R Medzhitov

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Innate immune recognition: mechanisms and pathways
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunol Rev 173:89-97. 2000
  2. ncbi request reprint Toll-like receptors and innate immunity
    R Medzhitov
    Section of Immunobiology, Yale University School Medicine, and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 1:135-45. 2001
  3. ncbi request reprint The Toll receptor family and microbial recognition
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Microbiol 8:452-6. 2000
  4. pmc ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
    E Kopp
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute HHMI, Yale University School of Medicine, New Haven, Connecticut 06520 USA
    Genes Dev 13:2059-71. 1999
  5. pmc Drosophila MyD88 is an adapter in the Toll signaling pathway
    T Horng
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 98:12654-8. 2001
  6. ncbi request reprint Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
  7. ncbi request reprint Toll-like receptors control activation of adaptive immune responses
    M Schnare
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:947-50. 2001
  8. ncbi request reprint TIRAP: an adapter molecule in the Toll signaling pathway
    T Horng
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:835-41. 2001
  9. ncbi request reprint The Toll-receptor family and control of innate immunity
    E B Kopp
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Curr Opin Immunol 11:13-8. 1999
  10. ncbi request reprint Toll-like receptors and their role in experimental models of microbial infection
    Salman T Qureshi
    Section of Immunology, Yale University School of Medicine, New Haven, CT 06510, USA
    Genes Immun 4:87-94. 2003

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Innate immune recognition: mechanisms and pathways
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Immunol Rev 173:89-97. 2000
    ..Pattern recognition receptors activate conserved host defense signaling pathways that control the expression of a variety of immune response genes...
  2. ncbi request reprint Toll-like receptors and innate immunity
    R Medzhitov
    Section of Immunobiology, Yale University School Medicine, and Howard Hughes Medical Institute, New Haven, Connecticut 06520, USA
    Nat Rev Immunol 1:135-45. 2001
    ..Recognition of microbial products by Toll-like receptors expressed on dendritic cells triggers functional maturation of dendritic cells and leads to initiation of antigen-specific adaptive immune responses...
  3. ncbi request reprint The Toll receptor family and microbial recognition
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Trends Microbiol 8:452-6. 2000
    ..Recent evidence suggests that an evolutionarily ancient family of Toll-like receptors plays a crucial role in the detection of microbial infection and the induction of immune and inflammatory responses...
  4. pmc ECSIT is an evolutionarily conserved intermediate in the Toll/IL-1 signal transduction pathway
    E Kopp
    Section of Immunobiology and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute HHMI, Yale University School of Medicine, New Haven, Connecticut 06520 USA
    Genes Dev 13:2059-71. 1999
    ..These results indicate an important role for ECSIT in signaling to NF-kappaB and suggest that processing of MEKK-1 is required for its function in the Toll/IL-1 pathway...
  5. pmc Drosophila MyD88 is an adapter in the Toll signaling pathway
    T Horng
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 98:12654-8. 2001
    ....
  6. ncbi request reprint Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    L Alexopoulou
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, 06520, USA
    Nature 413:732-8. 2001
    ..Moreover, poly(I:C) can induce activation of NF-kappaB and mitogen-activated protein (MAP) kinases independently of MyD88, and cause dendritic cells to mature...
  7. ncbi request reprint Toll-like receptors control activation of adaptive immune responses
    M Schnare
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:947-50. 2001
    ..These results suggest that distinct pathways of the innate immune system control activation of the two effector arms of adaptive immunity...
  8. ncbi request reprint TIRAP: an adapter molecule in the Toll signaling pathway
    T Horng
    Howard Hughes Medical Institute, Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Nat Immunol 2:835-41. 2001
    ..We have also shown that the double-stranded RNA-binding protein kinase PKR is a component of both the TIRAP- and MyD88-dependent signaling pathways...
  9. ncbi request reprint The Toll-receptor family and control of innate immunity
    E B Kopp
    Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA
    Curr Opin Immunol 11:13-8. 1999
    ..Toll receptors and the associated signaling pathways of nuclear factor kappaB may represent the most ancient host defense system found in mammals, insects and plants...
  10. ncbi request reprint Toll-like receptors and their role in experimental models of microbial infection
    Salman T Qureshi
    Section of Immunology, Yale University School of Medicine, New Haven, CT 06510, USA
    Genes Immun 4:87-94. 2003
    ..Experimental models of infection using TLR-deficient mice, as well as limited human studies, have clearly demonstrated the critical role of TLRs in host defense against most major groups of mammalian pathogens...
  11. ncbi request reprint Toll-like receptors and their ligands
    G M Barton
    Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar St, BML 458, New Haven, CT 06520, USA
    Curr Top Microbiol Immunol 270:81-92. 2002
    ..However, recent work has demonstrated that activation of TLRs is required for initiation of only certain adaptive immune responses...
  12. ncbi request reprint Lipoproteins take their toll on the host
    C A Janeway
    Section of Immunobiology, Yale University School of Medicine, P O Box 208011, New Haven, 06520 8011, USA
    Curr Biol 9:R879-82. 1999
    ..Recent evidence suggests that bacterial lipoproteins - major components of bacterial cell walls - are recognized by a member of the human TLR family...
  13. ncbi request reprint A human homologue of the Drosophila Toll protein signals activation of adaptive immunity
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520 8011, USA
    Nature 388:394-7. 1997
    ..1, which is required for the activation of naive T cells...
  14. ncbi request reprint Innate immunity: the virtues of a nonclonal system of recognition
    R Medzhitov
    Section of Immunobiology, Yale University School of Medicine and Howard Hughes Medical Institute, New Haven, Connecticut 06520 8011, USA
    Cell 91:295-8. 1997
  15. doi request reprint Emerging functions of basophils in protective and allergic immune responses
    C L Sokol
    Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA
    Mucosal Immunol 3:129-37. 2010
    ..These and other studies have illustrated the emerging role of basophils in the regulation of type 2 immunity...
  16. pmc Fly immunity: great expectations
    R Medzhitov
    Yale University School of Medicine, New Haven, CT 06520, USA
    Genome Biol 1:REVIEWS106. 2000
    ..Preliminary analysis of the Drosophila genome sequence reveals important similarities and differences between the functioning of mammalian and invertebrate immune systems...
  17. ncbi request reprint Role of the innate immune system and host-commensal mutualism
    S Rakoff-Nahoum
    Howard Hughes Medical Institute and Section of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Curr Top Microbiol Immunol 308:1-18. 2006
    ..Here we review the examples of the benefits of host-commensal interactions that are due to recognition of commensal microbial products by the host innate immune system...
  18. ncbi request reprint Role of toll-like receptors in tissue repair and tumorigenesis
    S Rakoff-Nahoum
    Howard Hughes Memorial Institute and Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Biochemistry (Mosc) 73:555-61. 2008
    ..This latter function of TLRs can also contribute to tumorigenesis. Here we review recent progress in understanding the role of TLRs in cancer development...
  19. doi request reprint Innate immune recognition of the indigenous microbial flora
    S Rakoff-Nahoum
    Department of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA
    Mucosal Immunol 1:S10-4. 2008
    ..In particular, we have focused on the function of innate microbial pattern recognition by Toll-like receptors in the context of tissue injury and repair, spontaneous colitis, and postnatal development...
  20. ncbi request reprint The specificity and orientation of a TCR to its peptide-MHC class II ligands
    D B Sant'Angelo
    Section of Immunobiology, Yale University School of Medicine, Howard Hughes Medical Institute, New Haven, Connecticut 06520 8033, USA
    Immunity 4:367-76. 1996
    ..Based on these results, we propose an orientation for the TCR of this cloned line and argue for its generality...
  21. pmc Evolutionary perspective on innate immune recognition
    A Mushegian
    Stowers Institute for Medical Research, Kansas City, MO 64110, USA
    J Cell Biol 155:705-10. 2001
    ..Analysis of human and Drosophila genomes demonstrates an ancient origin of innate immunity and the diversity of the mechanisms of innate immune recognition...
  22. ncbi request reprint Structural basis for signal transduction by the Toll/interleukin-1 receptor domains
    Y Xu
    Department of Biological Sciences, Columbia University, New York, New York 10027, USA
    Nature 408:111-5. 2000
    ....
  23. pmc Toll4 (TLR4) expression in cardiac myocytes in normal and failing myocardium
    S Frantz
    Cardiovascular Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Clin Invest 104:271-80. 1999
    ..Increased expression and signaling by TLR4, and perhaps other Toll homologues, may contribute to the activation of innate immunity in injured myocardium...