E C McNay

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Food for thought: fluctuations in brain extracellular glucose provide insight into the mechanisms of memory modulation
    Ewan C McNay
    Yale School of Medicine, USA
    Behav Cogn Neurosci Rev 1:264-80. 2002
  2. ncbi Age-related differences in hippocampal extracellular fluid glucose concentration during behavioral testing and following systemic glucose administration
    E C McNay
    Department of Psychology, Yale University, New Haven, Connecticut, USA
    J Gerontol A Biol Sci Med Sci 56:B66-71. 2001
  3. ncbi Insulin and ghrelin: peripheral hormones modulating memory and hippocampal function
    Ewan C McNay
    Yale School of Medicine, Section of Endocrinology, 1 Gilbert Street, New Haven, CT 06520, USA
    Curr Opin Pharmacol 7:628-32. 2007
  4. ncbi Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia
    Ewan C McNay
    Section of Endocrinology, Yale School of Medicine, One Gilbert Street, TAC S147, P O Box 208020, New Haven, CT 06519, USA
    Diabetes 55:1088-95. 2006
  5. ncbi From artificial cerebro-spinal fluid (aCSF) to artificial extracellular fluid (aECF): microdialysis perfusate composition effects on in vivo brain ECF glucose measurements
    Ewan C McNay
    Department of Internal Medicine, Sections of Endocrinology and Neuroendocrinology, Yale School of Medicine, New Haven, CT 06520 8020, USA
    J Neurosci Methods 132:35-43. 2004
  6. ncbi Effect of recurrent hypoglycemia on spatial cognition and cognitive metabolism in normal and diabetic rats
    Ewan C McNay
    Department of Internal Medicine, Section of Endocrinology, Yale School of Medicine, New Haven, Connecticut, USA
    Diabetes 53:418-25. 2004
  7. ncbi The impact of recurrent hypoglycemia on cognitive function in aging
    Ewan C McNay
    Section of Endocrinology, Yale University School of Medicine, TAC S147, One Gilbert Street, New Haven, CT 06519, USA
    Neurobiol Aging 26:76-9. 2005
  8. ncbi Fluctuations in brain glucose concentration during behavioral testing: dissociations between brain areas and between brain and blood
    E C McNay
    Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
    Neurobiol Learn Mem 75:325-37. 2001
  9. ncbi Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes
    X Fan
    Department of Internal Medicine and Endocrinology, Yale University, New Haven, CT 06520 8020, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1702-8. 2009
  10. ncbi Effects of recurrent antecedent hypoglycaemia and chronic hyperglycaemia on brainstem extra-cellular glucose concentrations during acute hypoglycaemia in conscious diabetic BB rats
    R J McCrimmon
    Department of Internal Medicine and Endocrinology, Yale University School of Medicine, P.O. Box 208020, New Haven CT 06520-8020, USA
    Diabetologia 46:1658-61. 2003

Research Grants

  1. Insulin in the hippocampus: memory enhancement and impact of type 2 diabetes
    Ewan McNay; Fiscal Year: 2007

Collaborators

Detail Information

Publications20

  1. ncbi Food for thought: fluctuations in brain extracellular glucose provide insight into the mechanisms of memory modulation
    Ewan C McNay
    Yale School of Medicine, USA
    Behav Cogn Neurosci Rev 1:264-80. 2002
    ..Together with results identifying downstream effects of such variance in glucose availability, the evidence leads to new thinking about glucose regulation of brain functions including memory...
  2. ncbi Age-related differences in hippocampal extracellular fluid glucose concentration during behavioral testing and following systemic glucose administration
    E C McNay
    Department of Psychology, Yale University, New Haven, Connecticut, USA
    J Gerontol A Biol Sci Med Sci 56:B66-71. 2001
    ....
  3. ncbi Insulin and ghrelin: peripheral hormones modulating memory and hippocampal function
    Ewan C McNay
    Yale School of Medicine, Section of Endocrinology, 1 Gilbert Street, New Haven, CT 06520, USA
    Curr Opin Pharmacol 7:628-32. 2007
    ..While insulin's effects appear to be specifically within the hippocampus, ghrelin may act at a range of sites within the limbic system...
  4. ncbi Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia
    Ewan C McNay
    Section of Endocrinology, Yale School of Medicine, One Gilbert Street, TAC S147, P O Box 208020, New Haven, CT 06519, USA
    Diabetes 55:1088-95. 2006
    ..The impact of recurrent hypoglycemia on cognition is multifaceted and includes both metabolic and electrophysiological components...
  5. ncbi From artificial cerebro-spinal fluid (aCSF) to artificial extracellular fluid (aECF): microdialysis perfusate composition effects on in vivo brain ECF glucose measurements
    Ewan C McNay
    Department of Internal Medicine, Sections of Endocrinology and Neuroendocrinology, Yale School of Medicine, New Haven, CT 06520 8020, USA
    J Neurosci Methods 132:35-43. 2004
    ..26 +/- .04 mM. Increased understanding of the impact of differences in the perfusate solutions used by different laboratories may provide a basis for reconciliation of apparently disparate microdialysis results within the literature...
  6. ncbi Effect of recurrent hypoglycemia on spatial cognition and cognitive metabolism in normal and diabetic rats
    Ewan C McNay
    Department of Internal Medicine, Section of Endocrinology, Yale School of Medicine, New Haven, Connecticut, USA
    Diabetes 53:418-25. 2004
    ..When glucose availability is limited, complex cognitive functioning seems to be adversely effected in RH animals, perhaps to better maintain and preserve basic brain functions...
  7. ncbi The impact of recurrent hypoglycemia on cognitive function in aging
    Ewan C McNay
    Section of Endocrinology, Yale University School of Medicine, TAC S147, One Gilbert Street, New Haven, CT 06519, USA
    Neurobiol Aging 26:76-9. 2005
    ..Recent data on the interaction between such recurrent hypoglycemia and aging in modulating cognition is reviewed, and the insights gained into mechanisms of age-related cognitive decline discussed...
  8. ncbi Fluctuations in brain glucose concentration during behavioral testing: dissociations between brain areas and between brain and blood
    E C McNay
    Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
    Neurobiol Learn Mem 75:325-37. 2001
    ....
  9. ncbi Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetes
    X Fan
    Department of Internal Medicine and Endocrinology, Yale University, New Haven, CT 06520 8020, USA
    Am J Physiol Regul Integr Comp Physiol 296:R1702-8. 2009
    ..Moreover, our data suggest that it may be possible to partially restore the hypoglycemia-specific glucagon secretory defect characteristic of T1DM through manipulation of VMH AMPK...
  10. ncbi Effects of recurrent antecedent hypoglycaemia and chronic hyperglycaemia on brainstem extra-cellular glucose concentrations during acute hypoglycaemia in conscious diabetic BB rats
    R J McCrimmon
    Department of Internal Medicine and Endocrinology, Yale University School of Medicine, P.O. Box 208020, New Haven CT 06520-8020, USA
    Diabetologia 46:1658-61. 2003
    ..The resistance to impaired brainstem function seen in recurrently hypoglycaemic rats during hypoglycaemia cannot simply be attributed to increased blood-brain barrier glucose transport within this brain region...
  11. ncbi Increases in extracellular fluid glucose levels in the rat hippocampus following an anesthetic dose of pentobarbital or ketamine-xylazine: an in vivo microdialysis study
    Clinton E Canal
    The Neuroscience Program, University of Illinois, Champaign, IL 61820, USA
    Physiol Behav 84:245-50. 2005
    ....
  12. ncbi Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentration
    Raimund I Herzog
    Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, CT 06520, USA
    Endocrinology 149:1499-504. 2008
    ..We conclude that glycogen supercompensation is not a major contributory factor to the pathogenesis of hypoglycemia-associated autonomic failure...
  13. ncbi Three classes of pyramidal neurons in layer V of rat perirhinal cortex
    James R Moyer
    Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
    Hippocampus 12:218-34. 2002
    ..These data further advance an emerging picture of PR as a cortical region with a unique distribution of cell types different from other cortical regions...
  14. ncbi Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia
    Rory J McCrimmon
    FRCP, Yale University School of Medicine, P O Box 208020, New Haven, CT 06520 8020, USA
    Diabetes 57:444-50. 2008
    ..To examine in vivo in a rodent model the potential role of AMP-activated protein kinase (AMPK) within the ventromedial hypothalamus (VMH) in glucose sensing during hypoglycemia...
  15. ncbi Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation
    Rory J McCrimmon
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    J Clin Invest 116:1723-30. 2006
    ..Our data suggest that regulation of the CRR is largely determined by the interaction between CRFR2-mediated suppression and CRFR1-mediated activation in the VMH...
  16. ncbi Ghrelin controls hippocampal spine synapse density and memory performance
    Sabrina Diano
    Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Nat Neurosci 9:381-8. 2006
    ..Our observations reveal an endogenous function of ghrelin that links metabolic control with higher brain functions and suggest novel therapeutic strategies to enhance learning and memory processes...
  17. ncbi Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses
    Mark L Evans
    Diabetes Endocrine Research Center, Fitkin 1, Yale School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Diabetes 53:2542-51. 2004
    ..Our data suggest that closing of K(ATP) channels in the VMH (much like the beta-cell) impairs defense mechanisms against glucose deprivation and therefore could contribute to defects in glucose counterregulation...
  18. ncbi Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats
    Rory J McCrimmon
    Department of Internal Medicine and Endocrinology, Yale University School of Medicine, Section of Endocrinology, P O Box 208020, New Haven, CT 06520 8020, USA
    Diabetes 54:3169-74. 2005
    ..We also conclude that KCOs may offer a future potential therapeutic option for individuals with insulin-treated diabetes who develop defective counterregulation...
  19. ncbi Modulation of memory with septal injections of morphine and glucose: effects on extracellular glucose levels in the hippocampus
    Ewan C McNay
    Section of Endocrinology, Yale University School of Medicine, USA
    Physiol Behav 87:298-303. 2006
    ....
  20. ncbi Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neurons
    Hongmei Li
    Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
    Proc Natl Acad Sci U S A 105:2169-74. 2008
    ..These findings suggest that Bcl-xL positively regulates Drp1 to alter mitochondrial function in a manner that stimulates synapse formation...

Research Grants2

  1. Insulin in the hippocampus: memory enhancement and impact of type 2 diabetes
    Ewan McNay; Fiscal Year: 2007
    ....