GIL G MOR

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc MyD88 predicts chemoresistance to paclitaxel in epithelial ovarian cancer
    Dan Arin Silasi
    Department of Obstetrics, Gynecology, and Reproductive Services, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Yale J Biol Med 79:153-63. 2006
  2. pmc TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214
    G Yin
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Oncogene 29:3545-53. 2010
  3. pmc The duplicitous origin of ovarian cancer
    Gil Mor
    Department of Obstetrics Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA
    Rambam Maimonides Med J 4:e0006. 2013
  4. pmc Constitutive proteasomal degradation of TWIST-1 in epithelial-ovarian cancer stem cells impacts differentiation and metastatic potential
    G Yin
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA
    Oncogene 32:39-49. 2013
  5. pmc Phenotypic modifications in ovarian cancer stem cells following Paclitaxel treatment
    Vinicius Craveiro
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, Connecticut
    Cancer Med 2:751-62. 2013
  6. pmc The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization
    Harriet M Kluger
    Department of Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Transl Med 5:6. 2007
  7. pmc KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells
    Ki Hyung Kim
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    J Transl Med 7:63. 2009
  8. pmc Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer
    Emiliano Cocco
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    BMC Cancer 10:349. 2010
  9. pmc Potential role of macrophages as immunoregulators of pregnancy
    Gil Mor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Reprod Biol Endocrinol 1:119. 2003
  10. doi request reprint Macrophages and pregnancy
    Gil Mor
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Reprod Sci 15:435-6. 2008

Collaborators

Detail Information

Publications74

  1. pmc MyD88 predicts chemoresistance to paclitaxel in epithelial ovarian cancer
    Dan Arin Silasi
    Department of Obstetrics, Gynecology, and Reproductive Services, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Yale J Biol Med 79:153-63. 2006
    ..The objective of this study was to determine the correlation of MyD88 expression in primary and recurrent epithelial ovarian cancers with the response to carboplatin and paclitaxel combination chemotherapy...
  2. pmc TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214
    G Yin
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Oncogene 29:3545-53. 2010
    ..Our data suggest that Twist1 may be an important regulator of 'stemness' in EOC cells. The regulation of MIR199A2/214 expression may be used as a potential therapeutic approach in EOC patients...
  3. pmc The duplicitous origin of ovarian cancer
    Gil Mor
    Department of Obstetrics Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA
    Rambam Maimonides Med J 4:e0006. 2013
    ..Understanding the complexity of the disease will facilitate devising new methods for fighting this cancer and improving the life of many women inflicted with the disease. ..
  4. pmc Constitutive proteasomal degradation of TWIST-1 in epithelial-ovarian cancer stem cells impacts differentiation and metastatic potential
    G Yin
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA
    Oncogene 32:39-49. 2013
    ..These findings are relevant for understanding the differentiation and metastasis process in EOC stem cells...
  5. pmc Phenotypic modifications in ovarian cancer stem cells following Paclitaxel treatment
    Vinicius Craveiro
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, Connecticut
    Cancer Med 2:751-62. 2013
    ....
  6. pmc The X-linked inhibitor of apoptosis protein (XIAP) is up-regulated in metastatic melanoma, and XIAP cleavage by Phenoxodiol is associated with Carboplatin sensitization
    Harriet M Kluger
    Department of Medicine, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    J Transl Med 5:6. 2007
    ..Targeting XIAP warrants additional investigation as a therapeutic approach for metastatic melanoma...
  7. pmc KSP inhibitor ARRY-520 as a substitute for Paclitaxel in Type I ovarian cancer cells
    Ki Hyung Kim
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    J Transl Med 7:63. 2009
    ..The objective of this study is to determine if the KSP inhibitor, ARRY-520, can be a substitute for Paclitaxel in patients with Type I EOC...
  8. pmc Clostridium perfringens enterotoxin carboxy-terminal fragment is a novel tumor-homing peptide for human ovarian cancer
    Emiliano Cocco
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    BMC Cancer 10:349. 2010
    ..Using high-throughput technologies to analyze genetic fingerprints of ovarian cancer, we have discovered extremely high expression of the genes encoding the proteins claudin-3 and claudin-4...
  9. pmc Potential role of macrophages as immunoregulators of pregnancy
    Gil Mor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Reprod Biol Endocrinol 1:119. 2003
    ..This review will focus on decidual macrophages and their role on apoptosis and cell clearance during pregnancy...
  10. doi request reprint Macrophages and pregnancy
    Gil Mor
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Reprod Sci 15:435-6. 2008
  11. pmc Serum protein markers for early detection of ovarian cancer
    Gil Mor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 102:7677-82. 2005
    ..However, the combination of the four analytes exhibited the following: sensitivity 95%, positive predictive value (PPV) 95%, specificity 95%, and negative predictive value (NPV) 94%, a considerable improvement on current methodology...
  12. ncbi request reprint Inflammation and pregnancy: the role of toll-like receptors in trophoblast-immune interaction
    Gil Mor
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, 333 Cedar St, FMB 301, New Haven, CT 06520, USA
    Ann N Y Acad Sci 1127:121-8. 2008
    ..Here we postulate that trophoblast cells successfully orchestrate their inflammatory environment and regulate immune cell differentiation and activation...
  13. ncbi request reprint Is the trophoblast an immune regulator? The role of Toll-like receptors during pregnancy
    Gil Mor
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT 06520, USA
    Crit Rev Immunol 25:375-88. 2005
    ....
  14. ncbi request reprint Regulation of fas ligand expression in breast cancer cells by estrogen: functional differences between estradiol and tamoxifen
    G Mor
    Department of Obstetrics and Gynecology, Yale University Medical School, 333 Cedar St FMB 202, New Haven, CT 06520, USA
    J Steroid Biochem Mol Biol 73:185-94. 2000
    ..These studies provide evidence that tamoxifen inhibits FasL expression, allowing the killing of cancer cells by activated lymphocytes. This partially explains the protective effect of tamoxifen against breast cancer...
  15. pmc Ovarian cancer stem cells and inflammation
    Gil Mor
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT, USA
    Cancer Biol Ther 11:708-13. 2011
    ..The source of recurrence and lack of response to chemotherapy is unknown. The focus of this review is to evaluate the question of recurrence and chemoresistance based on the concept of the cancer stem cells and inflammation...
  16. ncbi request reprint The role of the Fas/Fas ligand system in estrogen-induced thymic alteration
    G Mor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Reprod Immunol 46:298-307. 2001
    ..Estrogen induces atrophy in the thymus by an unknown mechanism. Since the Fas/FasL system is one of the main pathways in T cell apoptosis, we tested the hypothesis that estrogen-induced thymic atrophy is mediated by the Fas/FasL system...
  17. ncbi request reprint Plasmid DNA vaccines. Immunology, tolerance, and autoimmunity
    G Mor
    Department of Obstetrics and Gynecology, Reproductive Immunology Unit, Yale University School of Medicine, 333 Cedar St, New Haven, CT 06520 8063, USA
    Mol Biotechnol 19:245-50. 2001
    ....
  18. ncbi request reprint Role of the Fas/Fas ligand system in female reproductive organs: survival and apoptosis
    Gil Mor
    Department of Obstetrics and Gynecology, Yale University, School of Medicine, 333 Cedar St, FMB 202, New Haven, CT 06520 8063, USA
    Biochem Pharmacol 64:1305-15. 2002
    ..The Fas/Fas ligand system is an important mediator of apoptosis and is an excellent example of this apparently contradictory phenomenon...
  19. ncbi request reprint Interaction of the estrogen receptors with the Fas ligand promoter in human monocytes
    Gil Mor
    Department of Obstetrics and Gynecology, School of Medicine, Yale University, New Haven, CT 06520, USA
    J Immunol 170:114-22. 2003
    ..There is biological relevance to these findings in view of studies showing that accumulation of activated monocytes is involved in the pathogenesis of conditions such as vasculititis, arteriosclerosis, and rheumatoid arthritis...
  20. pmc Inflammation and pregnancy: the role of the immune system at the implantation site
    Gil Mor
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Reproductive Immunology Unit, School of Medicine, Yale University, New Haven, Connecticut, USA
    Ann N Y Acad Sci 1221:80-7. 2011
    ....
  21. pmc The immune system in pregnancy: a unique complexity
    Gil Mor
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, School of Medicine, Yale University, New Haven, CT 06520, USA
    Am J Reprod Immunol 63:425-33. 2010
    ....
  22. ncbi request reprint The Fas/FasL system in reproduction: survival and apoptosis
    Gil Mor
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA
    ScientificWorldJournal 2:1828-42. 2002
    ..The Fas/FasL system is an important mediator in apoptosis and is and excellent example of this apparently contradictory phenomenon...
  23. ncbi request reprint Phenoxodiol, a novel approach for the treatment of ovarian cancer
    Gil Mor
    Yale University, Department of Obstetrics and Gynecology and Reproductive Science, School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Curr Opin Investig Drugs 7:542-8. 2006
    ..In this review, the current understanding of the mechanism of action of phenoxodiol, its potential clinical application for the treatment of ovarian cancer and the concept of chemosensitization are discussed...
  24. ncbi request reprint Macrophages and apoptotic cell clearance during pregnancy
    Vikki M Abrahams
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Reprod Immunol 51:275-82. 2004
    ..The quick and effective removal of apoptotic cells by tissue macrophages represents an essential process, which prevents the release of self-antigens, and in the case of pregnancy, paternal alloantigens...
  25. ncbi request reprint Divergent trophoblast responses to bacterial products mediated by TLRs
    Vikki M Abrahams
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 173:4286-96. 2004
    ..Our findings provide a novel mechanism of pathogenesis for certain pregnancy complications in which there is engagement of the innate immune system...
  26. ncbi request reprint Differential regulation and function of the Fas/Fas ligand system in human trophoblast cells
    Sarit Aschkenazi
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 66:1853-61. 2002
    ..This "trophoblast-cytokine-Fas/FasL triad" determines the ability of the Fas/FasL system to regulate trophoblast viability and, consequently, the success or failure of pregnancy...
  27. pmc Activation of TLR3 in the trophoblast is associated with preterm delivery
    Kaori Koga
    Department of Obstetrics and Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT, USA
    Am J Reprod Immunol 61:196-212. 2009
    ..Previously, we described the expression of TLR3 by human trophoblast and their ability to respond to (Poly[I:C]). Here we evaluate the effect of Poly[I:C] on mouse pregnancy and characterize the local and systemic response...
  28. doi request reprint Diagnostic markers for early detection of ovarian cancer
    Irene Visintin
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Clin Cancer Res 14:1065-72. 2008
    ..In this study, we characterize and validate the combination of six serum biomarkers that discriminate between disease-free and ovarian cancer patients with high efficiency...
  29. ncbi request reprint Phenoxodiol--an isoflavone analog--induces apoptosis in chemoresistant ovarian cancer cells
    Marijke Kamsteeg
    Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, CT 06520, USA
    Oncogene 22:2611-20. 2003
    ..These findings demonstrate a novel nontoxic drug that controls FLIP/XIAP function and has the potential to eliminate tumor cells through Fas-mediated apoptosis...
  30. ncbi request reprint Apoptosis-based evaluation of chemosensitivity in ovarian cancer patients
    Maryann B Flick
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Soc Gynecol Investig 11:252-9. 2004
    ....
  31. doi request reprint Expression and function of toll-like receptors at the maternal-fetal interface
    Kaori Koga
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Reprod Sci 15:231-42. 2008
    ..The impact of TLR-mediated innate immune response will be discussed via animal model studies, as well as clinical observations...
  32. ncbi request reprint The Fas/Fas ligand system and cancer: immune privilege and apoptosis
    Vikki M Abrahams
    Department of Obstetrics and Gynecology, Yale University, School of Medicine, New Haven, CT 06520, USA
    Mol Biotechnol 25:19-30. 2003
    ..We have also characterized a new form of FasL, different from the classical membranal form, which is secreted by ovarian cancer cells. In this review we describe the main techniques used in these studies...
  33. pmc Molecular phenotyping of human ovarian cancer stem cells unravels the mechanisms for repair and chemoresistance
    Ayesha B Alvero
    Department of Obstetrics and Gynecology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Cell Cycle 8:158-66. 2009
    ..The identification and cloning of human OCSCs can aid in the development of better therapeutic approaches for ovarian cancer patients...
  34. ncbi request reprint TLR-4 signaling promotes tumor growth and paclitaxel chemoresistance in ovarian cancer
    Michael G Kelly
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Cancer Res 66:3859-68. 2006
    ..In addition, we provide new evidence that links TLR-4 signaling, inflammation, and chemoresistance in ovarian cancer cells...
  35. pmc Viral infection of the placenta leads to fetal inflammation and sensitization to bacterial products predisposing to preterm labor
    Ingrid Cardenas
    Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, Yale University, New Haven, CT 06520, USA
    J Immunol 185:1248-57. 2010
    ..This is relevant for making decisions associated with treatment and prevention during pandemics...
  36. pmc 7-(O)-Carboxymethyl daidzein conjugated to N-t-Boc-hexylenediamine: a novel compound capable of inducing cell death in epithelial ovarian cancer stem cells
    Jamie M Green
    Department of Obstetrics and Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer Biol Ther 8:1747-53. 2009
    ..This study describes a novel compound that can target the OCSCs. These findings may provide vital aide in improving overall survival in patients with EOC...
  37. ncbi request reprint A novel immortalized human endometrial stromal cell line with normal progestational response
    Graciela Krikun
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, 333 Cedar Street, P O Box 208063, New Haven, Connecticut 06520 8063, USA
    Endocrinology 145:2291-6. 2004
    ..In summary, an immortalized HESC line has been developed that is karyotypically, morphologically, and phenotypically similar to the primary parent cells, and it is a powerful and consistent resource for in vitro work...
  38. ncbi request reprint Phenoxodiol: pharmacology and clinical experience in cancer monotherapy and in combination with chemotherapeutic drugs
    Dan Arin Silasi
    Yale University School of Medicine, Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, New Haven, CT 06520, USA
    Expert Opin Pharmacother 10:1059-67. 2009
    ..The observation that an inverse relationship exists between dietary intake of isoflavones and cancer incidence has led to the evaluation of these compounds in cancer therapy...
  39. pmc TLR6 modulates first trimester trophoblast responses to peptidoglycan
    Vikki M Abrahams
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    J Immunol 180:6035-43. 2008
    ..Furthermore, the expression of TLR6 may be a key factor in determining whether the response to PDG would be apoptosis or inflammation...
  40. pmc NV-128, a novel isoflavone derivative, induces caspase-independent cell death through the Akt/mammalian target of rapamycin pathway
    Ayesha B Alvero
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Cancer 115:3204-16. 2009
    ..The authors report the characterization of NV-128 as an inducer of cell death through a caspase-independent pathway...
  41. pmc The placental syncytium and the pathophysiology of preeclampsia and intrauterine growth restriction: a novel assay to assess syncytial protein expression
    Seth Guller
    Department of Obstetrics Gynecology, Yale University School of Medicine, 333 Cedar Street, 339 FMB, P O Box 208063, New Haven, CT 06520 8063, USA
    Ann N Y Acad Sci 1127:129-33. 2008
    ....
  42. ncbi request reprint Resistance of ovarian carcinoma cells to docetaxel is XIAP dependent and reversible by phenoxodiol
    Eva Sapi
    Department of Obstetrics and Gynecology, Yale University School of Medicine, P O Box 208040, New Haven, CT 06520 8040, USA
    Oncol Res 14:567-78. 2004
    ..We demonstrate that phenoxodiol, by interfering with XIAP activity, functions as a chemosensitizer to docetaxel and could provide a more effective treatment for refractory ovarian cancer...
  43. pmc Viral ssRNA induces first trimester trophoblast apoptosis through an inflammatory mechanism
    Paulomi B Aldo
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USA
    Am J Reprod Immunol 64:27-37. 2010
    ..While viruses pose a major threat, little is known about their effect on early pregnancy, or the mechanisms involved. The objective of this study was to characterize the trophoblast response following exposure to viral ssRNA...
  44. ncbi request reprint Regulation of Fas ligand expression by estrogen in normal ovary
    Eva Sapi
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    J Soc Gynecol Investig 9:243-50. 2002
    ..In this study, we evaluated the expression of FasL in normal ovarian tissue during the normal female reproductive cycle with the goal of identifying potential hormones that can regulate FasL expression...
  45. ncbi request reprint Molecular mechanism of phenoxodiol-induced apoptosis in ovarian carcinoma cells
    Ayesha B Alvero
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer 106:599-608. 2006
    ..The objectives of this study were to determine whether phenoxodiol can also act as chemosensitizer to chemotherapeutic agents and to characterize the molecular mechanism behind its sensitizing effect...
  46. ncbi request reprint Hormonal regulation of apoptosis and the Fas and Fas ligand system in human endometrial cells
    Joon Song
    Department of Obstetrics and Gynecology, Yale University, School of Medicine, 333 Cedar St FMB 202, New Haven, CT 06520, USA
    Mol Hum Reprod 8:447-55. 2002
    ..Our results indicate that Fas-mediated apoptosis is important for endometrial cycling and suggest that dysregulation of the Fas/FasL interactions may have an important role in the development of endometrial cancer...
  47. ncbi request reprint Alterations in syncytiotrophoblast cytokine expression following treatment with lipopolysaccharide
    Yuehong Ma
    Department of Obstetrics, Gynecology and Reproductive Science, Yale University School of Medicine, New Haven, CT 06520 8063, USA
    Am J Reprod Immunol 55:12-8. 2006
    ..Responsiveness of this cell type to inflammatory compounds remains largely unelucidated...
  48. ncbi request reprint Macrophage migration inhibitory factor expression in ovarian cancer
    Rinki Agarwal
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Obstet Gynecol 196:348.e1-5. 2007
    ..We evaluated the hypothesis that ovarian cancer patients have significantly higher levels of serum macrophage migration inhibitory factor (MIF)...
  49. ncbi request reprint Inflammation, cancer and chemoresistance: taking advantage of the toll-like receptor signaling pathway
    Rui Chen
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA
    Am J Reprod Immunol 57:93-107. 2007
    ....
  50. ncbi request reprint Anti-tumor activity of phenoxodiol: from bench to clinic
    Ayesha B Alvero
    Yale University, Department of Obstetrics and Gynecology and Reproductive Sciences, School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Future Oncol 4:475-82. 2008
    ..This review will discuss the characterization of phenoxodiol's molecular mechanism and its current state in the clinic...
  51. pmc Phagocytosis of apoptotic trophoblast cells by human endometrial endothelial cells induces proinflammatory cytokine production
    Bing Peng
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Reprod Immunol 64:12-9. 2010
    ..The aim of this study was to show the cross talk between human endometrial endothelial cells (HEECs) and apoptotic trophoblast cells in an in vitro coculture model and its effect on cytokine production by HEECs...
  52. ncbi request reprint Mechanisms involved in the evolution of progestin resistance in human endometrial hyperplasia--precursor of endometrial cancer
    Sa Wang
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520 8070, USA
    Gynecol Oncol 88:108-17. 2003
    ..The aims of this study are to examine Fas/FasL expression in endometrial hyperplasia of pre- and postprogestin treatment samples and to study the Fas/FasL regulation in vitro with Ishikawa cells after progestin stimulation...
  53. ncbi request reprint Triapine (3-aminopyridine-2-carboxaldehyde thiosemicarbazone) induces apoptosis in ovarian cancer cells
    Ayesha B Alvero
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520 8063, USA
    J Soc Gynecol Investig 13:145-52. 2006
    ....
  54. ncbi request reprint Modulation of apoptosis to reverse chemoresistance
    Gil Mor
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 414:1-12. 2008
    ..In this chapter, we discuss the role of apoptosis in ovarian cancer and the use of phenoxodiol as a model for the regulation of apoptosis and potential use as chemosensitizer for chemoresistant ovarian cancer cells...
  55. pmc Identification of differentially expressed proteins in ovarian cancer using high-density protein microarrays
    Michael E Hudson
    Department of Molecular, Cellular, and Developmental Biology, Yale University, 210 Prospect Street, New Haven, CT 06520 8103, USA
    Proc Natl Acad Sci U S A 104:17494-9. 2007
    ..Overall our studies identified candidate tissue marker proteins for ovarian cancer and demonstrate that protein microarrays provide a powerful approach to identify proteins aberrantly expressed in disease states...
  56. ncbi request reprint XAF1 mediates tumor necrosis factor-alpha-induced apoptosis and X-linked inhibitor of apoptosis cleavage by acting through the mitochondrial pathway
    Shawn L Straszewski-Chavez
    Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 282:13059-72. 2007
    ..Aberrant XAF1 expression and/or localization may have consequences for normal pregnancy outcome...
  57. ncbi request reprint Correlation of caspase activity and in vitro chemo-response in epithelial ovarian cancer cell lines
    Ayesha B Alvero
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 414:79-82. 2008
    ..Our findings demonstrate that the use of the Caspase-Glotrade mark assay allows a simple, fast, and sensitive alternative for the evaluation of in vitro response to chemotherapy...
  58. ncbi request reprint Expression and secretion of antiviral factors by trophoblast cells following stimulation by the TLR-3 agonist, Poly(I : C)
    Vikki M Abrahams
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA
    Hum Reprod 21:2432-9. 2006
    ..Recent insight into the immunological capabilities of the trophoblast suggests that the placenta may function as an active barrier by recognizing and responding to pathogens through Toll-like receptors (TLRs)...
  59. ncbi request reprint The immortalization of human endometrial cells
    Graciela Krikun
    Department of Obstetrics and Gynecology, Yale University, New Haven, CT, USA
    Methods Mol Med 121:79-83. 2006
    ..In this article, we will address this approach in the establishment of immortalized endometrial cells and its value in facilitating in vitro studies...
  60. ncbi request reprint The role of apoptosis in the regulation of trophoblast survival and differentiation during pregnancy
    Shawn L Straszewski-Chavez
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, 333 Cedar Street FMB 301, New Haven, CT 06520, USA
    Endocr Rev 26:877-97. 2005
    ....
  61. ncbi request reprint Toll-like receptors and pregnancy: trophoblast as modulators of the immune response
    Kaori Koga
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Obstet Gynaecol Res 35:191-202. 2009
    ..We will describe potential functions of TLR in trophoblast cells, their recognition and response to microorganisms, and their involvement in innate immunity...
  62. ncbi request reprint Macrophage-trophoblast interactions
    Gil Mor
    Reproductive Immunology Unit, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Med 122:149-63. 2006
    ..The present chapter will describe some of the approaches used to study the interaction between macrophages and trophoblast cells...
  63. ncbi request reprint Estrogen to antiestrogen with a single methylene group resulting in an unusual steroidal selective estrogen receptor modulator
    Jing xin Zhang
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Clin Endocrinol Metab 89:3527-35. 2004
    ..E11-2,2 with its short, nonpolar side-chain, lacks this critical structure, presenting the possibility that it might act through a unique mechanism...
  64. ncbi request reprint Epithelial ovarian cancer cells secrete functional Fas ligand
    Vikki M Abrahams
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven Connecticut 06520, USA
    Cancer Res 63:5573-81. 2003
    ....
  65. ncbi request reprint ERCC1 genotype and phenotype in epithelial ovarian cancer identify patients likely to benefit from paclitaxel treatment in addition to platinum-based therapy
    Stephanie Smith
    Department of Epidemiology and Public Health, Yale University School of Medicine, 60 College St, New Haven, CT 06520 8034, USA
    J Clin Oncol 25:5172-9. 2007
    ..To investigate the effect of excision repair cross-complementation group 1 (ERCC1) on treatment response and survival of patients treated with platinum chemotherapy with or without paclitaxel...
  66. ncbi request reprint Detection of cancer-related proteins in fresh-frozen ovarian cancer samples using laser capture microdissection
    Dan Arin Silasi
    Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT, USA
    Methods Mol Biol 414:35-45. 2008
    ..Using this technique, we can detect proteins such as X-linked inhibitor of apoptosis protein (XIAP) and Fas ligand (FasL) with as little as 1000 cells...
  67. ncbi request reprint Phenoxodiol-Topotecan co-administration exhibit significant anti-tumor activity without major adverse side effects
    Ayesha B Alvero
    Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Biol Ther 6:612-7. 2007
    ..We previously showed that Phenoxodiol is able to sensitize epithelial ovarian cancer cells to Paclitaxel, Carboplatin, Gemcitabine, and Docetaxel. The aim of this study was to determine the value of Phenoxodiol-Topotecan coadministration...
  68. pmc AKT controls human first trimester trophoblast cell sensitivity to FAS-mediated apoptosis by regulating XIAP expression
    Shawn L Straszewski-Chavez
    Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Biol Reprod 82:146-52. 2010
    ....
  69. pmc Development and validation of a protein-based signature for the detection of ovarian cancer
    Kyongjin Kim
    Department of Obstetrics, Gynecology and Reproductive Sciences, Reproductive Immunology Unit, Yale University School of Medicine, 333 Cedar Street FMB 301, New Haven, CT 06520, USA
    Clin Lab Med 29:47-55. 2009
    ..The combination of these six proteins yielded 95.3% sensitivity and 99.4% specificity. The application of this test in the clinical context and the most appropriate population, which could benefit from the test, are discussed...
  70. ncbi request reprint A novel three-dimensional in vitro system to study trophoblast-endothelium cell interactions
    Paulomi B Aldo
    Department of Obstetrics, Gynecology, and Reproductive Sciences, Yale University School of Medicine, Yale University, New Haven, CT 06520, USA
    Am J Reprod Immunol 58:98-110. 2007
    ..We describe a novel in vitro model to evaluate endothelial-trophoblast interaction and signaling in a three-dimensional system...
  71. ncbi request reprint A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells
    Hui Li
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 321:1357-61. 2008
    ..These observations suggest that certain gene fusions may be pro-neoplastic owing to constitutive expression of chimeric gene products normally generated by trans-splicing of RNAs in developing tissues...
  72. ncbi request reprint Comparison of statistical methods for classification of ovarian cancer using mass spectrometry data
    Baolin Wu
    Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT, USA
    Bioinformatics 19:1636-43. 2003
    ..Although various statistical methods have been utilized to identify biomarkers from MS data, there has been no systematic comparison among these approaches in their relative ability to analyze MS data...
  73. ncbi request reprint In vitro and in vivo effects of combination of Trastuzumab (Herceptin) and Tamoxifen in breast cancer
    Chun Xia Wang
    Department of Internal Medicine Section of Medical Oncology, Yale University School of Medicine, 333 Cedar Street, Room NSB288, 06510, New Haven, CT 06510, USA
    Breast Cancer Res Treat 92:251-63. 2005
    ..Our results indicate that combined targeting of both peptide growth factor receptors and ERalpha represents a promising breast cancer treatment strategy...
  74. pmc Targeting the mitochondria activates two independent cell death pathways in ovarian cancer stem cells
    Ayesha B Alvero
    Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, Yale University, New Haven, CT 06520, USA
    Mol Cancer Ther 10:1385-93. 2011
    ..The demonstration that a compound can specifically target the mitochondria to induce cell death in this otherwise chemoresistant cell population opens a new venue for treating ovarian cancer patients...

Research Grants15

  1. MyD88-bearing tumors in immune-regulation and chemo-resistance
    GIL G MOR; Fiscal Year: 2010
    ....
  2. Apoptotic regulators in ovarian cancer
    GIL G MOR; Fiscal Year: 2010
    ....
  3. IMMUNE ACCEPTANCE OF PREGNANCY
    Gil Mor; Fiscal Year: 2001
    ..The significance of this proposal is not limited to reproductive problems. It is anticipated that these studies will lead to a better understanding of tumor behavior, actions of chemotherapeutic agents and transplant physiology. ..
  4. Fas/FasL System In Normal Mammary Gland Development
    Gil Mor; Fiscal Year: 2002
    ..With an improved foundation of the normal mammary physiology, we can advance the understanding of breast cancer, allowing the development of effective strategies for its treatment and prevention. ..
  5. Apoptotic regulators in ovarian cancer
    Gil Mor; Fiscal Year: 2009
    ....
  6. Fas/FasL System In Normal Mammary Gland Development
    Gil Mor; Fiscal Year: 2003
    ..With an improved foundation of the normal mammary physiology, we can advance the understanding of breast cancer, allowing the development of effective strategies for its treatment and prevention. ..
  7. MyD88-bearing tumors in immune-regulation and chemo-resistance
    Gil Mor; Fiscal Year: 2009
    ....
  8. Apoptotic regulators in ovarian cancer
    Gil Mor; Fiscal Year: 2009
    ....
  9. Apoptotic regulators in ovarian cancer
    Gil Mor; Fiscal Year: 2007
    ....
  10. Meeting of American Society for Reproductive Immunology:
    Gil Mor; Fiscal Year: 2003
    ..abstract_text> ..
  11. IMMUNE ACCEPTANCE OF PREGNANCY
    Gil Mor; Fiscal Year: 2002
    ..The significance of this proposal is not limited to reproductive problems. It is anticipated that these studies will lead to a better understanding of tumor behavior, actions of chemotherapeutic agents and transplant physiology. ..
  12. Fas/FasL System In Normal Mammary Gland Development
    Gil Mor; Fiscal Year: 2001
    ..With an improved foundation of the normal mammary physiology, we can advance the understanding of breast cancer, allowing the development of effective strategies for its treatment and prevention. ..
  13. IMMUNE ACCEPTANCE OF PREGNANCY
    Gil Mor; Fiscal Year: 2000
    ..The significance of this proposal is not limited to reproductive problems. It is anticipated that these studies will lead to a better understanding of tumor behavior, actions of chemotherapeutic agents and transplant physiology. ..