Sukanya Narasimhan

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the lyme disease spirochete
    Sukanya Narasimhan
    Section of Infectious Diseases, Department of Internal Medicine, Yale University, New Haven, CT 06520, USA Electronic address
    Cell Host Microbe 15:58-71. 2014
  2. pmc Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    BMC Microbiol 12:44. 2012
  3. pmc A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent
    Tim J Schuijt
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA
    Cell Host Microbe 10:136-46. 2011
  4. pmc Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands
    Lei Liu
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, PO Box 208022, New Haven, Connecticut 06520 8022, USA
    EMBO Rep 12:1196-203. 2011
  5. ncbi request reprint Disruption of the salivary protein 14 in Ixodes scapularis nymphs and impact on pathogen acquisition
    Joao H F Pedra
    Section of Rheumatology and Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
    Am J Trop Med Hyg 75:677-82. 2006
  6. pmc Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph
    Lili Zhang
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002079. 2011
  7. pmc A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector
    Sukanya Narasimhan
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Host Microbe 2:7-18. 2007
  8. pmc Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission
    Sukanya Narasimhan
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 2:e451. 2007
  9. pmc Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent
    Jianfeng Dai
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    PLoS Pathog 6:e1001205. 2010
  10. pmc Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis
    Lei Liu
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Infect Dis 206:1233-41. 2012

Research Grants

  1. Early tick salivary antigens as vaccine targets
    Sukanya Narasimhan; Fiscal Year: 2006
  2. BORRELIA BURGDORFERI GENE EXPRESSION IN TICK MIDGUT--ROL
    Sukanya Narasimhan; Fiscal Year: 2002
  3. Molecular analysis of tick-spirochete interactions
    Sukanya Narasimhan; Fiscal Year: 2003
  4. Tick gene expression- in the context of Lyme disease
    Sukanya Narasimhan; Fiscal Year: 2005

Collaborators

Detail Information

Publications24

  1. pmc Gut microbiota of the tick vector Ixodes scapularis modulate colonization of the lyme disease spirochete
    Sukanya Narasimhan
    Section of Infectious Diseases, Department of Internal Medicine, Yale University, New Haven, CT 06520, USA Electronic address
    Cell Host Microbe 15:58-71. 2014
    ..burgdorferi to efficiently colonize the gut epithelium. These data elucidate a functional link between the gut microbiota, STAT-signaling, and pathogen colonization in the context of the gut epithelial barrier of an arthropod vector. ..
  2. pmc Activation of the RpoN-RpoS regulatory pathway during the enzootic life cycle of Borrelia burgdorferi
    Zhiming Ouyang
    Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA
    BMC Microbiol 12:44. 2012
    ..burgdorferi, has been lacking...
  3. pmc A tick mannose-binding lectin inhibitor interferes with the vertebrate complement cascade to enhance transmission of the lyme disease agent
    Tim J Schuijt
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06420, USA
    Cell Host Microbe 10:136-46. 2011
    ....
  4. pmc Ixodes scapularis salivary gland protein P11 facilitates migration of Anaplasma phagocytophilum from the tick gut to salivary glands
    Lei Liu
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, 300 Cedar Street, PO Box 208022, New Haven, Connecticut 06520 8022, USA
    EMBO Rep 12:1196-203. 2011
    ..This report provides new insights into A. phagocytophilum infection of ticks and reveals new avenues to interrupt the life cycle of Anaplasma and related Rickettsial pathogens...
  5. ncbi request reprint Disruption of the salivary protein 14 in Ixodes scapularis nymphs and impact on pathogen acquisition
    Joao H F Pedra
    Section of Rheumatology and Section of Allergy and Clinical Immunology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
    Am J Trop Med Hyg 75:677-82. 2006
    ..B. burgdorferi and A. phagocytophilum acquisition was not affected 72 hours after feeding. Our results suggest that different mechanisms govern nymph and adult feeding in I. scapularis...
  6. pmc Molecular interactions that enable movement of the Lyme disease agent from the tick gut into the hemolymph
    Lili Zhang
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 7:e1002079. 2011
    ..burgdorferi burden in the tick hemolymph. Delineating the specific spirochete and arthropod ligands required for B. burgdorferi movement in the tick may lead to new strategies to interrupt the life cycle of the Lyme disease agent...
  7. pmc A tick antioxidant facilitates the Lyme disease agent's successful migration from the mammalian host to the arthropod vector
    Sukanya Narasimhan
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Host Microbe 2:7-18. 2007
    ..burgdorferi at the tick feeding site in mice. These data demonstrate that pathogens can exploit arthropod molecules to defuse mammalian responses in order to successfully enter the vector...
  8. pmc Immunity against Ixodes scapularis salivary proteins expressed within 24 hours of attachment thwarts tick feeding and impairs Borrelia transmission
    Sukanya Narasimhan
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 2:e451. 2007
    ..Defining this subset of proteins will promote a mechanistic understanding of novel I. scapularis proteins critical for the initiation of tick feeding and for Borrelia transmission...
  9. pmc Tick histamine release factor is critical for Ixodes scapularis engorgement and transmission of the lyme disease agent
    Jianfeng Dai
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA
    PLoS Pathog 6:e1001205. 2010
    ..These findings suggest that blocking tHRF might offer a viable strategy to complement ongoing efforts to develop vaccines to block tick feeding and transmission of tick-borne pathogens...
  10. pmc Ixodes scapularis JAK-STAT pathway regulates tick antimicrobial peptides, thereby controlling the agent of human granulocytic anaplasmosis
    Lei Liu
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, USA
    J Infect Dis 206:1233-41. 2012
    ..These data suggest that the JAK-STAT signaling pathway plays a key role in controlling A. phagocytophilum infection in ticks by regulating the expression of antimicrobial peptides...
  11. pmc Fucosylation enhances colonization of ticks by Anaplasma phagocytophilum
    Joao H F Pedra
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Microbiol 12:1222-34. 2010
    ..Our results uncover a novel mechanism of pathogen colonization in arthropods. Decoding mechanisms of pathogen invasion in ticks might expedite the development of new strategies to interfere with the life cycle of A. phagocytophilum...
  12. pmc An Ixodes scapularis protein required for survival of Anaplasma phagocytophilum in tick salivary glands
    Bindu Sukumaran
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 203:1507-17. 2006
    ..These data demonstrate the specific requirement of a pathogen for a tick salivary protein to persist within the arthropod and provide a paradigm for understanding how Rickettsia-like pathogens are maintained within vectors...
  13. pmc Characterization of Ixophilin, a thrombin inhibitor from the gut of Ixodes scapularis
    Sukanya Narasimhan
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 8:e68012. 2013
    ....
  14. pmc Toll-like receptors 1 and 2 heterodimers alter Borrelia burgdorferi gene expression in mice and ticks
    Erol Fikrig
    Section of Infectious Diseases, Department of Internal Medicine, 2Howard Hughes Medical Institute, and 3Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut
    J Infect Dis 200:1331-40. 2009
    ....
  15. pmc Antibodies against a tick protein, Salp15, protect mice from the Lyme disease agent
    Jianfeng Dai
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell Host Microbe 6:482-92. 2009
    ....
  16. pmc Anaplasma phagocytophilum AptA modulates Erk1/2 signalling
    Bindu Sukumaran
    Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8022, USA
    Cell Microbiol 13:47-61. 2011
    ..These observations reveal a major role for the bacterial protein, AptA, and the host protein, vimentin, in the activation of Erk1/2 during A. phagocytophilum infection...
  17. pmc Disruption of Ixodes scapularis anticoagulation by using RNA interference
    Sukanya Narasimhan
    Sections of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 101:1141-6. 2004
    ..These studies demonstrate that RNA interference can silence I. scapularis genes and disrupt their physiologic function in vivo, and they identify vaccine candidates that can alter vector engorgement...
  18. pmc Inhibition of neutrophil function by two tick salivary proteins
    Xiuyang Guo
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520 8031, USA
    Infect Immun 77:2320-9. 2009
    ..Our results suggest that ISL 929 and ISL 1373 contribute to the inhibition of PMN functions shown previously with tick saliva and support important roles for these inhibitory proteins in the modulation of PMN function in vivo...
  19. pmc Identification and characterization of Ixodes scapularis antigens that elicit tick immunity using yeast surface display
    Tim J Schuijt
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 6:e15926. 2011
    ..These studies also suggest that these antigens may serve as potential vaccine candidates to thwart tick feeding...
  20. pmc Borrelia burgdorferi transcriptome in the central nervous system of non-human primates
    Sukanya Narasimhan
    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 100:15953-8. 2003
    ..burgdorferi gene expression in vivo. The results provide a global snapshot of the spirochetal transcriptome in the CNS and should spur the design of experiments aimed at understanding the molecular basis of neuroborreliosis...
  21. pmc Examination of the Borrelia burgdorferi transcriptome in Ixodes scapularis during feeding
    Sukanya Narasimhan
    Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, L Diagnostics, New Haven, Connecticut 06520, USA
    J Bacteriol 184:3122-5. 2002
    ..These data demonstrate a new approach to the global analysis of B. burgdorferi genes that are preferentially expressed within the vector during feeding...
  22. pmc A Tick Gut Protein with Fibronectin III Domains Aids Borrelia burgdorferi Congregation to the Gut during Transmission
    Sukanya Narasimhan
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS Pathog 10:e1004278. 2014
    ..Our observations suggest that the interaction between Borrelia and Ixofin3D facilitates spirochete congregation to the gut during transmission, and provides a "molecular exit" direction for spirochete egress from the gut. ..
  23. ncbi request reprint Borrelia burgdorferi--traveling incognito?
    Erol Fikrig
    Section of Rheumatology, Department of Medicine, Yale University School of Medicine, Room 525A, 300 Cedar Street, New Haven, CT 06520 8031, USA
    Microbes Infect 8:1390-9. 2006
    ..The survival strategies utilized by the spirochete during transmission and the initial stages of infection are discussed...
  24. ncbi request reprint The Lyme disease agent exploits a tick protein to infect the mammalian host
    Nandhini Ramamoorthi
    Sections of Rheumatology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nature 436:573-7. 2005
    ..scapularis drastically reduced the capacity of tick-borne spirochaetes to infect mice. These results show the capacity of a pathogen to use a secreted arthropod protein to help it colonize the mammalian host...

Research Grants5

  1. Early tick salivary antigens as vaccine targets
    Sukanya Narasimhan; Fiscal Year: 2006
    ..The antigens will be prioritized based on their role in feeding and Borrelia transmission and vaccine candidates determined. Results obtained will provide the basis for future vaccine development studies. ..
  2. BORRELIA BURGDORFERI GENE EXPRESSION IN TICK MIDGUT--ROL
    Sukanya Narasimhan; Fiscal Year: 2002
    ..The investigation will also be conducive to the development of a useful molecular tool/approach to analyze the gene expression patterns of other vector-borne pathogens in their vector environment. ..
  3. Molecular analysis of tick-spirochete interactions
    Sukanya Narasimhan; Fiscal Year: 2003
    ..This investigation will also serve to pave the way for elucidation of mechanisms underlying transmission of other tick-borne pathogens. ..
  4. Tick gene expression- in the context of Lyme disease
    Sukanya Narasimhan; Fiscal Year: 2005
    ..This investigation may therefore serve to pave the way for elucidation of mechanisms underlying transmission of other tick-borne pathogens. ..