Ruslan M Medzhitov

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint HIV immunology needs a new direction
    Ruslan Medzhitov
    Ruslan Medzhitov is professor of immunobiology at Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA
    Nature 455:591. 2008
  2. pmc Fly immunity: great expectations
    R Medzhitov
    Yale University School of Medicine, New Haven, CT 06520, USA
    Genome Biol 1:REVIEWS106. 2000
  3. doi request reprint Origin and physiological roles of inflammation
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, TAC S 669, 300 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 454:428-35. 2008
  4. doi request reprint Inflammation 2010: new adventures of an old flame
    Ruslan Medzhitov
    Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 140:771-6. 2010
  5. doi request reprint Analysis of gene-environment interactions in postnatal development of the mammalian intestine
    Seth Rakoff-Nahoum
    Howard Hughes Medical Institute, Department of Immunobiology, Division of Infectious Diseases, Department of Medicine, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 112:1929-36. 2015
  6. pmc A plague on host defense
    Elizabeth Kopp
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 196:1009-12. 2002
  7. pmc Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response
    Caroline L Sokol
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 10:713-20. 2009
  8. pmc Antiviral defense: interferons and beyond
    Daniel B Stetson
    Howard Hughes Medical Institute, Yale University School of Medicine, CT 06520, USA
    J Exp Med 203:1837-41. 2006
  9. pmc MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice
    Namiko Hoshi
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Commun 3:1120. 2012
  10. pmc Evolutionary perspective on innate immune recognition
    A Mushegian
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    J Cell Biol 155:705-10. 2001

Research Grants

  1. TOLL RECEPTORS AND CONTROL OF MAMMALIAN IMMUNITY
    Ruslan Medzhitov; Fiscal Year: 2005

Collaborators

Detail Information

Publications33

  1. doi request reprint HIV immunology needs a new direction
    Ruslan Medzhitov
    Ruslan Medzhitov is professor of immunobiology at Yale University School of Medicine, 300 Cedar Street, New Haven, Connecticut 06520, USA
    Nature 455:591. 2008
  2. pmc Fly immunity: great expectations
    R Medzhitov
    Yale University School of Medicine, New Haven, CT 06520, USA
    Genome Biol 1:REVIEWS106. 2000
    ..Preliminary analysis of the Drosophila genome sequence reveals important similarities and differences between the functioning of mammalian and invertebrate immune systems...
  3. doi request reprint Origin and physiological roles of inflammation
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, TAC S 669, 300 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 454:428-35. 2008
    ..Para-inflammation is probably responsible for the chronic inflammatory conditions that are associated with modern human diseases...
  4. doi request reprint Inflammation 2010: new adventures of an old flame
    Ruslan Medzhitov
    Department of Immunobiology and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520, USA
    Cell 140:771-6. 2010
    ..Inflammation comes at the cost of a transient decline in tissue function, which can in turn contribute to the pathogenesis of diseases of altered homeostasis...
  5. doi request reprint Analysis of gene-environment interactions in postnatal development of the mammalian intestine
    Seth Rakoff-Nahoum
    Howard Hughes Medical Institute, Department of Immunobiology, Division of Infectious Diseases, Department of Medicine, Boston Children s Hospital and Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 112:1929-36. 2015
    ..Developmental timing, microbial colonization, and TIR signaling seem to play distinct and specific roles in regulation of gene-expression programs throughout postnatal development. ..
  6. pmc A plague on host defense
    Elizabeth Kopp
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    J Exp Med 196:1009-12. 2002
  7. pmc Basophils function as antigen-presenting cells for an allergen-induced T helper type 2 response
    Caroline L Sokol
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Immunol 10:713-20. 2009
    ..Thus, basophils function as antigen-presenting cells for T(H)2 differentiation in response to protease allergens...
  8. pmc Antiviral defense: interferons and beyond
    Daniel B Stetson
    Howard Hughes Medical Institute, Yale University School of Medicine, CT 06520, USA
    J Exp Med 203:1837-41. 2006
    ....
  9. pmc MyD88 signalling in colonic mononuclear phagocytes drives colitis in IL-10-deficient mice
    Namiko Hoshi
    Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Commun 3:1120. 2012
    ..Thus, gut bacterial sensing through MyD88 in mononuclear phagocytes drives inflammatory bowel disease when unopposed by interleukin-10...
  10. pmc Evolutionary perspective on innate immune recognition
    A Mushegian
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    J Cell Biol 155:705-10. 2001
    ..Analysis of human and Drosophila genomes demonstrates an ancient origin of innate immunity and the diversity of the mechanisms of innate immune recognition...
  11. doi request reprint Septic shock: on the importance of being tolerant
    Ruslan Medzhitov
    Howard Hughes Medical Institute, New Haven, CT 06510 USA Yale University School of Medicine, New Haven, CT 06510 USA Electronic address
    Immunity 39:799-800. 2013
    ..A study by Figueiredo et al. (2013) in this issue of Immunity demonstrates that administration of anthracyclines induces autophagy in vivo and has a powerful protective effect in a mouse model of sepsis. ..
  12. pmc Disease tolerance as a defense strategy
    Ruslan Medzhitov
    Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Science 335:936-41. 2012
    ..Analysis of disease tolerance mechanisms should provide new approaches for the treatment of infections and other diseases...
  13. ncbi request reprint Recognition of microorganisms and activation of the immune response
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, TAC S 669, 300 Cedar Street, New Haven, Connecticut 06510, USA
    Nature 449:819-26. 2007
    ..The connections between the various immune components are not fully understood, but recent progress brings us closer to an integrated view of the immune system and its function in host defence...
  14. ncbi request reprint Decoding the patterns of self and nonself by the innate immune system
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Science 296:298-300. 2002
    ..These patterns are deciphered by receptors that either induce or inhibit an immune response, depending on the meaning of these signals...
  15. doi request reprint Transcriptional control of the inflammatory response
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Nat Rev Immunol 9:692-703. 2009
    ..Here, we discuss the mechanisms of and the emerging principles in the transcriptional regulation of inflammatory responses in diverse physiological settings...
  16. pmc Highlights of 10 years of immunology in Nature Reviews Immunology
    Ruslan Medzhitov
    Howard Hughes Medical Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    Nat Rev Immunol 11:693-702. 2011
    ..We look forward to what the next 10 years of immunology research may bring...
  17. pmc ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
    E Kopp
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute HHMI, Yale University School of Medicine, New Haven, Connecticut 06520 USA
    Genes Dev 13:2059-71. 1999
    ..These results indicate an important role for ECSIT in signaling to NF-kappaB and suggest that processing of MEKK-1 is required for its function in the Toll/IL-1 pathway...
  18. pmc Drosophila MyD88 is an adapter in the Toll signaling pathway
    T Horng
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 98:12654-8. 2001
    ....
  19. ncbi request reprint A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nature 388:394-7. 1997
    ..1, which is required for the activation of naive T cells...
  20. ncbi request reprint Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  21. doi request reprint Innate immune recognition of the indigenous microbial flora
    S Rakoff-Nahoum
    Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA
    Mucosal Immunol 1:S10-4. 2008
    ..In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of tissue injury and repair, spontaneous colitis, and postnatal development...
  22. ncbi request reprint Toll-like receptors and their role in experimental models of microbial infection
    Salman T Qureshi
    Section of Immunology, Yale University School of Medicine, New Haven, CT 06510, USA
    Genes Immun 4:87-94. 2003
    ..Experimental models of infection using TLR-deficient mice, as well as limited human studies, have clearly demonstrated the critical role of TLRs in host defense against most major groups of mammalian pathogens...
  23. ncbi request reprint Toll-like receptors and their ligands
    G M Barton
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar St, BML 458, New Haven, CT 06520, USA
    Curr Top Microbiol Immunol 270:81-92. 2002
    ..However, recent work has demonstrated that activation of TLRs is required for initiation of only certain adaptive immune responses...
  24. ncbi request reprint Toll-like receptors and innate immunity
    R Medzhitov
    Section of Immunobiology, Yale University School Medicine, and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 1:135-45. 2001
    ..Recognition of microbial products by Toll-like receptors expressed on dendritic cells triggers functional maturation of dendritic cells and leads to initiation of antigen-specific adaptive immune responses...
  25. ncbi request reprint The Toll-receptor family and control of innate immunity
    E B Kopp
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Curr Opin Immunol 11:13-8. 1999
    ..Toll receptors and the associated signaling pathways of nuclear factor kappaB may represent the most ancient host defense system found in mammals, insects and plants...
  26. ncbi request reprint The Toll receptor family and microbial recognition
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Microbiol 8:452-6. 2000
    ..Recent evidence suggests that an evolutionarily ancient family of Toll-like receptors plays a crucial role in the detection of microbial infection and the induction of immune and inflammatory responses...
  27. ncbi request reprint Innate immune recognition: mechanisms and pathways
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunol Rev 173:89-97. 2000
    ..Pattern recognition receptors activate conserved host defense signaling pathways that control the expression of a variety of immune response genes...
  28. ncbi request reprint Lipoproteins take their toll on the host
    C A Janeway
    Section of Immunobiology, Yale University School of Medicine, P O Box 208011, New Haven, 06520 8011, USA
    Curr Biol 9:R879-82. 1999
    ..Recent evidence suggests that bacterial lipoproteins - major components of bacterial cell walls - are recognized by a member of the human TLR family...
  29. ncbi request reprint TIRAP: an adapter molecule in the Toll signaling pathway
    T Horng
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:835-41. 2001
    ..We have also shown that the double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways...
  30. ncbi request reprint Toll-like receptors control activation of adaptive immune responses
    M Schnare
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:947-50. 2001
    ..These results suggest that distinct pathways of the innate immune system control activation of the two effector arms of adaptive immunity...
  31. ncbi request reprint Role of the innate immune system and host-commensal mutualism
    S Rakoff-Nahoum
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Curr Top Microbiol Immunol 308:1-18. 2006
    ..Here we review the examples of the benefits of host-commensal interactions that are due to recognition of commensal microbial products by the host innate immune system...
  32. ncbi request reprint The specificity and orientation of a TCR to its peptide-MHC class II ligands
    D B Sant'Angelo
    Section of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, Connecticut 06520 8033, USA
    Immunity 4:367-76. 1996
    ..Based on these results, we propose an orientation for the TCR of this cloned line and argue for its generality...

Research Grants1

  1. TOLL RECEPTORS AND CONTROL OF MAMMALIAN IMMUNITY
    Ruslan Medzhitov; Fiscal Year: 2005
    ..Our ultimate goal is to understand whether activation of different TLRs results in the induction of distinct cellular and immune responses. ..