WALTHER H contact MOTHES

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions
    James B Munro
    Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    Science 346:759-63. 2014
  2. pmc Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells
    Maik J Lehmann
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 170:317-25. 2005
  3. pmc Murine leukemia virus spreading in mice impaired in the biogenesis of secretory lysosomes and Ca2+-regulated exocytosis
    Wai Tsing Chan
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 3:e2713. 2008
  4. pmc Assembly of the murine leukemia virus is directed towards sites of cell-cell contact
    Jing Jin
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA
    PLoS Biol 7:e1000163. 2009
  5. pmc Surface Transmission or Polarized Egress? Lessons Learned from HTLV Cell-to-Cell Transmission
    Jing Jin
    Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Ave, New Haven, CT 06536, USA
    Viruses 2:601-5. 2010
  6. pmc Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV
    Peng Zhong
    Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA
    PLoS ONE 8:e53138. 2013
  7. pmc Virus cell-to-cell transmission
    Walther Mothes
    Microbial Pathogenesis, Yale School of Medicine, 295 Congress Ave, BCMM 335, New Haven, CT 06536, USA
    J Virol 84:8360-8. 2010
  8. pmc Viral determinants of polarized assembly for the murine leukemia virus
    Jing Jin
    Microbial Pathogenesis, Yale School of Medicine, 295 Congress Ave, BCMM 335, New Haven, CT 06536, USA
    J Virol 85:7672-82. 2011

Research Grants

  1. Retroviral Egress via Multivesicular Bodies
    Walther Mothes; Fiscal Year: 2006

Collaborators

  • Nathan M Sherer
  • Jing Jin
  • James B Munro
  • Peng Zhong
  • David Derse
  • Gisela Heidecker
  • Pradeep D Uchil
  • Wai Tsing Chan
  • Maik J Lehmann
  • Wayne C Koff
  • Joel R Courter
  • Dennis R Burton
  • Jason Gorman
  • Peter D Kwong
  • Zhou Zhou
  • James Arthos
  • Xiaochu Ma
  • Amos B Smith
  • Scott C Blanchard
  • Anna Ilinskaya
  • Rosaline Truong
  • Batsukh Dorjbal
  • Luis M Agosto
  • Fei Li
  • Richard T Swank
  • Edward K Novak
  • Carolyn B Marks
  • Marc Pypaert

Detail Information

Publications8

  1. doi request reprint Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions
    James B Munro
    Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    Science 346:759-63. 2014
    ..The distinct properties of neutralization-sensitive and neutralization-resistant HIV-1 isolates support a dynamics-based mechanism of immune evasion and ligand recognition. ..
  2. pmc Actin- and myosin-driven movement of viruses along filopodia precedes their entry into cells
    Maik J Lehmann
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06536, USA
    J Cell Biol 170:317-25. 2005
    ..Our results reveal another example of viruses hijacking host machineries for efficient infection by using the inherent ability of filopodia to transport ligands to the cell body...
  3. pmc Murine leukemia virus spreading in mice impaired in the biogenesis of secretory lysosomes and Ca2+-regulated exocytosis
    Wai Tsing Chan
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 3:e2713. 2008
    ..Retroviruses have been observed to bud intracellularly into multivesicular bodies (MVB), in addition to the plasma membrane. Release from MVB is thought to occur by Ca(2+)-regulated fusion with the plasma membrane...
  4. pmc Assembly of the murine leukemia virus is directed towards sites of cell-cell contact
    Jing Jin
    Section of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA
    PLoS Biol 7:e1000163. 2009
    ..Our data describe a novel role for the viral Env glycoprotein in establishing cell-cell adhesion and polarization of assembly prior to becoming a fusion protein to allow virus entry into cells...
  5. pmc Surface Transmission or Polarized Egress? Lessons Learned from HTLV Cell-to-Cell Transmission
    Jing Jin
    Section of Microbial Pathogenesis, Yale University School of Medicine, 295 Congress Ave, New Haven, CT 06536, USA
    Viruses 2:601-5. 2010
    ..Guadagnini, S.; Robbiati, V.; Lasserre, R.; Gessain, A.; Gout, O.; Alcover, A.; Thoulouze, M.I. Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses. Nat. Med.2010, 16, 83-89...
  6. pmc Cell-to-cell transmission can overcome multiple donor and target cell barriers imposed on cell-free HIV
    Peng Zhong
    Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT, USA
    PLoS ONE 8:e53138. 2013
    ....
  7. pmc Virus cell-to-cell transmission
    Walther Mothes
    Microbial Pathogenesis, Yale School of Medicine, 295 Congress Ave, BCMM 335, New Haven, CT 06536, USA
    J Virol 84:8360-8. 2010
    ..An understanding of viral cell-to-cell spreading will enhance our ability to intervene in the efficient spreading of viral infections...
  8. pmc Viral determinants of polarized assembly for the murine leukemia virus
    Jing Jin
    Microbial Pathogenesis, Yale School of Medicine, 295 Congress Ave, BCMM 335, New Haven, CT 06536, USA
    J Virol 85:7672-82. 2011
    ..Rudnicka et al., J. Virol. 83:6234-6246, 2009). As such, we observed two distinct modes of virus cell-to-cell transmission that involve either polarized or nonpolarized assembly, but both result in virus transmission...

Research Grants1

  1. Retroviral Egress via Multivesicular Bodies
    Walther Mothes; Fiscal Year: 2006
    ..abstract_text> ..