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Genomes and Genes | Nancy A MoranSummaryAffiliation: Yale University Country: USA Publications
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Publications
Distinctive gut microbiota of honey bees assessed using deep sampling from individual worker beesNancy A Moran
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
PLoS ONE 7:e36393. 2012..Strains showed some differentiation between localities, especially for the Snodgrassella phylotype...
Lateral transfer of genes from fungi underlies carotenoid production in aphidsNancy A Moran
Department of Ecology and Evolutionary Biology, 1041 East Lowell Street, University of Arizona, Tucson, AZ 85721, USA
Science 328:624-7. 2010..A mutation causing an amino acid replacement in this desaturase results in loss of torulene and of red body color. Thus, aphids are animals that make their own carotenoids...- Convergent evolution of metabolic roles in bacterial co-symbionts of insectsJohn P McCutcheon
Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 106:15394-9. 2009.... - Diverse phage-encoded toxins in a protective insect endosymbiontPatrick H Degnan
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
Appl Environ Microbiol 74:6782-91. 2008..Thus, phage may act as a conduit for ongoing gene exchange among heritable endosymbionts... - Evolutionary origins of genomic repertoires in bacteriaEmmanuelle Lerat
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA
PLoS Biol 3:e130. 2005..Although our analyses are limited to the gamma-Proteobacteria, these results resolve a long-standing paradox-i.e., the ability to make robust phylogenetic inferences in light of substantial LGT... - Evolution and diversity of facultative symbionts from the aphid subfamily LachninaeGaelen R Burke
Department of Ecology and Evolutionary Biology, University of Arizona, 1041 East Lowell Street, Tucson, Arizona 85721 0088, USA
Appl Environ Microbiol 75:5328-35. 2009..Serratia symbiotica" with Cinara subgenus Cinara species and weigh against an obligate nutritional role. Finally, we show that species belonging to the subfamily Lachninae have a high incidence of facultative symbiont infection... - Evolutionary genetics of a defensive facultative symbiont of insects: exchange of toxin-encoding bacteriophagePatrick H Degnan
Department of Ecology and Evolutionary Biology, Biosciences West, Room 310, 1041 E Lowell Street, University of Arizona, Tucson, AZ 85721 0088, USA
Mol Ecol 17:916-29. 2008..pisum, one subclade of H. defensa appears to be universal within a subclade of the aphid genus Uroleucon, suggesting a transition from facultative, horizontal transmission to strictly vertical inheritance... 
The evolutionary history of quorum-sensing systems in bacteriaEmmanuelle Lerat
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
Mol Biol Evol 21:903-13. 2004..Gene phylogenies for the main LuxI/R family in Pseudomonas species imply a complex history of lateral transfer, ancestral duplication, and gene loss within the genus...- The dynamics and time scale of ongoing genomic erosion in symbiotic bacteriaNancy A Moran
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Science 323:379-82. 2009..Although purifying selection eliminates many mutations, some persist, resulting in ongoing loss of genes and DNA from this already tiny genome. Our results provide a general model for the stepwise process leading to genome reduction... - Regulation of transcription in a reduced bacterial genome: nutrient-provisioning genes of the obligate symbiont Buchnera aphidicolaNancy A Moran
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
J Bacteriol 187:4229-37. 2005..The irreversible losses of transcriptional regulators constrain ability to alter gene expression in the context of environmental fluctuations affecting the symbiotic partners... - From gene trees to organismal phylogeny in prokaryotes: the case of the gamma-ProteobacteriaEmmanuelle Lerat
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, USA
PLoS Biol 1:E19. 2003.... - Multiple introductions of the Spiroplasma bacterial endosymbiont into DrosophilaTamara S Haselkorn
Department of Ecology and Evolutionary Biology Biosciences, University of Arizona, Tucson, 85721 0088, USA
Mol Ecol 18:1294-305. 2009..Patterns of variation in Drosophila mitochondrial haplotypes in Spiroplasma-infected and uninfected flies imply imperfect vertical transmission in host populations and possible horizontal transmission... - The consequences of genetic drift for bacterial genome complexityChih Horng Kuo
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genome Res 19:1450-4. 2009..This ratio, which reflects the action of purifying selection across the entire genome, shows a strong inverse relationship with genome size, indicating that drift promotes genome reduction in bacteria... - Chromosome stability and gene loss in cockroach endosymbiontsZakee L Sabree
Center for Insect Science, University of Arizona, Tucson, Arizona 85721, USA
Appl Environ Microbiol 76:4076-9. 2010..We speculate that distant homologs may replace the functions of some eliminated genes through broadened substrate specificity... - A simple and distinctive microbiota associated with honey bees and bumble beesVincent G Martinson
Center for Insect Science, University of Arizona, 1007 East Lowell Street, Tucson, AZ 85721 0088, USA
Mol Ecol 20:619-28. 2011..Phylogenetic analyses provide a more refined taxonomic placement of the A. mellifera symbionts... - Population dynamics of defensive symbionts in aphidsKerry M Oliver
Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
Proc Biol Sci 275:293-9. 2008..The declining frequencies of Hamiltonella-infected aphids in population cages in the absence of parasitism indicate a probable cost to infection and may explain why Hamiltonella remains at intermediate frequencies in natural populations... - Symbiosis as an adaptive process and source of phenotypic complexityNancy A Moran
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 104:8627-33. 2007..Multiple symbionts often coexist in the same host, resulting in coadaptation among several phylogenetically distant genomes... - Hamiltonella defensa, genome evolution of protective bacterial endosymbiont from pathogenic ancestorsPatrick H Degnan
Department of Ecology and Evolutionary Biology, Arizona Genomics Institute, University of Arizona, Tucson, AZ 85721 USA
Proc Natl Acad Sci U S A 106:9063-8. 2009..The genome is also littered with mobile DNA, including phage-derived genes, plasmids, and insertion-sequence elements, highlighting its dynamic nature and the continued role horizontal gene transfer plays in shaping it... - Functional genomics of Buchnera and the ecology of aphid hostsNancy A Moran
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Mol Ecol 15:1251-61. 2006..Although information for other insect symbioses is relatively limited, studies on symbionts of carpenter ants and tsetse flies indicate many similarities to Buchnera... - Genomics and evolution of heritable bacterial symbiontsNancy A Moran
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Annu Rev Genet 42:165-90. 2008..In addition, insect symbionts provide some of the extremes of cellular genomes, including the smallest and the fastest evolving, raising new questions about the limits of evolution of life... - A dual-genome microarray for the pea aphid, Acyrthosiphon pisum, and its obligate bacterial symbiont, Buchnera aphidicolaAlex C C Wilson
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
BMC Genomics 7:50. 2006..Development of this dual-genome array represents a first attempt to characterize gene expression in this emerging model system... - Extracting single genomes from heterogenous DNA samples: a test case with Carsonella ruddii, the bacterial symbiont of psyllids (Insecta)Colin Dale
Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, Arizona 85721, USA
J Insect Sci 5:3. 2005..The resulting libraries were highly enriched in bacterial sequences. Through the use of alternate enzymes and partial digests, this technique can be adapted to yield virtually pure DNA libraries for individual bacterial species... - Nitrogen recycling and nutritional provisioning by Blattabacterium, the cockroach endosymbiontZakee L Sabree
Department of Ecology and Evolutionary Biology, University of Arizona, Center for Insect Science, Tucson, AZ 85721 0088, USA
Proc Natl Acad Sci U S A 106:19521-6. 2009.... - Origin and examination of a leafhopper facultative endosymbiontPatrick H Degnan
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT, USA
Curr Microbiol 62:1565-72. 2011..However, the slightly reduced genome size, abundance of mobile DNA, fastidious growth in culture, and efficient vertical transmission suggest that symbiosis with E. variegatus has had a significant impact on genome evolution in BEV... - Aphid thermal tolerance is governed by a point mutation in bacterial symbiontsHelen E Dunbar
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
PLoS Biol 5:e96. 2007..Other cases in which symbiont microevolution has a major effect on host ecological tolerance are likely to be widespread because of the high mutation rates of symbiotic bacteria and their crucial roles in host metabolism and development... - The players in a mutualistic symbiosis: insects, bacteria, viruses, and virulence genesNancy A Moran
Departments of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 87521, USA
Proc Natl Acad Sci U S A 102:16919-26. 2005..defensa life cycle. We propose that, in these mutualistic symbionts, phage-borne toxin genes provide defense to the aphid host and are a basis for the observed protection against eukaryotic parasites... - Dynamics of a recurrent Buchnera mutation that affects thermal tolerance of pea aphid hostsGaelen R Burke
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 186:367-72. 2010..This single base polymorphism in Buchnera has the potential to allow aphid populations to adapt quickly to prevailing conditions... - Costs and benefits of a superinfection of facultative symbionts in aphidsKerry M Oliver
Department of Entomology, University of Arizona, 410 Forbes Building, Tucson, AZ 85721, USA
Proc Biol Sci 273:1273-80. 2006..Our results indicate that in addition to host-symbiont interactions, interactions among the symbionts themselves probably play a critical role in determining the distributions of symbionts in natural populations... - Functional diversity within the simple gut microbiota of the honey beePhilipp Engel
Department of Ecology and Evolutionary Biology, Yale University, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 109:11002-7. 2012.... - Aphid genome expression reveals host-symbiont cooperation in the production of amino acidsAllison K Hansen
Department of Ecology and Evolutionary Biology, Yale University, West Haven, CT 06516 7388, USA
Proc Natl Acad Sci U S A 108:2849-54. 2011..Furthermore, the GOGAT cycle may be a key source of nitrogen fueling the integrated amino acid metabolism of the aphid-Buchnera partnership... - Phylogenetics and the cohesion of bacterial genomesVincent Daubin
Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ, 85721, USA
Science 301:829-32. 2003..Although comparisons of complete gene inventories indicate appreciable gain and loss of genes, orthologs available for phylogenetic reconstruction are consistent with a single tree... - Sequence conservation and functional constraint on intergenic spacers in reduced genomes of the obligate symbiont BuchneraPatrick H Degnan
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, United States of America
PLoS Genet 7:e1002252. 2011..Although pseudogene formation, and thus IGS formation, are ongoing processes in these genomes, a large proportion of intergenic spacers contain functional sequences... - Low and homogeneous copy number of plasmid-borne symbiont genes affecting host nutrition in Buchnera aphidicola of the aphid Uroleucon ambrosiaeGordon R Plague
Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
Mol Ecol 12:1095-100. 2003..Consequently, the plasmid location of trpEG combined with Buchnera's chromosomal polyploidy may functionally limit, rather than increase, tryptophan production within Uroleucon ambrosiae... - Comment on "The origins of genome complexity"Vincent Daubin
Department of Biochemistry and Molecular Biophysics, University of Arizona. Tuscon, AZ 85721, USA
Science 306:978; author reply 978. 2004 - Evolutionary relationships of three new species of Enterobacteriaceae living as symbionts of aphids and other insectsNancy A Moran
Department of Ecology and Evolutionary Biology, Biological Sciences West 310, University of Arizona, Tucson, Arizona 85721, USA
Appl Environ Microbiol 71:3302-10. 2005..The other two symbionts, here designated "Candidatus Hamiltonella defensa" and "Candidatus Regiella insecticola," are sister groups to one another and together show a relationship to species of Photorhabdus... - Massive genomic decay in Serratia symbiotica, a recently evolved symbiont of aphidsGaelen R Burke
Department of Ecology and Evolutionary Biology, The University of Arizona, USA
Genome Biol Evol 3:195-208. 2011..Analysis of mutational patterns showed that deletions are more common in neutral DNA. The S. symbiotica genome provides a rare opportunity to study genome evolution in a recently derived heritable symbiont... - Symbiosis and insect diversification: an ancient symbiont of sap-feeding insects from the bacterial phylum BacteroidetesNancy A Moran
Biological Sciences West 310, Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Appl Environ Microbiol 71:8802-10. 2005..quot;Candidatus Sulcia muelleri" is proposed as the name of the new symbiont... - Origin of an alternative genetic code in the extremely small and GC-rich genome of a bacterial symbiontJohn P McCutcheon
Center for Insect Science, University of Arizona, Tucson, AZ, USA
PLoS Genet 5:e1000565. 2009..Although it is not clear why this tiny genome lacks the low GC content typical of other small bacterial genomes, these observations support a role of genome reduction rather than base composition as a driver of codon reassignment... - Independent studies using deep sequencing resolve the same set of core bacterial species dominating gut communities of honey beesZakee L Sabree
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
PLoS ONE 7:e41250. 2012..The roles of these bacteria within bees, or the implications of the strain variation, are not yet clear... - Genome sequence of Blattabacterium sp. strain BGIGA, endosymbiont of the Blaberus giganteus cockroachCharlie Y Huang
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
J Bacteriol 194:4450-1. 2012..We report the complete genome sequence of the Blattabacterium sp. associated with the giant roach Blaberus giganteus... - Establishment of characteristic gut bacteria during development of the honeybee workerVincent G Martinson
Center for Insect Science, University of Arizona, Tucson, Arizona, USAa Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA
Appl Environ Microbiol 78:2830-40. 2012..mellifera ontogeny. We propose the names "Candidatus Snodgrassella alvi" and "Candidatus Gilliamella apicola" for the Beta and Gamma-1 phylotypes, respectively... - Diversification of genes for carotenoid biosynthesis in aphids following an ancient transfer from a fungusEva Novakova
Department of Ecology and Evolutionary Biology, Yale University, USA
Mol Biol Evol 29:313-23. 2012.... - Genomic basis of endosymbiont-conferred protection against an insect parasitoidAllison K Hansen
Department of Ecology and Evolutionary Biology, Yale University, West Haven, Connecticut 06516 7388, USA
Genome Res 22:106-14. 2012..Mechanisms through which these factors may target parasitoids are discussed... - Dynamics of genome evolution in facultative symbionts of aphidsPatrick H Degnan
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Environ Microbiol 12:2060-9. 2010..The divergence in gene sets and in genome architecture implies a history of rampant recombination and gene inactivation and the ongoing integration of mobile DNA (insertion sequence elements, prophage and plasmids)... - A genomic perspective on nutrient provisioning by bacterial symbionts of insectsNancy A Moran
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 100:14543-8. 2003.... - Genomic changes following host restriction in bacteriaNancy A Moran
Department of Ecology and Evolutionary Biology and Center for Insect Science, University of Arizona, Tucson, AZ 85721, USA
Curr Opin Genet Dev 14:627-33. 2004..Considerable variation also exists, however, in part reflecting unstudied aspects of the population structure and ecology of host-restricted bacterial lineages... - Parallel genomic evolution and metabolic interdependence in an ancient symbiosisJohn P McCutcheon
Center for Insect Science and Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721 0088, USA
Proc Natl Acad Sci U S A 104:19392-7. 2007..Analysis of the coding capacities of Sulcia and Baumannia reveals striking complementarity in metabolic capabilities... - Altered tRNA characteristics and 3' maturation in bacterial symbionts with reduced genomesAllison K Hansen
Department of Ecology and Evolutionary Biology, West Campus, Yale University, PO Box 27388 West Haven, CT 06516 7388, USA
Nucleic Acids Res 40:7870-84. 2012..Overall, our data suggest that endosymbiont genome evolution alters tRNA characteristics that are known to influence translational efficiency in their free-living relative... - Genome shrinkage and loss of nutrient-providing potential in the obligate symbiont of the primitive termite Mastotermes darwiniensisZakee L Sabree
Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut, USA
Appl Environ Microbiol 78:204-10. 2012.... - Consequences of reductive evolution for gene expression in an obligate endosymbiontJennifer L Wilcox
Department of Ecology and Evolutionary Biology, University of Arizona, BioSciences West Rm 310, Tucson 85721, USA
Mol Microbiol 48:1491-500. 2003..aphidicola. Our demonstration of a diminished stress response validates reports of temperature sensitivity in B. aphidicola and suggests that this reduced bacterial genome exhibits transcriptional inflexibility... - Variable incidence of Spiroplasma infections in natural populations of Drosophila speciesThomas Watts
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, United States of America
PLoS ONE 4:e5703. 2009..These findings suggest that Spiroplasma has other effects on hosts that allow it to persist, and that environmental or host variation affects transmission or persistence leading to differences among populations in infection frequencies... - Sexual acquisition of beneficial symbionts in aphidsNancy A Moran
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 103:12803-6. 2006..Because such transfer can generate coinfections, thereby creating opportunities for symbiont competition and recombination, paternal inheritance has major consequences for expectations regarding symbiont evolution... - Variation in resistance to parasitism in aphids is due to symbionts not host genotypeKerry M Oliver
Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 102:12795-800. 2005..Thus, acquisition of a heritable symbiont appears to be a major mode of adaptation to natural enemy pressure in these insects... - Costs and benefits of symbiont infection in aphids: variation among symbionts and across temperaturesJacob A Russell
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ, USA
Proc Biol Sci 273:603-10. 2006..insecticola under these same conditions. These findings reveal a role for heritable symbionts in the adaptation of aphids to their abiotic environments and add to an expanding body of knowledge on the adaptive significance of symbiosis... - Sources of variation in dietary requirements in an obligate nutritional symbiosisKevin J Vogel
Department of Ecology and Evolutionary Biology, The University of Arizona, Tucson, AZ 85721, USA
Proc Biol Sci 278:115-21. 2011..Our results indicate that variation among pea aphids in dependence on dietary amino acids can result from Buchnera mutation as well as variation in the host genotype... - Tracing the evolution of gene loss in obligate bacterial symbiontsNancy A Moran
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA
Curr Opin Microbiol 6:512-8. 2003..This pattern appears to be characteristic of symbiont evolution... - Heritable endosymbionts of DrosophilaMariana Mateos
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Genetics 174:363-76. 2006..Several new strains of Wolbachia and Spiroplasma were discovered, including ones divergent from any reported to date. The phylogenetic distribution of Wolbachia and Spiroplasma in Drosophila is discussed... - SymbiosisNancy A Moran
Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona 85721, USA
Curr Biol 16:R866-71. 2006 - Functional convergence in reduced genomes of bacterial symbionts spanning 200 My of evolutionJohn P McCutcheon
Center for Insect Science, University of Arizona, Arizona, USA
Genome Biol Evol 2:708-18. 2010.... - Facultative bacterial symbionts in aphids confer resistance to parasitic waspsKerry M Oliver
Department of Entomology, University of Arizona, Tucson, AZ 85721, USA
Proc Natl Acad Sci U S A 100:1803-7. 2003..This strong interaction between a symbiotic bacterium and a host natural enemy provides a mechanism for the persistence and spread of symbiotic bacteria... - Intracellular symbionts of sharpshooters (Insecta: Hemiptera: Cicadellinae) form a distinct clade with a small genomeNancy A Moran
Department of Ecology and Evolutionary Biology, Biological Sciences West 310, University of Arizona, Tucson 85721, USA
Environ Microbiol 5:116-26. 2003..A new genus and species name, 'Candidatus Baumannia cicadellinicola' (sp. nov.) is proposed for this newly characterized clade of symbiotic bacteria... - Type III secretion systems and the evolution of mutualistic endosymbiosisColin Dale
Department of Ecology and Evolutionary Biology, Center for Insect Science, and Department of Biochemistry and Molecular Biophysics, University of Arizona, Tucson, AZ 85721
Proc Natl Acad Sci U S A 99:12397-402. 2002..The function of inv/spa genes in maintaining symbiosis is demonstrated by the up-regulation of their expression under both in vivo and in vitro conditions that coincide with host cell invasion...