Irvin Modlin

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Natl Cancer Inst 100:1282-9. 2008
  2. ncbi request reprint A 5-decade analysis of 13,715 carcinoid tumors
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 97:934-59. 2003
  3. ncbi request reprint Carcinoid tumors of the stomach
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Surg Oncol 12:153-72. 2003
  4. ncbi request reprint Gastrointestinal neuroendocrine (carcinoid) tumours: current diagnosis and management
    Irvin M Modlin
    School of Medicine, Yale University, New Haven, Conn, USA
    Med J Aust 193:46-52. 2010
  5. pmc Comparison of PCR-based detection of chromogranin A mRNA with traditional histological lymph node staging of small intestinal neuroendocrine neoplasia
    Ben Lawrence
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 208602, USA
    BMC Res Notes 5:318. 2012
  6. pmc The clinical implications and biologic relevance of neurofilament expression in gastroenteropancreatic neuroendocrine neoplasms
    Simon Schimmack
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT, USA
    Cancer 118:2763-75. 2012
  7. pmc Differential signal pathway activation and 5-HT function: the role of gut enterochromaffin cells as oxygen sensors
    Martin Haugen
    Gastrointestinal Pathobiology Research Group, Yale Univ School of Medicine, New Haven, CT 06510, USA
    Am J Physiol Gastrointest Liver Physiol 303:G1164-73. 2012
  8. doi request reprint A clinical perspective on gastric neuroendocrine neoplasia
    Ben Lawrence
    Yale University School of Medicine, New Haven, CT 06520, USA
    Curr Gastroenterol Rep 13:101-9. 2011
  9. ncbi request reprint GeneChip, geNorm, and gastrointestinal tumors: novel reference genes for real-time PCR
    Mark Kidd
    Gastrointestinal Research Group, Yale University School of Medicine, New Haven, Connecticut, USA
    Physiol Genomics 30:363-70. 2007
  10. ncbi request reprint Therapeutic options for gastrointestinal carcinoids
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Clin Gastroenterol Hepatol 4:526-47. 2006

Collaborators

Detail Information

Publications37

  1. pmc Priorities for improving the management of gastroenteropancreatic neuroendocrine tumors
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    J Natl Cancer Inst 100:1282-9. 2008
    ....
  2. ncbi request reprint A 5-decade analysis of 13,715 carcinoid tumors
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 97:934-59. 2003
    ....
  3. ncbi request reprint Carcinoid tumors of the stomach
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Surg Oncol 12:153-72. 2003
    ..In addition, the clinical rationale of current diagnostic and therapeutic strategies will be examined, providing a logical basis for the formulation of appropriate management strategies for patient care...
  4. ncbi request reprint Gastrointestinal neuroendocrine (carcinoid) tumours: current diagnosis and management
    Irvin M Modlin
    School of Medicine, Yale University, New Haven, Conn, USA
    Med J Aust 193:46-52. 2010
    ..The overarching requirement for best management of patients with NETs is to ensure that they have ready access to experienced multidisciplinary clinician groups located within centres of appropriate subspecialty expertise...
  5. pmc Comparison of PCR-based detection of chromogranin A mRNA with traditional histological lymph node staging of small intestinal neuroendocrine neoplasia
    Ben Lawrence
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, CT 208602, USA
    BMC Res Notes 5:318. 2012
    ..We hypothesized that detection of CgA mRNA transcripts would be a more sensitive method of detecting these metastases...
  6. pmc The clinical implications and biologic relevance of neurofilament expression in gastroenteropancreatic neuroendocrine neoplasms
    Simon Schimmack
    Department of Gastroenterological Surgery, Yale University School of Medicine, New Haven, CT, USA
    Cancer 118:2763-75. 2012
    ..Given the role of internexin alpha (INA) in neuronal development, the authors assessed its function in neuroendocrine cell systems and the clinical implications of its expression as a GEP-NEN biomarker...
  7. pmc Differential signal pathway activation and 5-HT function: the role of gut enterochromaffin cells as oxygen sensors
    Martin Haugen
    Gastrointestinal Pathobiology Research Group, Yale Univ School of Medicine, New Haven, CT 06510, USA
    Am J Physiol Gastrointest Liver Physiol 303:G1164-73. 2012
    ..This results in alterations in 5-HT production and secretion and identifies that the chemomechanosensory role of EC cells extends to oxygen sensing...
  8. doi request reprint A clinical perspective on gastric neuroendocrine neoplasia
    Ben Lawrence
    Yale University School of Medicine, New Haven, CT 06520, USA
    Curr Gastroenterol Rep 13:101-9. 2011
    ..Elucidation of the precise biology of a gastric NET is critical to diagnosis and delineation of a type-specific management strategy...
  9. ncbi request reprint GeneChip, geNorm, and gastrointestinal tumors: novel reference genes for real-time PCR
    Mark Kidd
    Gastrointestinal Research Group, Yale University School of Medicine, New Haven, Connecticut, USA
    Physiol Genomics 30:363-70. 2007
    ....
  10. ncbi request reprint Therapeutic options for gastrointestinal carcinoids
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Clin Gastroenterol Hepatol 4:526-47. 2006
    ..The keystone of current therapy remains the long-acting somatostatin analogues that alleviate symptomatology and substantially improve quality of life with minimal adverse effects...
  11. ncbi request reprint Utility of molecular genetic signatures in the delineation of gastric neoplasia
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Cancer 106:1480-8. 2006
    ..This strategy provides a molecular basis to define neuroendocrine gastric carcinoids (GCs), neuronal stromal tumors (GISTs), or epithelial cell (gastric adenocarcinomas [GCAs])-derived tumors...
  12. ncbi request reprint A 50-year analysis of 562 gastric carcinoids: small tumor or larger problem?
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Am J Gastroenterol 99:23-32. 2004
    ..We sought to examine if there has been an increase in gastric carcinoid incidence time correlative with these parameters...
  13. ncbi request reprint Biology and management of gastric carcinoid tumours: a review
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Eur J Surg 168:669-83. 2002
    ..Gastric carcinoids, however, can be managed initially by endoscopic excision of accessible tumours, followed by regular endoscopic surveillance...
  14. ncbi request reprint Current status of gastrointestinal carcinoids
    Irvin M Modlin
    Gastric Pathobiology Research Group, GI Surgical Division, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Gastroenterology 128:1717-51. 2005
    ..Overall 5-year survival for carcinoids of the appendix is 98%, gastric (types I/II) is 81%, rectum is 87%, small intestinal is 60%, colonic carcinoids is 62%, and gastric type III/IV is 33%...
  15. ncbi request reprint Small bowel carcinoid (enterochromaffin cell) neoplasia exhibits transforming growth factor-beta1-mediated regulatory abnormalities including up-regulation of C-Myc and MTA1
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 109:2420-31. 2007
    ..Whether this phenomenon is common to small intestinal carcinoid tumors was investigated...
  16. ncbi request reprint Neuroendocrine tumors of the diffuse neuroendocrine system
    Bjorn I Gustafsson
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Curr Opin Oncol 20:1-12. 2008
    ..25% of all malignancies; their incidence is increasing by approximately 6% per year. The present review provides an overview on neuroendocrine tumors and focuses on general features and current diagnostic and therapeutic options...
  17. doi request reprint Gastroenteropancreatic neuroendocrine tumours
    Irvin M Modlin
    Department of Gastroenterological Surgery, Yale University, New Haven, CT 06520 8062, USA
    Lancet Oncol 9:61-72. 2008
    ..Progress is unlikely to occur without development of centers of excellence, with dedicated combined clinical teams to coordinate multicentre studies, maintain clinical and tissue databases, and refine molecularly targeted therapeutics...
  18. doi request reprint Inhibition of proliferation of small intestinal and bronchopulmonary neuroendocrine cell lines by using peptide analogs targeting receptors
    Mark Kidd
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 112:1404-14. 2008
    ....
  19. doi request reprint Bronchopulmonary neuroendocrine tumors
    Bjorn I Gustafsson
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Cancer 113:5-21. 2008
    ..This review provides a broad overview on BP-NETs and focuses on the evolution of the disease, general features, and current diagnostic and therapeutic options...
  20. doi request reprint Luminal regulation of normal and neoplastic human EC cell serotonin release is mediated by bile salts, amines, tastants, and olfactants
    Mark Kidd
    1Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Gastrointest Liver Physiol 295:G260-72. 2008
    ..Luminal EC cell regulation is likely to be as important as G cell regulation in gastric acid secretion; development of agents to target EC cell function is therefore a critical therapeutic goal...
  21. ncbi request reprint Carcinoid tumors and fibrosis: an association with no explanation
    Irvin M Modlin
    Gastric Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Am J Gastroenterol 99:2466-78. 2004
    ..In addition, we have provided more current mechanistic information in regard to the biological basis of fibrosis associated with small bowel carcinoid tumors...
  22. ncbi request reprint Multiple gastric carcinoids
    Irvin M Modlin
    J Am Coll Surg 198:174. 2004
  23. ncbi request reprint Alteration of DNA methylation status induced by epidermal growth factor in gastric cancer cell line, MKN-74
    Yoshiro Saikawa
    Department of Surgery, School of Medicine, Keio University, 35 Shinamachi, Shinjukuku, Tokyo 160 8582, Japan
    Anticancer Res 23:143-8. 2003
    ..1 nM EGF. Thus, we demonstrated that DNA methylation status is affected by EGF-stimulation with alteration of cell biological character...
  24. ncbi request reprint An analysis of rare carcinoid tumors: clarifying these clinical conundrums
    Irvin M Modlin
    Gastric Pathobiology Research Group, Yale University School of Medicine, 333 Cedar Street, P O Box 208062, New Haven, CT 06520 8062, USA
    World J Surg 29:92-101. 2005
    ..Familiarity with such unusual sites of origin will facilitate appropriate recognition and characterization of such tumors, allowing for timely intervention...
  25. ncbi request reprint A three-decade analysis of 3,911 small intestinal neuroendocrine tumors: the rapid pace of no progress
    Irvin M Modlin
    Gastrointestinal Pathobiology Research Group, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Am J Gastroenterol 102:1464-73. 2007
    ..We examined patterns, incidence, prognosis, and outcomes of these tumors over a 30-yr period...
  26. ncbi request reprint The molecular genetics of gastroenteropancreatic neuroendocrine tumors
    Michelle N Zikusoka
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 104:2292-309. 2005
    ..On the basis of the evolution of genetic information, enteric neuroendocrine lesions (carcinoids) and PETs may need to be classified as two distinct entities rather than grouped together as the single entity "GEP-NETs."..
  27. ncbi request reprint Multiple gastrointestinal stromal tumors and synchronous ileal carcinoids
    Michele Buragas
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Clin Pract Oncol 2:166-70; quiz 1 p following 170. 2005
    ..A gastric-wedge resection revealed an ulcerated 4.5 cm mass in the stomach, and exploration of the abdomen revealed two ileal carcinoid tumors, jejunal diverticula and reactive mesenteric lymphadenopathy...
  28. ncbi request reprint The role of genetic markers--NAP1L1, MAGE-D2, and MTA1--in defining small-intestinal carcinoid neoplasia
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, 333 Cedar Street, P O Box 208062, New Haven, Connecticut 06520 8062, USA
    Ann Surg Oncol 13:253-62. 2006
    ..We hypothesized that carcinoid malignancy could be defined by using quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) and immunohistochemical approaches that evaluate potential marker genes...
  29. pmc Q RT-PCR detection of chromogranin A: a new standard in the identification of neuroendocrine tumor disease
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Surg 243:273-80. 2006
    ..Message and protein expression of CgA was examined to evaluate the sensitivity of a PCR-based approach in the detection of covert neuroendocrine (NE) tissue...
  30. ncbi request reprint Siegfried Oberndorfer: origins and perspectives of carcinoid tumors
    Irvin M Modlin
    Gastric Pathobiology Research Group, Department of Surgery, Yale University School of Medinice, New Haven, CT 06520 8062, USA
    Hum Pathol 35:1440-51. 2004
    ..It also serves to memorialize the extraordinary accomplishments of Oberndorfer, whose vision exceeded his times...
  31. ncbi request reprint The functional characterization of normal and neoplastic human enterochromaffin cells
    Irvin M Modlin
    Department of Surgery, TMP202, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520, USA
    J Clin Endocrinol Metab 91:2340-8. 2006
    ....
  32. ncbi request reprint Microsatellite instability and gene mutations in transforming growth factor-beta type II receptor are absent in small bowel carcinoid tumors
    Mark Kidd
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut 06520 8062, USA
    Cancer 103:229-36. 2005
    ..The authors postulated that a similar mechanism occurred during the malignant evolution of small bowel carcinoid tumors...
  33. pmc Genetic differentiation of appendiceal tumor malignancy: a guide for the perplexed
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Ann Surg 244:52-60. 2006
    ..To use differential gene expression of candidate markers to discriminate benign appendiceal carcinoids (APCs) from malignant and mixed cell APCs...
  34. ncbi request reprint Gastrointestinal carcinoids: the evolution of diagnostic strategies
    Irvin M Modlin
    Department of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Gastroenterol 40:572-82. 2006
    ....
  35. ncbi request reprint Primary carcinoid tumor of the parotid gland: A case report and review of the literature
    Irvin M Modlin
    Gastric Pathobiology Research Group, Yale University School of Medicine, New Haven, Conn 06520 8062, USA
    Ear Nose Throat J 85:533-9. 2006
    ..In particular, it is important to differentiate them from metastatic tumors from other sites...
  36. ncbi request reprint Siegfried oberndorfer and the evolution of carcinoid disease
    Irvin M Modlin
    Gastric Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, New Haven, CT 06520 8062, USA
    Arch Surg 142:187-97. 2007
    ..This exploration of his life and times seeks to give Oberndorfer his well-deserved place in the pantheon of pathology and memorialize his unique observations that led to the discovery of the carcinoid tumor...
  37. ncbi request reprint Surgery of chronic pancreatitis: chronicle of confusion and despair
    Irvin M Modlin
    Gastrointestinal Surgical Pathobiology Research Group, Yale University School of Medicine, 333 Cedar Street, PO Box 208026, New Haven, Connecticut 06520, USA
    World J Surg 26:1382-96. 2002
    ..As Theodor Billroth, the greatest of the surgical innovators remarked: "An awareness of the past is necessary to comprehend the present, and without it no consideration of the future is possible."..

Research Grants7

  1. Molecular Strategies for Gastric Carcinoid Surgery
    Irvin Modlin; Fiscal Year: 2005
    ..A pre-operative determination of the neoplastic ECL cell gene expression relating to gastrin responsiveness will improve the rationale for therapeutic gastric or antral resection. ..
  2. Molecular strategies to define carcinoids and rationalize surgical intervention
    Irvin Modlin; Fiscal Year: 2007
    ..This will provide novel biological information and provide molecular data to identify occult metastasis predict spread and facilitate preemptive appropriate therapy. ..
  3. Molecular strategies to define carcinoids and rationalize surgical intervention
    Irvin Modlin; Fiscal Year: 2009
    ..This will provide novel biological information and provide molecular data to identify occult metastasis predict spread and facilitate preemptive appropriate therapy. ..