Laura Ment

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia
    Haijun Chen
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA
    Neurogenetics 8:131-5. 2007
  2. ncbi request reprint The etiology and outcome of cerebral ventriculomegaly at term in very low birth weight preterm infants
    L R Ment
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Pediatrics 104:243-8. 1999
  3. pmc A functional magnetic resonance imaging study of the long-term influences of early indomethacin exposure on language processing in the brains of prematurely born children
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06520, USA
    Pediatrics 118:961-70. 2006
  4. ncbi request reprint Prevention of intraventricular hemorrhage by indomethacin in male preterm infants
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    J Pediatr 145:832-4. 2004
  5. pmc Cortical recruitment patterns in children born prematurely compared with control subjects during a passive listening functional magnetic resonance imaging task
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Pediatr 149:490-8. 2006
  6. pmc Injury and recovery in the developing brain: evidence from functional MRI studies of prematurely born children
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Nat Clin Pract Neurol 3:558-71. 2007
  7. pmc Longitudinal brain volume changes in preterm and term control subjects during late childhood and adolescence
    Laura R Ment
    Departments of Pediatrics, Yale University School of Medicine, Department of Pediatrics, New Haven, CT 06520, USA
    Pediatrics 123:503-11. 2009
  8. ncbi request reprint Change in cognitive function over time in very low-birth-weight infants
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, Conn 06520, USA
    JAMA 289:705-11. 2003
  9. pmc Alterations in neural connectivity in preterm children at school age
    Yeisid Gozzo
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, P O Box 208064, New Haven, CT 06520 8064, USA
    Neuroimage 48:458-63. 2009
  10. ncbi request reprint Outcome of children in the indomethacin intraventricular hemorrhage prevention trial
    L R Ment
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06511, USA
    Pediatrics 105:485-91. 2000

Collaborators

Detail Information

Publications48

  1. pmc Functional analysis of a novel potassium channel (KCNA1) mutation in hereditary myokymia
    Haijun Chen
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT, USA
    Neurogenetics 8:131-5. 2007
    ..Electrophysiological studies of the mutant channel expressed in Xenopus oocytes indicated a loss of function. Co-expression of WT and mutant cRNAs significantly reduced whole-oocyte current compared to expression of WT Kv1.1 alone...
  2. ncbi request reprint The etiology and outcome of cerebral ventriculomegaly at term in very low birth weight preterm infants
    L R Ment
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Pediatrics 104:243-8. 1999
    ..We hypothesized that although the causes of VM are multiple, the incidence of handicap at 4.5 years of age in preterm infants with this ultrasonographic finding at term would be high...
  3. pmc A functional magnetic resonance imaging study of the long-term influences of early indomethacin exposure on language processing in the brains of prematurely born children
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, Connecticut 06520, USA
    Pediatrics 118:961-70. 2006
    ..Previous studies have demonstrated that indomethacin lowers the incidence and decreases the severity of intraventricular hemorrhage, as well as improves the cognitive outcome, in prematurely born male infants...
  4. ncbi request reprint Prevention of intraventricular hemorrhage by indomethacin in male preterm infants
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    J Pediatr 145:832-4. 2004
    ..Analysis of our cohort by sex showed indomethacin halved the incidence of IVH, eliminated parenchymal hemorrhage, and was associated with higher verbal scores at 3 to 8 years in boys...
  5. pmc Cortical recruitment patterns in children born prematurely compared with control subjects during a passive listening functional magnetic resonance imaging task
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520, USA
    J Pediatr 149:490-8. 2006
    ..To use functional magnetic resonance imaging (fMRI) to test the hypothesis that subjects who were born prematurely develop alternative systems for processing language...
  6. pmc Injury and recovery in the developing brain: evidence from functional MRI studies of prematurely born children
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Nat Clin Pract Neurol 3:558-71. 2007
    ....
  7. pmc Longitudinal brain volume changes in preterm and term control subjects during late childhood and adolescence
    Laura R Ment
    Departments of Pediatrics, Yale University School of Medicine, Department of Pediatrics, New Haven, CT 06520, USA
    Pediatrics 123:503-11. 2009
    ..Our goal was to test the hypothesis that preterm birth results in long-term dynamic changes in the developing brain...
  8. ncbi request reprint Change in cognitive function over time in very low-birth-weight infants
    Laura R Ment
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar St, New Haven, Conn 06520, USA
    JAMA 289:705-11. 2003
    ..However, recent experimental data suggest that the developing brain may recover from or compensate for injury...
  9. pmc Alterations in neural connectivity in preterm children at school age
    Yeisid Gozzo
    Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, P O Box 208064, New Haven, CT 06520 8064, USA
    Neuroimage 48:458-63. 2009
    ....
  10. ncbi request reprint Outcome of children in the indomethacin intraventricular hemorrhage prevention trial
    L R Ment
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06511, USA
    Pediatrics 105:485-91. 2000
    ..In addition, we hypothesized that the early administration of low-dose indomethacin would not be associated with an increase in the incidence of neurodevelopmental handicap at 4.5 years of age in our study children...
  11. ncbi request reprint Adaptive mechanisms of developing brain. The neuroradiologic assessment of the preterm infant
    L R Ment
    Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Perinatol 27:303-23. 2000
    ..Finally, the interesting observation that preterm infants fare as well as they do despite MR imaging-identified lesions might stimulate research studying the adaptive mechanisms of developing brain...
  12. pmc Consequence of preterm birth in early adolescence: the role of language on auditory short-term memory
    David Fraello
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
    J Child Neurol 26:738-42. 2011
    ..This study provides evidence of possible mechanisms for learning problems in former preterm infants...
  13. pmc Functional connectivity to a right hemisphere language center in prematurely born adolescents
    Eliza H Myers
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Neuroimage 51:1445-52. 2010
    ..439, p=0.019). Preterm adolescents engage a dorsal right hemisphere region for language at age 16years. Those with the greatest cognitive deficits demonstrate increasing reliance on this alternate pathway...
  14. pmc Alterations in functional connectivity for language in prematurely born adolescents
    Robin J Schafer
    Department of Diagnostic Imaging, Magnetic Resonance Research Center, Yale University School of Medicine, PO Box 208043, New Haven, CT 06520, USA
    Brain 132:661-70. 2009
    ..Plasticity in network connections may provide the substrate for improving language skills in the prematurely born...
  15. ncbi request reprint Cortical neurogenesis enhanced by chronic perinatal hypoxia
    Devon M Fagel
    Child Study Center, Yale University Medical School, 230 South Frontage Road, New Haven, CT 06520, USA
    Exp Neurol 199:77-91. 2006
    ..We suggest that cortical neurogenesis may play a significant role in repairing neuronal losses after neonatal injury...
  16. pmc Fgfr1 is required for cortical regeneration and repair after perinatal hypoxia
    Devon M Fagel
    Child Study Center, Yale University, New Haven, Connecticut 06520, USA
    J Neurosci 29:1202-11. 2009
    ..In contrast, there is incomplete recovery of inhibitory neurons after injury, which may account for persistent behavioral deficits...
  17. doi request reprint Imaging biomarkers of outcome in the developing preterm brain
    Laura R Ment
    Departments of Pediatrics and Neurology, Yale University School of Medicine, New Haven, CT, USA
    Lancet Neurol 8:1042-55. 2009
    ..Identification of early biomarkers for outcome could enable physicians and scientists to develop targeted pharmacological and behavioural therapies to restore functional connectivity...
  18. pmc Lasting effects of preterm birth and neonatal brain hemorrhage at 12 years of age
    Thuy Mai Luu
    Women and Infants Hospital, Department of Pediatrics, 101 Dudley St, Providence, RI 02905, USA
    Pediatrics 123:1037-44. 2009
    ....
  19. ncbi request reprint Preterm birth: a cost benefit analysis
    Susan Rushing
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06510, USA
    Semin Perinatol 28:444-50. 2004
    ..Postnatal administration of dexamethasone can lead to severe disability when administered before 7 to 10 days of life. Postnatal dexamethasone does not increase survival or decrease rates of chronic lung disease...
  20. pmc Astroglial cells in the external granular layer are precursors of cerebellar granule neurons in neonates
    John Silbereis
    Child Study Center, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Mol Cell Neurosci 44:362-73. 2010
    ..The identification of glial cells which function as neuronal progenitor cells profoundly impacts our understanding of cellular plasticity in the developing cerebellum...
  21. ncbi request reprint School-age outcomes of very low birth weight infants in the indomethacin intraventricular hemorrhage prevention trial
    Betty R Vohr
    Department of Pediatrics, Brown Medical School, Providence, Rhode Island, USA
    Pediatrics 111:e340-6. 2003
    ..The objective was to determine the effects of both IVH and indomethacin on cognitive, language, and achievement performance at 8 years of age...
  22. pmc Trajectories of receptive language development from 3 to 12 years of age for very preterm children
    Thuy Mai Luu
    Department of Pediatrics, Warren Alpert Medical School ofBrown University, Providence, Rhode Island, USA
    Pediatrics 124:333-41. 2009
    ..The goal was to examine whether indomethacin use, gender, neonatal, and sociodemographic factors predict patterns of receptive language development from 3 to 12 years of age in preterm children...
  23. ncbi request reprint Early postnatal astroglial cells produce multilineage precursors and neural stem cells in vivo
    Yosif M Ganat
    Child Study Center, Yale University Medical School, New Haven, Connecticut 06520, USA
    J Neurosci 26:8609-21. 2006
    ....
  24. doi request reprint Prematurely born children demonstrate white matter microstructural differences at 12 years of age, relative to term control subjects: an investigation of group and gender effects
    R Todd Constable
    Department of Diagnostic Imaging, Yale University School of Medicine, New Haven, CT 06520, USA
    Pediatrics 121:306-16. 2008
    ..The goal was to use diffusion tensor imaging to test the hypothesis that prematurely born children demonstrate long-term, white matter, microstructural differences, relative to term control subjects...
  25. ncbi request reprint Sickle cell disease complicated by post-streptococcal glomerulonephritis, cerebral hemorrhage and reversible posterior leucoencephalopathy syndrome
    Farzana D Pashankar
    Department of Pediatrics and Neurology, Yale University School of Medicine, New Haven, Connecticut, USA
    Pediatr Blood Cancer 50:864-6. 2008
    ..Similarly, because of the difference in prognosis between APSGN and other forms of sickle cell nephropathy, it is also important to differentiate these conditions...
  26. pmc Precursors with glial fibrillary acidic protein promoter activity transiently generate GABA interneurons in the postnatal cerebellum
    John Silbereis
    Child Study Center, Yale University School of Medicine, New Haven, CT 06520, USA
    Stem Cells 27:1152-63. 2009
    ..This restricted critical period implies that powerful inhibitory factors may restrict their fate potential in vivo at later stages of development...
  27. ncbi request reprint Neurodevelopment of C57B/L6 mouse brain assessed by in vivo diffusion tensor imaging
    Halima Chahboune
    Department of Diagnostic Radiology, Yale University, 300 Cedar Street, New Haven, CT 06510, USA
    NMR Biomed 20:375-82. 2007
    ..In summary, these results show that high-resolution DTI at high magnetic fields allows detection and quantification of brain structures throughout normal development in C57B/L6 mice in vivo...
  28. ncbi request reprint Astroglial cells in development, regeneration, and repair
    Flora M Vaccarino
    Child Study Center, Department of Neurobiology, Yale University Medical School, New Haven, CT, USA
    Neuroscientist 13:173-85. 2007
    ....
  29. ncbi request reprint Chronic neonatal hypoxia leads to long term decreases in the volume and cell number of the rat cerebral cortex
    Michael L Schwartz
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Semin Perinatol 28:379-88. 2004
    ..It is hypothesized that the mechanisms responsible for these alterations in cortical cell number may depend on the state of differentiation of the different cell types at the time of hypoxic exposure...
  30. pmc Disrupted synaptic development in the hypoxic newborn brain
    Sheila M Curristin
    Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA
    Proc Natl Acad Sci U S A 99:15729-34. 2002
    ..These patterns reveal a global dysynchrony in the maturation programs of the hypoxic developing brain, and offer insights into the vulnerabilities of processes that guide early postnatal cerebral maturation...
  31. ncbi request reprint An evidence-based approach to predicting low IQ in very preterm infants from the neurological examination: outcome data from the indomethacin Indomethacin Intraventricular Hemorrhage Prevention Trial
    Michael D Pleacher
    Department of Pediatrics, Division of Pediatric Neurology, Maine Medical Center, Portland, Maine, USA
    Pediatrics 113:416-9. 2004
    ..We conclude that the neurologic examination at 3 years old predicts FSIQ <70 at age 8 with LRs that allow evidence-based parental counseling and intervention planning...
  32. pmc Long-term outcome of preterm infants and the role of neuroimaging
    Eliza Myers
    Department of Pediatrics, Yale University School of Medicine, P O Box 208064, New Haven, CT 06520 8064, USA
    Clin Perinatol 36:773-89, vi. 2009
    ..New neuroimaging modalities and analysis tools are contributing to the understanding of neurologic sequelae of preterm birth by providing microstructural evidence of injury sustained by the preterm brain...
  33. pmc Hypoxic injury during neonatal development in murine brain: correlation between in vivo DTI findings and behavioral assessment
    Halima Chahboune
    Department of Diagnostic Radiology, Yale University, New Haven, CT 06510, USA
    Cereb Cortex 19:2891-901. 2009
    ..Thus, CSH mice revealed developmental and behavioral deficits that are similar to those observed in low birth weight preterm infants...
  34. pmc The diagnosis, management, and postnatal prevention of intraventricular hemorrhage in the preterm neonate
    Heather J McCrea
    Yale University School of Medicine, New Haven, CT 06510, USA
    Clin Perinatol 35:777-92, vii. 2008
    ..Randomized clinical prevention trials should provide long-term neurodevelopmental follow-up to assess the impact of preterm birth, injury, and pharmacologic intervention on the developing brain...
  35. pmc Hypoxia-induced developmental delays of inhibitory interneurons are reversed by environmental enrichment in the postnatal mouse forebrain
    Mila Komitova
    Child Study Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 33:13375-87. 2013
    ....
  36. ncbi request reprint Neonatal hypoxia suppresses oligodendrocyte Nogo-A and increases axonal sprouting in a rodent model for human prematurity
    Jared Weiss
    Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
    Exp Neurol 189:141-9. 2004
    ..Thus, hypoxia-induced reduction in myelin-derived axon outgrowth inhibitors appears to contribute axonal misconnection to the pathology of very low birth weight infants...
  37. ncbi request reprint Paracrine and autocrine functions of neuronal vascular endothelial growth factor (VEGF) in the central nervous system
    Omolara O Ogunshola
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 277:11410-5. 2002
    ..Thus, our in vitro data support a role for neuronal VEGF in both paracrine and autocrine signaling in the maintenance of neurons and endothelia in the central nervous system...
  38. ncbi request reprint Familial and genetic susceptibility to major neonatal morbidities in preterm twins
    Vineet Bhandari
    Department of Pediatrics, Yale University School of Medicine, New Haven, CT 06520 8064, USA
    Pediatrics 117:1901-6. 2006
    ..Intraventricular hemorrhage, necrotizing enterocolitis, and bronchopulmonary dysplasia remain significant causes of morbidity and mortality in preterm newborns...
  39. pmc COL4A1 mutation in preterm intraventricular hemorrhage
    Kaya Bilguvar
    Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06520, USA
    J Pediatr 155:743-5. 2009
    ..We report a rare variant in COL4A1 associated with intraventricular hemorrhage in dizygotic preterm twins. These results expand the spectrum of diseases attributable to mutations in type IV procollagens...
  40. ncbi request reprint Grade 3 to 4 intraventricular hemorrhage and Bayley scores predict outcome
    Laura R Ment
    Pediatrics 116:1597-8; author reply 1598. 2005
  41. pmc Volumetric analysis of regional cerebral development in preterm children
    Shelli R Kesler
    Stanford Psychiatry Neuroimaging Laboratory, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Pediatr Neurol 31:318-25. 2004
    ..Lower birth weight and the presence of intraventricular hemorrhage may increase the risk for neuroanatomic abnormality...
  42. ncbi request reprint Increased temporal lobe gyrification in preterm children
    Shelli R Kesler
    Stanford Psychiatry Neuroimaging Laboratory, Stanford University School of Medicine, Stanford, CA 94305 5719, USA
    Neuropsychologia 44:445-53. 2006
    ..Cortical development in the temporal lobe appears to be differentially vulnerable to preterm birth...
  43. ncbi request reprint Sex differences in cerebral volumes of 8-year-olds born preterm
    Allan L Reiss
    Stanford Psychiatry Neuroimaging Laboratory and Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305, USA
    J Pediatr 145:242-9. 2004
    ..These findings indicate that the sex of the very preterm newborn influences the mechanisms by which the developing brain is affected...
  44. pmc Brain volume reductions within multiple cognitive systems in male preterm children at age twelve
    Shelli R Kesler
    Center for Interdisciplinary Brain Sciences Research, Stanford University School of Medicine, Stanford, CA 94305 5795, USA
    J Pediatr 152:513-20, 520.e1. 2008
    ..To more precisely examine regional and subregional microstructural brain changes associated with preterm birth...
  45. ncbi request reprint Regional brain volumes and their later neurodevelopmental correlates in term and preterm infants
    Bradley S Peterson
    Columbia College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Pediatrics 111:939-48. 2003
    ..To compare regional brain volumes measured in term and preterm infants, and to correlate regional volumes with measures of neurodevelopmental outcome...
  46. ncbi request reprint A functional magnetic resonance imaging study of language processing and its cognitive correlates in prematurely born children
    Bradley S Peterson
    Columbia College of Physicians and Surgeons and the New York State Psychiatric Institute, New York, New York 10032, USA
    Pediatrics 110:1153-62. 2002
    ..Our aim was to compare brain activity associated with phonologic and semantic processing of language between term and preterm children using functional magnetic resonance imaging (fMRI)...
  47. pmc Preterm birth and the developing brain
    Laura R Ment
    Lancet Neurol 7:378-9. 2008
  48. ncbi request reprint Fetal stroke
    Koray Ozduman
    Department of Radiology, Stanford University School of Medicine, Stanford, California, USA
    Pediatr Neurol 30:151-62. 2004
    ..A better understanding of those risk factors predisposing a fetus to cerebral infarction may provide a basis for future therapeutic intervention trials. Ozduman K, Pober BR, Barnes P, Copel JA, Ogle EA, Duncan CC, Ment LR. Fetal stroke...

Research Grants26

  1. Multicenter Randomized Indomethacin IVH Prevention Trial
    Laura Ment; Fiscal Year: 2009
    ..Serial MRI scans will determine growth patterns of cortical regions across time. ..
  2. RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIAL
    Laura Ment; Fiscal Year: 2004
    ..Finally, multivariate statistical analyses will be performed to determine the independent and important predictors of cognitive outcome and function at 8 and 12 years C.A. ..
  3. ADAPTIVE MECHANISMS OF DEVELOPING BRAIN
    Laura Ment; Fiscal Year: 2007
    ..If the central hypothesis of our program is verified, then novel therapeutic approaches for the reduction of neurodevelopmental deficits in preterm infants may result...
  4. Gene Targets for Intraventricular Hemorrhage (IVH)
    Laura Ment; Fiscal Year: 2007
    ..DNA will be stored in the NINDS DNA Bank. ..
  5. Gene Targets for Intraventricular Hemorrhage (IVH)
    Laura Ment; Fiscal Year: 2009
    ..DNA will be stored in the NINDS DNA Bank. ..
  6. Gene Targets for Intraventricular Hemorrhage (IVH)
    Laura R Ment; Fiscal Year: 2010
    ..DNA will be stored in the NINDS DNA Bank. ..
  7. fMRI of Brain Development in Newborn Infants
    Laura Ment; Fiscal Year: 2002
    ....
  8. RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIAL
    Laura Ment; Fiscal Year: 1993
    ..The following parameters monitored for adverse effects of indomethacin: urinary output, serum electrolyte values, platelet count, clinical evidence for excessive bleeding. Long term neurodevelopmental follow-up studies will be performed...
  9. RANDOMIZED INDOMETHACIN GMH/IVH PREVENTION TRIAL
    Laura Ment; Fiscal Year: 1999
    ..Our secondary specific aims will study the influence of IVH on developmental outcome at 54 and 72 mo. C. A. and mMultivariate analyses will be performed to determine independent and important predictors of outcome at these two ages. ..
  10. Gene Targets for Intraventricular Hemorrhage (IVH)
    Laura R Ment; Fiscal Year: 2010
    ..DNA will be stored in the NINDS DNA Bank. ..