Michelle Y Monette
Affiliation: Yale University
- Regulatory activation is accompanied by movement in the C terminus of the Na-K-Cl cotransporter (NKCC1)Michelle Y Monette
Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut 06520, USA
J Biol Chem 287:2210-20. 2012..It is anticipated that when combined with structural information, our findings will provide a model for understanding the conformational changes that bring about NKCC1 regulation...
- Impacts of short-term acid and aluminum exposure on Atlantic salmon (Salmo salar) physiology: a direct comparison of parr and smoltsMichelle Y Monette
Organismic and Evolutionary Biology, University of Massachusetts, 611 North Pleasant Street, Amherst, MA 01003, USA
Aquat Toxicol 86:216-26. 2008..Instead, increased sensitivity of smolts is likely a result of both the acquisition of seawater tolerance while still in freshwater and heightened stress responsiveness in preparation for seawater entry and residence...
- Effects of short-term acid and aluminum exposure on the parr-smolt transformation in Atlantic salmon (Salmo salar): disruption of seawater tolerance and endocrine statusMichelle Y Monette
Graduate Program in Organismic and Evolutionary Biology, University of Massachusetts, 611 N Pleasant Street, Amherst, MA 01003, USA
Gen Comp Endocrinol 158:122-30. 2008..Loss of SW tolerance during short-term acid/Al exposure likely results from reductions in gill NKA and NKCC, possibly mediated by decreases in plasma IGF-I and T(3)...
- Rare mutations in the human Na-K-Cl cotransporter (NKCC2) associated with lower blood pressure exhibit impaired processing and transport functionMichelle Y Monette
Dept of Cellular and Molecular Physiology, Howard Hughes Medical Institute, Yale Univ School of Medicine, New Haven, CT 06520, USA
Am J Physiol Renal Physiol 300:F840-7. 2011..to identify functionally important residues by sequence conservation. Such mutations in hNKCC2A are likely to reduce renal salt reabsorption, providing a mechanism for lower blood pressure...
- Physiological, molecular, and cellular mechanisms of impaired seawater tolerance following exposure of Atlantic salmon, Salmo salar, smolts to acid and aluminumMichelle Y Monette
Organismic and Evolutionary Biology Program, University of Massachusetts, Amherst, MA 01003
Aquat Toxicol 99:17-32. 2010..When smolts are exposed to acid and low levels of Al, loss of seawater tolerance appears to be independent of these mechanisms and may result instead from a shift in the phenotype of MRCs present in the gill epithelium...
- Molecular motions involved in Na-K-Cl cotransporter-mediated ion transport and transporter activation revealed by internal cross-linking between transmembrane domains 10 and 11/12Michelle Y Monette
From the Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut 06520
J Biol Chem 289:7569-79. 2014....
- Phosphorylation state of the Na+-K+-Cl- cotransporter (NKCC1) in the gills of Atlantic killifish (Fundulus heteroclitus) during acclimation to water of varying salinityAndreas W Flemmer
Department of Cellular and Molecular Physiology, Yale University School of Medicine, PO Box 208026, New Haven, CT 06520, USA
J Exp Biol 213:1558-66. 2010..7-fold greater in SW-acclimated killifish relative to FW fish. Overall, these results demonstrate an important role of NKCC1 phosphorylation in the gill of Atlantic killifish during acute salinity acclimation...
- Functional expression of human NKCC1 from a synthetic cassette-based cDNA: introduction of extracellular epitope tags and removal of cysteinesSuma Somasekharan
Department of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut, United States of America
PLoS ONE 8:e82060. 2013..Together these advances are expected to greatly assist future studies of NKCC1. ..