Peter T Morgan

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Sleep, sleep-dependent procedural learning and vigilance in chronic cocaine users: Evidence for occult insomnia
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, Clinical Neuroscience Research Unit, 34 Park Street, New Haven, CT 06519, USA
    Drug Alcohol Depend 82:238-49. 2006
  2. ncbi request reprint Cocaine and sleep: early abstinence
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    ScientificWorldJournal 7:223-30. 2007
  3. pmc Cortical GABA levels in primary insomnia
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Sleep 35:807-14. 2012
  4. pmc Gender-related influences of parental alcoholism on the prevalence of psychiatric illnesses: analysis of the National Epidemiologic Survey on Alcohol and Related Conditions
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Alcohol Clin Exp Res 34:1759-67. 2010
  5. doi request reprint Normalizing effects of modafinil on sleep in chronic cocaine users
    Peter T Morgan
    Connecticut Mental Health Center, Yale University Department of Psychiatry, New Haven, CT 06519, USA
    Am J Psychiatry 167:331-40. 2010
  6. doi request reprint Retrograde effects of triazolam and zolpidem on sleep-dependent motor learning in humans
    Peter T Morgan
    Department of Psychiatry, Yale University, 34 Park Street, New Haven, CT 06519, USA
    J Sleep Res 19:157-64. 2010
  7. pmc Sex differences in sleep and sleep-dependent learning in abstinent cocaine users
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA
    Pharmacol Biochem Behav 93:54-8. 2009
  8. pmc Sleep architecture, cocaine and visual learning
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA
    Addiction 103:1344-52. 2008
  9. doi request reprint Pilot study of lorazepam and tiagabine effects on sleep, motor learning, and impulsivity in cocaine abstinence
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06519, USA
    Am J Drug Alcohol Abuse 34:692-702. 2008
  10. ncbi request reprint Cocaine users differ from normals on cognitive tasks which show poorer performance during drug abstinence
    Edward F Pace-Schott
    Department of Psychiatry, Harvard Medical School and Center for Sleep and Cognition, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Am J Drug Alcohol Abuse 34:109-21. 2008

Research Grants

Detail Information

Publications25

  1. ncbi request reprint Sleep, sleep-dependent procedural learning and vigilance in chronic cocaine users: Evidence for occult insomnia
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, Clinical Neuroscience Research Unit, 34 Park Street, New Haven, CT 06519, USA
    Drug Alcohol Depend 82:238-49. 2006
    ..However, they report subjectively improving sleep, indicating they are unaware of this "occult" insomnia. These results suggest the possibility of homeostatic sleep drive dysregulation in chronic cocaine users...
  2. ncbi request reprint Cocaine and sleep: early abstinence
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    ScientificWorldJournal 7:223-30. 2007
    ..Here we review the relevant literature on cocaine use and sleep, and discuss the possible relevance of this sleep disturbance in relationship to the underlying disorder and its treatment...
  3. pmc Cortical GABA levels in primary insomnia
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Sleep 35:807-14. 2012
    ..We sought to measure cortical GABA content through proton magnetic resonance spectroscopy (MRS) in persons with and without primary insomnia, and relate brain GABA levels to polysomnographic sleep measures...
  4. pmc Gender-related influences of parental alcoholism on the prevalence of psychiatric illnesses: analysis of the National Epidemiologic Survey on Alcohol and Related Conditions
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Alcohol Clin Exp Res 34:1759-67. 2010
    ..In this study, we tested the hypothesis that the gender of the parent with alcoholism and the gender of offspring affect the association between parental alcoholism and offspring psychiatric illness...
  5. doi request reprint Normalizing effects of modafinil on sleep in chronic cocaine users
    Peter T Morgan
    Connecticut Mental Health Center, Yale University Department of Psychiatry, New Haven, CT 06519, USA
    Am J Psychiatry 167:331-40. 2010
    ..The purpose of the present study was to determine the effect of morning-dosed modafinil on sleep and daytime sleepiness in chronic cocaine users...
  6. doi request reprint Retrograde effects of triazolam and zolpidem on sleep-dependent motor learning in humans
    Peter T Morgan
    Department of Psychiatry, Yale University, 34 Park Street, New Haven, CT 06519, USA
    J Sleep Res 19:157-64. 2010
    ..These data indicate that non-selective or alpha1-preferring benzodiazepine site allosteric activators can interfere with sleep-dependent memory consolidation...
  7. pmc Sex differences in sleep and sleep-dependent learning in abstinent cocaine users
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA
    Pharmacol Biochem Behav 93:54-8. 2009
    ..The absence of sleep disturbances in women suggests a need to understand the mechanisms underlying these differences, as such knowledge could lead to novel therapies in cocaine dependence...
  8. pmc Sleep architecture, cocaine and visual learning
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA
    Addiction 103:1344-52. 2008
    ..We hypothesized that sleep-related cognitive function would be impaired in chronic cocaine users, and that this impairment would be associated with abstinence-related changes in sleep architecture...
  9. doi request reprint Pilot study of lorazepam and tiagabine effects on sleep, motor learning, and impulsivity in cocaine abstinence
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06519, USA
    Am J Drug Alcohol Abuse 34:692-702. 2008
    ..To test the effects of mechanistically different GABA modulating agents on the disrupted sleep and cognitive function associated with abstinence from cocaine...
  10. ncbi request reprint Cocaine users differ from normals on cognitive tasks which show poorer performance during drug abstinence
    Edward F Pace-Schott
    Department of Psychiatry, Harvard Medical School and Center for Sleep and Cognition, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Am J Drug Alcohol Abuse 34:109-21. 2008
    ....
  11. pmc Guanfacine effects on stress, drug craving and prefrontal activation in cocaine dependent individuals: preliminary findings
    Helen C Fox
    The Connecticut Mental Health Center, Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA
    J Psychopharmacol 26:958-72. 2012
    ..Data suggest further exploration of guanfacine is warranted in terms of its potential for reducing stress-induced and cue-induced drug craving and arousal...
  12. pmc Regulation of cocaine self-administration in humans: lack of evidence for loading and maintenance phases
    Gustavo A Angarita
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Pharmacol Biochem Behav 95:51-5. 2010
    ..We sought to examine whether similar phases might characterize self-regulated cocaine use in humans...
  13. pmc Altered levels of sex and stress steroid hormones assessed daily over a 28-day cycle in early abstinent cocaine-dependent females
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 195:527-36. 2008
    ..There is growing evidence of alterations in brain stress and reward circuits associated with cocaine dependence. Sex differences are also documented and sex steroid hormones have been linked to cocaine reinforcement...
  14. pmc Prazosin effects on stress- and cue-induced craving and stress response in alcohol-dependent individuals: preliminary findings
    Helen C Fox
    The Connecticut Mental Health Center, Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Alcohol Clin Exp Res 36:351-60. 2012
    ..Here we report findings from a preliminary efficacy study of the alpha-1 receptor antagonist, prazosin, in modulating these relapse-relevant factors in alcohol-dependent individuals...
  15. pmc Methylphenidate remediates error-preceding activation of the default mode brain regions in cocaine-addicted individuals
    David Matuskey
    Department of Psychiatry, Yale University, New Haven, CT 06519, USA
    Psychiatry Res 214:116-21. 2013
    ....
  16. ncbi request reprint Sex steroid hormones, stress response, and drug craving in cocaine-dependent women: implications for relapse susceptibility
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Exp Clin Psychopharmacol 15:445-52. 2007
    ....
  17. pmc Night eating in obese treatment-seeking Hispanic patients with and without binge eating disorder
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Int J Eat Disord 45:787-91. 2012
    ..To examine the frequency of night eating (NE) and its relation to binge eating disorder (BED), eating-disorder psychopathology, depression, and metabolic variables in treatment-seeking obese Hispanic men and women...
  18. ncbi request reprint Self-reported paranoia during laboratory "binge" cocaine self-administration in humans
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Pharmacol Biochem Behav 83:249-56. 2006
    ..Such methods may facilitate our understanding of the vulnerability to CIP in humans...
  19. pmc Exploring weight gain in year before treatment for binge eating disorder: a different context for interpreting limited weight losses in treatment studies
    Kerstin K Blomquist
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520 8098, USA
    Int J Eat Disord 44:435-9. 2011
    ..To examine weight changes in obese patients with binge-eating disorder (BED) during the year before seeking treatment and to explore correlates of weight changes...
  20. pmc The effects of exogenous progesterone on drug craving and stress arousal in cocaine dependence: impact of gender and cue type
    Helen C Fox
    The Connecticut Mental Health Center, Yale University School of Medicine, Department of Psychiatry, 34 Park Street, New Haven, CT 06519, USA Electronic address
    Psychoneuroendocrinology 38:1532-44. 2013
    ..Thus, we conducted a double-blind placebo-controlled study assessing the efficacy of progesterone in reducing provoked drug craving, stress system arousal and improving cognitive performance in cocaine dependent men and women...
  21. pmc Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients
    Chiang Shan R Li
    Department of Psychiatry, Yale University, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 107:14455-9. 2010
    ..Altered ventromedial prefrontal activation and increased blood pressure may represent useful CNS and peripheral biomarkers in individualized treatment with methylphenidate for patients with cocaine dependence...
  22. pmc The impact of NMDA receptor blockade on human working memory-related prefrontal function and connectivity
    Naomi R Driesen
    1 Department of Psychiatry, Connecticut Mental Health Center, Yale University School of Medicine, New Haven, CT, USA 2 Department of Neurology, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 38:2613-22. 2013
    ..These results support the hypothesis that NMDA-Rs are critical for WM. The knowledge gained may be helpful in understanding disorders that might involve glutamatergic deficits such as schizophrenia and developing better treatments. ..
  23. pmc NMDA receptor function in large-scale anticorrelated neural systems with implications for cognition and schizophrenia
    Alan Anticevic
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 109:16720-5. 2012
    ..Together, the present findings establish links between glutamate's role in the organization of large-scale anticorrelated neural systems, cognition, and symptoms associated with schizophrenia in humans...
  24. pmc An examination of the food addiction construct in obese patients with binge eating disorder
    Ashley N Gearhardt
    Department of Psychology, Yale University, New Haven, CT 06511, USA
    Int J Eat Disord 45:657-63. 2012
    ..This study examined the psychometric properties of the Yale food addiction scale (YFAS) in obese patients with binge eating disorder (BED) and explored its association with measures of eating disorder and associated psychopathology...
  25. doi request reprint Chest tightness and palpitations associated with modafinil and consumption of free glutamate
    Peter T Morgan
    Am J Psychiatry 165:538. 2008

Research Grants1

  1. Modafinil, sleep architecture, and cocaine relapse
    Peter T Morgan; Fiscal Year: 2010
    ..If confirmed, this hypothesis will provide a neurophysiological explanation for the effectiveness o f modafinil and introduce sleep improvement as an essential part of the treatment of stimulant dependence. ..