Research Topics
| Peter T MorganSummaryAffiliation: Yale University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Sleep, sleep-dependent procedural learning and vigilance in chronic cocaine users: Evidence for occult insomniaPeter T Morgan
Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, Clinical Neuroscience Research Unit, 34 Park Street, New Haven, CT 06519, USA
Drug Alcohol Depend 82:238-49. 2006..However, they report subjectively improving sleep, indicating they are unaware of this "occult" insomnia. These results suggest the possibility of homeostatic sleep drive dysregulation in chronic cocaine users...- Cocaine and sleep: early abstinencePeter T Morgan
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
ScientificWorldJournal 7:223-30. 2007..Here we review the relevant literature on cocaine use and sleep, and discuss the possible relevance of this sleep disturbance in relationship to the underlying disorder and its treatment... 
Cortical GABA levels in primary insomniaPeter T Morgan
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Sleep 35:807-14. 2012..We sought to measure cortical GABA content through proton magnetic resonance spectroscopy (MRS) in persons with and without primary insomnia, and relate brain GABA levels to polysomnographic sleep measures...- Sex differences in sleep and sleep-dependent learning in abstinent cocaine usersPeter T Morgan
Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA
Pharmacol Biochem Behav 93:54-8. 2009..The absence of sleep disturbances in women suggests a need to understand the mechanisms underlying these differences, as such knowledge could lead to novel therapies in cocaine dependence... 
Sleep architecture, cocaine and visual learningPeter T Morgan
Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA
Addiction 103:1344-52. 2008..We hypothesized that sleep-related cognitive function would be impaired in chronic cocaine users, and that this impairment would be associated with abstinence-related changes in sleep architecture...- Pilot study of lorazepam and tiagabine effects on sleep, motor learning, and impulsivity in cocaine abstinencePeter T Morgan
Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06519, USA
Am J Drug Alcohol Abuse 34:692-702. 2008..To test the effects of mechanistically different GABA modulating agents on the disrupted sleep and cognitive function associated with abstinence from cocaine... - Normalizing effects of modafinil on sleep in chronic cocaine usersPeter T Morgan
Connecticut Mental Health Center, Yale University Department of Psychiatry, New Haven, CT 06519, USA
Am J Psychiatry 167:331-40. 2010..The purpose of the present study was to determine the effect of morning-dosed modafinil on sleep and daytime sleepiness in chronic cocaine users... - Retrograde effects of triazolam and zolpidem on sleep-dependent motor learning in humansPeter T Morgan
Department of Psychiatry, Yale University, 34 Park Street, New Haven, CT 06519, USA
J Sleep Res 19:157-64. 2010..These data indicate that non-selective or alpha1-preferring benzodiazepine site allosteric activators can interfere with sleep-dependent memory consolidation... - Gender-related influences of parental alcoholism on the prevalence of psychiatric illnesses: analysis of the National Epidemiologic Survey on Alcohol and Related ConditionsPeter T Morgan
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Alcohol Clin Exp Res 34:1759-67. 2010..In this study, we tested the hypothesis that the gender of the parent with alcoholism and the gender of offspring affect the association between parental alcoholism and offspring psychiatric illness... - Cocaine users differ from normals on cognitive tasks which show poorer performance during drug abstinenceEdward F Pace-Schott
Department of Psychiatry, Harvard Medical School and Center for Sleep and Cognition, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
Am J Drug Alcohol Abuse 34:109-21. 2008.... - Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findingsHelen C Fox
The Connecticut Mental Health Center, Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA
J Psychopharmacol 26:958-72. 2012..Data suggest further exploration of guanfacine is warranted in terms of its potential for reducing stress-induced and cue-induced drug craving and arousal... - Regulation of cocaine self-administration in humans: lack of evidence for loading and maintenance phasesGustavo A Angarita
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Pharmacol Biochem Behav 95:51-5. 2010..We sought to examine whether similar phases might characterize self-regulated cocaine use in humans... - Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent femalesHelen C Fox
Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
Psychopharmacology (Berl) 195:527-36. 2008..There is growing evidence of alterations in brain stress and reward circuits associated with cocaine dependence. Sex differences are also documented and sex steroid hormones have been linked to cocaine reinforcement... - Prazosin effects on stress- and cue-induced craving and stress response in alcohol-dependent individuals: preliminary findingsHelen C Fox
The Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
Alcohol Clin Exp Res 36:351-60. 2012..Here we report findings from a preliminary efficacy study of the alpha-1 receptor antagonist, prazosin, in modulating these relapse-relevant factors in alcohol-dependent individuals... - Sex steroid hormones, stress response, and drug craving in cocaine-dependent women: implications for relapse susceptibilityRajita Sinha
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Exp Clin Psychopharmacol 15:445-52. 2007.... - Night eating in obese treatment-seeking Hispanic patients with and without binge eating disorderCarlos M Grilo
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Int J Eat Disord 45:787-91. 2012..To examine the frequency of night eating (NE) and its relation to binge eating disorder (BED), eating-disorder psychopathology, depression, and metabolic variables in treatment-seeking obese Hispanic men and women... - Self-reported paranoia during laboratory "binge" cocaine self-administration in humansRasmon Kalayasiri
Department of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, USA
Pharmacol Biochem Behav 83:249-56. 2006..Such methods may facilitate our understanding of the vulnerability to CIP in humans... - Exploring weight gain in year before treatment for binge eating disorder: a different context for interpreting limited weight losses in treatment studiesKerstin K Blomquist
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520 8098, USA
Int J Eat Disord 44:435-9. 2011..To examine weight changes in obese patients with binge-eating disorder (BED) during the year before seeking treatment and to explore correlates of weight changes... - Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patientsChiang Shan R Li
Department of Psychiatry, Yale University, New Haven, CT 06519, USA
Proc Natl Acad Sci U S A 107:14455-9. 2010..Altered ventromedial prefrontal activation and increased blood pressure may represent useful CNS and peripheral biomarkers in individualized treatment with methylphenidate for patients with cocaine dependence... - NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophreniaAlan Anticevic
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 109:16720-5. 2012..Together, the present findings establish links between glutamate's role in the organization of large-scale anticorrelated neural systems, cognition, and symptoms associated with schizophrenia in humans... - An examination of the food addiction construct in obese patients with binge eating disorderAshley N Gearhardt
Department of Psychology, Yale University, New Haven, CT 06511, USA
Int J Eat Disord 45:657-63. 2012..This study examined the psychometric properties of the Yale food addiction scale (YFAS) in obese patients with binge eating disorder (BED) and explored its association with measures of eating disorder and associated psychopathology... - Chest tightness and palpitations associated with modafinil and consumption of free glutamatePeter T Morgan
Am J Psychiatry 165:538. 2008
Research Grants
- Modafinil, sleep architecture, and cocaine relapsePeter T Morgan; Fiscal Year: 2010..If confirmed, this hypothesis will provide a neurophysiological explanation for the effectiveness o f modafinil and introduce sleep improvement as an essential part of the treatment of stimulant dependence. ..