Research Topics
Species | Kitt Falk PetersenSummaryAffiliation: Yale University Country: USA Publications
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Publications
Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetesKitt Falk Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
N Engl J Med 350:664-71. 2004....- Skeletal muscle insulin resistance promotes increased hepatic de novo lipogenesis, hyperlipidemia, and hepatic steatosis in the elderlyClare Flannery
Corresponding author Kitt Falk Petersen
Diabetes 61:2711-7. 2012..02). These results strongly support the hypothesis that muscle insulin resistance in aging promotes hyperlipidemia and NAFLD by altering the pattern of postprandial carbohydrate storage away from muscle glycogen and into hepatic DNL... 
13C/31P NMR studies on the mechanism of insulin resistance in obesityK F Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
Diabetes 47:381-6. 1998..We conclude that insulin resistance in obesity can be mostly attributed to impairment of insulin-stimulated muscle glycogen synthesis due to a defect in glucose transport and/or phosphorylation activity...- New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopyKitt Falk Petersen
Department of Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
Obesity (Silver Spring) 14:34S-40S. 2006..In this review, we focus on some recent advances in our understanding of the pathogenesis of insulin resistance in humans that have been made using magnetic resonance spectroscopy... - Etiology of insulin resistanceKitt Falk Petersen
Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Med 119:S10-6. 2006..Understanding the cellular mechanism(s) of insulin resistance in turn offers the prospect of better targeted and more effective therapeutic interventions for treatment and prevention of type 2 diabetes... - Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetesKitt Falk Petersen
Yale University School of Medicine, Department of Internal Medicine, 300 Cedar St, S263 TAC, P O Box 9812, New Haven, CT 06520 8020, USA
Diabetes 54:603-8. 2005.... - Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophyKitt Falk Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
J Clin Invest 109:1345-50. 2002..These data suggest that leptin may represent an important new therapy to reverse the severe hepatic and muscle insulin resistance and associated hepatic steatosis in patients with lipodystrophy... - Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humansK F Petersen
Yale University School of Medicine, Department of Internal Medicine, New Haven, Connecticut 06520 8020, USA
Diabetologia 44:2018-24. 2001..To study the effects of a specific glucagon receptor antagonist (Bay 27-9955), on plasma glucose concentrations and rates of glucose production in response to hyperglucagonaemia in humans... - Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosisK F Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, Conneticut 06520 8020, USA
Am J Physiol 276:E529-35. 1999..These alterations are likely important contributing factors to their altered carbohydrate metabolism... - Mechanism of troglitazone action in type 2 diabetesK F Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
Diabetes 49:827-31. 2000.... - Stimulating effects of low-dose fructose on insulin-stimulated hepatic glycogen synthesis in humansK F Petersen
Department of Internal Medicine, Yale University School of Medicine, 333 Cedar St, FMP 104, New Haven, CT 06520 8020, USA
Diabetes 50:1263-8. 2001..Because net hepatic glycogen synthesis has been shown to be diminished in patients with poorly controlled type 1 and type 2 diabetes, stimulation of hepatic glycogen synthesis by this mechanism may be of potential therapeutic value... - Mitochondrial dysfunction in the elderly: possible role in insulin resistanceKitt Falk Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Science 300:1140-2. 2003..These data support the hypothesis that an age-associated decline in mitochondrial function contributes to insulin resistance in the elderly... - Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parentsKatsutaro Morino
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06536 8012, USA
J Clin Invest 115:3587-93. 2005.... - Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patientsDouglas E Befroy
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 8012, USA
Diabetes 56:1376-81. 2007.... - Apolipoprotein C3 gene variants in nonalcoholic fatty liver diseaseKitt Falk Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
N Engl J Med 362:1082-9. 2010..Nonalcoholic fatty liver disease is associated with hepatic insulin resistance and type 2 diabetes mellitus. Whether this association has a genetic basis is unknown... - Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individualsDouglas E Befroy
Departments of Internal Medicine, Diagnostic Radiology, Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
Proc Natl Acad Sci U S A 105:16701-6. 2008..Increased mitochondrial uncoupling may represent another mechanism by which exercise training enhances muscle insulin sensitivity via increased fatty acid oxidation in the resting state... - The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndromeKitt Falk Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
Proc Natl Acad Sci U S A 104:12587-94. 2007.... - Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetesKitt Falk Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
Proc Natl Acad Sci U S A 109:8236-40. 2012..In conclusion, these data support the hypothesis that IMCL accumulation plays an important role in causing muscle insulin resistance in young, lean IR offspring, and that both are reversible with modest weight loss... - Lipid-induced insulin resistance: unravelling the mechanismVarman T Samuel
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536 8012, USA
Lancet 375:2267-77. 2010..This unifying hypothesis accounts for the mechanism of insulin resistance in obesity, type 2 diabetes, lipodystrophy, and ageing; and the insulin-sensitising effects of thiazolidinediones... - Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individualsRasmus Rabøl
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
Proc Natl Acad Sci U S A 108:13705-9. 2011.... - Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humansSylvie Dufour
Department of Internal Medicine, Yale University School of Medicine, The Anlyan Center, S263, New Haven, CT 06520 8020, USA
Am J Physiol Endocrinol Metab 297:E231-5. 2009.... - Disordered lipid metabolism and the pathogenesis of insulin resistanceDavid B Savage
Department of Internal Medicine, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536 8012, USA
Physiol Rev 87:507-20. 2007..in 2004, we will concentrate on human studies involving the use of isotopes and/or magnetic resonance spectroscopy, occasionally drawing on mouse models which provide additional mechanistic insight... - Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposityRanjana Sinha
Department of Pediatrics, The Children's General Clinical Research Center at Yale University School of Medicine, New Haven, Connecticut 06510, USA
Diabetes 51:1022-7. 2002..The striking relationships between both IMCL and EMCL with insulin sensitivity in childhood suggest that these findings are not a consequence of aging but occur early in the natural course of obesity... - Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunctionKatsutaro Morino
Howard Hughes Medical Institute, Yale University School of Medicine, P O Box 9812, New Haven, CT 06536 8012, USA
Diabetes 55:S9-S15. 2006..By elucidating the cellular and molecular mechanisms responsible for insulin resistance, these studies provide potential new targets for the treatment and prevention of type 2 diabetes... - Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian menKitt Falk Petersen
Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06536, USA
Proc Natl Acad Sci U S A 103:18273-7. 2006.... - Disassociation of liver and muscle insulin resistance from ectopic lipid accumulation in low-birth-weight individualsSylvie Dufour
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
J Clin Endocrinol Metab 96:3873-80. 2011..Insulin resistance plays a prominent role in the development of T2D; however, the pathogenesis of T2D in LBW is controversial... - Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetesKatsutaro Morino
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT, USA
Diabetes 61:877-87. 2012..Taken together, these data suggest that decreased mitochondrial content in muscle of IR offspring may be due in part to reductions in LPL expression in skeletal muscle resulting in decreased PPAR-δ activation... - Regulation of net hepatic glycogenolysis and gluconeogenesis during exercise: impact of type 1 diabetesKitt Falk Petersen
Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, S263, P.O. Box 208020, New Haven, Connecticut 06520-8020, USA
J Clin Endocrinol Metab 89:4656-64. 2004..2) In contrast, moderately controlled type 1 diabetic subjects exhibit increased rates of GP both at rest and during exercise, which can be entirely accounted for by increased gluconeogenesis... - Mitochondrial dysfunction and type 2 diabetesRebecca Parish
Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, PO Box 208020, New Haven, CT 06520-8020, USA
Curr Diab Rep 5:177-83. 2005..Understanding the molecular and biochemical defects responsible for insulin resistance is beginning to unveil novel therapeutic targets for the treatment of the metabolic syndrome and type 2 diabetes... - Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEALHyeonjin Kim
Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8043, USA
Magn Reson Med 59:521-7. 2008..Therefore, protocol-specific establishment of cutoffs for liver fat content may be necessary... - Cellular mechanism of insulin resistance in skeletal muscleKitt Falk Petersen
Howard Hughes Medical Institute, Yale General Clinical Research Center, Yale University School of Medicine, PO Box 9812, New Haven, CT 06536-8012, USA
J R Soc Med 95:8-13. 2002 - A cluster of metabolic defects caused by mutation in a mitochondrial tRNAFrederick H Wilson
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
Science 306:1190-4. 2004..Given the known loss of mitochondrial function with aging, these findings may have implications for the common clustering of these metabolic disorders... - Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucoseGraeme F Mason
Department of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut 06520 8043, USA
J Neurochem 100:73-86. 2007..These results are consistent with observations made with arterial-venous differences and radiotracer methods... - Cellular mechanism of insulin resistance in nonalcoholic fatty liver diseaseNaoki Kumashiro
Howard Hughes Medical Institute and Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 108:16381-5. 2011.... - A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girlsThomas O Carpenter
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
J Clin Endocrinol Metab 91:4866-72. 2006..Limited studies suggest that dietary Mg intake and bone mineral density are correlated in adults, but no data from interventional studies in children and adolescents are available... - Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid contentSusanne Neschen
Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut 06520-8020, USA
Am J Physiol Endocrinol Metab 282:E395-401. 2002..In turn, an increased hepatic beta-oxidative capacity results in lower hepatic triglyceride/diacylglycerol and intramyocellular triglyceride/fatty acyl-CoA content... - Increased hypothalamic-pituitary-adrenal axis activity and hepatic insulin resistance in low-birth-weight ratsEsben S Buhl
Department of Pharmacology, Faculty of Health Sciences, Medical Department M, University of Aarhus, Aarhus, Denmark
Am J Physiol Endocrinol Metab 293:E1451-8. 2007.... - Effects of depletion exercise and light training on muscle glycogen supercompensation in menHarold W Goforth
Naval Health Research Center, San Diego, California 92186, USA
Am J Physiol Endocrinol Metab 285:E1304-11. 2003..Daily exercise at 65% VO2 peak for 20 min can be performed throughout the CHO-loading protocol without negatively affecting muscle glycogen supercompensation...
Research Grants
- NMR STUDIES:HEPATIC GLUCOSE METABOL IN HUMANS EXERCISINGKitt Petersen; Fiscal Year: 2003..The results of these studies should provide important new insight into the regulation of hepatic glucose metabolism in healthy and type 1 diabetic subjects. ..
- Mechanism of Insulin Resistance in AgedKitt Petersen; Fiscal Year: 2007..abstract_text> ..
- Mechanism of Insulin Resistance in the Aged.Kitt F Petersen; Fiscal Year: 2010....