Chandrashekhar Pasare

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Toll-like receptors and acquired immunity
    Chandrashekhar Pasare
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, 300 Cedar Street, TAC S660, New Haven, CT 06510, USA
    Semin Immunol 16:23-6. 2004
  2. ncbi Toll-dependent control mechanisms of CD4 T cell activation
    Chandrashekhar Pasare
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Immunity 21:733-41. 2004
  3. ncbi Control of B-cell responses by Toll-like receptors
    Chandrashekhar Pasare
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, 300 Cedar Street New Haven, Connecticut 06510, USA
    Nature 438:364-8. 2005
  4. ncbi Toll-like receptors: linking innate and adaptive immunity
    Chandrashekhar Pasare
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar Street, TAC S660, New Haven, CT 06510, USA
    Microbes Infect 6:1382-7. 2004
  5. ncbi Toll-like receptors: linking innate and adaptive immunity
    Chandrashekhar Pasare
    Howard Hughes Medical Institute, Section of Immunobiology, 300 Cedar Street, TAC S660, Yale University School of Medicine, New Haven, CT 06510, USA
    Adv Exp Med Biol 560:11-8. 2005
  6. ncbi Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    Chandrashekhar Pasare
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 299:1033-6. 2003
  7. ncbi Toll-like receptors: balancing host resistance with immune tolerance
    Chandrashekhar Pasare
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Curr Opin Immunol 15:677-82. 2003

Collaborators

Detail Information

Publications7

  1. ncbi Toll-like receptors and acquired immunity
    Chandrashekhar Pasare
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, 300 Cedar Street, TAC S660, New Haven, CT 06510, USA
    Semin Immunol 16:23-6. 2004
    ..Although TLRs have evolved to induce protective immune responses, under some circumstances, activation of these receptors may lead to autoimmune diseases...
  2. ncbi Toll-dependent control mechanisms of CD4 T cell activation
    Chandrashekhar Pasare
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06510, USA
    Immunity 21:733-41. 2004
    ..In addition we show that a TLR-induced signal(s) is required for memory CD4 T cell differentiation, but not for activation of memory T cells...
  3. ncbi Control of B-cell responses by Toll-like receptors
    Chandrashekhar Pasare
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, 300 Cedar Street New Haven, Connecticut 06510, USA
    Nature 438:364-8. 2005
    ..We find that, in addition to CD4+ T-cell help, generation of T-dependent antigen-specific antibody responses requires activation of TLRs in B cells...
  4. ncbi Toll-like receptors: linking innate and adaptive immunity
    Chandrashekhar Pasare
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 300 Cedar Street, TAC S660, New Haven, CT 06510, USA
    Microbes Infect 6:1382-7. 2004
    ..Although TLRs control induction of adaptive immunity, it is not clear at this point how responses are appropriately tailored by individual TLRs to the advantage of the host...
  5. ncbi Toll-like receptors: linking innate and adaptive immunity
    Chandrashekhar Pasare
    Howard Hughes Medical Institute, Section of Immunobiology, 300 Cedar Street, TAC S660, Yale University School of Medicine, New Haven, CT 06510, USA
    Adv Exp Med Biol 560:11-8. 2005
    ..How responses are tailored by individual TLRs to contain specific classes of pathogens is not yet clear...
  6. ncbi Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    Chandrashekhar Pasare
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 299:1033-6. 2003
    ..This block of suppressor activity was dependent in part on interleukin-6, which was induced by TLRs upon recognition of microbial products...
  7. ncbi Toll-like receptors: balancing host resistance with immune tolerance
    Chandrashekhar Pasare
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Curr Opin Immunol 15:677-82. 2003
    ..Thus, it is becoming clear that TLRs are important for induction of adaptive immune responses, but misguided responses can lead to autoimmune pathology...