David A Paltiel

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Simulating school closure policies for cost effective pandemic decision making
    Ozgur M Araz
    College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA
    BMC Public Health 12:449. 2012
  2. pmc Price, performance, and the FDA approval process: the example of home HIV testing
    A David Paltiel
    School of Medicine School of Management, Yale University, New Haven, Connecticut, USA
    Med Decis Making 30:217-23. 2010
  3. pmc HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness
    A David Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut 06520 8034, USA
    Clin Infect Dis 48:806-15. 2009
  4. ncbi request reprint Expanded HIV screening in the United States: effect on clinical outcomes, HIV transmission, and costs
    A David Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut 06520 8034, USA
    Ann Intern Med 145:797-806. 2006
  5. ncbi request reprint Expanded screening for HIV in the United States--an analysis of cost-effectiveness
    A David Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Conn 06520 8034, USA
    N Engl J Med 352:586-95. 2005
  6. ncbi request reprint Preevaluation of clinical trial data: the case of preemptive cytomegalovirus therapy in patients with human immunodeficiency virus
    A D Paltiel
    Dept of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    Clin Infect Dis 32:783-93. 2001
  7. ncbi request reprint Remarks on the role of economic modeling
    A D Paltiel
    Department of Epidemiology and Public Health, School of Medicine, Yale University, New Haven, Connecticut 06520 8034, USA
    Sex Transm Dis 27:610-6. 2000
  8. ncbi request reprint The cost-effectiveness of HIV testing: accounting for differential participation rates
    A D Paltiel
    Yale School of Medicine, New Haven, Connecticut, USA
    Med Decis Making 17:490-5. 1997
  9. ncbi request reprint A Monte Carlo simulation of advanced HIV disease: application to prevention of CMV infection
    A D Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut 06520 8034, USA
    Med Decis Making 18:S93-105. 1998
  10. ncbi request reprint Why training is the key to successful guideline implementation
    A D Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut, USA
    Pharmacoeconomics 12:297-302. 1997

Detail Information

Publications46

  1. pmc Simulating school closure policies for cost effective pandemic decision making
    Ozgur M Araz
    College of Public Health, University of Nebraska Medical Center, Omaha, NE 68198, USA
    BMC Public Health 12:449. 2012
    ..Around the globe, school closures were used sporadically to mitigate the 2009 H1N1 influenza pandemic. However, such closures can detrimentally impact economic and social life...
  2. pmc Price, performance, and the FDA approval process: the example of home HIV testing
    A David Paltiel
    School of Medicine School of Management, Yale University, New Haven, Connecticut, USA
    Med Decis Making 30:217-23. 2010
    ..In this article, the authors argue that additional information should be sought to evaluate the prevalence of undetected HIV in the end-user..
  3. pmc HIV preexposure prophylaxis in the United States: impact on lifetime infection risk, clinical outcomes, and cost-effectiveness
    A David Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut 06520 8034, USA
    Clin Infect Dis 48:806-15. 2009
    ..We sought to forecast clinical, epidemiologic, and economic outcomes of PrEP, taking into account uncertainties regarding efficacy, the risks of developing drug resistance and toxicity, behavioral disinhibition, and drug costs...
  4. ncbi request reprint Expanded HIV screening in the United States: effect on clinical outcomes, HIV transmission, and costs
    A David Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut 06520 8034, USA
    Ann Intern Med 145:797-806. 2006
    ..An extensive literature supports expanded HIV screening in the United States. However, the question of whom to test and how frequently remains controversial...
  5. ncbi request reprint Expanded screening for HIV in the United States--an analysis of cost-effectiveness
    A David Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Conn 06520 8034, USA
    N Engl J Med 352:586-95. 2005
    ..The effect of expanded screening for HIV is unknown in the era of effective antiretroviral therapy...
  6. ncbi request reprint Preevaluation of clinical trial data: the case of preemptive cytomegalovirus therapy in patients with human immunodeficiency virus
    A D Paltiel
    Dept of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT 06520 8034, USA
    Clin Infect Dis 32:783-93. 2001
    ..The upcoming trial should resolve the clinical uncertainty surrounding some of these assumptions...
  7. ncbi request reprint Remarks on the role of economic modeling
    A D Paltiel
    Department of Epidemiology and Public Health, School of Medicine, Yale University, New Haven, Connecticut 06520 8034, USA
    Sex Transm Dis 27:610-6. 2000
    ..Despite the growing scholarly acceptance of quantitative evaluation methods, modelers still struggle to define an appropriate role for their work at the decision-making level...
  8. ncbi request reprint The cost-effectiveness of HIV testing: accounting for differential participation rates
    A D Paltiel
    Yale School of Medicine, New Haven, Connecticut, USA
    Med Decis Making 17:490-5. 1997
    ..To understand the impact of differences in participation rates between infected and uninfected individuals on estimates of the cost-effectiveness of HIV screening...
  9. ncbi request reprint A Monte Carlo simulation of advanced HIV disease: application to prevention of CMV infection
    A D Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut 06520 8034, USA
    Med Decis Making 18:S93-105. 1998
    ..Disagreement exists among decision makers regarding the allocation of limited HIV patient care resources and, specifically, the comparative value of preventing opportunistic infections in late-stage disease...
  10. ncbi request reprint Why training is the key to successful guideline implementation
    A D Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, Connecticut, USA
    Pharmacoeconomics 12:297-302. 1997
    ....
  11. ncbi request reprint Five minutes with the Governor
    A D Paltiel
    Department of Epidemiology and Public Health, Yale School of Medicine Yale School of Management, New Haven, Connecticut 06520 8034, USA
    Med Decis Making 20:239-42. 2000
    ..A personal view of some key themes to be stressed in defining a vision for the field is presented...
  12. ncbi request reprint Fact, fiction, and fairness: resource allocation under the Ryan White CARE Act
    Erika G Martin
    Yale University, New Haven, Connecticut, USA
    Health Aff (Millwood) 25:1103-12. 2006
    ..Other state characteristics, such as poverty rates or racial/ethnic diversity, play a much smaller role...
  13. pmc Predicting the impact of a partially effective HIV vaccine and subsequent risk behavior change on the heterosexual HIV epidemic in low- and middle-income countries: A South African example
    Kyeen M Andersson
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510, USA
    J Acquir Immune Defic Syndr 46:78-90. 2007
    ..Even modestly effective HIV vaccines can confer enormous benefits in terms of HIV infections averted and decreased HIV prevalence. However, programs to reduce risk behavior may be important components of successful vaccination campaigns...
  14. ncbi request reprint Impact of site of care, race, and Hispanic ethnicity on medication use for childhood asthma
    Alexander N Ortega
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    Pediatrics 109:E1. 2002
    ..To understand the importance of source of care and other factors that influence differences in asthma medication use by race and Hispanic ethnicity...
  15. pmc Medical decision making in patients with knee pain, meniscal tear, and osteoarthritis
    Lisa G Suter
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, Room TAC S541, PO Box 208031, New Haven, CT 06520 8031, USA
    Arthritis Rheum 61:1531-8. 2009
    ..Our objective was to evaluate the capability of preoperative information to predict APM outcomes in OA...
  16. ncbi request reprint The effect of age and chronic illness on life expectancy after a diagnosis of colorectal cancer: implications for screening
    Cary P Gross
    Robert Wood Johnson Clinical Scholars Program and Primary Care Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Ann Intern Med 145:646-53. 2006
    ..Older adults with shorter life expectancies may receive less benefit from colorectal cancer screening than younger, healthier patients...
  17. ncbi request reprint Cost-effectiveness of HIV screening for incarcerated pregnant women
    Stephen Resch
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06510 2283, USA
    J Acquir Immune Defic Syndr 38:163-73. 2005
    ..In settings where HIV screening policies are not in place, however, the implementation of RPS can be expected to significantly reduce pediatric HIV cases and net health care expenditures...
  18. ncbi request reprint Cost advantage of dual-chamber versus single-chamber cardioverter-defibrillator implantation
    Zachary Goldberger
    School of Medicine, Yale University, New Haven, Connecticut 06520, USA
    J Am Coll Cardiol 46:850-7. 2005
    ..The purpose of this study was to determine the least expensive strategy for device selection in patients receiving implantable cardioverter-defibrillators (ICDs)...
  19. ncbi request reprint Age does not limit quality of life improvement in cardiac valve surgery
    Artyom Sedrakyan
    Division of Health Policy and Administration, Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut, USA
    J Am Coll Cardiol 42:1208-14. 2003
    ..We sought to determine the association of age with the change in quality of life (QOL) after valve surgery...
  20. ncbi request reprint Task force #2--the cost of prevention: can we afford it? Can we afford not to do it? 33rd Bethesda Conference
    Harlan M Krumholz
    Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Coll Cardiol 40:603-15. 2002
  21. ncbi request reprint Economic costs of influenza-related work absenteeism
    Manabu Akazawa
    Yale School of Medicine, New Haven, CT 06520, USA
    Value Health 6:107-15. 2003
    ..Influenza vaccinations are currently advocated only for individuals over age 50. However, vaccination of all working-age people may be warranted based on reduced absenteeism from work...
  22. ncbi request reprint Cost-effectiveness of an intervention to improve adherence to antiretroviral therapy in HIV-infected patients
    Kenneth A Freedberg
    Divisions of General Medicine and Infectious Diseases and the Partners AIDS Research Center, Massachusetts General Hospital, Boston, MA 02114, USA
    J Acquir Immune Defic Syndr 43:S113-8. 2006
    ..Adherence interventions with modest effectiveness are likely to provide long-term survival benefit to patients and to be cost-effective compared with other uses of HIV care funds...
  23. ncbi request reprint Forced expiratory volume in 1 second percentage improves the classification of severity among children with asthma
    Anne L Fuhlbrigge
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatrics 118:e347-55. 2006
    ..The objective of this analysis was to examine the association between FEV1% and future risk of exacerbations among a well-characterized population of children with asthma...
  24. ncbi request reprint Routine human immunodeficiency virus testing: an economic evaluation of current guidelines
    Rochelle P Walensky
    Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, and the Partners AIDS Research Center, Harvard Medical School, Boston, Massachusetts 02114, USA
    Am J Med 118:292-300. 2005
    ..Our objective was to evaluate the clinical effect and cost-effectiveness of current guidelines and of alternate HIV prevalence thresholds...
  25. pmc Scaling up antiretroviral therapy in South Africa: the impact of speed on survival
    Rochelle P Walensky
    The Divisions of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Boston, MA 02114, USA
    J Infect Dis 197:1324-32. 2008
    ..Only 33% of eligible human immunodeficiency virus (HIV)-infected patients in South Africa receive antiretroviral therapy (ART). We sought to estimate the impact of alternative ART scale-up scenarios on patient outcomes from 2007-2012...
  26. ncbi request reprint Optimal allocation of testing dollars: the example of HIV counseling, testing, and referral
    Rochelle P Walensky
    Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Med Decis Making 25:321-9. 2005
    ..Using the example of HIV testing, the authors explore the optimal targeting of funds within this pathway...
  27. pmc Modeling the potential impact of a prescription drug copayment increase on the adult asthmatic medicaid population
    Seung Jin Bae
    Department of Health Policy and Management, Harvard School of Public Health, Boston, MA, USA
    Value Health 11:110-8. 2008
    ..We sought to determine the likely health outcomes and cost shifts attributable to this copayment increase using the example of inhaled corticosteroids (ICS) use among adult asthmatic Medicaid beneficiaries...
  28. ncbi request reprint Lifetime cost of HIV care in France during the era of highly active antiretroviral therapy
    Yazdan Yazdanpanah
    Service Universitaire des Maladies Infectieuses et du Voyageur, Centre Hospitalier de Tourcoing, Faculte de Medecine de Lille, France
    Antivir Ther 7:257-66. 2002
    ..To estimate the treatment and health care costs of HIV infection or AIDS in France during the era of highly active antiretroviral therapy (HAART)...
  29. ncbi request reprint Projecting the cost-effectiveness of adherence interventions in persons with human immunodeficiency virus infection
    Sue J Goldie
    Center for Risk Analysis, Harvard School of Public Health, Boston, Massachusetts 02115 5924, USA
    Am J Med 115:632-41. 2003
    ..To explore the cost-effectiveness of interventions to improve adherence to combination antiretroviral therapy in patients with human immunodeficiency virus (HIV) infection...
  30. ncbi request reprint Cost-effectiveness of inhaled steroids in asthma: impact of effect on bone mineral density
    Anne L Fuhlbrigge
    Channing Laboratory, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Allergy Clin Immunol 117:359-66. 2006
    ..The effects of inhaled corticosteroid (ICS) preparations on bone health have been debated. Multiple analyses have been published examining the question, with mixed results...
  31. ncbi request reprint AIDS Drug Assistance Programs: highlighting inequities in human immunodeficiency virus-infection health care in the United States
    Rochelle P Walensky
    Division of Infectious Disease and the Partners AIDS Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Clin Infect Dis 35:606-10. 2002
    ..Cost-effectiveness analysis would offer a more informed basis for distribution of ADAP resources in an efficient and equitable manner, leading to a standardized national structure...
  32. ncbi request reprint A therapeutic HIV vaccine: how good is good enough?
    Rochelle P Walensky
    Department of Medicine, Massachusetts General Hospital, and the Partners AIDS Research Center, Harvard Medical School, Boston, MA 02114, USA
    Vaccine 22:4044-53. 2004
    ..91 months (cost-effectiveness ratio US$ 45,500/QALY). Even modestly effective therapeutic HIV vaccines may produce small but meaningful increases in life expectancy and compare favorably to alternative uses of scarce HIV care resources...
  33. ncbi request reprint Prophylaxis for human immunodeficiency virus-related Pneumocystis carinii pneumonia: using simulation modeling to inform clinical guidelines
    Sue J Goldie
    Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, 718 Huntington Ave, Second Floor, Boston, MA 02115 5924, USA
    Arch Intern Med 162:921-8. 2002
    ....
  34. ncbi request reprint Optimal frequency of CD4 cell count and HIV RNA monitoring prior to initiation of antiretroviral therapy in HIV-infected patients
    April D Kimmel
    Division of General Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Antivir Ther 10:41-52. 2005
    ..Guidelines regarding the frequency of CD4 cell count and HIV RNA monitoring in HIV-infected patients vary, with recommended strategies ranging from every 2 to every 6 months...
  35. ncbi request reprint The relationship of preventable opportunistic infections, HIV-1 RNA, and CD4 Cell counts to chronic mortality
    George R Seage
    Department of Epidemiology and Center for Risk Analysis, Department of Health Policy and Management, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    J Acquir Immune Defic Syndr 30:421-8. 2002
    ....
  36. ncbi request reprint A novel approach to defining the relationship between lung function and symptom status in asthma
    Karen M Kuntz
    Department of Health Policy and Management, Harvard School of Public Health, 718 Huntington Ave, Boston, MA, USA
    J Clin Epidemiol 55:11-8. 2002
    ..Functional relationships between FEV(1) percent predicted and asthma-related symptoms can be useful for inferring the effect on the symptoms of a population associated with overall improvements in lung function...
  37. ncbi request reprint Treatment for primary HIV infection: projecting outcomes of immediate, interrupted, or delayed therapy
    Rochelle P Walensky
    Division of Infectious Disease and the Partners AIDS Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, USA
    J Acquir Immune Defic Syndr 31:27-37. 2002
    ..These results can assist decision makers and those planning clinical trials in defining evidence-based performance measures for primary HIV infection treatment and future trials...
  38. pmc Cost-effectiveness of HIV testing and treatment in the United States
    Rochelle P Walensky
    Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
    Clin Infect Dis 45:S248-54. 2007
    ..This article reviews the methods and results of cost-effectiveness studies in the United States and articulates why routine, voluntary HIV testing is not only of crucial public health importance but also economically justified...
  39. pmc Cost-effectiveness of omalizumab in adults with severe asthma: results from the Asthma Policy Model
    Ann C Wu
    Department of Ambulatory Care and Prevention, Harvard Medical School and Children s Hospital, Boston, MA 02215 5301, USA
    J Allergy Clin Immunol 120:1146-52. 2007
    ..Given the high acquisition cost of omalizumab, its role and cost-effectiveness in disease management require definition...
  40. ncbi request reprint The cost-effectiveness of treatment for varicocele related infertility
    David F Penson
    Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA
    J Urol 168:2490-4. 2002
    ..We compared the cost-effectiveness of 4 treatment strategies for varicocele related infertility from the perspective of the health care payor and patient...
  41. pmc The effect of antiretroviral therapy on secondary transmission of HIV among men who have sex with men
    Alethea W McCormick
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Clin Infect Dis 44:1115-22. 2007
    ..However, the potential reduction in secondary transmission associated with ART may be offset by the longer duration of infectiousness...
  42. ncbi request reprint Rapid HIV testing at home: does it solve a problem or create one?
    Rochelle P Walensky
    Massachusetts General Hospital, Brigham and Women s Hospital, and the Center for AIDS Research, Harvard Medical School, Boston, Massachusetts 02114, USA
    Ann Intern Med 145:459-62. 2006
    ..S. citizens with unidentified HIV infection...
  43. ncbi request reprint A single measure of FEV1 is associated with risk of asthma attacks in long-term follow-up
    Barrett T Kitch
    Division of Pulmonary and Critical Care Medicine, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Chest 126:1875-82. 2004
    ..Clinical practice guidelines for asthma care emphasize the use of objective measures of asthma severity, and yet little data exist on the relationship between FEV(1) and asthma outcomes over long-term follow-up...
  44. ncbi request reprint The survival benefits of AIDS treatment in the United States
    Rochelle P Walensky
    Division of Infectious Disease and General Medicine, Massachusetts General Hospital, Boston 02114, USA
    J Infect Dis 194:11-9. 2006
    ..As widespread adoption of potent combination antiretroviral therapy (ART) reaches its tenth year, our objective was to quantify the cumulative survival benefits of acquired immunodeficiency syndrome (AIDS) care in the United States...
  45. ncbi request reprint Association between preference-based health-related quality of life and asthma severity
    Marilyn L Moy
    Division of Pulmonary and Critical Care Medicine and Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann Allergy Asthma Immunol 92:329-34. 2004
    ..International guidelines have been developed to guide medical management according to asthma severity defined by lung function and symptom frequency...
  46. ncbi request reprint Cost-effectiveness of enfuvirtide in treatment-experienced patients with advanced HIV disease
    Paul E Sax
    Division of Infectious Disease and the Partners AIDS Research Center, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Acquir Immune Defic Syndr 39:69-77. 2005
    ..Because of the high cost of ENF compared with other antiretroviral agents, our objectives were to determine the potential long-term clinical impact and cost-effectiveness of ENF in these patients...

Research Grants13

  1. Evaluating the Link between HIV Prevention and Treatment
    A Paltiel; Fiscal Year: 2009
    ....
  2. Evaluating the Link between HIV Prevention and Treatment
    A Paltiel; Fiscal Year: 2007
    ..During the initial funding cycle of this project, we have demonstrated our potential to exert an equally profound impact in the area of HIV testing and prevention policy. ..
  3. Evaluating the Link between HIV Prevention and Treatment
    A Paltiel; Fiscal Year: 2004
    ..Our aim, in the present proposal, is to exert an equally profound impact on priority setting in HIV testing and prevention. ..
  4. Effectiveness of Asthma Care: The Asthma Policy Model
    A Paltiel; Fiscal Year: 2004
    ..Cloutier), biostatistical analysis (Dr. Kuntz), and simulation modeling and economic evaluation (Dr. Paltiel) to explore cost-effective solutions to the asthma epidemic. ..
  5. Evaluating the Link between HIV Prevention and Treatment
    A David Paltiel; Fiscal Year: 2010
    ....