Elijah Paintsil

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV-Infected Children in Accra
    Allison Langs-Barlow
    Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520, USA
    AIDS Res Treat 2013:249171. 2013
  2. pmc Time to and Predictors of CD4+ T-Lymphocytes Recovery in HIV-Infected Children Initiating Highly Active Antiretroviral Therapy in Ghana
    Lorna Renner
    Department of Child Health, University of Ghana Medical School, Accra, Ghana
    AIDS Res Treat 2011:896040. 2011
  3. pmc Monitoring Antiretroviral Therapy in HIV-Infected Children in Resource-Limited Countries: A Tale of Two Epidemics
    Elijah Paintsil
    Departments of Pediatrics and Pharmacology, Yale School of Medicine, 333 Cedar Street, New Haven, T 06520, USA
    AIDS Res Treat 2011:280901. 2011
  4. pmc Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana
    Oliver Barry
    Departments of Pediatrics and Pharmacology, Yale School of Medicine, New Haven, CT, USA
    BMC Infect Dis 13:476. 2013
  5. pmc Deciphering the epidemic synergy of herpes simplex virus type 2 (HSV-2) on human immunodeficiency virus type 1 (HIV-1) infection among women in sub-Saharan Africa
    Musie Ghebremichael
    Harvard Medical School and Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA
    BMC Res Notes 5:451. 2012
  6. doi request reprint Update on recent guidelines for the management of urinary tract infections in children: the shifting paradigm
    Elijah Paintsil
    Departments of Pediatrics and Pharmacology, Yale School of Medicine, New Haven, Connecticut 06520 8064, USA
    Curr Opin Pediatr 25:88-94. 2013
  7. pmc Determinants of individual variation in intracellular accumulation of anti-HIV nucleoside analog metabolites
    Elijah Paintsil
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 55:895-903. 2011
  8. pmc Hepatitis C virus infection among drug injectors in St Petersburg, Russia: social and molecular epidemiology of an endemic infection
    Elijah Paintsil
    Yale University School of Medicine, New Haven, CT 06520, USA
    Addiction 104:1881-90. 2009
  9. pmc Survival of hepatitis C virus in syringes: implication for transmission among injection drug users
    Elijah Paintsil
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Infect Dis 202:984-90. 2010
  10. pmc Update on successes and challenges regarding mother-to-child transmission of HIV
    Elijah Paintsil
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Curr Opin Pediatr 21:94-101. 2009

Collaborators

Detail Information

Publications22

  1. pmc Performance of Clinical Criteria for Screening of Possible Antiretroviral Related Mitochondrial Toxicity in HIV-Infected Children in Accra
    Allison Langs-Barlow
    Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520, USA
    AIDS Res Treat 2013:249171. 2013
    ..However, as indicators of HAART exposure are associated with (+) EPF, it may be a candidate for prospective study of possible HAART related MT in resource-poor settings...
  2. pmc Time to and Predictors of CD4+ T-Lymphocytes Recovery in HIV-Infected Children Initiating Highly Active Antiretroviral Therapy in Ghana
    Lorna Renner
    Department of Child Health, University of Ghana Medical School, Accra, Ghana
    AIDS Res Treat 2011:896040. 2011
    ..Conclusions. A targeted approach based on predictors of CD4+ T-lymphocyte recovery can be a viable and cost-effective way of monitoring HAART in HIV-infected children in resource-limited settings...
  3. pmc Monitoring Antiretroviral Therapy in HIV-Infected Children in Resource-Limited Countries: A Tale of Two Epidemics
    Elijah Paintsil
    Departments of Pediatrics and Pharmacology, Yale School of Medicine, 333 Cedar Street, New Haven, T 06520, USA
    AIDS Res Treat 2011:280901. 2011
    ..Funding agencies and country programs should invest in validating the use of current technologies to optimize pediatric HIV care in resource-limited countries...
  4. pmc Effectiveness of first-line antiretroviral therapy and correlates of longitudinal changes in CD4 and viral load among HIV-infected children in Ghana
    Oliver Barry
    Departments of Pediatrics and Pharmacology, Yale School of Medicine, New Haven, CT, USA
    BMC Infect Dis 13:476. 2013
    ..We determined the effectiveness of first-line ART in a real world pediatric HIV clinic and explored associations between readily obtainable patient data and the trajectories of change in CD4 count and HIV viral load...
  5. pmc Deciphering the epidemic synergy of herpes simplex virus type 2 (HSV-2) on human immunodeficiency virus type 1 (HIV-1) infection among women in sub-Saharan Africa
    Musie Ghebremichael
    Harvard Medical School and Ragon Institute of MGH, MIT and Harvard, Boston, Massachusetts, USA
    BMC Res Notes 5:451. 2012
    ..The objective of our study was to identify the risk factors of HSV-2 and HIV-1 infections and to examine the association between the two infections...
  6. doi request reprint Update on recent guidelines for the management of urinary tract infections in children: the shifting paradigm
    Elijah Paintsil
    Departments of Pediatrics and Pharmacology, Yale School of Medicine, New Haven, Connecticut 06520 8064, USA
    Curr Opin Pediatr 25:88-94. 2013
    ..This review focuses on new additions to the literature on management of UTI from January 2011 to September 2012...
  7. pmc Determinants of individual variation in intracellular accumulation of anti-HIV nucleoside analog metabolites
    Elijah Paintsil
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 55:895-903. 2011
    ....
  8. pmc Hepatitis C virus infection among drug injectors in St Petersburg, Russia: social and molecular epidemiology of an endemic infection
    Elijah Paintsil
    Yale University School of Medicine, New Haven, CT 06520, USA
    Addiction 104:1881-90. 2009
    ..To understand the epidemiology and transmission patterns of hepatitis C virus (HCV), the predominant blood borne-pathogen infecting injection drug users (IDUs), in a part of the former Soviet Union...
  9. pmc Survival of hepatitis C virus in syringes: implication for transmission among injection drug users
    Elijah Paintsil
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Infect Dis 202:984-90. 2010
    ..We hypothesized that the high prevalence of hepatitis C virus (HCV) among injection drug users might be due to prolonged virus survival in contaminated syringes...
  10. pmc Update on successes and challenges regarding mother-to-child transmission of HIV
    Elijah Paintsil
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Curr Opin Pediatr 21:94-101. 2009
    ..This review outlines the successes made and the challenges that remain...
  11. pmc Absolute CD4+ T-lymphocyte count as a surrogate marker of pediatric human immunodeficiency virus disease progression
    Elijah Paintsil
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatr Infect Dis J 27:629-35. 2008
    ..We assessed the use of absolute CD4+ T-lymphocyte count as a surrogate marker of pediatric HIV disease progression...
  12. ncbi request reprint Pediatric community-acquired methicillin-resistant Staphylococcus aureus infection and colonization: trends and management
    Elijah Paintsil
    Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520 8064, USA
    Curr Opin Pediatr 19:75-82. 2007
    ..The scourge of community-acquired methicillin-resistant Staphylococcus aureus in pediatrics continues unabated. This review provides information on changes in epidemiology, therapeutic considerations, and measures to control the epidemic...
  13. pmc Intracellular metabolism and persistence of the anti-human immunodeficiency virus activity of 2',3'-didehydro-3'-deoxy-4'-ethynylthymidine, a novel thymidine analog
    Elijah Paintsil
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, SHM B226, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 51:3870-9. 2007
    ..4'-Ed4T is a promising antiviral candidate for HIV type 1 chemotherapy...
  14. pmc Impact of novel human immunodeficiency virus type 1 reverse transcriptase mutations P119S and T165A on 4'-ethynylthymidine analog resistance profile
    Guangwei Yang
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 53:4640-6. 2009
    ..g., more than 50-fold resistance) will be difficult to develop. The previously observed 130-fold resistance of the virus with P119S/T165A/M184V to 4'-Ed4T may be partly due to mutations both in the RT sequence and outside the RT sequence...
  15. ncbi request reprint The contribution of HIV fitness to the evolution pattern of reverse transcriptase inhibitor resistance
    Elijah Paintsil
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Med Virol 78:425-30. 2006
    ..We also surmise that drug resistance and fitness are competing forces underlying the emergence of nevirapine resistant mutants 103N and 181C...
  16. ncbi request reprint Care and management of the infant of the HIV-1-infected mother
    Elijah Paintsil
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Semin Perinatol 31:112-23. 2007
    ..These are discussed under four case scenarios that obstetric and pediatric providers frequently encounter in their practices...
  17. pmc Hepatitis C virus maintains infectivity for weeks after drying on inanimate surfaces at room temperature: implications for risks of transmission
    Elijah Paintsil
    Departments of Pediatrics and Pharmacology, Yale School of Medicine
    J Infect Dis 209:1205-11. 2014
    ..Hypothesizing that prolonged viability of HCV in fomites may contribute significantly to incidence, we determined the longevity of virus infectivity and the effectiveness of antiseptics...
  18. ncbi request reprint Virologic and host risk factors for mother-to-child transmission of HIV
    Shanmugapriya Selvaraj
    Department of Pediatrics, Yale School of Medicine, New Haven, CT 06520, USA
    Curr HIV Res 11:93-101. 2013
    ..Understanding the mechanisms, timing, and viral and host factors associated with MTCT of HIV will help to identify appropriate interventions and suitable antiretroviral chemoprophylaxis regimens to reduce or eliminate MTCT...
  19. pmc Prevalence and pattern of disclosure of HIV status in HIV-infected children in Ghana
    Stacey Kallem
    Department of Pediatrics and Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    AIDS Behav 15:1121-7. 2011
    ..The low prevalence of disclosure underscores the need for a systematic and a staged approach in disclosing HIV status to infected children in resource limited countries...
  20. pmc Comparative study of the persistence of anti-HIV activity of deoxynucleoside HIV reverse transcriptase inhibitors after removal from culture
    Elijah Paintsil
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520, USA
    AIDS Res Ther 6:5. 2009
    ..Therefore, a better indicator of the pharmacodynamic property of an inhibitor. The persistence of anti-HIV activity assay may complement in vitro potency assays to better predict in vivo performance of nucleoside analogs...
  21. pmc Analysis of deoxyribonucleotide pools in human cancer cell lines using a liquid chromatography coupled with tandem mass spectrometry technique
    Wei Zhang
    Department of Pharmacology, Section of Medical Oncology, Yale School of Medicine, New Haven, CT 06520, USA
    Biochem Pharmacol 82:411-7. 2011
    ..This LC/MS/MS assay is simple, fast, and sensitive, and it represents a significant advance over previously published methodologies...
  22. pmc Competitive fitness of nevirapine-resistant human immunodeficiency virus type 1 mutants
    Jennifer A Collins
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Virol 78:603-11. 2004
    ....