Ismene Petrakis

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence
    Ismene L Petrakis
    VA Connecticut Healthcare System, Yale University School of Medicine, West Haven, CT, USA
    Neuropsychopharmacology 37:996-1004. 2012
  2. doi request reprint Substance use comorbidity among veterans with posttraumatic stress disorder and other psychiatric illness
    Ismene L Petrakis
    Department of Psychiatry, Yale University, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Addict 20:185-9. 2011
  3. ncbi request reprint A rational approach to the pharmacotherapy of alcohol dependence
    Ismene L Petrakis
    Department of Psychiatry and School of Medicine, Yale University, New Haven, CT 06510, USA
    J Clin Psychopharmacol 26:S3-12. 2006
  4. ncbi request reprint Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder
    Ismene L Petrakis
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 60:777-83. 2006
  5. pmc Psychotic spectrum disorders and alcohol abuse: a review of pharmacotherapeutic strategies and a report on the effectiveness of naltrexone and disulfiram
    Ismene L Petrakis
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, 950 Campbell Avenue, Mail Code 116A, West Haven, CT 06516, USA
    Schizophr Bull 32:644-54. 2006
  6. ncbi request reprint Atypical antipsychotic medication and substance use-related outcomes in the treatment of schizophrenia
    Ismene L Petrakis
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Am J Addict 15:44-9. 2006
  7. ncbi request reprint Naltrexone and disulfiram in patients with alcohol dependence and current depression
    Ismene Petrakis
    Department of Psychiatry, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    J Clin Psychopharmacol 27:160-5. 2007
  8. ncbi request reprint Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut 06516, USA
    Biol Psychiatry 57:1128-37. 2005
  9. ncbi request reprint Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism
    Ismene L Petrakis
    West Haven VA Medical Center 116 A, 950 Campbell Ave, West Haven, CT 06516, USA
    Am J Psychiatry 161:1776-82. 2004
  10. ncbi request reprint The effect of tryptophan depletion on alcohol self-administration in non-treatment-seeking alcoholic individuals
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 26:969-75. 2002

Research Grants

  1. RESEARCH TRAINING FELLOWSHIP IN SUBSTANCE ABUSE
    Ismene Petrakis; Fiscal Year: 2007
  2. Translational Neuroscience Research in Alcoholism
    Ismene Petrakis; Fiscal Year: 2007
  3. Mecamylamine for the Treatment of Alcohol Dependence
    Ismene Petrakis; Fiscal Year: 2009
  4. Mecamylamine for the Treatment of Alcohol Dependence
    Ismene L Petrakis; Fiscal Year: 2010

Detail Information

Publications42

  1. pmc Noradrenergic vs serotonergic antidepressant with or without naltrexone for veterans with PTSD and comorbid alcohol dependence
    Ismene L Petrakis
    VA Connecticut Healthcare System, Yale University School of Medicine, West Haven, CT, USA
    Neuropsychopharmacology 37:996-1004. 2012
    ..This study was registered with ClinicalTrials.gov, registration number NCT00338962 and URL: http://clinicaltrials.gov/ct2/show/NCT00338962?term=desipramine+AND+alcohol+dependence+AND+depression&recr=Closed&rank=1...
  2. doi request reprint Substance use comorbidity among veterans with posttraumatic stress disorder and other psychiatric illness
    Ismene L Petrakis
    Department of Psychiatry, Yale University, VA Connecticut Healthcare System, West Haven, CT 06516, USA
    Am J Addict 20:185-9. 2011
    ..There are high rates of substance use disorders among veterans with mental illness. The highest rates of comorbidity occur among those with bipolar disorder and schizophrenia; and in post-VET veterans. ..
  3. ncbi request reprint A rational approach to the pharmacotherapy of alcohol dependence
    Ismene L Petrakis
    Department of Psychiatry and School of Medicine, Yale University, New Haven, CT 06510, USA
    J Clin Psychopharmacol 26:S3-12. 2006
    ..The treatment implications will also be discussed...
  4. ncbi request reprint Naltrexone and disulfiram in patients with alcohol dependence and comorbid post-traumatic stress disorder
    Ismene L Petrakis
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 60:777-83. 2006
    ....
  5. pmc Psychotic spectrum disorders and alcohol abuse: a review of pharmacotherapeutic strategies and a report on the effectiveness of naltrexone and disulfiram
    Ismene L Petrakis
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, 950 Campbell Avenue, Mail Code 116A, West Haven, CT 06516, USA
    Schizophr Bull 32:644-54. 2006
    ..Pharmacotherapeutic strategies should take into account the advantages and disadvantages of each medication. Future directions of pharmacotherapeutic options are also discussed...
  6. ncbi request reprint Atypical antipsychotic medication and substance use-related outcomes in the treatment of schizophrenia
    Ismene L Petrakis
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Am J Addict 15:44-9. 2006
    ..Patients treated with atypical antipsychotics achieved no greater improvement in substance-related outcomes that patients who were not...
  7. ncbi request reprint Naltrexone and disulfiram in patients with alcohol dependence and current depression
    Ismene Petrakis
    Department of Psychiatry, Yale University School of Medicine, Veterans Affairs Connecticut Healthcare System, West Haven Campus, West Haven, CT 06516, USA
    J Clin Psychopharmacol 27:160-5. 2007
    ..In particular, the effect of these medications on alcohol use outcomes and on specific psychiatric symptoms is still unknown in patients with the most common co-occurring disorder, major depression...
  8. ncbi request reprint Naltrexone and disulfiram in patients with alcohol dependence and comorbid psychiatric disorders
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut 06516, USA
    Biol Psychiatry 57:1128-37. 2005
    ..Disulfiram and naltrexone are approved by the Food and Drug Administration (FDA) for the treatment of alcoholism, but these agents have not been rigorously evaluated in dually diagnosed individuals...
  9. ncbi request reprint Altered NMDA glutamate receptor antagonist response in individuals with a family vulnerability to alcoholism
    Ismene L Petrakis
    West Haven VA Medical Center 116 A, 950 Campbell Ave, West Haven, CT 06516, USA
    Am J Psychiatry 161:1776-82. 2004
    ....
  10. ncbi request reprint The effect of tryptophan depletion on alcohol self-administration in non-treatment-seeking alcoholic individuals
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 26:969-75. 2002
    ....
  11. ncbi request reprint Effect of tryptophan depletion on alcohol cue-induced craving in abstinent alcoholic patients
    I L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 25:1151-5. 2001
    ..This study evaluated whether attenuation of serotonin synthesis via depletion of its precursor tryptophan reduces the magnitude of cue-induced craving for alcohol in recently abstinent alcoholic individuals...
  12. ncbi request reprint The use of antidepressants in alcohol-dependent veterans
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, Conn, USA
    J Clin Psychiatry 64:865-70. 2003
    ..Although some research reports suggest antidepressants may be an effective treatment for alcohol dependence, their clinical use has been controversial...
  13. ncbi request reprint Naltrexone augmentation of neuroleptic treatment in alcohol abusing patients with schizophrenia
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Psychopharmacology (Berl) 172:291-7. 2004
    ..The purpose of this study was to evaluate the efficacy of naltrexone in alcohol-abusing schizophrenic patients...
  14. ncbi request reprint Use of naltrexone in the treatment of alcoholism nationally in the Department of Veterans Affairs
    Ismene L Petrakis
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 27:1780-4. 2003
    ....
  15. ncbi request reprint The impact of personality disorders on alcohol-use outcomes in a pharmacotherapy trial for alcohol dependence and comorbid Axis I disorders
    Elizabeth Ralevski
    Department of Psychiatry, Yale University School of Medicine, West Haven, Connecticut, USA
    Am J Addict 16:443-9. 2007
    ..The findings suggest that naltrexone and disulfiram can be safely and effectively used with patients who have comorbid diagnoses of Axis I and Axis II disorders...
  16. doi request reprint Effects of acamprosate on cognition in a treatment study of patients with schizophrenia spectrum disorders and comorbid alcohol dependence
    Elizabeth Ralevski
    Yale University School of Medicine, Department of Psychiatry, 950 Campbell Ave, West Haven, CT 06516, USA
    J Nerv Ment Dis 199:499-505. 2011
    ..The finding that acamprosate had no negative effects on cognition is clinically relevant and reinforces previous reports that acamprosate can be used safely for alcohol reduction in this group of patients...
  17. ncbi request reprint The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neurotox Res 10:235-52. 2006
    ....
  18. ncbi request reprint Pharmacotherapy of alcohol use disorders
    Alessandra Buonopane
    Department of Psychiatry, School of Medicine, Yale University, New Haven, Connecticut, USA
    Subst Use Misuse 40:2001-20, 2043-8. 2005
    ..An overview of the serotonergic agents is also provided. Finally, future directions, including new medications and some clinical strategies that show promise but are not yet used extensively clinically, are mentioned...
  19. doi request reprint Preliminary findings on the interactive effects of IV ethanol and IV nicotine on human behavior and cognition: a laboratory study
    Elizabeth Ralevski
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Nicotine Tob Res 14:596-606. 2012
    ..The main objective of this study was to characterize the interactive effects of acute intravenous (IV) alcohol and nicotine administration on behavior and cognition in healthy nonsmokers...
  20. ncbi request reprint Gelatin "shots" as a new method for alcohol administration in a laboratory setting
    Elizabeth Ralevski
    Department of Psychiatry, Yale University School of Medicine, VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Alcohol Clin Exp Res 30:473-9. 2006
    ....
  21. ncbi request reprint Absence of significant interactive effects of high-dose D-cycloserine and ethanol in healthy human subjects: preliminary insights into ethanol actions at the glycine B site of NMDA glutamate receptors
    Louis Trevisan
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Alcohol Clin Exp Res 32:36-42. 2008
    ....
  22. doi request reprint Analgesic effects of ethanol are influenced by family history of alcoholism and neuroticism
    Elizabeth Ralevski
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Alcohol Clin Exp Res 34:1433-41. 2010
    ..The objective of this study was to consider the possible role of personality trait of neuroticism and family history of alcoholism on the experience of pain and their role in the analgesic response to an ethanol challenge...
  23. doi request reprint Epidemiology and management of alcohol dependence in individuals with post-traumatic stress disorder
    Elissa McCarthy
    VA Connecticut Healthcare System, Newington, Connecticut, USA
    CNS Drugs 24:997-1007. 2010
    ..The key element seems to be to ensure an adequate intervention for each disorder administered collaboratively...
  24. ncbi request reprint Effects of naltrexone and isradipine, alone or in combination, on cocaine responses in humans
    Mehmet Sofuoglu
    Department of Psychiatry, School of Medicine, Yale University, New Haven, CT, USA
    Pharmacol Biochem Behav 75:801-8. 2003
    ..These results suggest that isradipine alone or in combination with naltrexone attenuates some of the physiological effects of cocaine...
  25. pmc Dopamine and serotonin transporter availability in chronic heroin users: a [¹²³I]β-CIT SPECT imaging study
    Kelly P Cosgrove
    Yale University School of Medicine and the VACHS, New Haven, CT 06516, United States
    Psychiatry Res 184:192-5. 2010
    ..Heroin users had statistically similar striatal DA and brainstem and diencephalon 5-HT transporter availability compared with controls. No associations between transporter availability and heroin use characteristics were found...
  26. pmc SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals
    Irina Esterlis
    Department of Psychiatry, Yale University School of Medicine and the Veteran s Affairs Connecticut Healthcare System VACHS, West Haven, CT 06516, USA
    Drug Alcohol Depend 108:146-50. 2010
    ..We hypothesized that beta(2)*-nAChR availability would be altered by alcohol in heavy drinking nonsmokers...
  27. pmc Varenicline reduces alcohol self-administration in heavy-drinking smokers
    Sherry A McKee
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 66:185-90. 2009
    ..Varenicline, a partial nicotinic agonist with high affinity for the alpha4beta2 nAChR receptor, reduced ethanol intake in rodents. We aimed to test whether varenicline would reduce alcohol consumption and alcohol craving in humans...
  28. doi request reprint Ethanol and pain sensitivity: effects in healthy subjects using an acute pain paradigm
    Albert C Perrino
    Department of Anesthesiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Alcohol Clin Exp Res 32:952-8. 2008
    ....
  29. pmc Characterization of the interactive effects of glycine and D-cycloserine in men: further evidence for enhanced NMDA receptor function associated with human alcohol dependence
    John H Krystal
    Department of Psychiatry, NIAAA Center for the Translational Neuroscience of Alcoholism, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 36:701-10. 2011
    ..Thus, this study provided evidence that raising glycine levels accentuated the NMDA receptor antagonist-like effects of DCS and that alcohol-dependent patients showed tolerance to these DCS effects...
  30. ncbi request reprint NMDA receptor antagonism and the ethanol intoxication signal: from alcoholism risk to pharmacotherapy
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Ann N Y Acad Sci 1003:176-84. 2003
    ....
  31. ncbi request reprint Psychiatric safety of ketamine in psychopharmacology research
    Edward B Perry
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Psychopharmacology (Berl) 192:253-60. 2007
    ..Therefore, it is timely to revisit the safety of subanesthetic doses of ketamine in experimental psychopharmacology studies...
  32. pmc Sex differences in cocaine-dependent individuals' response to disulfiram treatment
    Charla Nich
    Yale University School of Medicine, VA Connecticut Health Care System, West Haven, USA
    Addict Behav 29:1123-8. 2004
    ..Reasons for this apparent sex-based response are not clear, but possible mechanisms worthy of greater study include differences in alcohol use by sex as well as differences in dopamine-mediated responses to cocaine and disulfiram...
  33. ncbi request reprint Cortical gamma-aminobutyric acid type A-benzodiazepine receptors in recovery from alcohol dependence: relationship to features of alcohol dependence and cigarette smoking
    Julie K Staley
    Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Arch Gen Psychiatry 62:877-88. 2005
    ..Adaptations in gamma-aminobutyric acid type A (GABA(A))-benzodiazepine receptors contribute to the neurobiology of human alcohol dependence and withdrawal...
  34. ncbi request reprint Altered NMDA glutamate receptor antagonist response in recovering ethanol-dependent patients
    John H Krystal
    Department of Veterans Affairs Alcohol Research Center, VA Connecticut Healthcare System 116 A, West Haven, CT, USA
    Neuropsychopharmacology 28:2020-8. 2003
    ..The alterations in NMDA receptor function observed in recovering ethanol-dependent patients may have important implications for ethanol tolerance, ethanol dependence, and the treatment of alcoholism...
  35. ncbi request reprint Gamma-aminobutyric acid type A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment
    John H Krystal
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, 950 Campbell Avenue, New Haven, CT 06516, USA
    Arch Gen Psychiatry 63:957-68. 2006
    ..Advances in molecular neuroscience, genetics, and neuroimaging provide new insights into the role of brain GABA systems in short- and long-term alcohol effects...
  36. ncbi request reprint N-methyl-D-aspartate glutamate receptors and alcoholism: reward, dependence, treatment, and vulnerability
    John H Krystal
    NIAAA Center for the Translational Neuroscience of Alcoholism, Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Pharmacol Ther 99:79-94. 2003
    ....
  37. pmc Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission
    Todd D Watson
    NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Int J Neuropsychopharmacol 12:357-70. 2009
    ..Overall, the data suggest that both the GABA-A and NMDA receptor systems modulate P3b and P3a. NMDA antagonism appears to lead to more varied effects on the neural correlates of novelty processing...
  38. ncbi request reprint Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smoking
    Graeme F Mason
    NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University, School of Medicine, New Haven, CT 06520, USA
    Biol Psychiatry 59:85-93. 2006
    ..This study's objective was to measure time-dependent cortical GABA levels with sobriety in ethanol-dependent patients with mild to moderate withdrawal severity, controlling for alcoholism-related neurotoxicity and smoking...
  39. ncbi request reprint Effect of memantine on cue-induced alcohol craving in recovering alcohol-dependent patients
    Evgeny M Krupitsky
    Pavlov State Medical University, St Petersburg, Russia
    Am J Psychiatry 164:519-23. 2007
    ..The authors assessed whether the NMDA receptor antagonist memantine reduces cue-induced alcohol craving and produces ethanol-like subjective effects...
  40. ncbi request reprint Yohimbine-induced withdrawal and anxiety symptoms in opioid-dependent patients
    Susan M Stine
    Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, 2761 E Jefferson Avenue, Detroit, MI 48207, USA
    Biol Psychiatry 51:642-51. 2002
    ..Alteration in noradrenergic regulation as well as alteration in the hypothalamic-pituitary-adrenal (HPA) axis have been associated with opioid dependence and acute abstinence symptoms...
  41. pmc Cost effectiveness of disulfiram: treating cocaine use in methadone-maintained patients
    Mireia Jofre-Bonet
    ICEH London School of Hygiene and Tropical Medicine, Keppel Street, Room 9 311, London WC1E 7HT, UK
    J Subst Abuse Treat 26:225-32. 2004
    ....
  42. ncbi request reprint Antiglutamatergic strategies for ethanol detoxification: comparison with placebo and diazepam
    Evgeny M Krupitsky
    St Petersburg Regional Center of Addictions and Psychopharmacology, Pavlov State Medical University, St Petersburg, Russia
    Alcohol Clin Exp Res 31:604-11. 2007
    ....

Research Grants7

  1. RESEARCH TRAINING FELLOWSHIP IN SUBSTANCE ABUSE
    Ismene Petrakis; Fiscal Year: 2007
    ..At the conclusion of training, applicants will be well suited for independent careers in translational or intervention research in the field of addiction. ..
  2. Translational Neuroscience Research in Alcoholism
    Ismene Petrakis; Fiscal Year: 2007
    ..At the conclusion of training, applicants will be well suited for independent careers in translational research in the field of alcoholism. ..
  3. Mecamylamine for the Treatment of Alcohol Dependence
    Ismene Petrakis; Fiscal Year: 2009
    ..We will also evaluate smoking use outcomes and use this study as a platform to conduct future studies. This is the first study conducted to evaluate mecamylamine as a potential pharmacotherapeutic agent for alcohol dependence. ..
  4. Mecamylamine for the Treatment of Alcohol Dependence
    Ismene L Petrakis; Fiscal Year: 2010
    ..We will also evaluate smoking use outcomes and use this study as a platform to conduct future studies. This is the first study conducted to evaluate mecamylamine as a potential pharmacotherapeutic agent for alcohol dependence. ..