James P Noonan

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint Regulatory DNAs and the evolution of human development
    James P Noonan
    Department of Genetics and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Curr Opin Genet Dev 19:557-64. 2009
  2. doi request reprint Genomics of long-range regulatory elements
    James P Noonan
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
    Annu Rev Genomics Hum Genet 11:1-23. 2010
  3. pmc Neanderthal genomics and the evolution of modern humans
    James P Noonan
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genome Res 20:547-53. 2010
  4. ncbi request reprint The DNA sequence and comparative analysis of human chromosome 5
    Jeremy Schmutz
    Stanford Human Genome Center, Department of Genetics, Stanford University School of Medicine, 975 California Ave, Palo Alto, California 94304, USA
    Nature 431:268-74. 2004
  5. pmc Coelacanth genome sequence reveals the evolutionary history of vertebrate genes
    James P Noonan
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Genome Res 14:2397-405. 2004
  6. doi request reprint Gene regulation and the origins of human biological uniqueness
    Samuel J Sholtis
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Genet 26:110-8. 2010
  7. pmc The genomic landscape of cohesin-associated chromatin interactions
    Laura E Demare
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Genome Res 23:1224-34. 2013
  8. pmc Gene conversion and the evolution of protocadherin gene cluster diversity
    James P Noonan
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Genome Res 14:354-66. 2004

Research Grants

Detail Information

Publications8

  1. doi request reprint Regulatory DNAs and the evolution of human development
    James P Noonan
    Department of Genetics and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA
    Curr Opin Genet Dev 19:557-64. 2009
    ....
  2. doi request reprint Genomics of long-range regulatory elements
    James P Noonan
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06510, USA
    Annu Rev Genomics Hum Genet 11:1-23. 2010
    ..We discuss the advantages and limitations of sequence conservation as a predictor of regulatory function and present complementary emerging technologies now being applied to annotate regulatory elements in vertebrate genomes...
  3. pmc Neanderthal genomics and the evolution of modern humans
    James P Noonan
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Genome Res 20:547-53. 2010
    ..A reconstructed Neanderthal genome sequence could be integrated into human-primate genome comparisons to help reveal the evolutionary genetic events that produced modern humans...
  4. ncbi request reprint The DNA sequence and comparative analysis of human chromosome 5
    Jeremy Schmutz
    Stanford Human Genome Center, Department of Genetics, Stanford University School of Medicine, 975 California Ave, Palo Alto, California 94304, USA
    Nature 431:268-74. 2004
    ..These duplications are very recent evolutionary events and probably have a mechanistic role in human physiological variation, as deletions in these regions are the cause of debilitating disorders including spinal muscular atrophy...
  5. pmc Coelacanth genome sequence reveals the evolutionary history of vertebrate genes
    James P Noonan
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Genome Res 14:2397-405. 2004
    ..Our results indicate that coelacanth provides the ideal outgroup sequence against which tetrapod genomes can be measured. We therefore present L. menadoensis as a candidate for whole-genome sequencing...
  6. doi request reprint Gene regulation and the origins of human biological uniqueness
    Samuel J Sholtis
    Department of Genetics, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Genet 26:110-8. 2010
    ..Although the evolutionary interpretation of these events is a subject of considerable debate, the technical and analytical means are now at hand to identify the set of evolutionary genetic events that shaped our species...
  7. pmc The genomic landscape of cohesin-associated chromatin interactions
    Laura E Demare
    Department of Genetics, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Genome Res 23:1224-34. 2013
    ..Our results reveal the diversity of cohesin-associated interactions in the genome and highlight their role in establishing the regulatory architecture of development. ..
  8. pmc Gene conversion and the evolution of protocadherin gene cluster diversity
    James P Noonan
    Department of Genetics, Stanford University School of Medicine, Stanford, California 94305 5120, USA
    Genome Res 14:354-66. 2004
    ..We propose that the combination of lineage-specific duplication, restricted gene conversion, and adaptive variation in diversified ectodomains drives vertebrate protocadherin cluster evolution...

Research Grants1

  1. Identifying enhancers with human-specific developmental functions
    James P Noonan; Fiscal Year: 2010
    ..Our research may thus shed light on the genetic and evolutionary basis of diseases that are unique to our species. ..