Peter Olausson

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents
    Peter Olausson
    Department of Psychiatry, Division of Molecular Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, 34 Park St, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 225:569-77. 2013
  2. pmc The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity
    P Olausson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuroscience 225:1-8. 2012
  3. ncbi request reprint Orbitofrontal cortex and cognitive-motivational impairments in psychostimulant addiction: evidence from experiments in the non-human primate
    Peter Olausson
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT 06508, USA
    Ann N Y Acad Sci 1121:610-38. 2007
  4. ncbi request reprint Nicotine-induced behavioral disinhibition and ethanol preference correlate after repeated nicotine treatment
    P Olausson
    Department of Pharmacology, Goteborg University, Box 431, SE 405 30, Goteborg, Sweden
    Eur J Pharmacol 417:117-23. 2001
  5. ncbi request reprint Effects of 5-HT1A and 5-HT2 receptor agonists on the behavioral and neurochemical consequences of repeated nicotine treatment
    P Olausson
    Department of Pharmacology, Goteborg University, Box 431, SE 405 30, Goteborg, Sweden
    Eur J Pharmacol 420:45-54. 2001
  6. ncbi request reprint Behavioral and neurochemical consequences of repeated nicotine treatment in the serotonin-depleted rat
    P Olausson
    Department of Pharmacology, Goteborg University, Box 431, 405 30 Goteborg, Sweden
    Psychopharmacology (Berl) 155:348-61. 2001
  7. ncbi request reprint Involvement of serotonin in nicotine dependence: processes relevant to positive and negative regulation of drug intake
    Peter Olausson
    Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, 34 Park Street, New Haven, CT 06508, USA
    Pharmacol Biochem Behav 71:757-71. 2002
  8. pmc Prior chronic cocaine exposure in mice induces persistent alterations in cognitive function
    Dilja D Krueger
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Ribicoff Research Facilities, New Haven, Connecticut, USA
    Behav Pharmacol 20:695-704. 2009
  9. pmc Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06508, USA
    Biol Psychiatry 64:884-90. 2008
  10. pmc Assessment of cognitive function in the heterozygous reeler mouse
    Dilja D Krueger
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Ribicoff Research Facilities, CMHC, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 189:95-104. 2006

Detail Information

Publications31

  1. pmc Persistent effects of prior chronic exposure to corticosterone on reward-related learning and motivation in rodents
    Peter Olausson
    Department of Psychiatry, Division of Molecular Psychiatry, Ribicoff Research Facilities, Yale University School of Medicine, 34 Park St, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 225:569-77. 2013
    ..We have previously reported that prior chronic corticosterone exposure to mice produces a lasting depressive-like state that can be reversed by chronic antidepressant treatment...
  2. pmc The tyrosine phosphatase STEP constrains amygdala-dependent memory formation and neuroplasticity
    P Olausson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuroscience 225:1-8. 2012
    ....
  3. ncbi request reprint Orbitofrontal cortex and cognitive-motivational impairments in psychostimulant addiction: evidence from experiments in the non-human primate
    Peter Olausson
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University, New Haven, CT 06508, USA
    Ann N Y Acad Sci 1121:610-38. 2007
    ....
  4. ncbi request reprint Nicotine-induced behavioral disinhibition and ethanol preference correlate after repeated nicotine treatment
    P Olausson
    Department of Pharmacology, Goteborg University, Box 431, SE 405 30, Goteborg, Sweden
    Eur J Pharmacol 417:117-23. 2001
    ....
  5. ncbi request reprint Effects of 5-HT1A and 5-HT2 receptor agonists on the behavioral and neurochemical consequences of repeated nicotine treatment
    P Olausson
    Department of Pharmacology, Goteborg University, Box 431, SE 405 30, Goteborg, Sweden
    Eur J Pharmacol 420:45-54. 2001
    ....
  6. ncbi request reprint Behavioral and neurochemical consequences of repeated nicotine treatment in the serotonin-depleted rat
    P Olausson
    Department of Pharmacology, Goteborg University, Box 431, 405 30 Goteborg, Sweden
    Psychopharmacology (Berl) 155:348-61. 2001
    ..Together, these behavioral consequences of drug intake may underlie the compulsive drug-seeking and -taking behaviors observed in drug abuse...
  7. ncbi request reprint Involvement of serotonin in nicotine dependence: processes relevant to positive and negative regulation of drug intake
    Peter Olausson
    Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, 34 Park Street, New Haven, CT 06508, USA
    Pharmacol Biochem Behav 71:757-71. 2002
    ..In particular, the evidence for a role of 5-HT neurotransmission in brain processes thought to be involved in positive and negative control of nicotine use will be examined, and potential clinical implications discussed...
  8. pmc Prior chronic cocaine exposure in mice induces persistent alterations in cognitive function
    Dilja D Krueger
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Ribicoff Research Facilities, New Haven, Connecticut, USA
    Behav Pharmacol 20:695-704. 2009
    ..These results indicate that prior chronic cocaine exposure in mice induces long-lasting alterations in cognitive functions associated with the prefrontal cortex...
  9. pmc Acute hippocampal brain-derived neurotrophic factor restores motivational and forced swim performance after corticosterone
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, Connecticut 06508, USA
    Biol Psychiatry 64:884-90. 2008
    ....
  10. pmc Assessment of cognitive function in the heterozygous reeler mouse
    Dilja D Krueger
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, Ribicoff Research Facilities, CMHC, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 189:95-104. 2006
    ..However, the effect of reelin haploinsufficiency on one of the cardinal symptoms of schizophrenia, the impairment of prefrontal-cortex-dependent cognitive function, has yet to be determined...
  11. ncbi request reprint Repeated nicotine exposure enhances reward-related learning in the rat
    Peter Olausson
    Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, New Haven, CT, USA
    Neuropsychopharmacology 28:1264-71. 2003
    ..In this study, all nicotine treatment schedules increased Pavlovian discriminative approach behavior and, thus, prior repeated exposure to nicotine, repeated postsession nicotine injections, or both, facilitated reward-related learning...
  12. pmc The striatal-enriched protein tyrosine phosphatase gates long-term potentiation and fear memory in the lateral amygdala
    Surojit Paul
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Psychiatry 61:1049-61. 2007
    ..Activation of the ERK pathway by the sequential recruitment of mitogen-activated protein kinases is well understood. In contrast, the proteins that inactivate this pathway are not as well characterized...
  13. ncbi request reprint Cdk5 modulates cocaine reward, motivation, and striatal neuron excitability
    David R Benavides
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    J Neurosci 27:12967-76. 2007
    ..These results suggest that Cdk5 acts as a negative regulator of neuronal excitability in the NAc and that Cdk5 may govern the behavioral effects of cocaine and motivation for reinforcement...
  14. pmc A history of corticosterone exposure regulates fear extinction and cortical NR2B, GluR2/3, and BDNF
    Shannon L Gourley
    Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA
    Neuropsychopharmacology 34:707-16. 2009
    ....
  15. ncbi request reprint Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A
    Natalie C Tronson
    Department of Psychiatry, Division of Molecular Psychiatry, Center for Genes and Behavior, Yale University School of Medicine, Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, 34 Park Street, New Haven, Connecticut 06508, USA
    Nat Neurosci 9:167-9. 2006
    ..This study demonstrates both a selective enhancement and an impairment of memory reconsolidation dependent on amygdalar PKA...
  16. ncbi request reprint Repeated nicotine exposure enhances responding with conditioned reinforcement
    Peter Olausson
    Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 173:98-104. 2004
    ..Clinical observations indicate that smoking depends strongly upon conditioned reinforcement (i.e., cues support smoking behavior); however, little is known about the effects of repeated nicotine exposure on these processes...
  17. pmc Inhibition of Cdk5 in the nucleus accumbens enhances the locomotor-activating and incentive-motivational effects of cocaine
    Jane R Taylor
    Department of Psychiatry, Division of Molecular Psychiatry and Center for Genes and Behavior, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 104:4147-52. 2007
    ....
  18. ncbi request reprint beta2-Subunit-containing nicotinic acetylcholine receptors are involved in nicotine-induced increases in conditioned reinforcement but not progressive ratio responding for food in C57BL/6 mice
    Darlene H Brunzell
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 184:328-38. 2006
    ..Nicotine administration potentiates conditioned reinforcement in rats, an effect that persists for weeks after chronic exposure. Little is known regarding the nicotinic receptor subtypes that may mediate this effect...
  19. ncbi request reprint DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation
    Peter Olausson
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 26:9196-204. 2006
    ....
  20. pmc The behavioral and biochemical effects of BDNF containing polymers implanted in the hippocampus of rats
    Rachael W Sirianni
    Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA
    Brain Res 1321:40-50. 2010
    ..It is evident from this work that both duration and magnitude of BDNF dosing are of critical importance in achieving functional outcome...
  21. pmc Regulator of calmodulin signaling knockout mice display anxiety-like behavior and motivational deficits
    Maya M Davis
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06508, USA
    Eur J Neurosci 35:300-8. 2012
    ..Together these results implicate a novel PKA-regulated phosphoprotein, RCS, in the etiology of motivational deficits and anxiety...
  22. ncbi request reprint Nicotine enhances responding with conditioned reinforcement
    Peter Olausson
    Department of Psychiatry, Laboratory of Molecular Psychiatry, Yale University, 34 Park Street, New Haven, CT 06508, USA
    Psychopharmacology (Berl) 171:173-8. 2004
    ..e. smoking) depends strongly upon conditioned reinforcement (i.e. cues support smoking behavior), little is known about whether nicotine directly affects motivational processes...
  23. ncbi request reprint Stimulation of protein kinase a activity in the rat amygdala enhances reward-related learning
    J David Jentsch
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Biol Psychiatry 52:111-8. 2002
    ....
  24. ncbi request reprint Impairments of reversal learning and response perseveration after repeated, intermittent cocaine administrations to monkeys
    J David Jentsch
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06508, USA
    Neuropsychopharmacology 26:183-90. 2002
    ..These findings suggest that long-term cocaine administration may disrupt orbitofrontal efferents to the striatum, resulting in impaired inhibition of established conditioned responses...
  25. ncbi request reprint Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat
    Evelyn K Lambe
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 25:5225-9. 2005
    ..We show for the first time that hypocretin can improve attentional processes relevant to executive functions of the prefrontal cortex...
  26. ncbi request reprint Nicotine induces disinhibitory behavior in the rat after subchronic peripheral nicotinic acetylcholine receptor blockade
    M Ericson
    Institute of Physiology and Pharmacology, Department of Pharmacology, PO Box 431, SE 405 30, Goteborg, Sweden
    Eur J Pharmacol 397:103-11. 2000
    ....
  27. pmc Targeting extinction and reconsolidation mechanisms to combat the impact of drug cues on addiction
    Jane R Taylor
    Department of Psychiatry, Division of Molecular Psychiatry, Yale University School of Medicine, S307 Connecticut Mental Health Center, Ribicoff Research Laboratories, 34 Park Street, New Haven, CT 06508, USA
    Neuropharmacology 56:186-95. 2009
    ....
  28. ncbi request reprint Effects of serotonergic manipulations on the behavioral sensitization and disinhibition associated with repeated amphetamine treatment
    P Olausson
    Department of Pharmacology, Institute of Physiology and Pharmacology, Goteborg University, Box 431, SE 405 30, Goteborg, Sweden
    Pharmacol Biochem Behav 66:211-20. 2000
    ..It appears likely that the antagonistic effects of 5-HTP and citalopram on behavioral disinhibition derive from a drug-induced facilitation of brain 5-HT neurotransmission...
  29. ncbi request reprint Behavioral sensitization to nicotine is associated with behavioral disinhibition; counteraction by citalopram
    P Olausson
    Department of Pharmacology, Institute of Physiology and Pharmacology, Goteborg University, Sweden
    Psychopharmacology (Berl) 142:111-9. 1999
    ..Since citalopram is a highly selective serotonin reuptake inhibitor, the effects of citalopram may be due to a facilitation of serotonin neurotransmission caused by the chronic citalopram treatment...
  30. ncbi request reprint Nicotinic mechanisms involved in the dopamine activating and reinforcing properties of ethanol
    B Söderpalm
    Department of Pharmacology, Institute of Physiology and Pharmacology, Goteborg University, Sweden
    Behav Brain Res 113:85-96. 2000
    ....
  31. ncbi request reprint Nicotinic acetylcholine receptors in the ventral tegmental area mediate the dopamine activating and reinforcing properties of ethanol cues
    Elin Löf
    Inst Neuroscience and Physiology, Sect Psychiatry and Neurochemistry, Sahlgrenska Academy, Göteborg University and Beroendekliniken, Sahlgrenska University Hospital, Gothenburg, Sweden
    Psychopharmacology (Berl) 195:333-43. 2007
    ..Cues associated with alcohol can elicit craving, support drug-seeking and precipitate relapse...