Kitt Falk Petersen

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    N Engl J Med 350:664-71. 2004
  2. ncbi request reprint 13C/31P NMR studies on the mechanism of insulin resistance in obesity
    K F Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    Diabetes 47:381-6. 1998
  3. pmc Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    J Clin Invest 109:1345-50. 2002
  4. pmc Etiology of insulin resistance
    Kitt Falk Petersen
    Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med 119:S10-6. 2006
  5. pmc New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy
    Kitt Falk Petersen
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Obesity (Silver Spring) 14:34S-40S. 2006
  6. ncbi request reprint Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans
    K F Petersen
    Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520 8020, USA
    Diabetologia 44:2018-24. 2001
  7. ncbi request reprint Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans
    K F Petersen
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St, FMP 104, New Haven, CT 06520 8020, USA
    Diabetes 50:1263-8. 2001
  8. ncbi request reprint Mechanism of troglitazone action in type 2 diabetes
    K F Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    Diabetes 49:827-31. 2000
  9. ncbi request reprint Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis
    K F Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Conneticut 06520 8020, USA
    Am J Physiol 276:E529-35. 1999
  10. pmc Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    Kitt Falk Petersen
    Yale University School of Medicine, Department of Internal Medicine, 300 Cedar St, S263 TAC, P O Box 9812, New Haven, CT 06520 8020, USA
    Diabetes 54:603-8. 2005

Research Grants

  1. NMR STUDIES:HEPATIC GLUCOSE METABOL IN HUMANS EXERCISING
    Kitt Petersen; Fiscal Year: 2003
  2. Mechanism of Insulin Resistance in Aged
    Kitt Petersen; Fiscal Year: 2003
  3. Mechanism of Insulin Resistance in Aged
    Kitt Petersen; Fiscal Year: 2004
  4. Mechanism of Insulin Resistance in Aged
    Kitt Petersen; Fiscal Year: 2005
  5. Mechanism of Insulin Resistance in Aged
    Kitt Petersen; Fiscal Year: 2006
  6. Mechanism of Insulin Resistance in Aged
    Kitt Petersen; Fiscal Year: 2007
  7. Mechanism of Insulin Resistance in the Aged.
    Kitt F Petersen; Fiscal Year: 2010

Collaborators

Detail Information

Publications43

  1. pmc Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    N Engl J Med 350:664-71. 2004
    ..Insulin resistance appears to be the best predictor of the development of diabetes in the children of patients with type 2 diabetes, but the mechanism responsible is unknown...
  2. ncbi request reprint 13C/31P NMR studies on the mechanism of insulin resistance in obesity
    K F Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    Diabetes 47:381-6. 1998
    ..We conclude that insulin resistance in obesity can be mostly attributed to impairment of insulin-stimulated muscle glycogen synthesis due to a defect in glucose transport and/or phosphorylation activity...
  3. pmc Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    J Clin Invest 109:1345-50. 2002
    ..These data suggest that leptin may represent an important new therapy to reverse the severe hepatic and muscle insulin resistance and associated hepatic steatosis in patients with lipodystrophy...
  4. pmc Etiology of insulin resistance
    Kitt Falk Petersen
    Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Med 119:S10-6. 2006
    ..Understanding the cellular mechanism(s) of insulin resistance in turn offers the prospect of better targeted and more effective therapeutic interventions for treatment and prevention of type 2 diabetes...
  5. pmc New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy
    Kitt Falk Petersen
    Department of Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Obesity (Silver Spring) 14:34S-40S. 2006
    ..In this review, we focus on some recent advances in our understanding of the pathogenesis of insulin resistance in humans that have been made using magnetic resonance spectroscopy...
  6. ncbi request reprint Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans
    K F Petersen
    Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520 8020, USA
    Diabetologia 44:2018-24. 2001
    ..To study the effects of a specific glucagon receptor antagonist (Bay 27-9955), on plasma glucose concentrations and rates of glucose production in response to hyperglucagonaemia in humans...
  7. ncbi request reprint Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humans
    K F Petersen
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St, FMP 104, New Haven, CT 06520 8020, USA
    Diabetes 50:1263-8. 2001
    ..Because net hepatic glycogen synthesis has been shown to be diminished in patients with poorly controlled type 1 and type 2 diabetes, stimulation of hepatic glycogen synthesis by this mechanism may be of potential therapeutic value...
  8. ncbi request reprint Mechanism of troglitazone action in type 2 diabetes
    K F Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    Diabetes 49:827-31. 2000
    ....
  9. ncbi request reprint Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis
    K F Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Conneticut 06520 8020, USA
    Am J Physiol 276:E529-35. 1999
    ..These alterations are likely important contributing factors to their altered carbohydrate metabolism...
  10. pmc Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes
    Kitt Falk Petersen
    Yale University School of Medicine, Department of Internal Medicine, 300 Cedar St, S263 TAC, P O Box 9812, New Haven, CT 06520 8020, USA
    Diabetes 54:603-8. 2005
    ....
  11. pmc Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents
    Katsutaro Morino
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536 8012, USA
    J Clin Invest 115:3587-93. 2005
    ....
  12. pmc Mitochondrial dysfunction in the elderly: possible role in insulin resistance
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 300:1140-2. 2003
    ..These data support the hypothesis that an age-associated decline in mitochondrial function contributes to insulin resistance in the elderly...
  13. pmc Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    N Engl J Med 362:1082-9. 2010
    ..Nonalcoholic fatty liver disease is associated with hepatic insulin resistance and type 2 diabetes mellitus. Whether this association has a genetic basis is unknown...
  14. pmc Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients
    Douglas E Befroy
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 8012, USA
    Diabetes 56:1376-81. 2007
    ....
  15. pmc Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderly
    Clare Flannery
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    Diabetes 61:2711-7. 2012
    ..02). These results strongly support the hypothesis that muscle insulin resistance in aging promotes hyperlipidemia and NAFLD by altering the pattern of postprandial carbohydrate storage away from muscle glycogen and into hepatic DNL...
  16. pmc The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 104:12587-94. 2007
    ....
  17. pmc Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals
    Douglas E Befroy
    Departments of Internal Medicine, Diagnostic Radiology, Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 105:16701-6. 2008
    ..Increased mitochondrial uncoupling may represent another mechanism by which exercise training enhances muscle insulin sensitivity via increased fatty acid oxidation in the resting state...
  18. pmc Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 109:8236-40. 2012
    ..In conclusion, these data support the hypothesis that IMCL accumulation plays an important role in causing muscle insulin resistance in young, lean IR offspring, and that both are reversible with modest weight loss...
  19. pmc Lipid-induced insulin resistance: unravelling the mechanism
    Varman T Samuel
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Lancet 375:2267-77. 2010
    ..This unifying hypothesis accounts for the mechanism of insulin resistance in obesity, type 2 diabetes, lipodystrophy, and ageing; and the insulin-sensitising effects of thiazolidinediones...
  20. pmc Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance
    Naoki Kumashiro
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes 62:2183-94. 2013
    ..Tissue-specific inhibition of pyruvate carboxylase is a potential therapeutic approach for nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. ..
  21. pmc ³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism
    Douglas E Befroy
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Diabetes 61:2669-78. 2012
    ..Also discussed are potential limitations of the technique, complementary methods for assessing oxidative metabolism, and whether the P(i) → ATP flux is a viable biomarker of metabolic function in vivo...
  22. pmc Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans
    Sylvie Dufour
    Department of Internal Medicine, Yale University School of Medicine, The Anlyan Center, S263, New Haven, CT 06520 8020, USA
    Am J Physiol Endocrinol Metab 297:E231-5. 2009
    ....
  23. pmc Disordered lipid metabolism and the pathogenesis of insulin resistance
    David B Savage
    Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536 8012, USA
    Physiol Rev 87:507-20. 2007
    ..in 2004, we will concentrate on human studies involving the use of isotopes and/or magnetic resonance spectroscopy, occasionally drawing on mouse models which provide additional mechanistic insight...
  24. pmc Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy
    Douglas E Befroy
    1 Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA 2 Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA 3
    Nat Med 20:98-102. 2014
    ..This method will be useful for understanding the pathogenesis of nonalcoholic fatty liver disease and type 2 diabetes, as well as for assessing the effectiveness of new therapies targeting these pathways in humans. ..
  25. pmc Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction
    Katsutaro Morino
    Howard Hughes Medical Institute, Yale University School of Medicine, P O Box 9812, New Haven, CT 06536 8012, USA
    Diabetes 55:S9-S15. 2006
    ..By elucidating the cellular and molecular mechanisms responsible for insulin resistance, these studies provide potential new targets for the treatment and prevention of type 2 diabetes...
  26. pmc Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 103:18273-7. 2006
    ....
  27. ncbi request reprint Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity
    Ranjana Sinha
    Department of Pediatrics, The Children s General Clinical Research Center at Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Diabetes 51:1022-7. 2002
    ..The striking relationships between both IMCL and EMCL with insulin sensitivity in childhood suggest that these findings are not a consequence of aging but occur early in the natural course of obesity...
  28. pmc Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance
    Joao Paulo G Camporez
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 9812, USA
    Endocrinology 154:1021-8. 2013
    ....
  29. pmc Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals
    Rasmus Rabøl
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
    Proc Natl Acad Sci U S A 108:13705-9. 2011
    ....
  30. pmc Disassociation of liver and muscle insulin resistance from ectopic lipid accumulation in low-birth-weight individuals
    Sylvie Dufour
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    J Clin Endocrinol Metab 96:3873-80. 2011
    ..Insulin resistance plays a prominent role in the development of T2D; however, the pathogenesis of T2D in LBW is controversial...
  31. pmc Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes
    Katsutaro Morino
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA
    Diabetes 61:877-87. 2012
    ..Taken together, these data suggest that decreased mitochondrial content in muscle of IR offspring may be due in part to reductions in LPL expression in skeletal muscle resulting in decreased PPAR-δ activation...
  32. pmc Regulation of net hepatic glycogenolysis and gluconeogenesis during exercise: impact of type 1 diabetes
    Kitt Falk Petersen
    Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, S263, P O Box 208020, New Haven, Connecticut 06520 8020, USA
    J Clin Endocrinol Metab 89:4656-64. 2004
    ..2) In contrast, moderately controlled type 1 diabetic subjects exhibit increased rates of GP both at rest and during exercise, which can be entirely accounted for by increased gluconeogenesis...
  33. pmc Mitochondrial dysfunction and type 2 diabetes
    Rebecca Parish
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208020, New Haven, CT 06520 8020, USA
    Curr Diab Rep 5:177-83. 2005
    ..Understanding the molecular and biochemical defects responsible for insulin resistance is beginning to unveil novel therapeutic targets for the treatment of the metabolic syndrome and type 2 diabetes...
  34. pmc Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL
    Hyeonjin Kim
    Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8043, USA
    Magn Reson Med 59:521-7. 2008
    ..Therefore, protocol-specific establishment of cutoffs for liver fat content may be necessary...
  35. pmc Cellular mechanism of insulin resistance in skeletal muscle
    Kitt Falk Petersen
    Howard Hughes Medical Institute, Yale General Clinical Research Center, Yale University School of Medicine, PO Box 9812, New Haven, CT 06536 8012, USA
    J R Soc Med 95:8-13. 2002
  36. pmc Increased brain lactate concentrations without increased lactate oxidation during hypoglycemia in type 1 diabetic individuals
    Henk M De Feyter
    Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Diabetes 62:3075-80. 2013
    ..Taken together, these data suggest that in addition to increased MCA transport at the blood-brain barrier, there may be additional metabolic adaptations that contribute to hypoglycemia unawareness in patients with T1D. ..
  37. pmc Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose
    Graeme F Mason
    Department of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut 06520 8043, USA
    J Neurochem 100:73-86. 2007
    ..These results are consistent with observations made with arterial-venous differences and radiotracer methods...
  38. pmc A cluster of metabolic defects caused by mutation in a mitochondrial tRNA
    Frederick H Wilson
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 306:1190-4. 2004
    ..Given the known loss of mitochondrial function with aging, these findings may have implications for the common clustering of these metabolic disorders...
  39. pmc A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls
    Thomas O Carpenter
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    J Clin Endocrinol Metab 91:4866-72. 2006
    ..Limited studies suggest that dietary Mg intake and bone mineral density are correlated in adults, but no data from interventional studies in children and adolescents are available...
  40. pmc Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease
    Naoki Kumashiro
    Howard Hughes Medical Institute and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 108:16381-5. 2011
    ....
  41. pmc Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content
    Susanne Neschen
    Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    Am J Physiol Endocrinol Metab 282:E395-401. 2002
    ..In turn, an increased hepatic beta-oxidative capacity results in lower hepatic triglyceride/diacylglycerol and intramyocellular triglyceride/fatty acyl-CoA content...
  42. pmc Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight rats
    Esben S Buhl
    Department of Pharmacology, Faculty of Health Sciences, Medical Department M, University of Aarhus, Aarhus, Denmark
    Am J Physiol Endocrinol Metab 293:E1451-8. 2007
    ....
  43. pmc Effects of depletion exercise and light training on muscle glycogen supercompensation in men
    Harold W Goforth
    Naval Health Research Center, San Diego, California 92186, USA
    Am J Physiol Endocrinol Metab 285:E1304-11. 2003
    ..Daily exercise at 65% VO2 peak for 20 min can be performed throughout the CHO-loading protocol without negatively affecting muscle glycogen supercompensation...

Research Grants7

  1. NMR STUDIES:HEPATIC GLUCOSE METABOL IN HUMANS EXERCISING
    Kitt Petersen; Fiscal Year: 2003
    ..The results of these studies should provide important new insight into the regulation of hepatic glucose metabolism in healthy and type 1 diabetic subjects. ..
  2. Mechanism of Insulin Resistance in Aged
    Kitt Petersen; Fiscal Year: 2003
    ..abstract_text> ..
  3. Mechanism of Insulin Resistance in Aged
    Kitt Petersen; Fiscal Year: 2004
    ..abstract_text> ..
  4. Mechanism of Insulin Resistance in Aged
    Kitt Petersen; Fiscal Year: 2005
    ..abstract_text> ..
  5. Mechanism of Insulin Resistance in Aged
    Kitt Petersen; Fiscal Year: 2006
    ..abstract_text> ..
  6. Mechanism of Insulin Resistance in Aged
    Kitt Petersen; Fiscal Year: 2007
    ..abstract_text> ..
  7. Mechanism of Insulin Resistance in the Aged.
    Kitt F Petersen; Fiscal Year: 2010
    ....