Research Topics
| Laura MentSummaryAffiliation: Yale University Country: USA Publications
Research Grants
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Detail Information
Publications
Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymiaHaijun Chen
Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA
Neurogenetics 8:131-5. 2007..Electrophysiological studies of the mutant channel expressed in Xenopus oocytes indicated a loss of function. Co-expression of WT and mutant cRNAs significantly reduced whole-oocyte current compared to expression of WT Kv1.1 alone...
The etiology and outcome of cerebral ventriculomegaly at term in very low birth weight preterm infantsL R Ment
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
Pediatrics 104:243-8. 1999..We hypothesized that although the causes of VM are multiple, the incidence of handicap at 4.5 years of age in preterm infants with this ultrasonographic finding at term would be high...
Longitudinal brain volume changes in preterm and term control subjects during late childhood and adolescenceLaura R Ment
Departments of Pediatrics, Yale University School of Medicine, Department of Pediatrics, New Haven, CT 06520, USA
Pediatrics 123:503-11. 2009..Our goal was to test the hypothesis that preterm birth results in long-term dynamic changes in the developing brain...- Alterations in neural connectivity in preterm children at school ageYeisid Gozzo
Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, P O Box 208064, New Haven, CT 06520 8064, USA
Neuroimage 48:458-63. 2009.... - Cortical recruitment patterns in children born prematurely compared with control subjects during a passive listening functional magnetic resonance imaging taskLaura R Ment
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
J Pediatr 149:490-8. 2006..To use functional magnetic resonance imaging (fMRI) to test the hypothesis that subjects who were born prematurely develop alternative systems for processing language... - Prevention of intraventricular hemorrhage by indomethacin in male preterm infantsLaura R Ment
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
J Pediatr 145:832-4. 2004..Analysis of our cohort by sex showed indomethacin halved the incidence of IVH, eliminated parenchymal hemorrhage, and was associated with higher verbal scores at 3 to 8 years in boys... - Change in cognitive function over time in very low-birth-weight infantsLaura R Ment
Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, Conn 06520, USA
JAMA 289:705-11. 2003..However, recent experimental data suggest that the developing brain may recover from or compensate for injury... - A functional magnetic resonance imaging study of the long-term influences of early indomethacin exposure on language processing in the brains of prematurely born childrenLaura R Ment
Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06520, USA
Pediatrics 118:961-70. 2006..Previous studies have demonstrated that indomethacin lowers the incidence and decreases the severity of intraventricular hemorrhage, as well as improves the cognitive outcome, in prematurely born male infants... - Injury and recovery in the developing brain: evidence from functional MRI studies of prematurely born childrenLaura R Ment
Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
Nat Clin Pract Neurol 3:558-71. 2007.... - Adaptive mechanisms of developing brain. The neuroradiologic assessment of the preterm infantL R Ment
Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
Clin Perinatol 27:303-23. 2000..Finally, the interesting observation that preterm infants fare as well as they do despite MR imaging-identified lesions might stimulate research studying the adaptive mechanisms of developing brain... - Outcome of children in the indomethacin intraventricular hemorrhage prevention trialL R Ment
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06511, USA
Pediatrics 105:485-91. 2000..In addition, we hypothesized that the early administration of low-dose indomethacin would not be associated with an increase in the incidence of neurodevelopmental handicap at 4.5 years of age in our study children... 
Consequence of preterm birth in early adolescence: the role of language on auditory short-term memoryDavid Fraello
Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
J Child Neurol 26:738-42. 2011..This study provides evidence of possible mechanisms for learning problems in former preterm infants...- Functional connectivity to a right hemisphere language center in prematurely born adolescentsEliza H Myers
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
Neuroimage 51:1445-52. 2010..439, p=0.019). Preterm adolescents engage a dorsal right hemisphere region for language at age 16years. Those with the greatest cognitive deficits demonstrate increasing reliance on this alternate pathway... - Alterations in functional connectivity for language in prematurely born adolescentsRobin J Schafer
Department of Diagnostic Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, PO Box 208043, New Haven, CT 06520, USA
Brain 132:661-70. 2009..Plasticity in network connections may provide the substrate for improving language skills in the prematurely born... - Cortical neurogenesis enhanced by chronic perinatal hypoxiaDevon M Fagel
Child Study Center, Yale University Medical School, 230 South Frontage Road, New Haven, CT 06520, USA
Exp Neurol 199:77-91. 2006..We suggest that cortical neurogenesis may play a significant role in repairing neuronal losses after neonatal injury... - Fgfr1 is required for cortical regeneration and repair after perinatal hypoxiaDevon M Fagel
Child Study Center, Yale University, New Haven, Connecticut 06520, USA
J Neurosci 29:1202-11. 2009..In contrast, there is incomplete recovery of inhibitory neurons after injury, which may account for persistent behavioral deficits... - Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of ageThuy Mai Luu
Women and Infants Hospital, Department of Pediatrics, 101 Dudley St, Providence, RI 02905, USA
Pediatrics 123:1037-44. 2009.... - Imaging biomarkers of outcome in the developing preterm brainLaura R Ment
Departments of Pediatrics and Neurology, Yale University School of Medicine, New Haven, CT, USA
Lancet Neurol 8:1042-55. 2009..Identification of early biomarkers for outcome could enable physicians and scientists to develop targeted pharmacological and behavioural therapies to restore functional connectivity... - Preterm birth: a cost benefit analysisSusan Rushing
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06510, USA
Semin Perinatol 28:444-50. 2004..Postnatal administration of dexamethasone can lead to severe disability when administered before 7 to 10 days of life. Postnatal dexamethasone does not increase survival or decrease rates of chronic lung disease... - Trajectories of receptive language development from 3 to 12 years of age for very preterm childrenThuy Mai Luu
Department of Pediatrics, Warren Alpert Medical School ofBrown University, Providence, Rhode Island, USA
Pediatrics 124:333-41. 2009..The goal was to examine whether indomethacin use, gender, neonatal, and sociodemographic factors predict patterns of receptive language development from 3 to 12 years of age in preterm children... - School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trialBetty R Vohr
Department of Pediatrics, Brown Medical School, Providence, Rhode Island, USA
Pediatrics 111:e340-6. 2003..The objective was to determine the effects of both IVH and indomethacin on cognitive, language, and achievement performance at 8 years of age... - Astroglial cells in the external granular layer are precursors of cerebellar granule neurons in neonatesJohn Silbereis
Child Study Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Mol Cell Neurosci 44:362-73. 2010..The identification of glial cells which function as neuronal progenitor cells profoundly impacts our understanding of cellular plasticity in the developing cerebellum... - Early postnatal astroglial cells produce multilineage precursors and neural stem cells in vivoYosif M Ganat
Child Study Center, Yale University Medical School, New Haven, Connecticut 06520, USA
J Neurosci 26:8609-21. 2006.... - Prematurely born children demonstrate white matter microstructural differences at 12 years of age, relative to term control subjects: an investigation of group and gender effectsR Todd Constable
Department of Diagnostic Imaging, Yale University School of Medicine, New Haven, CT 06520, USA
Pediatrics 121:306-16. 2008..The goal was to use diffusion tensor imaging to test the hypothesis that prematurely born children demonstrate long-term, white matter, microstructural differences, relative to term control subjects... - Precursors with glial fibrillary acidic protein promoter activity transiently generate GABA interneurons in the postnatal cerebellumJohn Silbereis
Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
Stem Cells 27:1152-63. 2009..This restricted critical period implies that powerful inhibitory factors may restrict their fate potential in vivo at later stages of development... - Neurodevelopment of C57B/L6 mouse brain assessed by in vivo diffusion tensor imagingHalima Chahboune
Department of Diagnostic Radiology, Yale University, 300 Cedar Street, New Haven, CT 06510, USA
NMR Biomed 20:375-82. 2007..In summary, these results show that high-resolution DTI at high magnetic fields allows detection and quantification of brain structures throughout normal development in C57B/L6 mice in vivo... - Astroglial cells in development, regeneration, and repairFlora M Vaccarino
Child Study Center, Department of Neurobiology, Yale University Medical School, New Haven, CT, USA
Neuroscientist 13:173-85. 2007.... - Sickle cell disease complicated by post-streptococcal glomerulonephritis, cerebral hemorrhage and reversible posterior leucoencephalopathy syndromeFarzana D Pashankar
Department of Pediatrics and Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
Pediatr Blood Cancer 50:864-6. 2008..Similarly, because of the difference in prognosis between APSGN and other forms of sickle cell nephropathy, it is also important to differentiate these conditions... - Disrupted synaptic development in the hypoxic newborn brainSheila M Curristin
Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
Proc Natl Acad Sci U S A 99:15729-34. 2002..These patterns reveal a global dysynchrony in the maturation programs of the hypoxic developing brain, and offer insights into the vulnerabilities of processes that guide early postnatal cerebral maturation... - Chronic neonatal hypoxia leads to long term decreases in the volume and cell number of the rat cerebral cortexMichael L Schwartz
Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
Semin Perinatol 28:379-88. 2004..It is hypothesized that the mechanisms responsible for these alterations in cortical cell number may depend on the state of differentiation of the different cell types at the time of hypoxic exposure... - An evidence-based approach to predicting low IQ in very preterm infants from the neurological examination: outcome data from the indomethacin Indomethacin Intraventricular Hemorrhage Prevention TrialMichael D Pleacher
Department of Pediatrics, Division of Pediatric Neurology, Maine Medical Center, Portland, Maine, USA
Pediatrics 113:416-9. 2004..We conclude that the neurologic examination at 3 years old predicts FSIQ <70 at age 8 with LRs that allow evidence-based parental counseling and intervention planning... - Long-term outcome of preterm infants and the role of neuroimagingEliza Myers
Department of Pediatrics, Yale University School of Medicine, P O Box 208064, New Haven, CT 06520 8064, USA
Clin Perinatol 36:773-89, vi. 2009..New neuroimaging modalities and analysis tools are contributing to the understanding of neurologic sequelae of preterm birth by providing microstructural evidence of injury sustained by the preterm brain... - Hypoxic injury during neonatal development in murine brain: correlation between in vivo DTI findings and behavioral assessmentHalima Chahboune
Department of Diagnostic Radiology, Yale University, New Haven, CT 06510, USA
Cereb Cortex 19:2891-901. 2009..Thus, CSH mice revealed developmental and behavioral deficits that are similar to those observed in low birth weight preterm infants... - The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonateHeather J McCrea
Yale University School of Medicine, New Haven, CT 06510, USA
Clin Perinatol 35:777-92, vii. 2008..Randomized clinical prevention trials should provide long-term neurodevelopmental follow-up to assess the impact of preterm birth, injury, and pharmacologic intervention on the developing brain... - Neonatal hypoxia suppresses oligodendrocyte Nogo-A and increases axonal sprouting in a rodent model for human prematurityJared Weiss
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
Exp Neurol 189:141-9. 2004..Thus, hypoxia-induced reduction in myelin-derived axon outgrowth inhibitors appears to contribute axonal misconnection to the pathology of very low birth weight infants... - Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous systemOmolara O Ogunshola
Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Biol Chem 277:11410-5. 2002..Thus, our in vitro data support a role for neuronal VEGF in both paracrine and autocrine signaling in the maintenance of neurons and endothelia in the central nervous system... - Familial and genetic susceptibility to major neonatal morbidities in preterm twinsVineet Bhandari
Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520-8064, USA
Pediatrics 117:1901-6. 2006..These data demonstrate, for the first time, the significant genetic susceptibility for bronchopulmonary dysplasia in preterm infants... - COL4A1 mutation in preterm intraventricular hemorrhageKaya Bilguvar
Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
J Pediatr 155:743-5. 2009..We report a rare variant in COL4A1 associated with intraventricular hemorrhage in dizygotic preterm twins. These results expand the spectrum of diseases attributable to mutations in type IV procollagens... - Increased temporal lobe gyrification in preterm childrenShelli R Kesler
Stanford Psychiatry Neuroimaging Laboratory, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
Neuropsychologia 44:445-53. 2006..Cortical development in the temporal lobe appears to be differentially vulnerable to preterm birth... - Regional brain volumes and their later neurodevelopmental correlates in term and preterm infantsBradley S Peterson
Columbia College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
Pediatrics 111:939-48. 2003..To compare regional brain volumes measured in term and preterm infants, and to correlate regional volumes with measures of neurodevelopmental outcome... - Volumetric analysis of regional cerebral development in preterm childrenShelli R Kesler
Stanford Psychiatry Neuroimaging Laboratory, Stanford University School of Medicine, Stanford, CA 94305-5719, USA
Pediatr Neurol 31:318-25. 2004..Lower birth weight and the presence of intraventricular hemorrhage may increase the risk for neuroanatomic abnormality... - Brain volume reductions within multiple cognitive systems in male preterm children at age twelveShelli R Kesler
Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CA 94305 5795, USA
J Pediatr 152:513-20, 520.e1. 2008..To more precisely examine regional and subregional microstructural brain changes associated with preterm birth... - Sex differences in cerebral volumes of 8-year-olds born pretermAllan L Reiss
Stanford Psychiatry Neuroimaging Laboratory and Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
J Pediatr 145:242-9. 2004..These findings indicate that the sex of the very preterm newborn influences the mechanisms by which the developing brain is affected... - Grade 3 to 4 intraventricular hemorrhage and Bayley scores predict outcomeLaura R Ment
Pediatrics 116:1597-8; author reply 1598. 2005 - Fetal strokeKoray Ozduman
Department of Radiology, Stanford University School of Medicine, Stanford, California, USA
Pediatr Neurol 30:151-62. 2004..A better understanding of those risk factors predisposing a fetus to cerebral infarction may provide a basis for future therapeutic intervention trials.Ozduman K, Pober BR, Barnes P, Copel JA, Ogle EA, Duncan CC, Ment LR. Fetal stroke... - Preterm birth and the developing brainLaura R Ment
Lancet Neurol 7:378-9. 2008 - A functional magnetic resonance imaging study of language processing and its cognitive correlates in prematurely born childrenBradley S Peterson
Columbia College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
Pediatrics 110:1153-62. 2002..Our aim was to compare brain activity associated with phonologic and semantic processing of language between term and preterm children using functional magnetic resonance imaging (fMRI)...
Research Grants
- Multicenter Randomized Indomethacin IVH Prevention TrialLaura Ment; Fiscal Year: 2009..Serial MRI scans will determine growth patterns of cortical regions across time. ..
- RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIALLaura Ment; Fiscal Year: 2004..Finally, multivariate statistical analyses will be performed to determine the independent and important predictors of cognitive outcome and function at 8 and 12 years C.A. ..
- ADAPTIVE MECHANISMS OF DEVELOPING BRAINLaura Ment; Fiscal Year: 2007..If the central hypothesis of our program is verified, then novel therapeutic approaches for the reduction of neurodevelopmental deficits in preterm infants may result...
- Gene Targets for Intraventricular Hemorrhage (IVH)Laura Ment; Fiscal Year: 2007..DNA will be stored in the NINDS DNA Bank. ..
- Gene Targets for Intraventricular Hemorrhage (IVH)Laura Ment; Fiscal Year: 2009..DNA will be stored in the NINDS DNA Bank. ..
- Gene Targets for Intraventricular Hemorrhage (IVH)Laura R Ment; Fiscal Year: 2010..DNA will be stored in the NINDS DNA Bank. ..
- fMRI of Brain Development in Newborn InfantsLaura Ment; Fiscal Year: 2002....
- RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIALLaura Ment; Fiscal Year: 1993..The following parameters monitored for adverse effects of indomethacin: urinary output, serum electrolyte values, platelet count, clinical evidence for excessive bleeding. Long term neurodevelopmental follow-up studies will be performed...
- RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIALLaura Ment; Fiscal Year: 1999..Our secondary specific aims will study the influence of IVH on developmental outcome at 54 and 72 mo. C. A. and mMultivariate analyses will be performed to determine independent and important predictors of outcome at these two ages. ..
- Gene Targets for Intraventricular Hemorrhage (IVH)Laura R Ment; Fiscal Year: 2010..DNA will be stored in the NINDS DNA Bank. ..