MELINDA MARY PETTIGREW

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Genetic diversity of paired middle-ear and pharyngeal nontypeable Haemophilus influenzae isolates from children with acute otitis media
    Zachary J Berrens
    University of Michigan, Department of Pediatrics and Communicable Diseases, L2224 Women s Hospital, Ann Arbor, MI 48109 5244, USA
    J Clin Microbiol 45:3764-7. 2007
  2. pmc Microbial communities of the upper respiratory tract and otitis media in children
    Alison S Laufer
    Yale School of Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    MBio 2:e00245-10. 2011
  3. pmc Streptococcus pneumoniae clonal complex 199: genetic diversity and tissue-specific virulence
    Jonathan C Thomas
    Division of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e18649. 2011
  4. pmc Upper respiratory tract microbial communities, acute otitis media pathogens, and antibiotic use in healthy and sick children
    Melinda M Pettigrew
    Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA
    Appl Environ Microbiol 78:6262-70. 2012
  5. pmc Microbial interactions during upper respiratory tract infections
    Melinda M Pettigrew
    Yale School of Public Health, New Haven, Connecticut 06520 8034, USA
    Emerg Infect Dis 14:1584-91. 2008
  6. pmc Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Med Genet 8:15. 2007
  7. pmc Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Med Genet 7:68. 2006
  8. pmc Variation in the presence of neuraminidase genes among Streptococcus pneumoniae isolates with identical sequence types
    Melinda M Pettigrew
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, P O Box 208034, New Haven, CT 06520 8034, USA
    Infect Immun 74:3360-5. 2006
  9. pmc Genomic subtraction followed by dot blot screening of Streptococcus pneumoniae clinical and carriage isolates identifies genetic differences associated with strains that cause otitis media
    Melinda M Pettigrew
    Yale University School of Medicine, Department of Epidemiology and Public Health, 60 College Street, P O Box 208034, New Haven, CT 06520 8034, USA
    Infect Immun 73:2805-11. 2005
  10. ncbi request reprint Association of early-onset otitis media in infants and exposure to household mould
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Paediatr Perinat Epidemiol 18:441-7. 2004

Collaborators

Detail Information

Publications23

  1. pmc Genetic diversity of paired middle-ear and pharyngeal nontypeable Haemophilus influenzae isolates from children with acute otitis media
    Zachary J Berrens
    University of Michigan, Department of Pediatrics and Communicable Diseases, L2224 Women s Hospital, Ann Arbor, MI 48109 5244, USA
    J Clin Microbiol 45:3764-7. 2007
    ..From five children, all ear and throat isolates were identical. The bacterial populations in these specimens showed less diversity than populations in throat isolates of healthy children...
  2. pmc Microbial communities of the upper respiratory tract and otitis media in children
    Alison S Laufer
    Yale School of Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    MBio 2:e00245-10. 2011
    ..Increased understanding of upper respiratory tract microbial communities will contribute to the development of otitis media treatment and prevention strategies...
  3. pmc Streptococcus pneumoniae clonal complex 199: genetic diversity and tissue-specific virulence
    Jonathan C Thomas
    Division of Epidemiology of Microbial Diseases, Yale School of Public Health, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e18649. 2011
    ..These studies have implications for the long-term effectiveness of conjugate vaccines. Ideally, future vaccines would target common proteins to effectively reduce carriage and disease in the vaccinated population...
  4. pmc Upper respiratory tract microbial communities, acute otitis media pathogens, and antibiotic use in healthy and sick children
    Melinda M Pettigrew
    Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, USA
    Appl Environ Microbiol 78:6262-70. 2012
    ..51; 95% CI, 0.31 to 0.83). An increased understanding of polymicrobial interactions will facilitate the development of effective AOM prevention strategies...
  5. pmc Microbial interactions during upper respiratory tract infections
    Melinda M Pettigrew
    Yale School of Public Health, New Haven, Connecticut 06520 8034, USA
    Emerg Infect Dis 14:1584-91. 2008
    ..influenzae and S. aureus. Polymicrobial interactions differed by number and species of bacteria present. Antimicrobial therapy and vaccination strategies targeting specific bacterial species may alter the flora in unforeseen ways...
  6. pmc Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Med Genet 8:15. 2007
    ....
  7. pmc Association of surfactant protein A polymorphisms with otitis media in infants at risk for asthma
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    BMC Med Genet 7:68. 2006
    ....
  8. pmc Variation in the presence of neuraminidase genes among Streptococcus pneumoniae isolates with identical sequence types
    Melinda M Pettigrew
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College Street, P O Box 208034, New Haven, CT 06520 8034, USA
    Infect Immun 74:3360-5. 2006
    ..Studies that both incorporate MLST and take into account additional virulence determinants will provide a greater understanding of the pneumococcal virulence potential...
  9. pmc Genomic subtraction followed by dot blot screening of Streptococcus pneumoniae clinical and carriage isolates identifies genetic differences associated with strains that cause otitis media
    Melinda M Pettigrew
    Yale University School of Medicine, Department of Epidemiology and Public Health, 60 College Street, P O Box 208034, New Haven, CT 06520 8034, USA
    Infect Immun 73:2805-11. 2005
    ..These studies have identified two genes of potential importance in otitis media virulence. Further studies are warranted to outline the precise role of these genes in otitis media pathogenesis...
  10. ncbi request reprint Association of early-onset otitis media in infants and exposure to household mould
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Paediatr Perinat Epidemiol 18:441-7. 2004
    ..We also found associations between day-care outside of the home and birth during the summer or fall season with early otitis media. This study is suggestive of a relationship between otitis media and mould that warrants further study...
  11. ncbi request reprint An array of diverse microbial genomes
    Melinda M Pettigrew
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520 8034, USA
    Trends Biotechnol 22:491-3. 2004
    ..These slides can then be probed for the presence of specific genes allowing researchers to draw inferences regarding important differences between related strains that differ in their pathogenic potential...
  12. pmc Viral-bacterial interactions and risk of acute otitis media complicating upper respiratory tract infection
    Melinda M Pettigrew
    Yale School of Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    J Clin Microbiol 49:3750-5. 2011
    ..Acute otitis media prevention efforts should consider methods for reducing infections caused by respiratory syncytial virus, bocavirus, and adenovirus in addition to acute otitis media bacterial pathogens...
  13. ncbi request reprint Infant otitis media and the use of secondary heating sources
    Melinda M Pettigrew
    Yale Center for Perinatal, Pediatric and Environmental Epidemiology, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven Connecticut 06520 8034, USA
    Epidemiology 15:13-20. 2004
    ..This prospective study investigated the association of exposure to indoor secondary heating sources with otitis media and recurrent otitis media risk in infants...
  14. pmc Capacity of serotype 19A and 15B/C Streptococcus pneumoniae isolates for experimental otitis media: Implications for the conjugate vaccine
    Alison S Laufer
    Division of Epidemiology of Microbial Diseases, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520, United States
    Vaccine 28:2450-7. 2010
    ..Serotype 19A is included in new conjugate vaccine formulations while serotype 15B/C is not. Non-capsular vaccine targets will be important in disease prevention efforts...
  15. pmc Multilocus sequence typing and pulsed field gel electrophoresis of otitis media causing pathogens
    Jonathan C Thomas
    Yale University School of Public Health, New Haven, CT, USA
    Methods Mol Biol 493:179-90. 2009
    ..Consequently, knowledge of both techniques is important for laboratories intending to study the molecular epidemiology of otitis media-associated bacterial pathogens...
  16. ncbi request reprint Behavioral intentions in sexual partnerships following a diagnosis of Chlamydia trachomatis
    Linda M Niccolai
    Yale School of Medicine, Department of Epidemiology and Public Health, New Haven, CT 06520, USA
    Prev Med 46:170-6. 2008
    ..To describe behavioral intentions regarding notification of sex partners and continuation of sexual relationships after a Chlamydia trachomatis diagnosis among women...
  17. doi request reprint Behavioural sources of repeat Chlamydia trachomatis infections: importance of different sex partners
    Linda M Niccolai
    Yale School of Public Health, 60 College Street, New Haven, CT 06520, USA
    Sex Transm Infect 87:248-53. 2011
    ..To examine sources of repeat Chlamydia trachomatis infections using behavioural and molecular methods...
  18. doi request reprint Comparison of sexual partnership characteristics and associations with inconsistent condom use among a sample of adolescents and adult women diagnosed with Chlamydia trachomatis
    Hillary B S Foulkes
    Yale School of Medicine, Department of Epidemiology and Public Health and Center for Interdisciplinary Research on AIDS, New Haven, Connecticut, USA
    J Womens Health (Larchmt) 18:393-9. 2009
    ..This analysis compared characteristics of female adolescent and adult sexual partnerships and related these characteristics to inconsistent condom use...
  19. pmc Streptococcus pneumoniae serotype 6C: an intra- and interclonal complex comparison
    J C Thomas
    Yale University, School of Public Health, New Haven, CT 06520 8034, USA
    J Bacteriol 193:3409-10. 2011
    ..Serotype 6C isolates are increasing in prevalence and becoming progressively more resistant to antibiotics. As a result, these strains are likely to become more important in the near future...
  20. ncbi request reprint Predictors for Haemophilus influenzae colonization, antibiotic resistance and for sharing an identical isolate among children attending 16 licensed day-care centers in Michigan
    Cibele Barbosa-Cesnik
    Department of Epidemiology, University of Michigan, School of Public Health, Ann Arbor, MI 48109, USA
    Pediatr Infect Dis J 25:219-23. 2006
    ..influenzae colonization, antibiotic resistance and predictors for colonization and sharing an identical isolate with at least 1 other child in the same day-care centers among children attending 16 day-care centers...
  21. ncbi request reprint Diversity and sharing of Haemophilus influenzae strains colonizing healthy children attending day-care centers
    Rand S Farjo
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109 0244, USA
    Pediatr Infect Dis J 23:41-6. 2004
    ..This study describes the prevalence rates of H. influenzae colonization in a large number of children attending day-care centers and examines the genetic diversity of colonizing strains and the degree of sharing among children...
  22. pmc Prevalence of the hifBC, hmw1A, hmw2A, hmwC, and hia Genes in Haemophilus influenzae Isolates
    I Zafer Ecevit
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109 0244, USA
    J Clin Microbiol 42:3065-72. 2004
    ..influenzae isolates and suggest that hemagglutinating pili may play a larger role in H. influenzae nasopharyngeal colonization than in acute otitis media whereas the HMW adhesins may be virulence factors for acute otitis media...
  23. ncbi request reprint Duration of breastfeeding, daycare, and physician visits among infants 6 months and younger
    Melinda M Pettigrew
    Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
    Ann Epidemiol 13:431-5. 2003
    ..To describe the association between duration of breastfeeding and an illness requiring a visit to a health care provider within the past 30 days (IRHP) among infants </= 6 months...

Research Grants5

  1. Gene Discovery for Pneumococcal Otitis Media
    Melinda Pettigrew; Fiscal Year: 2005
    ..Discovery of additional factors involved in streptococcal OM will facilitate the development of new strategies for the control and prevention of this important disease. ..
  2. Molecular epidemiologic identification of pneumococcal tissue specific genes
    Melinda Pettigrew; Fiscal Year: 2007
    ..A greater understanding of the genetic factors that influence the virulence potential of pneumococcal clones is critical to our ability to develop effective methods to control, prevent, and treat these important infections. ..
  3. Molecular epidemiologic identification of pneumococcal tissue specific genes
    Melinda Pettigrew; Fiscal Year: 2009
    ..A greater understanding of the genetic factors that influence the virulence potential of pneumococcal clones is critical to our ability to develop effective methods to control, prevent, and treat these important infections. ..
  4. Molecular epidemiologic identification of pneumococcal tissue specific genes
    MELINDA MARY PETTIGREW; Fiscal Year: 2010
    ..A greater understanding of the genetic factors that influence the virulence potential of pneumococcal clones is critical to our ability to develop effective methods to control, prevent, and treat these important infections. ..