Alexander Neumeister

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Differential performance on tasks of affective processing and decision-making in patients with Panic Disorder and Panic Disorder with comorbid Major Depressive Disorder
    Johanna S Kaplan
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, DHHS, Bethesda MD, USA
    J Affect Disord 95:165-71. 2006
  2. ncbi request reprint Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:1750-6. 2006
  3. ncbi request reprint Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
  4. ncbi request reprint Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
    Alexander Neumeister
    Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 57:935-7. 2005
  5. ncbi request reprint Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjects
    Alexander Neumeister
    NIMH Mood and Anxiety Disorders Program, Bethesda, MD, USA
    Am J Psychiatry 162:805-7. 2005
  6. ncbi request reprint Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter
    Alexander Neumeister
    Clinical Neuroscience Division, Department of Psychiatry, VA National Center for PTSD 116 A, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 174:512-24. 2004
  7. ncbi request reprint Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006
  8. ncbi request reprint Cerebral metabolic effects of intravenous glycine in healthy human subjects
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    J Clin Psychopharmacol 26:595-9. 2006
  9. ncbi request reprint Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
  10. pmc Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892 1030, USA
    Eur Neuropsychopharmacol 23:822-9. 2013

Research Grants

Detail Information

Publications61

  1. ncbi request reprint Differential performance on tasks of affective processing and decision-making in patients with Panic Disorder and Panic Disorder with comorbid Major Depressive Disorder
    Johanna S Kaplan
    Mood and Anxiety Disorders Program, National Institute of Mental Health, NIH, DHHS, Bethesda MD, USA
    J Affect Disord 95:165-71. 2006
    ..The present study investigated neuropsychological functioning in patients with PD and PD + MDD by focusing on tasks that assess attention, psychomotor speed, executive function, decision-making, and affective processing...
  2. ncbi request reprint Effects of a alpha 2C-adrenoreceptor gene polymorphism on neural responses to facial expressions in depression
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, West Haven, CT 06516, USA
    Neuropsychopharmacology 31:1750-6. 2006
    ..These results suggest that the alpha2CDel322-325-AR confers a change in brain function implicating this alpha2-AR subtype into the pathophysiology of MDD...
  3. ncbi request reprint Sympathoneural and adrenomedullary functional effects of alpha2C-adrenoreceptor gene polymorphism in healthy humans
    Alexander Neumeister
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics and Pathophysiology, NIMH, NIH, Bethesda, MD, USA
    Pharmacogenet Genomics 15:143-9. 2005
    ..In-frame deletion of the alpha2C-adrenoreceptor subtype (alpha2CDel322-325) increases the risk of congestive heart failure. Increased delivery of catecholamines to cardiovascular receptors might explain this increased risk...
  4. ncbi request reprint Reduced hippocampal volume in unmedicated, remitted patients with major depression versus control subjects
    Alexander Neumeister
    Section on Experimental Therapeutics and Pathophysiology, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 57:935-7. 2005
    ..Hippocampal volumes obtained from a group of medication-free, remitted subjects with recurrent major depressive disorder (MDD) were compared against corresponding measures from healthy controls...
  5. ncbi request reprint Effects of tryptophan depletion on serum levels of brain-derived neurotrophic factor in unmedicated patients with remitted depression and healthy subjects
    Alexander Neumeister
    NIMH Mood and Anxiety Disorders Program, Bethesda, MD, USA
    Am J Psychiatry 162:805-7. 2005
    ....
  6. ncbi request reprint Implications of genetic research on the role of the serotonin in depression: emphasis on the serotonin type 1A receptor and the serotonin transporter
    Alexander Neumeister
    Clinical Neuroscience Division, Department of Psychiatry, VA National Center for PTSD 116 A, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Psychopharmacology (Berl) 174:512-24. 2004
    ....
  7. ncbi request reprint Differential effects of 5-HTTLPR genotypes on the behavioral and neural responses to tryptophan depletion in patients with major depression and controls
    Alexander Neumeister
    Molecular Imaging Program of the Clinical Neuroscience Division, Department of Psychiatry, Yale University School of Medicine, 950 Campbell Avenue, West Haven, CT 06516, USA
    Arch Gen Psychiatry 63:978-86. 2006
    ....
  8. ncbi request reprint Cerebral metabolic effects of intravenous glycine in healthy human subjects
    Alexander Neumeister
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    J Clin Psychopharmacol 26:595-9. 2006
    ....
  9. ncbi request reprint Neural and behavioral responses to tryptophan depletion in unmedicated patients with remitted major depressive disorder and controls
    Alexander Neumeister
    Section on Experimental Therapeutics, Mood and Anxiety Disorders Program, National Institute of Mental Health, Bethesda, MD 20892 2670, USA
    Arch Gen Psychiatry 61:765-73. 2004
    ....
  10. pmc Reduced post-synaptic serotonin type 1A receptor binding in bipolar depression
    Allison C Nugent
    National Institute of Mental Health, Experimental Therapeutics and Pathophysiology Branch, NIMH, NIH, Bethesda, MD 20892 1030, USA
    Eur Neuropsychopharmacol 23:822-9. 2013
    ..These findings suggest that 5-HT(1A) receptor binding is abnormally reduced in BD, and this abnormality may particularly involve the postsynaptic 5-HT(1A) receptor system of individuals with a tendency toward cortisol hypersecretion...
  11. pmc The effect of early trauma exposure on serotonin type 1B receptor expression revealed by reduced selective radioligand binding
    James W Murrough
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, USA
    Arch Gen Psychiatry 68:892-900. 2011
    ..However, the specific role of the serotonin type 1B receptor has not been studied in patients with PTSD...
  12. ncbi request reprint No change in serotonin type 1A receptor binding in patients with posttraumatic stress disorder
    Omer Bonne
    Section of Experimental Therapeutics, NIMH Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Am J Psychiatry 162:383-5. 2005
    ..In the present study, the authors sought an association between 5HT1AR binding and posttraumatic stress disorder (PTSD)...
  13. pmc Serotonin transporter genotype and depressive phenotype determination by discriminant analysis of glucose metabolism under acute tryptophan depletion
    Allison C Nugent
    Section on Neuroimaging in Mood and Anxiety Disorders, National Institute of Mental Health, NIH, Bethesda, MD 20892 0940, USA
    Neuroimage 43:764-74. 2008
    ..The robust nature of the classification results indicates that much of the variance in metabolic response to ATD is accounted for by genotypic and phenotypic category...
  14. pmc Age effects on serotonin receptor 1B as assessed by PET
    David Matuskey
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Nucl Med 53:1411-4. 2012
    ..This paper addresses whether the availability of 5-hydroxytryptamine receptor 1B (5-HT(1B)) is seen to decrease with aging via PET imaging...
  15. pmc Reduced amygdala serotonin transporter binding in posttraumatic stress disorder
    James W Murrough
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Biol Psychiatry 70:1033-8. 2011
    ....
  16. ncbi request reprint Association between serotonin transporter gene promoter polymorphism (5HTTLPR) and behavioral responses to tryptophan depletion in healthy women with and without family history of depression
    Alexander Neumeister
    National Institutes of Health, NIMH, Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670
    Arch Gen Psychiatry 59:613-20. 2002
    ..We studied the behavioral responses to tryptophan depletion (TD) in healthy women with and without a first-degree family history of depression and examined the relationship to 5HTTLPR alleles...
  17. pmc Plasma NPY concentrations during tryptophan and sham depletion in medication-free patients with remitted depression
    Christoph Czermak
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    J Affect Disord 110:277-81. 2008
    ..Neuropeptide Y (NPY) and serotonergic systems have been implicated in the pathophysiology of depression but have not yet been linked together...
  18. pmc Effects of yohimbine and hydrocortisone on panic symptoms, autonomic responses, and attention to threat in healthy adults
    Roma A Vasa
    Department of Psychiatry, Kennedy Krieger Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21211, USA
    Psychopharmacology (Berl) 204:445-55. 2009
    ..Few studies examine how these two neurochemical systems interact to influence anxiety and attention in humans...
  19. pmc Serotonin 1B receptor imaging in alcohol dependence
    Jian Hu
    Molecular Imaging Program, Clinical Neurosciences Division, VA National Center for PTSD, VA Connecticut Healthcare System, West Haven, Connecticut, USA
    Biol Psychiatry 67:800-3. 2010
    ..Because of its central role in AD, we were particularly interested in ventral striatal 5-HT(1B)R BP(ND) values...
  20. pmc Reduced ventral striatal/ventral pallidal serotonin1B receptor binding potential in major depressive disorder
    James W Murrough
    Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA
    Psychopharmacology (Berl) 213:547-53. 2011
    ..In particular, 5-HT(1B) heteroreceptors located within the striatum have been shown to play an essential role in antidepressant action...
  21. pmc Tracer kinetic modeling of [(11)C]AFM, a new PET imaging agent for the serotonin transporter
    Mika Naganawa
    Diagnostic Radiology, PET Center, Yale University School of Medicine, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 33:1886-96. 2013
    ..The MA1 and MRTM2 methods were best for parametric imaging. These results showed that [(11)C]AFM is a suitable PET radioligand to image and quantify SERT in humans. ..
  22. pmc Association of posttraumatic stress disorder with reduced in vivo norepinephrine transporter availability in the locus coeruleus
    Robert H Pietrzak
    Clinical Neurosciences Division, National Center for Posttraumatic Stress Disorder, Veterans Affairs Connecticut Healthcare System, West Haven2Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut
    JAMA Psychiatry 70:1199-205. 2013
    ..However, it is unclear whether such models are relevant to posttraumatic stress disorder (PTSD), which has been linked to noradrenergic dysfunction in humans...
  23. pmc Serotonin 1B receptor imaging in pathological gambling
    Marc N Potenza
    Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    World J Biol Psychiatry 14:139-45. 2013
    ....
  24. pmc Noradrenergic and serotonergic mechanisms in the neurobiology of posttraumatic stress disorder and resilience
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Brain Res 1293:13-23. 2009
    ....
  25. ncbi request reprint Reduced serotonin type 1A receptor binding in panic disorder
    Alexander Neumeister
    National Institutes of Health, National Institute of Mental Health, Mood and Anxiety Disorders Program, Bethesda, Maryland 20892 2670, USA
    J Neurosci 24:589-91. 2004
    ..These results provide for the first time in vivo evidence for the involvement of 5-HT(1A)Rs in the pathophysiology of PD...
  26. pmc Habenula volume in bipolar disorder and major depressive disorder: a high-resolution magnetic resonance imaging study
    Jonathan B Savitz
    Mood and Anxiety Disorders Program, National Institutes of Health National Institute of Mental Health, Bethesda, Maryland, USA
    Biol Psychiatry 69:336-43. 2011
    ..We conducted the first magnetic resonance imaging analysis of habenula volume in MDD and bipolar disorder (BD)...
  27. pmc PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[(11)C]O-methylreboxetine and HRRT
    Yu Shin Ding
    Yale PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8048, USA
    Synapse 64:30-8. 2010
    ....
  28. pmc Decreased norepinephrine transporter availability in obesity: Positron Emission Tomography imaging with (S,S)-[(11)C]O-methylreboxetine
    Chiang Shan R Li
    Department of Psychiatry, Yale University, New Haven, CT, USA Department of Neurobiology, Yale University, New Haven, CT, USA Interdepartmental Neuroscience Program, Yale University, New Haven, CT, USA
    Neuroimage 86:306-10. 2014
    ..Here we report findings evaluating NET availability in individuals with obesity and matched lean (i.e., normal weight) comparison subjects...
  29. ncbi request reprint Evidence for continuing neuropsychological impairments in depression
    Petra Weiland-Fiedler
    Mood and Anxiety Disorders Program, National Institute of Mental Health, North Drive, Building 15K, Room 200, Bethesda, MD 20892 2670, USA
    J Affect Disord 82:253-8. 2004
    ..The purpose of the present study was to describe the neuropsychological functioning of fully remitted, unmedicated patients with a history of MDD by focusing on tasks related to prefrontal cortex functioning...
  30. doi request reprint beta2 Nicotinic acetylcholine receptor availability in post-traumatic stress disorder
    Christoph Czermak
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Int J Neuropsychopharmacol 11:419-24. 2008
    ..66, p=0.019, Bonferroni corrected). These findings not only suggest an involvement of beta2-nAChRs in the pathophysiology of PTSD but also raise the possibility that this receptor may be a novel molecular target for drug development...
  31. pmc Prefrontal cortical abnormalities in currently depressed versus currently remitted patients with major depressive disorder
    Giacomo Salvadore
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, Bethesda, MD 20892, USA
    Neuroimage 54:2643-51. 2011
    ..Consistent with other neuroimaging and post-mortem neuropathological studies of MDD, we also found evidence of decreased white matter in patients with dMDD and rMDD...
  32. ncbi request reprint Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy
    Gregor Hasler
    Mood and Anxiety Disorders Program, Section on Experimental Therapeutics, National Institutes of Health, Bethesda, MD 20892 2670, USA
    Biol Psychiatry 58:969-73. 2005
    ..As a result, the current study investigates whether GABA levels in the prefrontal cortex differ between unmedicated subjects with remitted major depressive disorder (rMDD) and healthy control subjects...
  33. pmc Sustained low-grade pro-inflammatory state in unmedicated, remitted women with major depressive disorder as evidenced by elevated serum levels of the acute phase proteins C-reactive protein and serum amyloid A
    Mitchel A Kling
    Clinical Neuroendocrinology Branch, Division of Intramural Research Programs, National Institute of Mental Health, Bethesda, MD 20892 1284, USA
    Biol Psychiatry 62:309-13. 2007
    ..Elevations of the inflammatory markers C-reactive protein (CRP) and serum amyloid A (SAA) predict increased CAD risk in populations; few data on these markers exist in MDD, particularly in remitted patients...
  34. pmc Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans
    Jean Dominique Gallezot
    PET Center, Department of Diagnostic Radiology, Yale University, New Haven, Connecticut, USA
    J Cereb Blood Flow Metab 30:196-210. 2010
    ..Parametric images of the volume of distribution or binding potential of [(11)C]P943 could be computed using both MA1 and MRTM2. The results show that [(11)C]P943 provides quantitative measurements of 5-HT(1B) binding potential...
  35. pmc Linking plasma cortisol levels to phenotypic heterogeneity of posttraumatic stress symptomatology
    Charlotte A C Horn
    Department of Psychiatry, New York University School of Medicine, New York, NY, USA Department of Radiology, New York University School of Medicine, New York, NY, USA
    Psychoneuroendocrinology 39:88-93. 2014
    ..However, little is known about how altered HPA-axis function is related to this contemporary phenotypic model of PTSD...
  36. pmc Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder
    Jonathan Savitz
    Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH NIMH, Bethesda, MD
    Sci Rep 2:308. 2012
    ..The rCBF in the right amygdala was significantly correlated with depression severity. Conceivably, the limbic response to invasive physical stress is greater in MDD subjects than in HCs...
  37. ncbi request reprint Unmedicated, remitted patients with major depression have decreased serum immunoglobulin A
    Philip W Gold
    Clinical Neuroendocrinology Branch, NIH NIMH, 10 Center Drive, Bethesda, MD 20892, USA
    Neurosci Lett 520:1-5. 2012
    ..In the light of the fact that IgA serves many immunomodulatory, anti-inflammatory roles, this finding supports the concept that major depressive illness represents a proinflammatory state...
  38. pmc Tryptophan depletion and emotional processing in healthy volunteers at high risk for depression
    Adriana Feder
    Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA
    Biol Psychiatry 69:804-7. 2011
    ..The present study compared the effects of acute tryptophan depletion (ATD) on both an emotional processing and a planning task in never-depressed healthy volunteers at high and low familial risk for depression...
  39. doi request reprint Cognitive dysfunction in depression: neurocircuitry and new therapeutic strategies
    James W Murrough
    Mood and Anxiety Disorders Program, Department of Psychiatry, Mount Sinai School of Medicine, New York, NY, USA
    Neurobiol Learn Mem 96:553-63. 2011
    ..Finally, we highlight potential new pharmacological and non-pharmacological therapeutic strategies for MDD based on an evolving mechanistic understanding of the disorder...
  40. ncbi request reprint Hippocampus, VI. Depression and the Hippocampus
    Alexander Neumeister
    UT Southwestern Medical Center, Department of Psychiatry, Dallas, TX 75390 9070, USA
    Am J Psychiatry 162:1057. 2005
  41. ncbi request reprint Tryptophan depletion, serotonin, and depression: where do we stand?
    Alexander Neumeister
    National Institute for Mental Health s Mood and Anxiety Disorders Program, Bethesda, MD 20892 2670, USA
    Psychopharmacol Bull 37:99-115. 2003
    ..This may lead to the development of truly novel treatment approaches for depression...
  42. ncbi request reprint Attention bias variability and symptoms of posttraumatic stress disorder
    Brian M Iacoviello
    Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, New York, USA
    J Trauma Stress 27:232-9. 2014
    ..Attention-bias variability could be a useful marker for attentional impairment related to threat cues associated with mood and anxiety symptoms after trauma exposure...
  43. doi request reprint It is time to take a stand for medical research and against terrorism targeting medical scientists
    John H Krystal
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Biol Psychiatry 63:725-7. 2008
  44. ncbi request reprint Typologies of posttraumatic stress disorder in the U.S. adult population
    Robert H Pietrzak
    United States Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, VA Connecticut Healthcare System, West Haven, CT, USA Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA Electronic address
    J Affect Disord 162:102-6. 2014
    ..However, data are lacking regarding the predominant, population-based typologies of this disorder, and how they are linked to trauma-related characteristics, psychiatric comorbidities, and health-related quality of life...
  45. ncbi request reprint Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy
    Omer Bonne
    Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institute of Health, 15K North Drive, Rm 200, Bethesda, MD 20892 2670, USA
    Neurosci Biobehav Rev 28:65-94. 2004
    ..The implications of this model for the discovery of novel pharmacological approaches to the treatment of severe psychological distress are discussed...
  46. ncbi request reprint Anxiety symptoms, cerebral amyloid burden and memory decline in healthy older adults without dementia: 3-year prospective cohort study
    Robert H Pietrzak
    Robert H Pietrzak, PhD, MPH, J Cobb Scott, PhD, United States Department of Veterans Affairs National Center for Posttraumatic Stress Disorder, Clinical Neurosciences Division, VA Connecticut Healthcare System, West Haven and Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA Alexander Neumeister, MD, Departments of Psychiatry and Radiology, New York University School of Medicine, New York, USA Yen Ying Lim, PhD, The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia David Ames, MD, Academic Unit for Psychiatry of Old Age, St Vincent s Health, Department of Psychiatry, The University of Melbourne, Kew and National Ageing Research Institute, Parkville, Victoria, Australia Kathryn A Ellis, PhD, The Florey Institute of Neuroscience and Mental Health, Parkville, Academic Unit for Psychiatry of Old Age, St Vincent s Health, Department of Psychiatry, The University of Melbourne, Kew and National Ageing Research Institute, Parkville, Victoria, Pest Infestation Laboratory
    Br J Psychiatry 204:400-1. 2014
    ..These findings suggest that interventions to mitigate anxiety symptoms may help delay memory decline in otherwise healthy older adults with elevated beta-amyloid. ..
  47. pmc Recent progress in understanding the pathophysiology of post-traumatic stress disorder: implications for targeted pharmacological treatment
    Christopher R Bailey
    Johns Hopkins University School of Medicine, Baltimore, MD, USA
    CNS Drugs 27:221-32. 2013
    ....
  48. doi request reprint Differential conditioned fear response predicts duloxetine treatment outcome in male veterans with PTSD: a pilot study
    Deane E Aikins
    Department of Psychiatry, Yale University, 300 George Street, New Haven, CT 06511, USA
    Psychiatry Res 188:453-5. 2011
    ..These data provide initial evidence of a putative biomarker of selective treatment response in PTSD...
  49. ncbi request reprint Interactive effects of sex and 5-HTTLPR on mood and impulsivity during tryptophan depletion in healthy people
    Espen Walderhaug
    Department of Psychology, University of Oslo, Blindern, 0317 Oslo, Norway
    Biol Psychiatry 62:593-9. 2007
    ..We also studied the relative contribution of a functional length triallelic polymorphism in the promoter region of the serotonin transporter, designated 5-HTTLPR, to the behavioral responses to ATD...
  50. ncbi request reprint Receptor and transporter imaging studies in schizophrenia, depression, bulimia and Tourette's disorder--implications for psychopharmacology
    Siegfried Kasper
    Department of General Psychiatry, University of Vienna, Wahringer Gurtel 18 20, 1090 Vienna, Austria
    World J Biol Psychiatry 3:133-46. 2002
    ..Our data provide insight into the pathophysiology of neuropsychiatric disorders and may guide future psychopharmacological drug developments...
  51. ncbi request reprint Effects of tryptophan depletion and catecholamine depletion on immune parameters in patients with seasonal affective disorder in remission with light therapy
    Jürgen Stastny
    Department of General Psychiatry, University of Vienna, Vienna, Austria
    Biol Psychiatry 53:332-7. 2003
    ....
  52. ncbi request reprint Circadian clock-related polymorphisms in seasonal affective disorder and their relevance to diurnal preference
    Carolina Johansson
    Neurogenetics Unit, Department of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden
    Neuropsychopharmacology 28:734-9. 2003
    ..In conclusion, our results suggest involvement of circadian clock-related polymorphisms both in susceptibility to SAD and diurnal preference...
  53. ncbi request reprint Experimental evaluation of an altered tryptophan metabolism in fibromyalgia
    Markus J Schwarz
    Psychiatric Hospital, University of Munich, Nussbaumstr 7, D 80336 Munich, Germany
    Adv Exp Med Biol 527:265-75. 2003
    ..Our findings may have diagnostic as well as therapeutic implications in the field of fibromyalgia...
  54. ncbi request reprint Role of family history and 5-HTTLPR polymorphism in female seasonal affective disorder patients with and without premenstrual dysphoric disorder
    Nicole Praschak-Rieder
    Department of General Psychiatry, University of Vienna, Waehringer Guertel 18 20, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 12:129-34. 2002
    ..The elevated rate of affective disorders in relatives of patients with SAD and PMDD suggests higher genetic vulnerability in this subgroup when compared to patients with SAD alone...
  55. pmc Reduced posterior hippocampal volume in posttraumatic stress disorder
    Omer Bonne
    Department of Psychiatry, Hadassah Hebrew University Medical Center, Jerusalem, Israel
    J Clin Psychiatry 69:1087-91. 2008
    ..Hippocampal volume is reduced in posttraumatic stress disorder (PTSD). In the present study, we sought to determine whether volume loss is homogenously distributed or confined to a certain part of the structure...
  56. ncbi request reprint Untangling depression and anxiety: clinical challenges
    Martin B Keller
    J Clin Psychiatry 66:1477-84. 2005
  57. pmc Neural response to catecholamine depletion in unmedicated subjects with major depressive disorder in remission and healthy subjects
    Gregor Hasler
    Department of Psychiatry, University Hospital, Culmannstrasse 8, 8091 Zurich, Switzerland
    Arch Gen Psychiatry 65:521-31. 2008
    ..An instructive paradigm for more directly investigating the relationship between catecholaminergic function and depression has involved the mood response to experimental catecholamine depletion (CD)...
  58. ncbi request reprint Seasonal affective disorder and the G-protein beta-3-subunit C825T polymorphism
    Carolina Johansson
    Neurogenetics Unit, Department of Molecular Medicine, Center for Molecular Medicine L8 00, Karolinska Institutet and Karolinska Hospital, S 171 76 Stockholm, Sweden
    Biol Psychiatry 55:317-9. 2004
    ..Association with seasonal affective disorder (SAD) has been found for the higher activity T-allele of the G-protein beta-3-subunit C825T polymorphism...
  59. ncbi request reprint Serotonin transporter promoter gene polymorphic region (5-HTTLPR) and personality in female patients with seasonal affective disorder and in healthy controls
    Nikolaus Thierry
    Department of General Psychiatry, Waehringer Guertel 18 20, University of Vienna, A 1090 Vienna, Austria
    Eur Neuropsychopharmacol 14:53-8. 2004
    ..The s allele was associated with lower Self-Directedness scores in SAD patients, whereas there were no significant differences in TCI dimensions between patients and controls in carriers of the long allele...
  60. ncbi request reprint C825T polymorphism in the G protein beta3-subunit gene is associated with seasonal affective disorder
    Matthaus Willeit
    Department of General Psychiatry, University Hospital of Psychiatry, Vienna, Austria
    Biol Psychiatry 54:682-6. 2003
    ....
  61. ncbi request reprint A Cys 23-Ser 23 substitution in the 5-HT(2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study
    Nicole Praschak-Rieder
    Department of General Psychiatry, Medical University of Vienna, Austria
    J Psychiatr Res 39:561-7. 2005
    ....

Research Grants2

  1. Norepinephrine Transporter Imaging in Alcohol Dependence and Obesity (8 of 14)
    Alexander Neumeister; Fiscal Year: 2008
    ..abstract_text> ..