatal Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
J Matern Fetal Neonatal Med 24:673-9. 2011..To evaluate cord blood erythropoietin (EPO) and interleukin-6 (IL-6) levels to predict preterm infants at risk of developing intraventricular hemorrhage (IVH)...
Ultrasonographic evaluation of myometrial thickness and prediction of a successful external cephalic versionCatalin S Buhimschi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, CT, USA
Obstet Gynecol 118:913-20. 2011..To test the hypothesis that myometrial thickness predicts the success of external cephalic version...
Modulation of amniotic fluid activin-a and inhibin-a in women with preterm premature rupture of the membranes and infection-induced preterm birthVictor A Rosenberg
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Reprod Immunol 67:122-31. 2012..We explored activation of amniotic fluid (AF) activin-A and inhibin-A system in women with intra-amniotic infection and preterm premature rupture of the membranes (PPROM)...
Ultrasonographic evaluation of myometrial thickness in twin pregnanciesAnna K Sfakianaki
Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Obstet Gynecol 198:530.e1-10. 2008..The objective of the study was to evaluate longitudinally the in vivo changes in myometrial thickness (MT) during gestation in patients carrying twin gestations in relation to pregnancy outcome...
Activation of the receptor for advanced glycation end products system in women with severe preeclampsiaEmily A Oliver
Yale University School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, 333 Cedar Street, LLCI 804, New Haven, Connecticut 06520, USA
J Clin Endocrinol Metab 96:689-98. 2011..Soluble forms of RAGE [soluble RAGE (sRAGE), endogenous secretory (esRAGE)] bind RAGE ligands, thereby preventing downstream signaling and damage...
Nucleated red blood cells are a direct response to mediators of inflammation in newborns with early-onset neonatal sepsisAntonette T Dulay
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
Am J Obstet Gynecol 198:426.e1-9. 2008..We sought to determine whether fetal inflammation is associated with an elevation in neonatal NRBC count in the setting of inflammation-associated preterm birth...
A comprehensive obstetrics patient safety program improves safety climate and cultureChristian M Pettker
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Am J Obstet Gynecol 204:216.e1-6. 2011..The purpose of this study was to determine the effect of an obstetrics patient safety program on staff safety culture...
Acceleration/ejection time ratio in the fetal pulmonary artery predicts fetal lung maturityHumberto Azpurua
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Am J Obstet Gynecol 203:40.e1-8. 2010..The aim of this study was to determine whether sonographic fetal pulmonary artery flow velocity waveforms correlate with amniotic fluid biomarkers of fetal lung maturity...
A low vaginal "pool" amniotic fluid glucose measurement is a predictive but not a sensitive marker for infection in women with preterm premature rupture of membranesCatalin S Buhimschi
Department of Obstetrics, Gynecology, and Reproductive Science, Yale University, New Haven, CT 06520, USA
Am J Obstet Gynecol 194:309-16. 2006....
Serum and urine inhibin A but not free activin A are endocrine biomarkers of severe pre-eclampsiaBenjamin D Hamar
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520 8063, USA
Am J Obstet Gynecol 195:1636-45. 2006..We sought to evaluate serum and urine levels of inhibin A and free activin A in normal and hypertensive pregnancies...
The receptor for advanced glycation end products (RAGE) system in women with intraamniotic infection and inflammationIrina A Buhimschi
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
Am J Obstet Gynecol 196:181.e1-13. 2007..sRAGE, a competitive soluble RAGE receptor, inhibits RAGE ligands. Here we aimed to investigate the presence and changes in components of the RAGE system in women with intra-amniotic infection and inflammation...
Lactate dehydrogenase isoform activity mapping in patients with intra-amniotic infectionLissa K Magloire
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, New Haven, CT 06520, USA
Am J Obstet Gynecol 195:1045-52. 2006..Five distinct lactate dehydrogenase isoenzymes have been described. We sought to illustrate the specific amniotic fluid lactate dehydrogenase isoenzyme activity profiles in women with intra-amniotic infection...
Antenatal lamivudine to reduce perinatal hepatitis B transmission: a cost-effectiveness analysisUnzila A Nayeri
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
Am J Obstet Gynecol 207:231.e1-7. 2012..This study aimed to determine whether administration of lamivudine to pregnant women with chronic hepatitis B in the third trimester is a cost-effective strategy in preventing perinatal transmission...
Ultrasound evaluation of the uterine scar after cesarean delivery: a randomized controlled trial of one- and two-layer closureBenjamin D Hamar
Yale School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Biology, New Haven, Connecticut, USA
Obstet Gynecol 110:808-13. 2007..To survey the uterine scar thickness by ultrasonography in women randomly assigned to one- or two-layer hysterotomy closure after primary cesarean delivery...
Maternal postoperative complications after nonobstetric antenatal surgeryElisabeth A Erekson
Yale University School of Medicine, Department of Obstetrics, Gynecology, and Reproductive Sciences, New Haven, CT 06520 8063, USA
J Matern Fetal Neonatal Med 25:2639-44. 2012..Our primary objective is to estimate the occurrence of major maternal 30 day postoperative complications after nonobstetric antenatal surgery...
Burkitt's lymphoma of the ovary in pregnancyLissa K Magloire
Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
Obstet Gynecol 108:743-5. 2006..Burkitt's lymphoma is a rapidly growing and, if untreated, rapidly fatal tumor derived from B-lymphocytes. The occurrence of Burkitt's lymphoma during pregnancy is rare...
Pregestational diabetes with extreme insulin resistance: use of U-500 insulin in pregnancyLisa C Zuckerwise
Division of Maternal Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
Obstet Gynecol 120:439-42. 2012..U-500 insulin is a concentrated form of regular insulin that can be a valuable tool in the treatment of patients with severe insulin resistance...
Indications contributing to the increasing cesarean delivery rateEmma L Barber
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale School of Medicine, New Haven, Connecticut, USA
Obstet Gynecol 118:29-38. 2011..To examine physician-documented indications for cesarean delivery in order to investigate the specific factors contributing to the increasing cesarean delivery rate...
Morbidity of appendectomy and cholecystectomy in pregnant and nonpregnant womenMark T Silvestri
Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
Obstet Gynecol 118:1261-70. 2011....
Neonatal mortality for low-risk women by method of deliveryChristian M Pettker
Birth 34:100-1; author reply 101-2. 2007
