Godfrey Pearlson

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint Distinguishing between schizophrenia and other psychotic disorders
    Godfrey D Pearlson
    To whom correspondence should be addressed Whitehall Building 207, ONRC, IOL, 200 Washington Street, Hartford, CT 06106, US tel 860 545 7678, fax 860 545 7797, E mail
    Schizophr Bull 40:501-3. 2014
  2. ncbi request reprint Structural and functional magnetic resonance imaging in psychiatric disorders
    Godfrey D Pearlson
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06106, USA
    Can J Psychiatry 52:158-66. 2007
  3. pmc Schizophrenia, psychiatric genetics, and Darwinian psychiatry: an evolutionary framework
    Godfrey D Pearlson
    The Olin Neuropsychiatry Research Center, 200 Retreat Avenue, Whitehall Building, Hartford, CT 06106, USA
    Schizophr Bull 34:722-33. 2008
  4. ncbi request reprint Endophenotypes, dimensions, risks: is psychosis analogous to common inherited medical illnesses?
    Godfrey D Pearlson
    Olin Neuropsychiatry Research Center, Hartford, Connecticut 06106, USA
    Clin EEG Neurosci 39:73-7. 2008
  5. pmc Brain connectivity is not only lower but different in schizophrenia: a combined anatomical and functional approach
    Pawel Skudlarski
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut 06106, USA
    Biol Psychiatry 68:61-9. 2010
  6. pmc Alcohol dose effects on brain circuits during simulated driving: an fMRI study
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Connecticut, USA
    Hum Brain Mapp 30:1257-70. 2009
  7. pmc Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut, United States of America
    PLoS ONE 4:e7911. 2009
  8. ncbi request reprint A functional magnetic resonance imaging study of working memory abnormalities in schizophrenia
    Matthew R Johnson
    Olin Neuropsychiatry Research Center, The Institute of Living at Hartford Hospital, Hartford, CT, USA
    Biol Psychiatry 60:11-21. 2006
  9. pmc A virtual reality apartment as a measure of medication management skills in patients with schizophrenia: a pilot study
    Matthew M Kurtz
    Schizophrenia Rehabilitation Program, Institute of Living, 200 Retreat Avenue, Hartford, CT 06106, USA
    Schizophr Bull 33:1162-70. 2007
  10. ncbi request reprint Aberrant "default mode" functional connectivity in schizophrenia
    Abigail G Garrity
    Trinity College, Hartford, CT, USA
    Am J Psychiatry 164:450-7. 2007

Research Grants

Detail Information

Publications67

  1. doi request reprint Distinguishing between schizophrenia and other psychotic disorders
    Godfrey D Pearlson
    To whom correspondence should be addressed Whitehall Building 207, ONRC, IOL, 200 Washington Street, Hartford, CT 06106, US tel 860 545 7678, fax 860 545 7797, E mail
    Schizophr Bull 40:501-3. 2014
    ....
  2. ncbi request reprint Structural and functional magnetic resonance imaging in psychiatric disorders
    Godfrey D Pearlson
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06106, USA
    Can J Psychiatry 52:158-66. 2007
    ..To report on recent advances in both structural and functional brain imaging studies in psychiatry and to highlight their importance for the field...
  3. pmc Schizophrenia, psychiatric genetics, and Darwinian psychiatry: an evolutionary framework
    Godfrey D Pearlson
    The Olin Neuropsychiatry Research Center, 200 Retreat Avenue, Whitehall Building, Hartford, CT 06106, USA
    Schizophr Bull 34:722-33. 2008
    ..In this article, we will examine some of these proposed ideas and offer suggestions for future research...
  4. ncbi request reprint Endophenotypes, dimensions, risks: is psychosis analogous to common inherited medical illnesses?
    Godfrey D Pearlson
    Olin Neuropsychiatry Research Center, Hartford, Connecticut 06106, USA
    Clin EEG Neurosci 39:73-7. 2008
    ..We discuss this perspective in the context of an endophenotypic and biological marker approach to understanding schizophrenia and present a research strategy to compare schizophrenia endophenotypes to risk for common medical illnesses...
  5. pmc Brain connectivity is not only lower but different in schizophrenia: a combined anatomical and functional approach
    Pawel Skudlarski
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, Connecticut 06106, USA
    Biol Psychiatry 68:61-9. 2010
    ..Simultaneous measure of anatomical and functional connectivity and its interactions allow for better understanding of schizophrenia-related alternations in brain connectivity...
  6. pmc Alcohol dose effects on brain circuits during simulated driving: an fMRI study
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Connecticut, USA
    Hum Brain Mapp 30:1257-70. 2009
    ..Overall, results suggest that alcohol (especially at high doses) causes significant impairment of both driving behavior and brain functionality related to motor planning and control, goal directedness, error monitoring, and memory...
  7. pmc Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut, United States of America
    PLoS ONE 4:e7911. 2009
    ..Numerous neuroimaging studies report abnormal regional brain activity during working memory performance in schizophrenia, but few have examined brain network integration as determined by "functional connectivity" analyses...
  8. ncbi request reprint A functional magnetic resonance imaging study of working memory abnormalities in schizophrenia
    Matthew R Johnson
    Olin Neuropsychiatry Research Center, The Institute of Living at Hartford Hospital, Hartford, CT, USA
    Biol Psychiatry 60:11-21. 2006
    ..We examined neural function changes at several WM loads to derive a more complete picture of WM dysfunction in schizophrenia...
  9. pmc A virtual reality apartment as a measure of medication management skills in patients with schizophrenia: a pilot study
    Matthew M Kurtz
    Schizophrenia Rehabilitation Program, Institute of Living, 200 Retreat Avenue, Hartford, CT 06106, USA
    Schizophr Bull 33:1162-70. 2007
    ..This is the first study, to our knowledge, to provide evidence for the utility of VR technology in the assessment of instrumental role functioning in patients with schizophrenia...
  10. ncbi request reprint Aberrant "default mode" functional connectivity in schizophrenia
    Abigail G Garrity
    Trinity College, Hartford, CT, USA
    Am J Psychiatry 164:450-7. 2007
    ..It was hypothesized that the default mode network would show abnormal activation and connectivity in patients with schizophrenia...
  11. pmc Functional neural networks underlying response inhibition in adolescents and adults
    Michael C Stevens
    Olin Neuropsychiatry Research Center, Hartford, CT 06106, United
    Behav Brain Res 181:12-22. 2007
    ..We identify and characterize several age-related differences in the function of neural circuits that are associated with behavioral performance changes across adolescent development...
  12. pmc Diffusion tensor imaging in schizophrenia: relationship to symptoms
    Laurie R Skelly
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Schizophr Res 98:157-62. 2008
    ....
  13. pmc Effects of alcohol on performance on a distraction task during simulated driving
    Allyssa J Allen
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, 200 Retreat Avenue, Hartford, Connecticut 06106, USA
    Alcohol Clin Exp Res 33:617-25. 2009
    ..Previous functional MRI (fMRI) studies of the VO task have shown activation in the anterior cingulate, hippocampus, and prefrontal cortex. Thus, we predicted dose-dependent decreases in activation of these areas during VO performance...
  14. ncbi request reprint Abnormal object recall and anterior cingulate overactivation correlate with formal thought disorder in schizophrenia
    Michal Assaf
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Biol Psychiatry 59:452-9. 2006
    ..An influential theory is that FTD results from impaired semantic memory processing. We explored the neural correlates of semantic memory retrieval in schizophrenia using an imaging task assessing semantic object recall...
  15. pmc An fMRI study of working memory in first-degree unaffected relatives of schizophrenia patients
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, 200 Retreat Avenue, Hartford, CT 06106, USA
    Schizophr Res 104:85-95. 2008
    ..Additionally, fMRI differences in both conditions were modulated by load, with a parametric increase in between-group differences with load in several key regions during encoding and an opposite effect during response selection...
  16. ncbi request reprint The vulnerability to alcohol and substance abuse in individuals diagnosed with schizophrenia
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neurotox Res 10:235-52. 2006
    ..The focus on distinctions between motivation and reward with respect to substance abuse risk by schizophrenic patients suggests a need for a reconsideration of the construct of "negative symptoms" for this dually-diagnosed patient group...
  17. ncbi request reprint An adaptive reflexive processing model of neurocognitive function: supporting evidence from a large scale (n = 100) fMRI study of an auditory oddball task
    Kent A Kiehl
    Olin Neuropsychiatry Research Center, The Institute of Living, Hartford, CT 06106, USA
    Neuroimage 25:899-915. 2005
    ..This process may be termed 'adaptive reflexive processing.' The implications of these results for interpreting functional MRI studies are discussed...
  18. ncbi request reprint Alcohol intoxication effects on simulated driving: exploring alcohol-dose effects on brain activation using functional MRI
    Vince D Calhoun
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT, USA
    Neuropsychopharmacology 29:2097-17. 2004
    ..The fMRI data also suggest that the deficits observed in alcohol intoxication may be modulated primarily through OF/anterior cingulate, motor and cerebellar regions as opposed to attentional areas in frontoparietal cortex...
  19. ncbi request reprint Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability
    Tandy J Miller
    Yale University, New Haven, CT, USA
    Schizophr Bull 29:703-15. 2003
    ..It also presents data suggesting that excellent interrater reliability can be established for diagnosis in a day-and-a-half-long training workshop...
  20. ncbi request reprint Alcohol intoxication effects on visual perception: an fMRI study
    Vince D Calhoun
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06106, USA
    Hum Brain Mapp 21:15-26. 2004
    ..e., increased in spatial extent) at the higher dose. Alcohol, thus, appears to have both global and local effects upon the neural correlates of the MVPT-R task, some of which are dose dependent...
  21. ncbi request reprint fMRI hippocampal activity during a virtual radial arm maze
    Robert S Astur
    Olin Neuropsychiatry Research Center, Institute of Living, 200 Retreat Avenue, Hartford, Connecticut 06106, USA
    Appl Psychophysiol Biofeedback 30:307-17. 2005
    ..Hence, this virtual reality version may be used to assess the integrity of hippocampus so as to predict risk or severity in a variety of psychiatric disorders...
  22. pmc Aberrant localization of synchronous hemodynamic activity in auditory cortex reliably characterizes schizophrenia
    Vince D Calhoun
    Institute of Living, Olin Neuropsychiatry Research Center, 200 Retreat Avenue, Hartford, CT 06106, USA
    Biol Psychiatry 55:842-9. 2004
    ..In this study, we attempted to examine auditory cortex function using an intrinsic, task-uncorrelated measure...
  23. pmc Brain network dynamics during error commission
    Michael C Stevens
    Olin Neuropsychiatry Research Center, The Institute of Living Hartford Hospital, Hartford, Connecticut 06106, USA
    Hum Brain Mapp 30:24-37. 2009
    ..These findings characterize the spatial structure of neural networks underlying error commission and identify neurobiological differences between adolescents and adults...
  24. pmc Endophenotypes in schizophrenia: a selective review
    Allyssa J Allen
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, 200 Retreat Avenue, Hartford, CT 06106, United States
    Schizophr Res 109:24-37. 2009
    ..The purpose of this review was to provide a summary of the existing data on the most extensively published endophenotypes for schizophrenia...
  25. pmc A method for multitask fMRI data fusion applied to schizophrenia
    Vince D Calhoun
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06106, USA
    Hum Brain Mapp 27:598-610. 2006
    ..It thus provides a way to integrate and probe brain networks using a variety of tasks and may increase our understanding of coordinated brain networks and the impact of pathology upon them...
  26. pmc Population admixture modulates risk for alcohol dependence
    Lingjun Zuo
    Department of Psychiatry, Yale University School of Medicine, VA Psychiatry 116A2, West Haven, CT 06516, USA
    Hum Genet 125:605-13. 2009
    ..We cannot exclude the possibility that the results might have been influenced by selection bias due to the multisite nature of the study...
  27. ncbi request reprint Alternative forms of the Rey Auditory Verbal Learning Test: a review
    Keith A Hawkins
    Yale University School of Medicine and the Olin Neuropsychiatric Research Center of the Institute of Living, Hartford Hospital, CT, USA
    Behav Neurol 15:99-107. 2004
    ..The available data on alternative AVLT forms are summarized, and recommendations regarding form development and the determination of form equivalence are offered...
  28. pmc Temporal sequence of hemispheric network activation during semantic processing: a functional network connectivity analysis
    Michal Assaf
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, CT, United States
    Brain Cogn 70:238-46. 2009
    ..poorer performers of the SORT. These results indicate an early activation of the RH that is closely followed by activation of the LH, to facilitate performance during word retrieval from SM...
  29. ncbi request reprint Functional neural circuits for mental timekeeping
    Michael C Stevens
    Olin Neuropsychiatry Research Center, Hartford, Connecticut 06106, USA
    Hum Brain Mapp 28:394-408. 2007
    ..These findings are discussed within the context of current biological and information processing models of neural timekeeping...
  30. pmc Modulation of temporally coherent brain networks estimated using ICA at rest and during cognitive tasks
    Vince D Calhoun
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06106, USA
    Hum Brain Mapp 29:828-38. 2008
    ..In summary, TCNs show considerable promise as potential imaging biological markers of brain diseases, though each network needs to be studied in more detail...
  31. ncbi request reprint An FMRI auditory oddball study of combined-subtype attention deficit hyperactivity disorder
    Michael C Stevens
    Olin Neuropsychiatry Research Center, Whitehall Building, Institute of Living Hartford Hospital, Hartford, CT 06106, USA
    Am J Psychiatry 164:1737-49. 2007
    ..However, the relationship between abnormal neurocognition and dysfunction in specific brain regions in ADHD remains unclear...
  32. pmc A method for functional network connectivity among spatially independent resting-state components in schizophrenia
    Madiha J Jafri
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Neuroimage 39:1666-81. 2008
    ..Significant differences between patient and control connectivity in different networks were revealed possibly reflecting deficiencies in cortical processing in patients...
  33. pmc Anomalous neural circuit function in schizophrenia during a virtual Morris water task
    Bradley S Folley
    The Olin Neuropsychiatry Research Center, Hartford, CT, USA
    Neuroimage 49:3373-84. 2010
    ..GLM analysis elucidated several comparable regions, with the exception of the hippocampus. Inefficient allocentric learning and memory in patients may be related to an inability to recruit appropriate task-dependent neural circuits...
  34. ncbi request reprint Functional MRI study of a serial reaction time task in Huntington's disease
    Jin Suh Kim
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, 400 Washington St, Hartford, CT 06106, USA
    Psychiatry Res 131:23-30. 2004
    ..The variable striatal activity in the Huntington's group suggests early functional loss possibly associated with previously demonstrated early atrophy of these same neural structures...
  35. doi request reprint Measuring brain connectivity: diffusion tensor imaging validates resting state temporal correlations
    Pawel Skudlarski
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford Hospital, Hartford, 06106 CT, USA
    Neuroimage 43:554-61. 2008
    ..The combination of both techniques presented here allows for further combining them to provide richer representation of brain connectivity both in the healthy brain and in clinical conditions...
  36. pmc Age-related cognitive gains are mediated by the effects of white matter development on brain network integration
    Michael C Stevens
    Olin Neuropsychiatry Research Center, Whitehall Building, The Institute of Living Hartford Hospital, Hartford, CT 06106, USA
    Neuroimage 48:738-46. 2009
    ....
  37. pmc Physiogenomic analysis of localized FMRI brain activity in schizophrenia
    Andreas Windemuth
    Genomas, Inc, Hartford, CT, 06106, USA
    Ann Biomed Eng 36:877-88. 2008
    ..The results of this study support the physiogenomic analysis of neuroimaging data to discover associations between genotype and disease-related phenotypes...
  38. ncbi request reprint Simulated driving and brain imaging: combining behavior, brain activity, and virtual reality
    Kara N Carvalho
    Trinity University, Hartford, CT 06106, USA
    CNS Spectr 11:52-62. 2006
    ..Various clinical questions can be addressed, including both the role of alcohol as a modulator of brain function and regional brain activation related to elements of driving...
  39. pmc Disruptions in functional network connectivity during alcohol intoxicated driving
    Catherine I Rzepecki-Smith
    Olin Neuropsychiatry Research Center, Institute of Living Hartford Hospital, Hartford, Connecticut, USA
    Alcohol Clin Exp Res 34:479-87. 2010
    ..However, the functional connectivity between these circuits has not yet been explored in order to determine how these networks communicate with each other during sober and alcohol-intoxicated states...
  40. pmc A large scale (N=400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometry
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, CT 06106, USA
    Schizophr Res 101:95-105. 2008
    ..However, results from these studies vary widely, likely due to different methodological or statistical approaches...
  41. ncbi request reprint Neural correlates of the object-recall process in semantic memory
    Michal Assaf
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, United States
    Psychiatry Res 147:115-26. 2006
    ..Understanding the circuit that normally mediates this process is relevant for schizophrenia, where many regions in this circuit are functionally abnormal and semantic memory is impaired...
  42. pmc Temporal lobe and "default" hemodynamic brain modes discriminate between schizophrenia and bipolar disorder
    Vince D Calhoun
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut, USA
    Hum Brain Mapp 29:1265-75. 2008
    ..A combination of two such hemodynamic brain networks shows promise as a biomarker for schizophrenia and bipolar disorder...
  43. ncbi request reprint Source density-driven independent component analysis approach for fMRI data
    Baoming Hong
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, Connecticut 06106, USA
    Hum Brain Mapp 25:297-307. 2005
    ..Our experimental results show that the source density-driven ICA method can improve performance further by incorporating some a priori information into ICA analysis of fMRI signals...
  44. pmc Absence of established sex differences in patients with schizophrenia on a two-dimensional object array task
    Seth L Shipman
    Olin Neuropsychiatry Research Center Institute of Living, Hartford, CT 06106, United States
    Psychiatry Res 166:158-65. 2009
    ..However, the female advantage is completely absent in patients with schizophrenia. This finding has important implications for the interpretation of clinical and physiological sex differences present in schizophrenia...
  45. pmc Investigating the behavioral and self-report constructs of impulsivity domains using principal component analysis
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut 06106, USA
    Behav Pharmacol 20:390-9. 2009
    ..In addition, our supplemental analysis also suggested that the impulsivity constructs were largely, but not entirely the same within the healthy and ARA groups...
  46. pmc Sex differences in the effects of marijuana on simulated driving performance
    Beth M Anderson
    Olin Neuropsychiatry Research Center, 200 Retreat Avenue Whitehall Bldg, Hartford Hospital Institute of Living, Hartford, CT 06106, USA
    J Psychoactive Drugs 42:19-30. 2010
    ..No differences attributable to sex were observed. This study enhances the current literature by identifying distracted driving and the integration of prior experience as particularly problematic under the influence of marijuana...
  47. doi request reprint Changes in the interaction of resting-state neural networks from adolescence to adulthood
    Michael C Stevens
    Olin Neuropsychiatry Research Center, Institute of Living Hartford Hospital, Hartford, Connecticut 06106, USA
    Hum Brain Mapp 30:2356-66. 2009
    ..These results contribute to an emerging understanding that activity in widely distributed networks thought to underlie complex cognition influences activity in other networks...
  48. ncbi request reprint Voxel-based morphometry versus region of interest: a comparison of two methods for analyzing gray matter differences in schizophrenia
    Nicole R Giuliani
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Whitehall Building, 200 Retreat Avenue, Hartford, CT 06106, USA
    Schizophr Res 74:135-47. 2005
    ..Although VBM is rapid and fully automated, it is not a replacement for manual ROI-based analyses. Both methods provide different types of information and should thus be used in tandem...
  49. ncbi request reprint Different activation dynamics in multiple neural systems during simulated driving
    Vince D Calhoun
    Division of Psychiatric Neuro Imaging, Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland 21205, USA
    Hum Brain Mapp 16:158-67. 2002
    ..Increases in cerebellar and occipital areas, presumably related to complex visuomotor integration, are activated during driving but not associated with driving speed...
  50. ncbi request reprint Hippocampal and ventricular volumes in psychotic and nonpsychotic bipolar patients compared with schizophrenia patients and community control subjects: a pilot study
    Heather C Strasser
    Division of Psychiatric Neuroimaging, Johns Hopkins University, Baltimore, Catonsville, Maryland
    Biol Psychiatry 57:633-9. 2005
    ..One possibility is that volumetric abnormalities are determined by disease subtype. Prior evidence suggests that psychotic (PBP) and nonpsychotic (NPBP) forms of BP are two subtypes that might differ in pathophysiology...
  51. ncbi request reprint Driving simulator performance in schizophrenia
    Sarah A St Germain
    Schizophr Res 74:121-2. 2005
  52. pmc Neuropsychological functioning in bipolar disorder and schizophrenia
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7218, and Olin Neuropsychiatric Research Center, Hartford Hospital Institute of Living, CT, USA
    Biol Psychiatry 62:179-86. 2007
    ..Some patients with bipolar disorder (BD) demonstrate neuropsychological deficits even when stable. However, it remains unclear whether these differ qualitatively from those seen in schizophrenia (SZ)...
  53. ncbi request reprint The relationship of recency discrimination to explicit memory and executive functioning
    Kevin J Manning
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Int Neuropsychol Soc 13:710-5. 2007
    ....
  54. ncbi request reprint Functional brain changes in presymptomatic Huntington's disease
    Sarah A J Reading
    Department of Psychiatry, Johns Hopkins University, Baltimore, MD 21287, USA
    Ann Neurol 55:879-83. 2004
    ..In the setting of normal cognitive performance, presymptomatic HD subjects had significantly and specifically less activation in the left anterior cingulate cortex (BA 24, 32) compared with matched controls...
  55. doi request reprint Frequency and bases of abnormal performance by healthy adults on neuropsychological testing
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287 7218, USA
    J Int Neuropsychol Soc 14:436-45. 2008
    ..However, it eliminated the contribution of these variables to rates of abnormal test performance. These findings raise fundamental questions about the nature and interpretation of abnormal test performance by normal, healthy adults...
  56. ncbi request reprint MRI parcellation of the frontal lobe in boys with attention deficit hyperactivity disorder or Tourette syndrome
    Wendy R Kates
    Division of Psychiatric Neuroimaging, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Psychiatry Res 116:63-81. 2002
    ....
  57. ncbi request reprint Diffusion tensor imaging in schizophrenia
    Richard A A Kanaan
    Section of Neuroimaging, Institute of Psychiatry, London, United Kingdom
    Biol Psychiatry 58:921-9. 2005
    ..A systematic review of DTI studies in schizophrenia was undertaken to test the hypothesis that DTI can detect white matter differences between schizophrenia patients and normal control subjects...
  58. doi request reprint Augmentation of behavior therapy with D-cycloserine for obsessive-compulsive disorder
    Sabine Wilhelm
    Obsessive Compulsive Disorder Clinic, Department of Psychiatry, Massachusetts General Hospital, Boston, MA 02114, USA
    Am J Psychiatry 165:335-41; quiz 409. 2008
    ..This study examined whether d-cycloserine, a partial agonist at the N-methyl-D-aspartate (NMDA) glutamatergic receptor, enhances the efficacy of behavior therapy for obsessive-compulsive disorder (OCD)...
  59. ncbi request reprint Examining the range of normal intraindividual variability in neuropsychological test performance
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Int Neuropsychol Soc 9:864-70. 2003
    ..These data reveal that marked intraindividual variability is very common in normal adults, and underscore the need to base diagnostic inferences on clinically recognizable patterns rather than psychometric variability alone...
  60. ncbi request reprint Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking
    Susumu Mori
    Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Magn Reson Med 47:215-23. 2002
    ..As a first illustration of this technical capability, a reduction in brain connectivity in a patient with a childhood neurodegenerative disease (X-linked adrenoleukodystrophy) was demonstrated...
  61. ncbi request reprint How well does IQ predict neuropsychological test performance in normal adults?
    Catherine M Diaz-Asper
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Int Neuropsychol Soc 10:82-90. 2004
    ..These findings confirm that IQ predicts concurrent neuropsychological performance across the entire spectrum of intelligence, but more so among persons of average IQ or less than among those with above average IQ...
  62. ncbi request reprint Morphometric assessment of the heteromodal association cortex in schizophrenia
    Robert W Buchanan
    Maryland Psychiatric Research Center, Catonsville 21228, USA
    Am J Psychiatry 161:322-31. 2004
    ..To test this hypothesis, the authors measured prefrontal, inferior parietal, and superior temporal gyrus volumes and examined the pattern of connections among these regions...
  63. ncbi request reprint Decreased frontal white-matter volume in chronic substance abuse
    Thomas E Schlaepfer
    Department of Psychiatry, University Hospital, Bonn, Germany
    Int J Neuropsychopharmacol 9:147-53. 2006
    ....
  64. ncbi request reprint The use of word-reading to estimate "premorbid" ability in cognitive domains other than intelligence
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA
    J Int Neuropsychol Soc 11:784-7. 2005
    ....
  65. ncbi request reprint Neuroanatomic variation in monozygotic twin pairs discordant for the narrow phenotype for autism
    Wendy R Kates
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Psychiatry 161:539-46. 2004
    ..The authors examined the relationship of twin pair differences in clinical phenotype to differences in neuroanatomic phenotype...
  66. ncbi request reprint Serum uric acid and cognitive function in community-dwelling older adults
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
    Neuropsychology 21:136-40. 2007
    ..05). Despite its antioxidant properties, these findings suggest that even mild elevations of UA might increase the risk of cognitive decline among older adults...

Research Grants49

  1. Schizophrenia Biomarkers: Memory, Genes and fMRI
    Godfrey Pearlson; Fiscal Year: 2009
    ..It will be conducted in a recently established neuroimaging research center with direct access to large numbers of SZ patients and their siblings. ..
  2. Reward, Impulsivity and Cocaine Addiction; fMRI Studies
    Godfrey Pearlson; Fiscal Year: 2007
    ..Overall, we thus plan to elucidate the inter-relationship between two important substance abuse-related factors at both a behavioral and a neural circuit level. ..
  3. fMRI Imaging of Alcohol-Intoxicated Driving
    Godfrey Pearlson; Fiscal Year: 2007
    ..Together, these allow dissection of alcohol's effects on the multiple overlapping neural circuits associated with performance of complex, driving-related cognitive tasks. ..
  4. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Godfrey Pearlson; Fiscal Year: 2007
    ....
  5. QUANTITATIVE STRUCTURAL NEUROIMAGING IN PSYCHOSIS
    Godfrey Pearlson; Fiscal Year: 2003
    ..The combination of advantages referred to above will help us to provide answers to hypotheses ranging from the level of inherited abnormalities to that of disease outcome. ..
  6. Alcohol Use in College Students:Cognition and fMRI
    Godfrey D Pearlson; Fiscal Year: 2010
    ..Findings from this study will provide important insights on risk factors for problem drinking and how alcohol use impacts the developing adolescent brain. ..
  7. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Godfrey D Pearlson; Fiscal Year: 2010
    ....
  8. Quantitative Neuroimaging in Psychosis; DTI Studies
    Godfrey Pearlson; Fiscal Year: 2007
    ..In addition, novel data fusion techniques will be used to combine information across imaging modalities. ..
  9. Quantitative Neuroimaging in Psychosis
    Godfrey Pearlson; Fiscal Year: 2007
    ..abstract_text> ..
  10. Bipolar & Schizophrenia Consortium for Parsing Intermediate Phenotypes
    Godfrey Pearlson; Fiscal Year: 2009
    ....
  11. Schizophrenia Biomarkers: Memory, Genes and fMRI
    Godfrey Pearlson; Fiscal Year: 2007
    ..It will be conducted in a recently established neuroimaging research center with direct access to large numbers of SZ patients and their siblings. ..
  12. NEURO-IMAGING & NEUROPSYCHOLOGIC IMPAIRMENT IN PSYCHOSIS
    Godfrey Pearlson; Fiscal Year: 1991
    ..For that reason a second control group will consist of matched patients with bipolar affective disorder, who will also undergo all of the above investigations...
  13. Reward, Impulsivity and Cocaine Addiction; fMRI Studies
    Godfrey Pearlson; Fiscal Year: 2009
    ..Overall, we thus plan to elucidate the inter-relationship between two important substance abuse-related factors at both a behavioral and a neural circuit level. ..
  14. Alcohol Use in College Students:Cognition and fMRI
    Godfrey Pearlson; Fiscal Year: 2009
    ..Findings from this study will provide important insights on risk factors for problem drinking and how alcohol use impacts the developing adolescent brain. ..
  15. Schizophrenia Biomarkers: Memory Genes and fMRI
    Godfrey D Pearlson; Fiscal Year: 2010
    ..It will be conducted in a recently established neuroimaging research center with direct access to large numbers of SZ patients and their siblings. ..