John M Pawelek

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Salmonella pathogenicity island-2 and anticancer activity in mice
    John M Pawelek
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    Cancer Gene Ther 9:813-8. 2002
  2. ncbi request reprint Bacteria as tumour-targeting vectors
    John M Pawelek
    Department of Dermatology, Yale University School of Medicine, Yale, CT 06520 8059, USA
    Lancet Oncol 4:548-56. 2003
  3. doi request reprint Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis
    John M Pawelek
    Department of Dermatology and the Yale Cancer Center, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520 08059, USA
    Nat Rev Cancer 8:377-86. 2008
  4. doi request reprint Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer
    John M Pawelek
    Department of Dermatology and the Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    Chin J Cancer 33:133-9. 2014
  5. ncbi request reprint Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion?
    John Pawelek
    Department of Dermatology, Yale University School of Medicine, New Haven, Conn 06520 8059, USA
    Contrib Microbiol 13:138-55. 2006
  6. pmc Viewing malignant melanoma cells as macrophage-tumor hybrids
    John M Pawelek
    Department of Dermatology and the Yale Cancer Center, Yale School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520 8059, USA
    Cell Adh Migr 1:2-6. 2007
  7. ncbi request reprint Approaches to increasing skin melanin with MSH analogs and synthetic melanins
    J M Pawelek
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    Pigment Cell Res 14:155-60. 2001
  8. ncbi request reprint Tumour cell hybridization and metastasis revisited
    J M Pawelek
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Melanoma Res 10:507-14. 2000
  9. ncbi request reprint Altered N-glycosylation in macrophage x melanoma fusion hybrids
    J M Pawelek
    Dept of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Mol Biol (Noisy-le-grand) 45:1011-27. 1999
  10. ncbi request reprint Tumour-cell fusion as a source of myeloid traits in cancer
    John M Pawelek
    Department of Dermatology and Yale Cancer Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8059, USA
    Lancet Oncol 6:988-93. 2005

Detail Information

Publications24

  1. ncbi request reprint Salmonella pathogenicity island-2 and anticancer activity in mice
    John M Pawelek
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    Cancer Gene Ther 9:813-8. 2002
    ..Thus, SPI-2 is essential for the Salmonella antitumor effects, perhaps by aiding bacterial amplification within tumors, and is the first identified genetic system for this Salmonella phenotype...
  2. ncbi request reprint Bacteria as tumour-targeting vectors
    John M Pawelek
    Department of Dermatology, Yale University School of Medicine, Yale, CT 06520 8059, USA
    Lancet Oncol 4:548-56. 2003
    ..In this review we provide a historical discussion of this area, and describe the development of the bacteria, which are currently being prepared for use in clinical trials in patients with cancer...
  3. doi request reprint Fusion of tumour cells with bone marrow-derived cells: a unifying explanation for metastasis
    John M Pawelek
    Department of Dermatology and the Yale Cancer Center, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520 08059, USA
    Nat Rev Cancer 8:377-86. 2008
    ..Molecular studies indicate that gene expression in such hybrids reflects a metastatic phenotype. Should BMDC-tumour fusion be found to underlie invasion and metastasis in human cancer, new approaches for therapy would surely follow...
  4. doi request reprint Fusion of bone marrow-derived cells with cancer cells: metastasis as a secondary disease in cancer
    John M Pawelek
    Department of Dermatology and the Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    Chin J Cancer 33:133-9. 2014
    ..In this scenario, leukocyte fusion with a cancer cell is a secondary disease superimposed upon the early tumor, giving birth to a new, malignant cell with a leukocyte-cancer cell hybrid epigenome. ..
  5. ncbi request reprint Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion?
    John Pawelek
    Department of Dermatology, Yale University School of Medicine, New Haven, Conn 06520 8059, USA
    Contrib Microbiol 13:138-55. 2006
    ..We suggest that Beta1,6-branched oligosaccharides in human cancer may reflect widespread tumor cell fusion. Viewing the cancer cell as a myeloid hybrid provides new approaches towards understanding and treating this complex disease...
  6. pmc Viewing malignant melanoma cells as macrophage-tumor hybrids
    John M Pawelek
    Department of Dermatology and the Yale Cancer Center, Yale School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520 8059, USA
    Cell Adh Migr 1:2-6. 2007
    ..The results suggest that invasive and metastatic CMM might well arise through fusion and genomic hybridization between melanoma cells and migratory bone marrow-derived cells...
  7. ncbi request reprint Approaches to increasing skin melanin with MSH analogs and synthetic melanins
    J M Pawelek
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    Pigment Cell Res 14:155-60. 2001
    ....
  8. ncbi request reprint Tumour cell hybridization and metastasis revisited
    J M Pawelek
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Melanoma Res 10:507-14. 2000
    ....
  9. ncbi request reprint Altered N-glycosylation in macrophage x melanoma fusion hybrids
    J M Pawelek
    Dept of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Mol Biol (Noisy-le-grand) 45:1011-27. 1999
    ....
  10. ncbi request reprint Tumour-cell fusion as a source of myeloid traits in cancer
    John M Pawelek
    Department of Dermatology and Yale Cancer Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8059, USA
    Lancet Oncol 6:988-93. 2005
    ..Understanding metastatic cells as myeloid-tumour hybrids suggests new strategies for diagnosis, treatment, and prevention of malignant disease...
  11. doi request reprint The cancer cell--leukocyte fusion theory of metastasis
    John M Pawelek
    Department of Dermatology and the Yale Cancer Center, Yale University School of Medicine, New Haven, Connecticut, USA
    Adv Cancer Res 101:397-444. 2008
    ..If BMDC-tumor cell fusion underlies invasion and metastasis in human cancer, new approaches for therapeutic intervention would be mandated...
  12. doi request reprint Leukocyte-cancer cell fusion: initiator of the warburg effect in malignancy?
    Rossitza Lazova
    Department of Dermatology, Yale Cancer Center, Yale University School of Medicine, New Haven, CT, 06520 8059, USA
    Adv Exp Med Biol 714:151-72. 2011
    ....
  13. doi request reprint Why do melanomas get so dark?
    Rossitza Lazova
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520 8059, USA
    Exp Dermatol 18:934-8. 2009
    ..In any event, pigmentation in melanoma, long considered as a secondary aspect of the malignancy, may be a visible warning that the cells have gained competence for invasion and metastasis...
  14. doi request reprint Upregulation of alpha and beta integrin subunits in metastatic macrophage-melanoma fusion hybrids
    Ashok K Chakraborty
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut, USA
    Melanoma Res 19:343-9. 2009
    ..This adds further support for the theory that generation of a metastatic phenotype may be initiated through a single event: fusion of migratory bone marrow-derived cells with cancer cells...
  15. ncbi request reprint Polymerization of 5,6-dihydroxyindole-2-carboxylic acid to melanin by the pmel 17/silver locus protein
    A K Chakraborty
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Eur J Biochem 236:180-8. 1996
    ....
  16. doi request reprint Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome
    Rossitza Lazova
    Departments of Dermatology and Pathology, Yale Cancer Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Clin Cancer Res 18:370-9. 2012
    ..Accordingly, we investigated LC3B as an autophagosome marker by analyzing nearly 1,400 tumors from 20 types of cancer, focusing on correlations with clinical outcomes in melanoma and breast cancer...
  17. ncbi request reprint Beta1,6-branched oligosaccharides and coarse vesicles: a common, pervasive phenotype in melanoma and other human cancers
    Tamara Handerson
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520 8059, USA
    Cancer Res 63:5363-9. 2003
    ..The origin of this phenotype and its biological significance are as yet unclear and will require considerable further study...
  18. ncbi request reprint Tumor-targeted Salmonella as a novel anticancer vector
    J M Pawelek
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 57:4537-44. 1997
    ..The results demonstrate that attenuated Salmonella would be useful both for inherent antitumor activity and delivery of therapeutic proteins to cancer cells in vivo...
  19. ncbi request reprint UV light and MSH receptors
    A K Chakraborty
    Department of Dermatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Ann N Y Acad Sci 885:100-16. 1999
    ..The results add support to the hypothesis that the effects of UVB on cutaneous melanogenesis are mediated through a series of coordinated events in which MSH receptors and POMC-derived peptides play a central role...
  20. ncbi request reprint Human monocyte x mouse melanoma fusion hybrids express human gene
    A K Chakraborty
    Department of Dermatology, Yale University School of Medicine, New Haven, CT 06520, USA
    Gene 275:103-6. 2001
    ..This observation may lead us to find contributory genes from monocyte and/or macrophage that are responsible for modulating the genotypes and hence the phenotypes in the hybrids...
  21. ncbi request reprint GnT-V, macrophage and cancer metastasis: a common link
    A K Chakraborty
    Yale University School of Medicine, Department of Dermatology, 333 Cedar Street, New Haven, Connecticut 06520, USA
    Clin Exp Metastasis 20:365-73. 2003
    ....
  22. ncbi request reprint Construction of VNP20009: a novel, genetically stable antibiotic-sensitive strain of tumor-targeting Salmonella for parenteral administration in humans
    Kenneth Brooks Low
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Med 90:47-60. 2004
  23. ncbi request reprint Lipid A mutant Salmonella with suppressed virulence and TNFalpha induction retain tumor-targeting in vivo
    K B Low
    Department of Therapeutic Radiology, Yale University, School of Medicine, New Haven, CT 05620, USA
    Nat Biotechnol 17:37-41. 1999
    ..Lipid modification of tumor-specific bacterial vectors provides a means for reducing septic shock and further suggests that the antitumor activity of these bacteria may be independent of TNFalpha...
  24. doi request reprint Cancer-cell fusion with migratory bone-marrow-derived cells as an explanation for metastasis: new therapeutic paradigms
    John M Pawelek
    Future Oncol 4:449-52. 2008