E C McNay
Affiliation: Yale University
- Food for thought: fluctuations in brain extracellular glucose provide insight into the mechanisms of memory modulationEwan C McNay
Yale School of Medicine, USA
Behav Cogn Neurosci Rev 1:264-80. 2002..Together with results identifying downstream effects of such variance in glucose availability, the evidence leads to new thinking about glucose regulation of brain functions including memory...
- Age-related differences in hippocampal extracellular fluid glucose concentration during behavioral testing and following systemic glucose administrationE C McNay
Department of Psychology, Yale University, New Haven, Connecticut, USA
J Gerontol A Biol Sci Med Sci 56:B66-71. 2001....
- Insulin and ghrelin: peripheral hormones modulating memory and hippocampal functionEwan C McNay
Yale School of Medicine, Section of Endocrinology, 1 Gilbert Street, New Haven, CT 06520, USA
Curr Opin Pharmacol 7:628-32. 2007..While insulin's effects appear to be specifically within the hippocampus, ghrelin may act at a range of sites within the limbic system...
- Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemiaEwan C McNay
Section of Endocrinology, Yale School of Medicine, One Gilbert Street, TAC S147, P O Box 208020, New Haven, CT 06519, USA
Diabetes 55:1088-95. 2006..The impact of recurrent hypoglycemia on cognition is multifaceted and includes both metabolic and electrophysiological components...
- From artificial cerebro-spinal fluid (aCSF) to artificial extracellular fluid (aECF): microdialysis perfusate composition effects on in vivo brain ECF glucose measurementsEwan C McNay
Department of Internal Medicine, Sections of Endocrinology and Neuroendocrinology, Yale School of Medicine, New Haven, CT 06520 8020, USA
J Neurosci Methods 132:35-43. 2004..26 +/- .04 mM. Increased understanding of the impact of differences in the perfusate solutions used by different laboratories may provide a basis for reconciliation of apparently disparate microdialysis results within the literature...
- Effect of recurrent hypoglycemia on spatial cognition and cognitive metabolism in normal and diabetic ratsEwan C McNay
Department of Internal Medicine, Section of Endocrinology, Yale School of Medicine, New Haven, Connecticut, USA
Diabetes 53:418-25. 2004..When glucose availability is limited, complex cognitive functioning seems to be adversely effected in RH animals, perhaps to better maintain and preserve basic brain functions...
- The impact of recurrent hypoglycemia on cognitive function in agingEwan C McNay
Section of Endocrinology, Yale University School of Medicine, TAC S147, One Gilbert Street, New Haven, CT 06519, USA
Neurobiol Aging 26:76-9. 2005..Recent data on the interaction between such recurrent hypoglycemia and aging in modulating cognition is reviewed, and the insights gained into mechanisms of age-related cognitive decline discussed...
- Fluctuations in brain glucose concentration during behavioral testing: dissociations between brain areas and between brain and bloodE C McNay
Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
Neurobiol Learn Mem 75:325-37. 2001....
- Hypothalamic AMP-activated protein kinase activation with AICAR amplifies counterregulatory responses to hypoglycemia in a rodent model of type 1 diabetesX Fan
Department of Internal Medicine and Endocrinology, Yale University, New Haven, CT 06520 8020, USA
Am J Physiol Regul Integr Comp Physiol 296:R1702-8. 2009..Moreover, our data suggest that it may be possible to partially restore the hypoglycemia-specific glucagon secretory defect characteristic of T1DM through manipulation of VMH AMPK...
- Effects of recurrent antecedent hypoglycaemia and chronic hyperglycaemia on brainstem extra-cellular glucose concentrations during acute hypoglycaemia in conscious diabetic BB ratsR J McCrimmon
Department of Internal Medicine and Endocrinology, Yale University School of Medicine, P.O. Box 208020, New Haven CT 06520-8020, USA
Diabetologia 46:1658-61. 2003..The resistance to impaired brainstem function seen in recurrently hypoglycaemic rats during hypoglycaemia cannot simply be attributed to increased blood-brain barrier glucose transport within this brain region...
- Increases in extracellular fluid glucose levels in the rat hippocampus following an anesthetic dose of pentobarbital or ketamine-xylazine: an in vivo microdialysis studyClinton E Canal
The Neuroscience Program, University of Illinois, Champaign, IL 61820, USA
Physiol Behav 84:245-50. 2005....
- Effect of acute and recurrent hypoglycemia on changes in brain glycogen concentrationRaimund I Herzog
Department of Internal Medicine, Section of Endocrinology, Yale University School of Medicine, New Haven, CT 06520, USA
Endocrinology 149:1499-504. 2008..We conclude that glycogen supercompensation is not a major contributory factor to the pathogenesis of hypoglycemia-associated autonomic failure...
- Three classes of pyramidal neurons in layer V of rat perirhinal cortexJames R Moyer
Department of Psychology, Yale University, New Haven, Connecticut 06520, USA
Hippocampus 12:218-34. 2002..These data further advance an emerging picture of PR as a cortical region with a unique distribution of cell types different from other cortical regions...
- Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemiaRory J McCrimmon
FRCP, Yale University School of Medicine, P O Box 208020, New Haven, CT 06520 8020, USA
Diabetes 57:444-50. 2008..To examine in vivo in a rodent model the potential role of AMP-activated protein kinase (AMPK) within the ventromedial hypothalamus (VMH) in glucose sensing during hypoglycemia...
- Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulationRory J McCrimmon
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
J Clin Invest 116:1723-30. 2006..Our data suggest that regulation of the CRR is largely determined by the interaction between CRFR2-mediated suppression and CRFR1-mediated activation in the VMH...
- Ghrelin controls hippocampal spine synapse density and memory performanceSabrina Diano
Department of Obstetrics and Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Nat Neurosci 9:381-8. 2006..Our observations reveal an endogenous function of ghrelin that links metabolic control with higher brain functions and suggest novel therapeutic strategies to enhance learning and memory processes...
- Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responsesMark L Evans
Diabetes Endocrine Research Center, Fitkin 1, Yale School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
Diabetes 53:2542-51. 2004..Our data suggest that closing of K(ATP) channels in the VMH (much like the beta-cell) impairs defense mechanisms against glucose deprivation and therefore could contribute to defects in glucose counterregulation...
- Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic ratsRory J McCrimmon
Department of Internal Medicine and Endocrinology, Yale University School of Medicine, Section of Endocrinology, P O Box 208020, New Haven, CT 06520 8020, USA
Diabetes 54:3169-74. 2005..We also conclude that KCOs may offer a future potential therapeutic option for individuals with insulin-treated diabetes who develop defective counterregulation...
- Modulation of memory with septal injections of morphine and glucose: effects on extracellular glucose levels in the hippocampusEwan C McNay
Section of Endocrinology, Yale University School of Medicine, USA
Physiol Behav 87:298-303. 2006....
- Bcl-xL induces Drp1-dependent synapse formation in cultured hippocampal neuronsHongmei Li
Department of Internal Medicine, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 105:2169-74. 2008..These findings suggest that Bcl-xL positively regulates Drp1 to alter mitochondrial function in a manner that stimulates synapse formation...
- Insulin in the hippocampus: memory enhancement and impact of type 2 diabetesEwan McNay; Fiscal Year: 2007....