Hemmo H Meyer

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4
    Hemmo H Meyer
    Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, SHM, C441, PO Box 208002, New Haven, CT 06520 8002, USA
    EMBO J 21:5645-52. 2002
  2. pmc Structural insights into the p97-Ufd1-Npl4 complex
    Valerie E Pye
    Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 104:467-72. 2007
  3. ncbi request reprint Golgi reassembly after mitosis: the AAA family meets the ubiquitin family
    Hemmo H Meyer
    Swiss Federal School of Technology ETH, Institute of Biochemistry, Zurich, Switzerland
    Biochim Biophys Acta 1744:481-92. 2005
  4. ncbi request reprint Golgi reassembly after mitosis: the AAA family meets the ubiquitin family
    Hemmo H Meyer
    Swiss Federal School of Technology ETH, Institute of Biochemistry, ETH Honggerberg HPM, Zurich
    Biochim Biophys Acta 1744:108-19. 2005
  5. ncbi request reprint The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism
    Roland M Bruderer
    Swiss Federal School of Technology, Institute of Biochemistry, ETH Honggerberg HPM, Zurich 8093, Switzerland
    J Biol Chem 279:49609-16. 2004
  6. pmc VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments
    Yanzhuang Wang
    Institute of Biochemistry, ETH Hoenggerberg, HPM G17 1, 8093 Zurich, Switzerland
    J Cell Biol 164:973-8. 2004
  7. pmc Ubiquitin interactions of NZF zinc fingers
    Steven L Alam
    Department of Biochemistry, University of Utah, Salt Lake City, UT, USA
    EMBO J 23:1411-21. 2004
  8. ncbi request reprint The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis
    Kan Cao
    Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, Baltimore, MD 21210, USA
    Cell 115:355-67. 2003
  9. pmc Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4
    Bin Wang
    Department of Biochemistry, University of Utah, Salt Lake City 84132, USA
    J Biol Chem 278:20225-34. 2003
  10. pmc Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
    Yihong Ye
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    J Cell Biol 162:71-84. 2003

Collaborators

  • Yanzhuang Wang
  • Steven L Alam
  • WESLEY IAN SUNDQUIST
  • S D Emr
  • Yihong Ye
  • Valerie E Pye
  • Rivka L Isaacson
  • Kristijan Ramadan
  • Xiaodong Zhang
  • Paul S Freemont
  • Roland M Bruderer
  • Bin Wang
  • Kan Cao
  • Steve Matthews
  • Oliver Popp
  • Roland Bruderer
  • Fabienne Beuron
  • Peter Simpson
  • Tina Baur
  • Fabio M Spiga
  • Monica Gotta
  • Carol V Robinson
  • Catherine A Keetch
  • Ciaran McKeown
  • Catherine Brasseur
  • Darrell R Davis
  • Reiko Nakajima
  • Marielle Payne
  • Yixian Zheng
  • Timothy L Stemmler

Detail Information

Publications12

  1. pmc Direct binding of ubiquitin conjugates by the mammalian p97 adaptor complexes, p47 and Ufd1-Npl4
    Hemmo H Meyer
    Department of Cell Biology, Yale University School of Medicine, 333 Cedar Street, SHM, C441, PO Box 208002, New Haven, CT 06520 8002, USA
    EMBO J 21:5645-52. 2002
    ..The UBA domain is required for the function of p47 in mitotic Golgi reassembly. Together, these data suggest that ubiquitin recognition is a common feature of p97-mediated reactions...
  2. pmc Structural insights into the p97-Ufd1-Npl4 complex
    Valerie E Pye
    Division of Molecular Biosciences, Faculty of Natural Sciences, Imperial College London, London SW7 2AZ, United Kingdom
    Proc Natl Acad Sci U S A 104:467-72. 2007
    ....
  3. ncbi request reprint Golgi reassembly after mitosis: the AAA family meets the ubiquitin family
    Hemmo H Meyer
    Swiss Federal School of Technology ETH, Institute of Biochemistry, Zurich, Switzerland
    Biochim Biophys Acta 1744:481-92. 2005
    ..Here, these findings are reviewed and discussed in the context of the increasingly evident role of ubiquitin in membrane traffic processes...
  4. ncbi request reprint Golgi reassembly after mitosis: the AAA family meets the ubiquitin family
    Hemmo H Meyer
    Swiss Federal School of Technology ETH, Institute of Biochemistry, ETH Honggerberg HPM, Zurich
    Biochim Biophys Acta 1744:108-19. 2005
    ..Here, these findings are reviewed and discussed in the context of the increasingly evident role of ubiquitin in membrane traffic processes...
  5. ncbi request reprint The AAA ATPase p97/VCP interacts with its alternative co-factors, Ufd1-Npl4 and p47, through a common bipartite binding mechanism
    Roland M Bruderer
    Swiss Federal School of Technology, Institute of Biochemistry, ETH Honggerberg HPM, Zurich 8093, Switzerland
    J Biol Chem 279:49609-16. 2004
    ..Therefore, the binding sites alone do not regulate p97 directly but rather serve as anchor points to position adapter-specific domains at critical locations to modulate p97-mediated reactions...
  6. pmc VCIP135 acts as a deubiquitinating enzyme during p97-p47-mediated reassembly of mitotic Golgi fragments
    Yanzhuang Wang
    Institute of Biochemistry, ETH Hoenggerberg, HPM G17 1, 8093 Zurich, Switzerland
    J Cell Biol 164:973-8. 2004
    ..Together, these data reveal a cycle of ubiquitylation and deubiquitination that regulates Golgi membrane dynamics during mitosis. Furthermore, they represent the first evidence for a proteasome-independent function of p97/Cdc48...
  7. pmc Ubiquitin interactions of NZF zinc fingers
    Steven L Alam
    Department of Biochemistry, University of Utah, Salt Lake City, UT, USA
    EMBO J 23:1411-21. 2004
    ..Thus, the NZF is a versatile protein recognition domain that is used to bind ubiquitylated proteins during vacuolar protein sorting, and probably many other biological processes...
  8. ncbi request reprint The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis
    Kan Cao
    Department of Embryology, Carnegie Institution of Washington and Howard Hughes Medical Institute, Baltimore, MD 21210, USA
    Cell 115:355-67. 2003
    ..Therefore, Cdc48/p97-Ufd1-Npl4 is an essential chaperone that regulates transformation of the microtubule structure as cells reenter interphase...
  9. pmc Structure and ubiquitin interactions of the conserved zinc finger domain of Npl4
    Bin Wang
    Department of Biochemistry, University of Utah, Salt Lake City 84132, USA
    J Biol Chem 278:20225-34. 2003
    ..Our studies reveal the structure of this versatile class of protein binding domains and provide a means for identifying the subset of NZF domains likely to bind ubiquitin...
  10. pmc Function of the p97-Ufd1-Npl4 complex in retrotranslocation from the ER to the cytosol: dual recognition of nonubiquitinated polypeptide segments and polyubiquitin chains
    Yihong Ye
    Howard Hughes Medical Institute and Department of Cell Biology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115, USA
    J Cell Biol 162:71-84. 2003
    ....
  11. ncbi request reprint Detailed structural insights into the p97-Npl4-Ufd1 interface
    Rivka L Isaacson
    Division of Molecular Biosciences, Imperial College London, Biochemistry Building, South Kensington, London SW7 2AZ, United Kingdom
    J Biol Chem 282:21361-9. 2007
    ..We calculated a structural model for the p97 N-Npl4 UBD complex, and a comparison with the p97-p47 adaptor complex reveals subtle differences in p97 adaptor recognition and specificity...
  12. ncbi request reprint Cdc48/p97 promotes reformation of the nucleus by extracting the kinase Aurora B from chromatin
    Kristijan Ramadan
    Institute of Biochemistry, ETH Zurich, 8093 Zurich, Switzerland
    Nature 450:1258-62. 2007
    ..These data reveal an essential pathway that regulates reformation of the nucleus after mitosis and defines ubiquitin-dependent protein extraction as a common mechanism of Cdc48/p97 activity also during nucleus formation...