Peter Moore

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint How should we think about the ribosome?
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, Connecticut 06520 8107, USA
    Annu Rev Biophys 41:1-19. 2012
  2. doi request reprint The effects of thermal disorder on the solution-scattering profiles of macromolecules
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, Connecticut Electronic address
    Biophys J 106:1489-96. 2014
  3. pmc A short, informal history of the biological sciences at Yale University
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, Connecticut, USA
    Yale J Biol Med 85:551-8. 2012
  4. pmc Neutrons, magnets, and photons: a career in structural biology
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 287:805-18. 2012
  5. ncbi request reprint Structural biology. A ribosomal coup: E. coli at last!
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, CT 06520 8107, USA
    Science 310:793-5. 2005
  6. ncbi request reprint Let's call the whole thing off: some thoughts on the protein structure initiative
    Peter B Moore
    Department of Chemistry, Yale University, 350 Prospect Street, New Haven, CT 06520 8107, USA
    Structure 15:1350-2. 2007
  7. pmc The ribosome returned
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, CT 06520 8107, USA
    J Biol 8:8. 2009
  8. doi request reprint On the relationship between diffraction patterns and motions in macromolecular crystals
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, CT 06520 8107, USA
    Structure 17:1307-15. 2009
  9. pmc The roles of RNA in the synthesis of protein
    Peter B Moore
    Department of Molecular Biophysics, Yale University, New Haven, Connecticut 208114, USA
    Cold Spring Harb Perspect Biol 3:a003780. 2011
  10. pmc After the ribosome structures: how does peptidyl transferase work?
    Peter B Moore
    Department of Chemistry, Howard Hughes Medical Institute, Yale University, 350 Edwards Street, New Haven, CT 06520 8107, USA
    RNA 9:155-9. 2003

Research Grants

  1. RIBOSOME STRUCTURE/FUNCTION
    Peter Moore; Fiscal Year: 2001
  2. STRUCTURE AND PHYSICAL PROPERTIES OF RNA
    Peter Moore; Fiscal Year: 2007
  3. Upgrade of X-Ray Diffractometers
    Peter Moore; Fiscal Year: 2005
  4. STRUCTURE AND PHYSICAL PROPERTIES OF RNA
    Peter Moore; Fiscal Year: 2003
  5. NMR Console Upgrade and Cryoprobe
    Peter Moore; Fiscal Year: 2002

Collaborators

Detail Information

Publications33

  1. doi request reprint How should we think about the ribosome?
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, Connecticut 06520 8107, USA
    Annu Rev Biophys 41:1-19. 2012
    ..The reasoning that underlies these assertions will be explained, and a more general issue explored, namely what can be said today about the modus operandi of the ribosome. What kind of a device is it?..
  2. doi request reprint The effects of thermal disorder on the solution-scattering profiles of macromolecules
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, Connecticut Electronic address
    Biophys J 106:1489-96. 2014
    ....
  3. pmc A short, informal history of the biological sciences at Yale University
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, Connecticut, USA
    Yale J Biol Med 85:551-8. 2012
    ..This essay is a lightly edited version of my account of the history of the biological sciences outside the Medical School...
  4. pmc Neutrons, magnets, and photons: a career in structural biology
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 287:805-18. 2012
    ..Only in such an opportunity-rich environment would someone like me have stood a chance. The contrast between that world and the dog-eat-dog world young scientists confront today is stark...
  5. ncbi request reprint Structural biology. A ribosomal coup: E. coli at last!
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, CT 06520 8107, USA
    Science 310:793-5. 2005
  6. ncbi request reprint Let's call the whole thing off: some thoughts on the protein structure initiative
    Peter B Moore
    Department of Chemistry, Yale University, 350 Prospect Street, New Haven, CT 06520 8107, USA
    Structure 15:1350-2. 2007
  7. pmc The ribosome returned
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, CT 06520 8107, USA
    J Biol 8:8. 2009
    ..This review provides a brief account of how this structural revolution came to pass, and the impact it has had on our understanding of how the ribosome decodes messenger RNAs...
  8. doi request reprint On the relationship between diffraction patterns and motions in macromolecular crystals
    Peter B Moore
    Department of Chemistry, Yale University, New Haven, CT 06520 8107, USA
    Structure 17:1307-15. 2009
    ..Here it is pointed out that all such models should be treated with caution until it is shown that they are consistent with the diffuse scatter produced by the crystals that provided the diffraction data from which they derive...
  9. pmc The roles of RNA in the synthesis of protein
    Peter B Moore
    Department of Molecular Biophysics, Yale University, New Haven, Connecticut 208114, USA
    Cold Spring Harb Perspect Biol 3:a003780. 2011
    ..This review emphasizes what has been learned about the mechanism of peptide bond formation, the antibiotics that inhibit ribosome function, and the fidelity of decoding...
  10. pmc After the ribosome structures: how does peptidyl transferase work?
    Peter B Moore
    Department of Chemistry, Howard Hughes Medical Institute, Yale University, 350 Edwards Street, New Haven, CT 06520 8107, USA
    RNA 9:155-9. 2003
    ..of the site enhance the rate of peptide-bond formation chemically? Do intact ribosomes make peptide bonds the same way as the isolated large subunits that have been the source of all this atomic resolution structural information?..
  11. ncbi request reprint The involvement of RNA in ribosome function
    Peter B Moore
    Department of Molecular Biophysics and Biochemistry, Yale University, PO Box 208107, New Haven, Connecticut 06520 8107, USA
    Nature 418:229-35. 2002
    ..Recent structural work has demonstrated a profound involvement of the ribosome's RNA component in all aspects of its function, supporting the hypothesis that proteins were added to the ribosome late in its evolution...
  12. pmc The structure of a ribosomal protein S8/spc operon mRNA complex
    Helen J Merianos
    Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA
    RNA 10:954-64. 2004
    ..S8 binding must repress the translation of its own mRNA by inhibiting the formation of a ribosomal initiation complex at the start of the L5 cistron...
  13. ncbi request reprint A pre-translocational intermediate in protein synthesis observed in crystals of enzymatically active 50S subunits
    T Martin Schmeing
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    Nat Struct Biol 9:225-30. 2002
    ..Thus, this structure represents a state that occurs after peptide bond formation but before the hybrid state of protein synthesis...
  14. ncbi request reprint The structures of four macrolide antibiotics bound to the large ribosomal subunit
    Jeffrey L Hansen
    Department of Molecular Biophysics and Biochemistry, New Haven, Connecticut 06520, USA
    Mol Cell 10:117-28. 2002
    ..coli). Mutations in 23S rRNA that result in clinical resistance render the binding site less complementary to macrolides...
  15. ncbi request reprint The structural basis of large ribosomal subunit function
    Peter B Moore
    Departments of Molecular Biophysics and Biochemistry, Chemistry, Yale University, New Haven, Connecticut 06520, USA
    Annu Rev Biochem 72:813-50. 2003
    ..The work reviewed, taken as a whole, proves beyond doubt that the ribosome is an RNA enzyme, as had long been surmised on the basis of less conclusive evidence...
  16. pmc The contribution of metal ions to the structural stability of the large ribosomal subunit
    Daniel J Klein
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Ave, New Haven, CT 06520 8114, USA
    RNA 10:1366-79. 2004
    ....
  17. ncbi request reprint The solution structure of the loop E region of the 5S rRNA from spinach chloroplasts
    Pramodh Vallurupalli
    Department of Chemistry, Yale University, New Haven, CT 06520 8107, USA
    J Mol Biol 325:843-56. 2003
    ..coli, which binds to the loop E region of both intact E.coli 5S rRNA and to oligonucleotides containing that sequence, also binds to the chloroplast-derived oligonucleotide discussed here...
  18. ncbi request reprint Gene replacement in Haloarcula marismortui: construction of a strain with two of its three chromosomal rRNA operons deleted
    Daqi Tu
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, P O Box 208114, New Haven, CT 06520 8114, USA
    Extremophiles 9:427-35. 2005
    ..The structural consequences of these and other such mutations can be determined with unusual accuracy because crystals of the large ribosomal subunit of H. marismortui diffract to atomic resolution...
  19. doi request reprint Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit
    Joseph A Ippolito
    Department of Structure Based Drug Design, Rib X Pharmaceuticals Inc, 300 George Street, Suite 301, New Haven, CT 06511, USA
    J Med Chem 51:3353-6. 2008
    ..These results provide a structural basis for the discovery of improved oxazolidinones active against emerging drug-resistant clinical strains...
  20. ncbi request reprint Structures of MLSBK antibiotics bound to mutated large ribosomal subunits provide a structural explanation for resistance
    Daqi Tu
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520, USA
    Cell 121:257-70. 2005
    ..coli) that stacks between them. The structure of large subunit containing a three residue deletion mutant of L22 shows a change in the L22 structure and exit tunnel shape that illuminates its macrolide resistance phenotype...
  21. ncbi request reprint Structures of five antibiotics bound at the peptidyl transferase center of the large ribosomal subunit
    Jeffrey L Hansen
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520 8114, USA
    J Mol Biol 330:1061-75. 2003
    ..Virginiamycin M occupies portions of both the A and P-site, and induces a conformational change in the ribosome. Blasticidin S base-pairs with the P-loop and thereby mimics C74 and C75 of a P-site bound tRNA...
  22. pmc Mutations outside the anisomycin-binding site can make ribosomes drug-resistant
    Gregor Blaha
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    J Mol Biol 379:505-19. 2008
    ..The conformational effects of some mutations of the second kind propagate through the ribosome for considerable distances and are reversed when A-site substrates bind to the ribosome...
  23. ncbi request reprint RNA, the first macromolecular catalyst: the ribosome is a ribozyme
    Thomas A Steitz
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA
    Trends Biochem Sci 28:411-8. 2003
    ..The structures of the large subunit bound to a variety of antibiotics explain the effects of antibiotic resistance mutations and provide promise for the development of new antibiotics...
  24. pmc Structures of triacetyloleandomycin and mycalamide A bind to the large ribosomal subunit of Haloarcula marismortui
    Güliz Gürel
    Department of Chemistry, Yale University, New Haven, CT 06520, USA
    Antimicrob Agents Chemother 53:5010-4. 2009
    ..Mycalamide A binds to the E site and inhibits protein synthesis by occupying the space normally occupied by the CCA end of E-site-bound tRNAs...
  25. pmc U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome
    Güliz Gürel
    Department of Chemistry, Yale University, New Haven, CT 06520, USA
    J Mol Biol 389:146-56. 2009
    ..In the ribosome, the position of U2504 is controlled by its interactions with neighboring nucleotides, whose identities vary among kingdoms...
  26. pmc Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit
    T Martin Schmeing
    Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520 8114, USA
    RNA 9:1345-52. 2003
    ..It appears that the E site on the 50S subunit was formed by only RNA in the last common ancestor of the three kingdoms, since the proteins at the E sites of H. marismortui and Deinucoccus radiodurans large subunits are not homologous...
  27. pmc Negamycin binds to the wall of the nascent chain exit tunnel of the 50S ribosomal subunit
    Susan J Schroeder
    Department of Chemistry, Yale University, New Haven, Connecticut 06520 8107, USA
    Antimicrob Agents Chemother 51:4462-5. 2007
    ..The mechanism of antibiotic action and the function of this unexplored tunnel region remain intriguingly elusive...
  28. ncbi request reprint Solution structure of an rRNA substrate bound to the pseudouridylation pocket of a box H/ACA snoRNA
    Hong Jin
    Department of Chemistry, Yale University, New Haven, CT 06520, USA
    Mol Cell 26:205-15. 2007
    ..The topology of the complex explains why the access of substrate sequences to snoRNPs is facile and how uridine selection may occur when these complexes form...
  29. pmc The crystal structure of a 26-nucleotide RNA containing a hook-turn
    Szilvia Szep
    Department of Chemistry, Yale University, New Haven, Connecticut 06520, USA
    RNA 9:44-51. 2003
    ..Similar structures, which we call hook-turns, occur in 16S and 23S rRNAs. They are found at places where the two strands of a helix separate at an A/G juxtaposition to interact with other sequences...
  30. pmc Structural insights into peptide bond formation
    Jeffrey L Hansen
    Department of Molecular Biophysics and Biochemistry, Yale University, 266 Whitney Avenue, New Haven, CT 06520 8114, USA
    Proc Natl Acad Sci U S A 99:11670-5. 2002
    ..These interactions position the alpha amino group adjacent to the carbonyl carbon of esterified P site substrate in an orientation suitable for a nucleophilic attack...
  31. pmc The structures of antibiotics bound to the E site region of the 50 S ribosomal subunit of Haloarcula marismortui: 13-deoxytedanolide and girodazole
    Susan J Schroeder
    Department of Chemistry, Yale University, New Haven, CT 06520 8107, USA
    J Mol Biol 367:1471-9. 2007
    ..Girodazole is specific for eukarytes and archaea because it makes interactions with L15 that are not possible in eubacteria...
  32. ncbi request reprint The solution structure of ribosomal protein L18 from Bacillus stearothermophilus
    Catherine F Turner
    Department of Chemistry, Yale University, New Haven, CT 06520 8107, USA
    J Mol Biol 335:679-84. 2004
    ..This conformational peculiarity should not prevent BstL18 from functioning in the ribosome the same way as other L18s...
  33. ncbi request reprint The ribosome revealed
    Peter B Moore
    Trends Biochem Sci 30:281-3. 2005

Research Grants17

  1. RIBOSOME STRUCTURE/FUNCTION
    Peter Moore; Fiscal Year: 2001
    ..The structures of all new crystals obtained that are suitable for crystallographic analysis will be pursued. Third, the crustal structure of elongation factor G (EF-G) complexed with a GTP analogue will be solved. ..
  2. STRUCTURE AND PHYSICAL PROPERTIES OF RNA
    Peter Moore; Fiscal Year: 2007
    ..Biochemical experiments will be done to determine whether RNA/RNA interactions of the sort hypothesized are possible, and structures will be obtained for a snoRNA, with and without an appropriate rRNA sequence bound. ..
  3. Upgrade of X-Ray Diffractometers
    Peter Moore; Fiscal Year: 2005
    ..It is anticipated that this upgrade will significantly increase the rate at which structures are determined at Yale. ..
  4. STRUCTURE AND PHYSICAL PROPERTIES OF RNA
    Peter Moore; Fiscal Year: 2003
    ..abstract_text> ..
  5. NMR Console Upgrade and Cryoprobe
    Peter Moore; Fiscal Year: 2002
    ..There are several structural biology projects under consideration that demand this sensitivity because the molecules of interest aggregate at the concentrations required when standard probes are used. ..