E J Nestler

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Molecular mechanisms of opiate and cocaine addiction
    E J Nestler
    Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Curr Opin Neurobiol 7:713-9. 1997
  2. ncbi Molecular and cellular basis of addiction
    E J Nestler
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Science 278:58-63. 1997
  3. ncbi Relapse to drug-seeking: neural and molecular mechanisms
    D W Self
    Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Drug Alcohol Depend 51:49-60. 1998
  4. ncbi Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1
    W A Carlezon
    Division of Molecular Psychiatry, Center for Genes and Behavior, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Neurosci 20:RC62. 2000
  5. ncbi Acquisition and maintenance of intravenous cocaine self-administration in Lewis and Fischer inbred rat strains
    T A Kosten
    Department of Psychiatry, Yale University School of Medicine, and Connecticut Mental Health Center, New Haven 06508, USA
    Brain Res 778:418-29. 1997
  6. ncbi Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass
    N A Sims
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Bone 30:32-9. 2002
  7. ncbi Differential behavioral responses to cocaine are associated with dynamics of mesolimbic dopamine proteins in Lewis and Fischer 344 rats
    C N Haile
    Divisions of Substance Abuse and Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA
    Synapse 41:179-90. 2001
  8. ncbi Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures
    N Hiroi
    Laboratory of Molecular Psychiatry, Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 18:6952-62. 1998
  9. ncbi Strain-selective effects of corticosterone on locomotor sensitization to cocaine and on levels of tyrosine hydroxylase and glucocorticoid receptor in the ventral tegmental area
    J Ortiz
    Department of Psychiatry, Yale University School of Medicine, Connecticut, Mental Health Center, New Haven 06508, USA
    Neuroscience 67:383-97. 1995
  10. ncbi Induction of nuclear factor-kappaB in nucleus accumbens by chronic cocaine administration
    E Ang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurochem 79:221-4. 2001

Collaborators

Detail Information

Publications35

  1. ncbi Molecular mechanisms of opiate and cocaine addiction
    E J Nestler
    Laboratory of Molecular Psychiatry, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Curr Opin Neurobiol 7:713-9. 1997
    ..In addition, recent work has focused on a role for transcription factors, and the associated alterations in gene expression, in mediating part of this long-lasting, drug-induced molecular and behavioral plasticity...
  2. ncbi Molecular and cellular basis of addiction
    E J Nestler
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Science 278:58-63. 1997
    ..Understanding the molecular and cellular basis of addictive states will lead to major changes in how addiction is viewed and ultimately treated...
  3. ncbi Relapse to drug-seeking: neural and molecular mechanisms
    D W Self
    Division of Molecular Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Drug Alcohol Depend 51:49-60. 1998
    ..A detailed understanding of the neural and molecular basis of relapse will facilitate efforts to develop truly effective treatments and preventive measures...
  4. ncbi Distinct sites of opiate reward and aversion within the midbrain identified using a herpes simplex virus vector expressing GluR1
    W A Carlezon
    Division of Molecular Psychiatry, Center for Genes and Behavior, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Neurosci 20:RC62. 2000
    ..These results suggest that distinct substrates within the VTA itself differentially contribute to the rewarding and aversive properties of opiates...
  5. ncbi Acquisition and maintenance of intravenous cocaine self-administration in Lewis and Fischer inbred rat strains
    T A Kosten
    Department of Psychiatry, Yale University School of Medicine, and Connecticut Mental Health Center, New Haven 06508, USA
    Brain Res 778:418-29. 1997
    ..Further, because acquisition of drug self-administration is an animal model of vulnerability to drug addiction, these inbred strains may be useful to study factors underlying such vulnerability...
  6. ncbi Regulating DeltaFosB expression in adult Tet-Off-DeltaFosB transgenic mice alters bone formation and bone mass
    N A Sims
    Department of Cell Biology, Yale University School of Medicine, New Haven, CT 06520 8044, USA
    Bone 30:32-9. 2002
    ..Despite this dramatic reduction, no alteration in bone resorption was detected. These results clearly demonstrate that DeltaFosB regulates bone formation and bone mass in adult mice with no effect on bone resorption...
  7. ncbi Differential behavioral responses to cocaine are associated with dynamics of mesolimbic dopamine proteins in Lewis and Fischer 344 rats
    C N Haile
    Divisions of Substance Abuse and Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06508, USA
    Synapse 41:179-90. 2001
    ..LEW rats. These results suggest that behavioral responsiveness to chronic cocaine exposure may reflect dynamics of mesolimbic dopamine protein levels and demonstrate the role of genetic background in responsiveness to cocaine...
  8. ncbi Essential role of the fosB gene in molecular, cellular, and behavioral actions of chronic electroconvulsive seizures
    N Hiroi
    Laboratory of Molecular Psychiatry, Departments of Psychiatry and Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 18:6952-62. 1998
    ..These findings identify fosB gene products as transcription factors critical for molecular, electrophysiological, and behavioral adaptations to motor seizures...
  9. ncbi Strain-selective effects of corticosterone on locomotor sensitization to cocaine and on levels of tyrosine hydroxylase and glucocorticoid receptor in the ventral tegmental area
    J Ortiz
    Department of Psychiatry, Yale University School of Medicine, Connecticut, Mental Health Center, New Haven 06508, USA
    Neuroscience 67:383-97. 1995
    ....
  10. ncbi Induction of nuclear factor-kappaB in nucleus accumbens by chronic cocaine administration
    E Ang
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    J Neurochem 79:221-4. 2001
    ..These results establish NF-kappaB as a putative target for DeltaFosB and implicate NF-kappaB signaling pathways in the long-term adaptations of nucleus accumbens neurons to cocaine...
  11. ncbi DeltaFosB: a molecular mediator of long-term neural and behavioral plasticity
    E J Nestler
    Laboratory of Molecular Psychiatry and Center for Genes and Behavior Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Brain Res 835:10-7. 1999
    ....
  12. ncbi Neuronal and behavioural abnormalities in striatal function in DARPP-32-mutant mice
    N Hiroi
    Laboratory of Molecular Psychiatry, Center for Genes and Behaviour, Yale University School of Medicine, New Haven, CT 06508, USA
    Eur J Neurosci 11:1114-8. 1999
    ..These data show that DARPP-32 is involved in regulating substance P expression in the striatonigral pathway, and in biochemical and behavioural plasticity with chronic administration of cocaine...
  13. ncbi Morphine down-regulates melanocortin-4 receptor expression in brain regions that mediate opiate addiction
    J D Alvaro
    Laboratory of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    Mol Pharmacol 50:583-91. 1996
    ....
  14. ncbi Behavioral interactions caused by combined administration of morphine and MK-801 in rats
    W A Carlezon
    Department of Psychiatry, McLean Hospital, Belmont, MA 02478, USA
    Psychopharmacology (Berl) 151:261-72. 2000
    ..However, evidence in the existing literature suggests that some of MK-801's effects are additive (or synergistic) with those of morphine...
  15. ncbi Cloning and characterization of RGS9-2: a striatal-enriched alternatively spliced product of the RGS9 gene
    Z Rahman
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06508, USA
    J Neurosci 19:2016-26. 1999
    ..The distinct C-terminal domains of RGS9-2 and RGS9-1 presumably contribute to unique regulatory properties in the neural and retinal cells in which these proteins are selectively expressed...
  16. ncbi Altered responsiveness to cocaine and increased immobility in the forced swim test associated with elevated cAMP response element-binding protein expression in nucleus accumbens
    A M Pliakas
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 21:7397-403. 2001
    ..Exposure to the FST itself dramatically increased CREB function in the NAc. These findings raise the possibility that CREB-mediated transcription within the NAc regulates dysphoric states...
  17. ncbi Elevated levels of DeltaFosB and RGS9 in striatum in Parkinson's disease
    P K Tekumalla
    Laboratory of Molecular Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut, USA
    Biol Psychiatry 50:813-6. 2001
    ..Knowledge of these adaptations can help us understand the changes in striatal function associated with Parkinson's disease and assist in the development of novel treatments...
  18. ncbi DeltaFosB-induced cataract
    M B Kelz
    Laboratory of Molecular Psychiatry and Center for Genes and Behavior, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut, USA
    Invest Ophthalmol Vis Sci 41:3523-38. 2000
    ..The objective of this study was to investigate a possible relationship between posterior subcapsular cataract (PSC) formation and expression of the transcription factor DeltaFosB...
  19. ncbi Distinct roles for spinophilin and neurabin in dopamine-mediated plasticity
    P B Allen
    Department of Psychiatry, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Neuroscience 140:897-911. 2006
    ..These data establish a requirement for synaptic scaffolding in dopamine-mediated responses, and further indicate that spinophilin and neurabin play distinct roles in dopaminergic signal transduction and psychostimulant response...
  20. pmc Distinct patterns of DeltaFosB induction in brain by drugs of abuse
    L I Perrotti
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, Texas 75390 9070, USA
    Synapse 62:358-69. 2008
    ....
  21. ncbi Long-term memory is facilitated by cAMP response element-binding protein overexpression in the amygdala
    S A Josselyn
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06508, USA
    J Neurosci 21:2404-12. 2001
    ..These results suggest that CREB activity in the amygdala serves as a molecular switch for the formation of LTM in fear conditioning...
  22. ncbi Cloning and localization of the hyperpolarization-activated cyclic nucleotide-gated channel family in rat brain
    L M Monteggia
    Laboratory of Molecular Psychiatry and Yale Center for Genes and Behavior, Yale University School of Medicine, 34 Park Street, New Haven, CT 06508, USA
    Brain Res Mol Brain Res 81:129-39. 2000
    ..These variations in regional specificity of HCN channels could generate important differences in neuronal pacemaker activity across brain systems...
  23. ncbi Learning about addiction from the genome
    E J Nestler
    Department of Psychiatry, The University of Texas Southwestern Medical Center, Dallas 75390 9070, USA
    Nature 409:834-5. 2001
    ..We illustrate this potential impact by searching a draft sequence of the human genome for genes related to desensitization of receptors that mediate the actions of drugs of abuse on the nervous system...
  24. ncbi Overexpression of DeltaFosB transcription factor(s) increases bone formation and inhibits adipogenesis
    G Sabatakos
    Departments of Cell Biology and Orthopaedics, Yale University School of Medicine SHM IE 55, 333 Cedar St, New Haven, Connecticut 06520 8044, USA
    Nat Med 6:985-90. 2000
    ..Because osteoblasts and adipocytes are thought to share a common precursor, it is concluded that DeltaFosB transcriptionally regulates osteoblastogenesis, possibly at the expense of adipogenesis...
  25. ncbi Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor
    B A Horger
    Laboratory of Molecular Psychiatry, Departments of Psychiatry, Pharmacology, and Neurobiology, Yale University School of Medicine, Connecticut Mental Health Center, New Haven, Connecticut 06520, USA
    J Neurosci 19:4110-22. 1999
    ..These results demonstrate the profound effects of BDNF on the enhancement of both cocaine-induced locomotion and facilitation of CR and suggest a possible role for BDNF in long-term adaptations of the brain to cocaine...
  26. ncbi Ezrin and osteonectin, two proteins associated with cell shape and growth, are enriched in the locus coeruleus
    C Bergson
    Laboratory of Molecular Psychiatry, Departments of Psychiatry and Pharmacology, Yale University School of Medicine, and Connecticut Mental Health Center, New Haven, Connecticut 06508
    Mol Cell Neurosci 4:64-73. 1993
    ....
  27. ncbi Sequence and expression of a neuropeptide Y receptor cDNA
    J Rimland
    Laboratory of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508
    Mol Pharmacol 40:869-75. 1991
    ..This cDNA clone will be useful for studies of the regulation and function of NPY receptors, as well as for the isolation of related NPY receptor subtypes...
  28. ncbi Regulators of G-protein signaling (RGS) proteins: region-specific expression of nine subtypes in rat brain
    S J Gold
    Laboratory of Molecular Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06508, USA
    J Neurosci 17:8024-37. 1997
    ....
  29. pmc FosB mutant mice: loss of chronic cocaine induction of Fos-related proteins and heightened sensitivity to cocaine's psychomotor and rewarding effects
    N Hiroi
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06508, USA
    Proc Natl Acad Sci U S A 94:10397-402. 1997
    ..This finding demonstrates that a Fos family member protein plays a functional role in behavioral responses to drugs of abuse and implicates fosB gene products as important determinants of cocaine abuse...
  30. ncbi DARPP-32: regulator of the efficacy of dopaminergic neurotransmission
    A A Fienberg
    Laboratory of Molecular and Cellular Neuroscience, The Rockefeller University, New York, NY 10021, USA
    Science 281:838-42. 1998
    ..The results show that DARPP-32 plays a central role in regulating the efficacy of dopaminergic neurotransmission...
  31. ncbi Increased vulnerability to cocaine in mice lacking the serotonin-1B receptor
    B A Rocha
    Department of Pharmacology, University of North Texas Health Science Center, Fort Worth 76107, USA
    Nature 393:175-8. 1998
    ..This altered state might be responsible for their increased vulnerability to cocaine...
  32. ncbi Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal
    S Akbarian
    Whitehead Institute for Biomedical Research, Cambridge, MA, USA
    Mol Psychiatry 6:593-604. 2001
    ..NT-3 expressed by non-catecholaminergic neurons may modulate opiate withdrawal and noradrenergic signalling...
  33. pmc Dopamine receptor regulating factor, DRRF: a zinc finger transcription factor
    C K Hwang
    Genetic Pharmacology Unit, Experimental Therapeutics Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892 1406, USA
    Proc Natl Acad Sci U S A 98:7558-63. 2001
    ..The latter observations provide a basis for dopamine receptor regulation after these manipulations. We conclude that DRRF is important for modulating dopaminergic transmission in the brain...
  34. ncbi Inducible, brain region-specific expression of a dominant negative mutant of c-Jun in transgenic mice decreases sensitivity to cocaine
    M C Peakman
    Department of Exploratory Medicinal Sciences and CNS Discovery, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Brain Res 970:73-86. 2003
    ..Taken together, these results provide further support for an important role of AP-1-mediated transcription in some of the behavioral and molecular mechanisms underlying cocaine addiction...
  35. ncbi Regulation of GluR2 promoter activity by neurotrophic factors via a neuron-restrictive silencer element
    S Brene
    Department of Neuroscience, Karolinska Institute, S 171 77 Stockholm, Sweden
    Eur J Neurosci 12:1525-33. 2000
    ..Together, these findings suggest that GluR2 expression can be regulated by neurotrophic factors via an apparently novel mechanism involving the NRSE present within the GluR2 gene promoter...