Frederick Naftolin

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Mouse ascites golgi (MAG) mucin expression and regulation by progesterone in the rat uterus
    L B Schwartz
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Soc Gynecol Investig 8:216-23. 2001
  2. ncbi request reprint Postmenopausal hormone therapy: new questions and the case for new clinical trials
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 13:139-47. 2006
  3. ncbi request reprint Prevention during the menopause is critical for good health: skin studies support protracted hormone therapy
    Frederick Naftolin
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Fertil Steril 84:293-4; discussion 295. 2005
  4. ncbi request reprint The Women's Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition
    Frederick Naftolin
    Yale University, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 81:1498-501. 2004
  5. ncbi request reprint Keeping medicine and science together
    Frederick Naftolin
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, P O Box 208063, New Haven, Connecticut 06520 8063, USA
    Exp Biol Med (Maywood) 229:437-8. 2004
  6. ncbi request reprint Estrogen synthetase (aromatase) immunohistochemistry reveals concordance between avian and rodent limbic systems and hypothalami
    F Naftolin
    Reproductive Neuroscience Unit, Department of Obstetrics and Gynecology and Center for Research in Reproductive Biology, Yale University, New Haven, Connecticut 06520, USA
    Exp Biol Med (Maywood) 226:717-25. 2001
  7. ncbi request reprint The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    J Psychopharmacol 21:414-20. 2007
  8. ncbi request reprint Low-dose estrogen therapy for prevention of osteoporosis: working our way back to monotherapy
    Susan Richman
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, CT 06520, USA
    Menopause 13:148-55. 2006
  9. ncbi request reprint Estrogen-induced hypothalamic synaptic plasticity and pituitary sensitization in the control of the estrogen-induced gonadotrophin surge
    Frederick Naftolin
    Reproductive Neuroscience Unit, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Reprod Sci 14:101-16. 2007
  10. ncbi request reprint Estradiol and tryptophan depletion interact to modulate cognition in menopausal women
    Zenab Amin
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 31:2489-97. 2006

Detail Information

Publications44

  1. ncbi request reprint Mouse ascites golgi (MAG) mucin expression and regulation by progesterone in the rat uterus
    L B Schwartz
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    J Soc Gynecol Investig 8:216-23. 2001
    ..CONCLUSION: Our results suggest that the MAG epitope is cyclically expressed and induced by P in rat endometrial glands...
  2. ncbi request reprint Postmenopausal hormone therapy: new questions and the case for new clinical trials
    JoAnn E Manson
    Division of Preventive Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Menopause 13:139-47. 2006
    ....
  3. ncbi request reprint Prevention during the menopause is critical for good health: skin studies support protracted hormone therapy
    Frederick Naftolin
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Fertil Steril 84:293-4; discussion 295. 2005
    ..Estrogen replacement therapy maintains the skin. Similar effects must be investigated in other organ systems...
  4. ncbi request reprint The Women's Health Initiative could not have detected cardioprotective effects of starting hormone therapy during the menopausal transition
    Frederick Naftolin
    Yale University, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, Connecticut 06520 8063, USA
    Fertil Steril 81:1498-501. 2004
    ..Randomized controlled trials are urgently needed to test cardioprotection in women starting treatment during the menopausal transition...
  5. ncbi request reprint Keeping medicine and science together
    Frederick Naftolin
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University, P O Box 208063, New Haven, Connecticut 06520 8063, USA
    Exp Biol Med (Maywood) 229:437-8. 2004
  6. ncbi request reprint Estrogen synthetase (aromatase) immunohistochemistry reveals concordance between avian and rodent limbic systems and hypothalami
    F Naftolin
    Reproductive Neuroscience Unit, Department of Obstetrics and Gynecology and Center for Research in Reproductive Biology, Yale University, New Haven, Connecticut 06520, USA
    Exp Biol Med (Maywood) 226:717-25. 2001
    ....
  7. ncbi request reprint The resistance to depressive relapse in menopausal women undergoing tryptophan depletion: preliminary findings
    C Neill Epperson
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    J Psychopharmacol 21:414-20. 2007
    ..While preliminary, the results suggest that serotonin may be less critical to the pathogenesis of depression during the menopause...
  8. ncbi request reprint Low-dose estrogen therapy for prevention of osteoporosis: working our way back to monotherapy
    Susan Richman
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, New Haven, CT 06520, USA
    Menopause 13:148-55. 2006
    ..Additional studies are warranted to shed further light on the possible benefits of low-dose estrogen monotherapy for the prevention of bone loss in postmenopausal women...
  9. ncbi request reprint Estrogen-induced hypothalamic synaptic plasticity and pituitary sensitization in the control of the estrogen-induced gonadotrophin surge
    Frederick Naftolin
    Reproductive Neuroscience Unit, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Reprod Sci 14:101-16. 2007
    ..This enhanced understanding of the mechanics of gonadotrophin control clarifies elements of the involved feedback loops and opens the way to a better understanding of the neurobiology of reproduction...
  10. ncbi request reprint Estradiol and tryptophan depletion interact to modulate cognition in menopausal women
    Zenab Amin
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511, USA
    Neuropsychopharmacology 31:2489-97. 2006
    ..These data support the interaction of estrogen and 5-HT in nonreproductive behavior in humans as well as highlight the role of ovarian steroids in cognition...
  11. ncbi request reprint Menopause: developing a rational treatment plan
    Danielle Vitiello
    Division of Reproductive Endocrinology, Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut, USA
    Gynecol Endocrinol 23:682-91. 2007
    ..Through the use of extensive patient history, quality-of-life questionnaires and powerful biological profiling, we may be able to develop a rational approach to menopausal HT that safely guides our patients through this transition...
  12. ncbi request reprint Diagnostic microarray: an array of possibilities for parasitology
    A Fadiel
    Department of OBGYN, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Egypt Soc Parasitol 34:65-82. 2004
    ..As microarray technology improves and its cost decreases, the role of ability to "see" the molecular biology pathways involved in parasite host relationships will place this technology at the forefront of parasite research...
  13. ncbi request reprint Protein misfolding and misprocessing in complex disease
    A Fadiel
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06520, USA
    Protein Pept Lett 12:499-506. 2005
    ....
  14. ncbi request reprint Heterogeneity in the neuropeptide Y-containing neurons of the rat arcuate nucleus: GABAergic and non-GABAergic subpopulations
    T L Horvath
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Brain Res 756:283-6. 1997
    ..This heterogeneity in the neuropeptide Y-producing perikarya of the hypothalamus may help explain adverse neuroendocrine and behavioral effects of arcuate nucleus neuropeptide Y...
  15. ncbi request reprint Aromatase in axonal processes of early postnatal hypothalamic and limbic areas including the cingulate cortex
    T L Horvath
    Department of Obstetrics and Gynecology, New Haven, CT 06520, U S A
    J Steroid Biochem Mol Biol 61:349-57. 1997
    ....
  16. ncbi request reprint Effect of estrogen on brain activation patterns in postmenopausal women during working memory tasks
    S E Shaywitz
    Department of Pediatrics, School of Medicine, Yale University, New Haven, Conn 06510 8064, USA
    JAMA 281:1197-202. 1999
    ....
  17. ncbi request reprint Fasting-induced increase in type II iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus
    S Diano
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endocrinology 139:2879-84. 1998
    ..This local hyperthyroidism may, in turn, induce the suppression of TRH under these conditions...
  18. ncbi request reprint Estrogen is essential for maintaining nigrostriatal dopamine neurons in primates: implications for Parkinson's disease and memory
    C Leranth
    Departments of Obstetrics and Gynecology, Psychiatry, Pharmacology, and Neurosurgery and Section of Neurobiology, Yale University, School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Neurosci 20:8604-9. 2000
    ....
  19. ncbi request reprint Mitochondrial uncoupling protein 2 (UCP2) in the nonhuman primate brain and pituitary
    S Diano
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Endocrinology 141:4226-38. 2000
    ..The abundance and distribution pattern of UCP2 in the primate brain and pituitary suggest that this protein is evolutionary conserved and may relate to central autonomic, endocrine and metabolic regulation...
  20. ncbi request reprint Regulation of fas ligand expression in breast cancer cells by estrogen: functional differences between estradiol and tamoxifen
    G Mor
    Department of Obstetrics and Gynecology, Yale University Medical School, 333 Cedar St FMB 202, New Haven, CT 06520, USA
    J Steroid Biochem Mol Biol 73:185-94. 2000
    ..These studies provide evidence that tamoxifen inhibits FasL expression, allowing the killing of cancer cells by activated lymphocytes. This partially explains the protective effect of tamoxifen against breast cancer...
  21. ncbi request reprint The influence of environmental adaptation on bacterial genome structure
    A Fadiel
    The Bioinformatics Supercomputing Centre, The Hospital for Sick Children, Toronto, ON, Canada
    Lett Appl Microbiol 40:12-8. 2005
    ..The aim of this investigation was to explore genomic changes mandated by organismal adaptation to its ecological niches...
  22. ncbi request reprint Estradiol prevents neural tau hyperphosphorylation characteristic of Alzheimer's disease
    Margarita Alvarez-de-la-Rosa
    Department of Obstetrics and Gynecology, Yale University, P O Box 208063, New Haven, CT 06520 8063, USA
    Ann N Y Acad Sci 1052:210-24. 2005
    ..This assumes special significance because the estrogen action was found to be sexually dimorphic in rat cortical neurons and differentiation-sensitive in human neuroblastoma cells...
  23. ncbi request reprint 17alpha-methyl testosterone is a competitive inhibitor of aromatase activity in Jar choriocarcinoma cells and macrophage-like THP-1 cells in culture
    G Mor
    Department of Obstetrics and Gynecology, Center for Research in Reproductive Biology and Reproductive Neuroscience Unit, Yale University Medical School, 333 Cedar Street, FMB 335, New Haven, CT 06520 8063, USA
    J Steroid Biochem Mol Biol 79:239-46. 2001
    ..17alpha-methyl testosterone may, as a functional androgen and orally active steroidal inhibitor of endogenous estrogen production, also offer special possibilities for the prevention/treatment of hormone-sensitive cancers...
  24. ncbi request reprint Estrogen, synaptic plasticity and hypothalamic reproductive aging
    A J Hung
    Reproductive Neuroscience Unit, Department of Obstetrics and Gynecology, Yale University School of Medicine, P O Box 208063, 333 Cedar Street, FMB 335, New Haven, CT 06520 8063, USA
    Exp Gerontol 38:53-9. 2003
    ....
  25. pmc Roles of Fas and Fas ligand during mammary gland remodeling
    J Song
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Clin Invest 106:1209-20. 2000
    ..Furthermore, this autocrine induction of apoptosis may prevent accumulation of cells with mutations and subsequent neoplastic development. Failure of the Fas/FasL signal could contribute to tumor development...
  26. ncbi request reprint Better oral reading and short-term memory in midlife, postmenopausal women taking estrogen
    Sally E Shaywitz
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06510 8064, USA
    Menopause 10:420-6. 2003
    ..For the most part, the cognitive processes studied have involved memory; to our knowledge, no previous studies have specifically examined the effects of estrogen on women's reading ability...
  27. ncbi request reprint Estradiol-induced ezrin overexpression in ovarian cancer: a new signaling domain for estrogen
    Joon Song
    Department of Obstetrics and Gynecology, Yale University, P O Box 208063, 333 Cedar Street, FMB 331, New Haven, CT 06520 8063, USA
    Cancer Lett 220:57-65. 2005
    ..This previously unreported effect of estrogen on ezrin expression may play a role in the clinical course of estrogen-sensitive cancers and other normal or diseased cell actions...
  28. ncbi request reprint Hormonal regulation of apoptosis and the Fas and Fas ligand system in human endometrial cells
    Joon Song
    Department of Obstetrics and Gynecology, Yale University, School of Medicine, 333 Cedar St FMB 202, New Haven, CT 06520, USA
    Mol Hum Reprod 8:447-55. 2002
    ..Our results indicate that Fas-mediated apoptosis is important for endometrial cycling and suggest that dysregulation of the Fas/FasL interactions may have an important role in the development of endometrial cancer...
  29. ncbi request reprint Ovarian epithelial carcinoma tyrosine phosphorylation, cell proliferation, and ezrin translocation are stimulated by interleukin 1alpha and epidermal growth factor
    Z Chen
    Yale University, School of Medicine, Obstetrics and Gynecology Department, New Haven, Connecticut 06520-8063, USA
    Cancer 92:3068-75. 2001
    ..The authors' results may partially explain why OVCA patients with positive macrophage colony stimulating factor (a chemoattractant of IL-1alpha secreting monocytes) or EGF receptors (c-erb B-2) have a poor prognosis...
  30. ncbi request reprint Estrogen and the aging brain
    I Silva
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar St, FMB 335, PO Box 208063, New Haven, CT 06520-8063, USA
    Maturitas 38:95-100; discussion 100-1. 2001
    ..This has potentially lethal consequences for brain cells, and may contribute to brain pathologies such as Alzheimer's disease...
  31. ncbi request reprint Estrogen and microglia: A regulatory system that affects the brain
    G Mor
    Department of Obstetrics and Gynecology and Center for Reproductive Biology, Yale University Medical School, 333 Cedar St FMB 202, New Haven, Connecticut 06520, USA
    J Neurobiol 40:484-96. 1999
    ..Moreover, we present evidence for the presence of estrogen receptor-beta (ERbeta) in rat microglial cells...
  32. ncbi request reprint Immunohistochemical localization of aromatase cytochrome P-450 and estradiol dehydrogenase in the syncytiotrophoblast of the human placenta
    N Fournet-Dulguerov
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06510
    J Clin Endocrinol Metab 65:757-64. 1987
    ..These findings suggest that the syncytiotrophoblast is actively involved in the synthesis and metabolism of estrogens and in their role in placental endocrine function...
  33. ncbi request reprint Is the WHI relevant to HRT started in the perimenopause?
    S Mitchell Harman
    Kronos Longevity Research Institute, Phoenix, AZ, USA
    Endocrine 24:195-202. 2004
    ..Furthermore, animal and clinical evidence supports the use of lower doses of estrogen than were employed in the WHI in older/longer postmenopausal women...
  34. ncbi request reprint Is the estrogen controversy over? Deconstructing the Women's Health Initiative study: a critical evaluation of the evidence
    S Mitchell Harman
    Kronos Longevity Research Institute, 2222 E Highland, Ste 220, Phoenix, AZ 85016, USA
    Ann N Y Acad Sci 1052:43-56. 2005
    ..It will examine surrogate end points as well as risk factors for atherosclerosis...
  35. ncbi request reprint Phytoestrogens: are they really estrogen mimics?
    Frederick Naftolin
    Fertil Steril 77:15-7. 2002
  36. ncbi request reprint Women, hormones, and clinical trials: a beginning, not an end
    Virginia M Miller
    J Appl Physiol 99:381-3. 2005
  37. ncbi request reprint Estrogen, estrogen treatment and the post-reproductive woman's brain
    Frederick Naftolin
    Department of Obstetrics and Gynecology New York University, New York 10016, USA
    Maturitas 57:23-6. 2007
    ..This review will therefore address the full picture, with stress on the later-life role of estrogen in the brain...
  38. ncbi request reprint Direct identification of proteins from T47D cells and murine brain tissue by matrix-assisted laser desorption/ionization post-source decay/collision-induced dissociation
    Paul H Pevsner
    Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA
    Rapid Commun Mass Spectrom 21:429-36. 2007
    ..Refinements in preparation techniques may improve this approach to provide a tool for quantitative proteomics and clinical analysis...
  39. ncbi request reprint Development of low-dose reproductive hormone therapies in China
    Qinsheng Ge
    Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China
    Gynecol Endocrinol 22:636-45. 2006
    ..These results highlight the urgent need for larger, prospective trials of long-term low-dose HRT started during the perimenopausal period...
  40. ncbi request reprint Is progestogen supplementation of ERT really necessary?
    Frederick Naftolin
    Menopause 9:1-2. 2002
  41. ncbi request reprint Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway
    Tommaso Simoncini
    Molecular and Cellular Gynecological Endocrinology Laboratory, Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Mol Endocrinol 20:1756-71. 2006
    ..Furthermore, exposure of this estrogen receptor-dependent, nongenomic action of estrogen on human vascular endothelial cells is especially relevant to the present interest in the role of estrogen in cardiovascular protection...
  42. ncbi request reprint Stopping HABITS
    Hugh S Taylor
    Lancet 363:1476; author reply 1477. 2004
  43. ncbi request reprint Progesterone abolishes estrogen and/or atorvastatin endothelial dependent vasodilatory effects
    Frederick Naftolin
    Atherosclerosis 181:411; author reply 413. 2005
  44. pmc Estradiol-induced synaptic remodeling of tyrosine hydroxylase immunopositive neurons in the rat arcuate nucleus
    Eszter Csakvari
    Laboratory of Molecular Neurobiology, Institute of Biophysics, Biological Research Center, H 6701 Szeged, Hungary
    Endocrinology 149:4137-41. 2008
    ..The hormone-induced plastic changes in synaptic connectivity of TH-IR neurons may serve as the morphological basis for the cyclical regulation of the anterior pituitary...