Thomas McGlashan

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi Treating schizophrenia earlier in life and the potential for prevention
    T H McGlashan
    Yale Psychiatric Research, PO Box 208099, New Haven, CT 06520, USA
    Curr Psychiatry Rep 2:386-92. 2000
  2. ncbi The borderline personality disorder practice guidelines: the good, the bad, and the realistic
    T H McGlashan
    Yale Psychiatric Institute, Yale University, New Haven, CT, USA
    J Personal Disord 16:119-21. 2002
  3. ncbi Premorbid adjustment, onset types, and prognostic scaling: still informative?
    T H McGlashan
    Yale University School of Medicine, New Haven, CT 06519, USA
    Schizophr Bull 34:801-5. 2008
  4. ncbi Recruitment and treatment practices for help-seeking "prodromal" patients
    Thomas H McGlashan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Schizophr Bull 33:715-26. 2007
  5. ncbi Is active psychosis neurotoxic?
    T H McGlashan
    Schizophr Bull 32:609-13. 2006
  6. ncbi At issue: is natural selection rendering schizophrenia less severe?
    T H McGlashan
    Schizophr Bull 32:428-9. 2006
  7. ncbi Eugen Bleuler: centennial anniversary of his 1911 publication of Dementia Praecox or the group of schizophrenias
    Thomas H McGlashan
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Schizophr Bull 37:1101-3. 2011
  8. ncbi Pre-onset detection and intervention research in schizophrenia psychoses: current estimates of benefit and risk
    T H McGlashan
    Yale Psychiatric Research, New Haven, CT 06520 8098, USA
    Schizophr Bull 27:563-70. 2001
  9. ncbi Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis
    Thomas H McGlashan
    Department of Psychiatry, Yale University School of Medicine, 301 Cedar St, New Haven, CT 06519, USA
    Am J Psychiatry 163:790-9. 2006
  10. ncbi The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis. I. Study rationale and design
    T H McGlashan
    Department of Psychiatry, Yale University School of Medicine, 301 Cedar Street, New Haven, CT 06519, USA
    Schizophr Res 61:7-18. 2003

Research Grants

  1. LONGITUDINAL STUDY OF PERSONALITY DISORDERS
    Thomas McGlashan; Fiscal Year: 2000
  2. COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER
    Thomas McGlashan; Fiscal Year: 2007
  3. COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER
    Thomas McGlashan; Fiscal Year: 2004
  4. EARLY DETECTION AND INTERVENTION IN PSYCHOSIS
    Thomas McGlashan; Fiscal Year: 2003

Detail Information

Publications102 found, 100 shown here

  1. ncbi Treating schizophrenia earlier in life and the potential for prevention
    T H McGlashan
    Yale Psychiatric Research, PO Box 208099, New Haven, CT 06520, USA
    Curr Psychiatry Rep 2:386-92. 2000
    ..The research bearing upon the early phase of disorder, especially that presented recently at the March/April 2000 meeting of The International Early Psychosis Association in New York, is reviewed...
  2. ncbi The borderline personality disorder practice guidelines: the good, the bad, and the realistic
    T H McGlashan
    Yale Psychiatric Institute, Yale University, New Haven, CT, USA
    J Personal Disord 16:119-21. 2002
  3. ncbi Premorbid adjustment, onset types, and prognostic scaling: still informative?
    T H McGlashan
    Yale University School of Medicine, New Haven, CT 06519, USA
    Schizophr Bull 34:801-5. 2008
    ..The concepts and scales that have evolved focus on types of premorbid adjustment and illness onset. Enduring highlights of this literature will be described, and its current and future utility will be discussed...
  4. ncbi Recruitment and treatment practices for help-seeking "prodromal" patients
    Thomas H McGlashan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Schizophr Bull 33:715-26. 2007
    ..References for details are noted...
  5. ncbi Is active psychosis neurotoxic?
    T H McGlashan
    Schizophr Bull 32:609-13. 2006
    ..The clinical and neurobiological evidence for its validity is visited and found wanting. Synaptic plasticity, not neurotoxicity, appears to be the mediating process...
  6. ncbi At issue: is natural selection rendering schizophrenia less severe?
    T H McGlashan
    Schizophr Bull 32:428-9. 2006
  7. ncbi Eugen Bleuler: centennial anniversary of his 1911 publication of Dementia Praecox or the group of schizophrenias
    Thomas H McGlashan
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Schizophr Bull 37:1101-3. 2011
    ....
  8. ncbi Pre-onset detection and intervention research in schizophrenia psychoses: current estimates of benefit and risk
    T H McGlashan
    Yale Psychiatric Research, New Haven, CT 06520 8098, USA
    Schizophr Bull 27:563-70. 2001
    ..It is concluded that we do not have enough data yet to justify pre-onset detection and intervention as standard practice, but we do have enough data concerning risk and benefit to justify pre-onset detection and intervention research...
  9. ncbi Randomized, double-blind trial of olanzapine versus placebo in patients prodromally symptomatic for psychosis
    Thomas H McGlashan
    Department of Psychiatry, Yale University School of Medicine, 301 Cedar St, New Haven, CT 06519, USA
    Am J Psychiatry 163:790-9. 2006
    ..This study assessed the efficacy of olanzapine in delaying or preventing conversion to psychosis and reducing symptoms in people with prodromal symptoms of schizophrenia...
  10. ncbi The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis. I. Study rationale and design
    T H McGlashan
    Department of Psychiatry, Yale University School of Medicine, 301 Cedar Street, New Haven, CT 06519, USA
    Schizophr Res 61:7-18. 2003
    ..The companion report will address sample recruitment and the clinical phenomenology at baseline of this putative "prodromal" entity...
  11. ncbi Rationale and parameters for medication-free research in psychosis
    Thomas H McGlashan
    Schizophr Bull 32:300-2. 2006
  12. ncbi Schizophrenia as a disorder of developmentally reduced synaptic connectivity
    T H McGlashan
    Yale University School of Medicine, New Haven, Conn, USA
    Arch Gen Psychiatry 57:637-48. 2000
    ..We discuss some of the model's predictions and questions raised for basic research, early detection, and preventive intervention...
  13. ncbi Psychosis as a disorder of reduced cathectic capacity: Freud's analysis of the Schreber case revisited
    Thomas H McGlashan
    Schizophr Bull 35:476-81. 2009
    ..e., of diminished (organic) cathectic capacity for normal mental and affective investments in life...
  14. ncbi Early detection and intervention in psychosis: an ethical paradigm shift
    Thomas H McGlashan
    Yale Psychiatric Research, Yale University School of Medicine, 301 Cedar Street, New Haven, CT 06519, USA
    Br J Psychiatry Suppl 48:s113-5. 2005
    ..The ethics of early intervention are undergoing a paradigm shift, a shift that supports early intervention research as being necessary to bring empirical balance to territory that is currently overpopulated with zealous opinions...
  15. ncbi Two-year prevalence and stability of individual DSM-IV criteria for schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders: toward a hybrid model of axis II disorders
    Thomas H McGlashan
    Collaborative Longitudinal Personality Disorder Study, Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    Am J Psychiatry 162:883-9. 2005
    ..This study tracked the individual criteria of four DSM-IV personality disorders-borderline, schizotypal, avoidant, and obsessive-compulsive personality disorders-and how they change over 2 years...
  16. ncbi Short-term diagnostic stability of schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders
    M Tracie Shea
    Department of Psychiatry and Human Behavior, Brown University Medical School, Duncan Building, 700 Butler Drive, Providence, RI 20906, USA
    Am J Psychiatry 159:2036-41. 2002
    ..Personality disorders may be characterized by stable trait constellations that fluctuate in degree of maladaptive expression...
  17. ncbi Neuropsychology of the prodrome to psychosis in the NAPLS consortium: relationship to family history and conversion to psychosis
    Larry J Seidman
    Department of Psychiatry, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Arch Gen Psychiatry 67:578-88. 2010
    ..Early detection and prospective evaluation of clinical high-risk (CHR) individuals who may develop schizophrenia or other psychotic disorders is critical for predicting psychosis onset and for testing preventive interventions...
  18. ncbi Treatment utilization by patients with personality disorders
    D S Bender
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI, USA
    Am J Psychiatry 158:295-302. 2001
    ..Utilization of mental health treatment was compared in patients with personality disorders and patients with major depressive disorder without personality disorder...
  19. ncbi Comparable family burden in families of clinical high-risk and recent-onset psychosis patients
    Celine Wong
    Department of Psychiatry, Columbia University, New York, USA
    Early Interv Psychiatry 2:256-61. 2008
    ..In this exploratory study, we examined the extent of burden reported by families of patients during a putative prodromal period and in the after-math of psychosis onset...
  20. ncbi Stigma in families of individuals in early stages of psychotic illness: family stigma and early psychosis
    Celine Wong
    Department of Psychiatry, Columbia University, New York, New York, USA
    Early Interv Psychiatry 3:108-15. 2009
    ..These forms of stigma may present a barrier to help seeking. However, little is known about stigma in the early stages of evolving psychotic disorder...
  21. ncbi The PRIME North America randomized double-blind clinical trial of olanzapine versus placebo in patients at risk of being prodromally symptomatic for psychosis. II. Baseline characteristics of the "prodromal" sample
    T J Miller
    Yale University, New Haven, CT, USA
    Schizophr Res 61:19-30. 2003
    ..Subsequent reports will detail the effects of drug versus placebo on prodromal symptoms, neuropsychological profile, and the rate of conversion to psychosis...
  22. ncbi Concurrent and predictive validity of the personality disorder diagnosis in adolescent inpatients
    K N Levy
    Yale Psychiatric Institute, New Haven, Conn, USA
    Am J Psychiatry 156:1522-8. 1999
    ..The authors investigated the concurrent and predictive validity of the DSM-III-R diagnosis of personality disorder in adolescents by means of baseline and follow-up assessments of inpatients treated at the Yale Psychiatric Institute...
  23. ncbi Internal consistency, intercriterion overlap and diagnostic efficiency of criteria sets for DSM-IV schizotypal, borderline, avoidant and obsessive-compulsive personality disorders
    C M Grilo
    Collaborative Longitudinal Personality Study, Yale University School of Medicine, PO Box 208098, 301 Cedar Street, New Haven, CT 06520, USA
    Acta Psychiatr Scand 104:264-72. 2001
    ..Diagnostic efficiency statistics provide guidance regarding usefulness of criteria for inclusion or exclusion...
  24. ncbi Self-reported coping strategies in families of patients in early stages of psychotic disorder: an exploratory study
    Ruth Gerson
    Department of Psychiatry, New York University, New York, New York, USA
    Early Interv Psychiatry 5:76-80. 2011
    ..g. reinterpretation) and potentially maladaptive 'avoidant' strategies (denial/disengagement, use of alcohol and drugs). Little is known about coping strategies used by families of individuals with incipient or emergent psychosis...
  25. ncbi Neuropsychological status of subjects at high risk for a first episode of psychosis
    K A Hawkins
    Yale University School of Medicine, New Haven, CT 06519, USA
    Schizophr Res 67:115-22. 2004
    ....
  26. ncbi Factor analysis of the DSM-III-R borderline personality disorder criteria in psychiatric inpatients
    C A Sanislow
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520 8038, USA
    Am J Psychiatry 157:1629-33. 2000
    ..The goal of this study was to examine the factor structure of the DSM-III-R criteria for borderline personality disorder in young adult psychiatric inpatients...
  27. ncbi Treatment outcome of personality disorders
    C A Sanislow
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520 8038, USA
    Can J Psychiatry 43:237-50. 1998
    ..To review the treatment outcome of personality disorders...
  28. ncbi Reduced corticocortical connectivity can induce speech perception pathology and hallucinated 'voices'
    R E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520 8038, USA
    Schizophr Res 30:137-41. 1998
    ..The model also demonstrates how a 'hypodopaminergic' state can reverse cognitive pathology arising from connectivity disturbances...
  29. ncbi Frequency of personality disorders in two age cohorts of psychiatric inpatients
    C M Grilo
    Yale Psychiatric Institute, New Haven, CT 06520, USA
    Am J Psychiatry 155:140-2. 1998
    ..The authors examined the frequency of DSM-III-R personality disorders in adolescent and young adult psychiatric inpatients...
  30. ncbi Using a speech perception neural network computer simulation to contrast neuroanatomic versus neuromodulatory models of auditory hallucinations
    R E Hoffman
    Department of Psychiatry, Yale University School of Medicine, Yale New Haven Psychiatric Hospital, New Haven, CT 06519, USA
    Pharmacopsychiatry 39:S54-64. 2006
    ..These data suggest that the primary pathophysiology of schizophrenia arises from curtailed connectivity in working memory systems and that dopaminergic alterations reflect secondary compensatory adjustments...
  31. ncbi Longitudinal diagnostic efficiency of DSM-IV criteria for obsessive-compulsive personality disorder: a 2-year prospective study
    C M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Acta Psychiatr Scand 110:64-8. 2004
    ..To examine the longitudinal diagnostic efficiency of the DSM-IV criteria for obsessive-compulsive personality disorder (OCPD)...
  32. ncbi Factorial structure of the Scale of Prodromal Symptoms
    K A Hawkins
    Room 530, CMHC, Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Schizophr Res 68:339-47. 2004
    ..The independence of this component from the positive and negative symptom factors suggests that the structure obtained suggests a clinical continuity between the at-risk presentations seen in this sample and established schizophrenia...
  33. ncbi Stability and course of personality disorders: the need to consider comorbidities and continuities between axis I psychiatric disorders and axis II personality disorders
    C M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Psychiatr Q 71:291-307. 2000
    ..The Collaborative Longitudinal Personality Disorder Study (CLPS) is described briefly vis-a-vis some of these major issues...
  34. ncbi Comorbidity of borderline personality disorder with other personality disorders in hospitalized adolescents and adults
    D F Becker
    Yale Psychiatric Institute, Yale University, New Haven, Connecticut, USA
    Am J Psychiatry 157:2011-6. 2000
    ..For comparison, the comorbidity of borderline personality disorder with other personality disorders was also examined in a series of adults consecutively admitted to the same hospital during the same period...
  35. ncbi Personality traits as prospective predictors of suicide attempts
    S Yen
    Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI 02906, USA
    Acta Psychiatr Scand 120:222-9. 2009
    ..To examine higher order personality factors of negative affectivity (NA) and disinhibition (DIS), as well as lower order facets of impulsivity, as prospective predictors of suicide attempts in a predominantly personality disordered sample...
  36. ncbi Psychosis treatment prior to psychosis onset: ethical issues
    T H McGlashan
    Department of Psychiatry, Yale University School of Medicine, P O Box 208098, New Haven, CT 06520 8098, USA
    Schizophr Res 51:47-54. 2001
    ....
  37. ncbi Estimated yield of early detection of prodromal or first episode patients by screening first degree relatives of schizophrenic patients
    S W Woods
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Schizophr Res 52:21-7. 2001
    ..The yield of new cases obtained by screening relatives of current patients appears to be low if the purpose is to recruit a sample for an early intervention study over a relatively short period of time...
  38. ncbi Neural network models of schizophrenia
    R E Hoffman
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520-8099, USA
    Neuroscientist 7:441-54. 2001
    ..Neural network simulations provide empirically testable concepts linking phenomenological, cognitive, and neurobiological findings in schizophrenia...
  39. ncbi Shortened duration of untreated first episode of psychosis: changes in patient characteristics at treatment
    T K Larsen
    Department of Psychiatry, Yale University, New Haven, Conn, USA
    Am J Psychiatry 158:1917-9. 2001
    ..This study examined whether duration of untreated psychosis can be shortened in patients with first episodes of DSM-IV schizophrenia spectrum disorders and whether shorted duration alters patient appearance at treatment...
  40. ncbi Families' experience with seeking treatment for recent-onset psychosis
    Ruth Gerson
    Department of Psychiatry, Cambridge Health Alliance, 1493 Cambridge St, Cambridge, MA 02139, USA
    Psychiatr Serv 60:812-6. 2009
    ..Qualitative research methods were used to understand the experiences of families seeking treatment for young people with recent-onset psychosis; such knowledge can inform services design...
  41. ncbi Stressful life events as predictors of functioning: findings from the collaborative longitudinal personality disorders study
    M E Pagano
    Department of Psychiatry and Human Behavior, Brown University Medical School, Providence, RI 02912, USA
    Acta Psychiatr Scand 110:421-9. 2004
    ..We examined the extent to which PD subjects differ in rates of life events and the extent to which life events impact psychosocial functioning...
  42. ncbi Applicability of personality disorder criteria in late adolescence: internal consistency and criterion overlap 2 years after psychiatric hospitalization
    D F Becker
    Yale University School of Medicine, New Haven, CT, USA
    J Pers Disord 15:255-62. 2001
    ....
  43. ncbi Avoidant personality disorder and social phobia: distinct enough to be separate disorders?
    E Ralevski
    Yale University School of Medicine, New Haven, CT 06519, USA
    Acta Psychiatr Scand 112:208-14. 2005
    ..The purpose of this study was to examine whether in patients diagnosed with AVPD, the co-occurrence of SP adds to its severity. We hypothesized that the addition of SP will not add to the severity of AVPD alone...
  44. ncbi Improvement in borderline personality disorder in relationship to age
    M Tracie Shea
    Department of Psychiatry and Human Behavior, Brown University, Providence, RI 02906, USA
    Acta Psychiatr Scand 119:143-8. 2009
    ..This study examined age-related change in borderline criteria and functional impairment, testing the hypothesis that older age would be associated with relatively more improvement than younger age...
  45. ncbi Posttraumatic stress disorder symptoms in Bosnian refugees 3 1/2 years after resettlement
    Dolores Vojvoda
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    J Rehabil Res Dev 45:421-6. 2008
    ..Women refugees and those who had not mastered the English language appeared to be more vulnerable to persisting psychological effects of trauma...
  46. ncbi Early detection and intervention in schizophrenia: research
    T H McGlashan
    Yale Psychiatric Institute, New Haven, CT 06520, USA
    Schizophr Bull 22:327-45. 1996
    ..The technical challenges of this research are substantial, but the potential gains for our understanding of schizophrenia and treatment make the effort compelling...
  47. ncbi PTSD symptoms in Bosnian refugees 1 year after resettlement in the United States
    S M Weine
    Department of Psychiatry, Yale University, New Haven, Conn, USA
    Am J Psychiatry 155:562-4. 1998
    ....
  48. ncbi Stability and change of DSM-III-R personality disorder dimensions in adolescents followed up 2 years after psychiatric hospitalization
    C M Grilo
    Department of Psychiatry, Yale University School of Medicine, 301 Cedar Street, New Haven, CT 06519, USA
    Compr Psychiatry 42:364-8. 2001
    ..Alternatively, our findings may be viewed as consistent with reports in the adult literature that personality disorders may improve over time, and can potentially benefit from treatment...
  49. ncbi Schizotypal Personality Questionnaire-Brief: factor structure and convergent validity in inpatient adolescents
    S R Axelrod
    Yale Psychiatric Research at Congress Place, Yale University School of Medicine, West Haven, CT, USA
    J Pers Disord 15:168-79. 2001
    ..We concluded that the SPQ-B is a promising measure for evaluating schizotypal personality disorder features, specifically interpersonal and cognitive-perceptual deficits, with adolescent psychiatric inpatients...
  50. ncbi Depressive experiences in inpatients with borderline personality disorder
    Kenneth N Levy
    Department of Psychology, Pennsylvania State University, 521 Moore Building, University Park, PA 16802, USA
    Psychiatr Q 78:129-43. 2007
    ..Findings suggest the importance of considering phenomenological aspects of depression in borderline pathology...
  51. ncbi Personality traits predict current and future functioning comparably for individuals with major depressive and personality disorders
    Christopher J Hopwood
    Department of Psychology, Texas A and M University, College Station, Texas, USA
    J Nerv Ment Dis 195:266-9. 2007
    ..The data suggest that personality traits are significant and equally relevant predictors of functioning for both groups. The utility of assessing personality traits for individuals with both Axis I and II disorders is thus supported...
  52. ncbi The representation of borderline, avoidant, obsessive-compulsive, and schizotypal personality disorders by the five-factor model
    Leslie C Morey
    Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    J Pers Disord 16:215-34. 2002
    ..Differences between personality disorders may reflect diverse interactions among the dimensions, rather than differences on single dimensions...
  53. ncbi Natural course of bulimia nervosa and of eating disorder not otherwise specified: 5-year prospective study of remissions, relapses, and the effects of personality disorder psychopathology
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn 06519, USA
    J Clin Psychiatry 68:738-46. 2007
    ..To examine prospectively the natural course of bulimia nervosa and eating disorder not otherwise specified (EDNOS) and to test for the effects of personality disorder psychopathology on remission and relapse...
  54. ncbi A comparison of interview and self-report methods for the assessment of borderline personality disorder criteria
    Christopher J Hopwood
    Department of Psychology, Texas A and M University, USA
    Psychol Assess 20:81-5. 2008
    ....
  55. ncbi North American Prodrome Longitudinal Study: a collaborative multisite approach to prodromal schizophrenia research
    Jean Addington
    Centre for Addiction and Mental Health, 250 College Street, Toronto, Ontario, M5T 1R8, Canada
    Schizophr Bull 33:665-72. 2007
    ....
  56. ncbi Substance abuse in first-episode non-affective psychosis
    Tor K Larsen
    Stavanger University Hospital, Division for Psychiatry, Norway
    Schizophr Res 88:55-62. 2006
    ..The premorbid profiles of the substance abusers were clearly different from the non-abusers. Drug abusers, in particular, were more socially active both premorbidly and during the year preceding the start of treatment...
  57. ncbi Traumatic exposure and posttraumatic stress disorder in borderline, schizotypal, avoidant, and obsessive-compulsive personality disorders: findings from the collaborative longitudinal personality disorders study
    Shirley Yen
    Department of Psychiatry, Brown University Medical School, 700 Butler Drive, Providence, RI 02906, USA
    J Nerv Ment Dis 190:510-8. 2002
    ..In addition, they support an association between severity of PD and severity of traumatic exposure, as indicated by earlier trauma onset, trauma of an assaultive and personal nature, and more types of traumatic events...
  58. ncbi Descriptive and longitudinal observations on the relationship of borderline personality disorder and bipolar disorder
    John G Gunderson
    McLean Hospital, Department of Psychiatry, Belmont, MA
    Am J Psychiatry 163:1173-8. 2006
    ....
  59. ncbi Co-occurrence of DSM-IV personality disorders with borderline personality disorder
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, 301 Cedar Street, P.O. Box 208098, New Haven, Connecticut 06519, USA
    J Nerv Ment Dis 190:552-4. 2002
  60. ncbi Comorbid diagnoses in patients meeting criteria for the schizophrenia prodrome
    Joanna L Rosen
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520 8098, USA
    Schizophr Res 85:124-31. 2006
    ..These findings lay the groundwork for further examination of the role that comorbid conditions play in the development, course, and severity of schizophrenia...
  61. ncbi Identifying unmet therapeutic domains in schizophrenia patients: the early contributions of Wayne Fenton from Chestnut Lodge
    Thomas H McGlashan
    Department of Psychiatry, Yale University, USA
    Schizophr Bull 33:1086-92. 2007
    ..The results have radically changed the paradigm for discovery with emphasis on impaired cognition and negative symptom psychopathology...
  62. ncbi Longitudinal diagnostic efficiency of DSM-IV criteria for borderline personality disorder: a 2-year prospective study
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Can J Psychiatry 52:357-62. 2007
    ..To examine the longitudinal diagnostic efficiency of the DSM-IV criteria for borderline personality disorder (BPD)...
  63. ncbi Functional impairment in patients with schizotypal, borderline, avoidant, or obsessive-compulsive personality disorder
    Andrew E Skodol
    Collaborative Longitudinal Personality Disorders Study
    Am J Psychiatry 159:276-83. 2002
    ..CONCLUSIONS: Personality disorders are a significant source of psychiatric morbidity, accounting for more impairment in functioning than major depressive disorder alone...
  64. ncbi Treatment histories of patients with a syndrome putatively prodromal to schizophrenia
    Adrian Preda
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Psychiatr Serv 53:342-4. 2002
    ..These data suggest that patients who present with a syndrome putatively prodromal to schizophrenia constitute a clinical population. Research into treatment interventions is indicated...
  65. ncbi Prospective observations of emerging psychosis
    Joanna Lifshey Rosen
    Prevention through Risk Identification, Management, and Education (PRIME) Clinic, Department of Psychiatry, Yale University School of Medicine, Yale Psychiatric Research at Congress Place, 301 Cedar Street, New Haven, Connecticut 06519, USA
    J Nerv Ment Dis 190:133-41. 2002
    ..Discussion focuses on the dimensional quality of the transition both from the prodrome to psychosis and from psychosis to recovery...
  66. ncbi Prospective diagnosis of the initial prodrome for schizophrenia based on the Structured Interview for Prodromal Syndromes: preliminary evidence of interrater reliability and predictive validity
    Tandy J Miller
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Am J Psychiatry 159:863-5. 2002
    ....
  67. ncbi DSM-IV axis II comorbidity with borderline personality disorder in monolingual Hispanic psychiatric outpatients
    Carlos M Grilo
    Yale Psychiatric Research at Congress Place, Department of Psychiatry, Yale University School of Medicine, 301 Cedar Street, 2nd Floor, P. O. Box 208098, New Haven, Connecticut 06520, USA
    J Nerv Ment Dis 190:324-30. 2002
    ..The BPD diagnosis may represent a broader range of psychopathology in Hispanic men than women...
  68. ncbi Confirmatory factor analysis of DSM-IV borderline, schizotypal, avoidant and obsessive-compulsive personality disorders: findings from the Collaborative Longitudinal Personality Disorders Study
    Charles A Sanislow
    Yale University School of Medicine, New Haven, CT 06520-8098, USA
    Acta Psychiatr Scand 105:28-36. 2002
    ..CONCLUSION: Support is provided for the DSM-IV disorder-level classification for schizotypal, borderline, avoidant and obsessive-compulsive personality disorders in a treatment-seeking sample...
  69. ncbi Early detection and intervention of psychosis. A review
    Raimo K R Salokangas
    Department of Psychiatry, University of Turku, Turku, Finland
    Nord J Psychiatry 62:92-105. 2008
    ..However, more large-scale studies and clinical case descriptions of treatment of patients with sub-threshold psychotic symptoms are needed...
  70. ncbi Aripiprazole in the treatment of the psychosis prodrome: an open-label pilot study
    Scott W Woods
    Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Br J Psychiatry Suppl 51:s96-101. 2007
    ..Research studies for the treatment of the putative prodromal phase of psychotic disorders have begun to appear...
  71. ncbi One-year effect of changing duration of untreated psychosis in a single catchment area
    Tor K Larsen
    Stavanger University Hospital, Psychiatric Clinic, Division for Psychiatry, and Department of Psychiatry, University of Bergen, Norway
    Br J Psychiatry Suppl 51:s128-32. 2007
    ..There is highly replicated positive correlation between longer duration of untreated psychosis and poorer outcome...
  72. ncbi Extracting spurious messages from noise and risk of schizophrenia-spectrum disorders in a prodromal population
    Ralph E Hoffman
    Yale New Haven Psychiatric Hospital, 184 Liberty Street LV108, New Haven, CT 06519, USA
    Br J Psychiatry 191:355-6. 2007
    ..no drug) and length of speech illusion, with the latter strongly predicting subsequent conversion during medication-free intervals but not during olanzapine treatment...
  73. ncbi Predictors of 2-year outcome for patients with borderline personality disorder
    John G Gunderson
    McLean Hospital, 155 Mill St, Belmont, MA 02478, USA
    Am J Psychiatry 163:822-6. 2006
    ..The primary purpose of this report was to investigate whether characteristics of subjects with borderline personality disorder observed at baseline can predict variations in outcome at the 2-year follow-up...
  74. ncbi Effects of development on olanzapine-associated adverse events
    Scott W Woods
    Department of Psychiatry, Yale University, New Haven, CT, USA
    J Am Acad Child Adolesc Psychiatry 41:1439-46. 2002
    ..Atypical antipsychotic medications are increasingly prescribed for child and adolescent patients. Relatively little information on adverse events (AEs), specifically in children or adolescents taking atypical antipsychotics, is available...
  75. ncbi Two-year stability and change of schizotypal, borderline, avoidant, and obsessive-compulsive personality disorders
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Consult Clin Psychol 72:767-75. 2004
    ..Dimensionally, these findings suggest that PDs may be characterized by maladaptive trait constellations that are stable in their structure (individual differences) but can change in severity or expression over time...
  76. ncbi Temporal coherence of criteria for four personality disorders
    Leslie C Morey
    Department of Psychology, Texas A and M University, College Station, TX 77843 4235, USA
    J Pers Disord 18:394-8. 2004
    ..72 across 4 disorders), and reasonably specific to that syndrome relative to the other disorders. The results support the validity of these criterion sets as representing coherent syndromes...
  77. ncbi Major depressive disorder and borderline personality disorder revisited: longitudinal interactions
    John G Gunderson
    Harvard Medical School and McLean Hospital, Boston, Mass 02478, USA
    J Clin Psychiatry 65:1049-56. 2004
    ..This report investigates the longitudinal association of changes in major depressive disorder (MDD) and borderline personality disorder...
  78. ncbi Premorbid adjustment in first-episode non-affective psychosis: distinct patterns of pre-onset course
    Tor K Larsen
    Psychiatric Clinic, Armauer Hansensv 20, PO Box 8100, N 4068 Stavanger, Norway
    Br J Psychiatry 185:108-15. 2004
    ..Knowledge about premorbid development in psychosis can shed light upon theories about aetiology and schizophrenic heterogeneity, and form a basis for early detection initiatives...
  79. ncbi Borderline personality disorder criteria associated with prospectively observed suicidal behavior
    Shirley Yen
    Department of Psychiatry and Human Behavior, Brown University, 700 Butler Drive, Duncan Building, Providence, RI 02906, USA
    Am J Psychiatry 161:1296-8. 2004
    ..Since major depressive disorder did not significantly predict suicidal behaviors, the reactivity associated with affective instability (more so than negative mood states) appears to be a critical element in predicting suicidal behaviors...
  80. ncbi The natural course of bulimia nervosa and eating disorder not otherwise specified is not influenced by personality disorders
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Int J Eat Disord 34:319-30. 2003
    ..To examine prospectively the natural course of bulimia nervosa (BN) and eating disorder not otherwise specified (EDNOS) and to test the effects of personality disorder (PD) comorbidity on the outcomes...
  81. ncbi The longitudinal relationship of personality traits and disorders
    Megan B Warner
    Texas A and M University, College Station, TX 77483, USA
    J Abnorm Psychol 113:217-27. 2004
    ....
  82. ncbi The representation of four personality disorders by the schedule for nonadaptive and adaptive personality dimensional model of personality
    Leslie C Morey
    Department of Psychology, Texas A and M University, College Station, Texas 77843 4235, USA
    Psychol Assess 15:326-32. 2003
    ..Furthermore, the model appeared to successfully distinguish specific PDs, a property that represents a particular challenge for dimensional models of personality...
  83. ncbi Practice guideline for the treatment of patients with schizophrenia, second edition
    Anthony F Lehman
    Am J Psychiatry 161:1-56. 2004
  84. ncbi Commentary: Progress, issues, and implications of prodromal research: an inside view
    Thomas H McGlashan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Schizophr Bull 29:851-8. 2003
    ..It is concluded that prodromal research holds much promise but will require the formal collaboration of many investigators and the availability of resources for sustained efforts to recruit what amounts to an incidence sample...
  85. ncbi Prodromal assessment with the structured interview for prodromal syndromes and the scale of prodromal symptoms: predictive validity, interrater reliability, and training to reliability
    Tandy J Miller
    Yale University, New Haven, CT, USA
    Schizophr Bull 29:703-15. 2003
    ..It also presents data suggesting that excellent interrater reliability can be established for diagnosis in a day-and-a-half-long training workshop...
  86. ncbi Ethnicity and four personality disorders
    Denise A Chavira
    Department of Psychiatry, University of California San Diego, La Jolla, CA 92037, USA
    Compr Psychiatry 44:483-91. 2003
    ..The factors contributing to these differences warrant further investigation...
  87. ncbi Gender differences in borderline personality disorder: findings from the Collaborative Longitudinal Personality Disorders Study
    Dawn M Johnson
    Summa Health System, St Thomas Hospital, Akron, OH 44310, USA
    Compr Psychiatry 44:284-92. 2003
    ..For example, no difference was found in rates of major depressive disorder, a condition that is more prevalent in females. Thus, BPD pathology may be a prevailing characterization that can attenuate usual gender-based distinctions...
  88. ncbi Associations in the course of personality disorders and Axis I disorders over time
    M Tracie Shea
    Department of Psychiatry and Human Behavior, Brown University Medical School, Duncan Building, 700 Butler Drive, Providence, RI 20906, USA
    J Abnorm Psychol 113:499-508. 2004
    ..Two of the four personality disorders under examination (STPD and OCPD) showed little or no association with Axis I disorders...
  89. ncbi Two-year prospective naturalistic study of remission from major depressive disorder as a function of personality disorder comorbidity
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    J Consult Clin Psychol 73:78-85. 2005
    ..These PDs emerged as robust predictors of slowed remission from MDD even when controlling for other negative prognostic predictors...
  90. ncbi Diagnostic efficiency of borderline personality disorder criteria in hospitalized adolescents: comparison with hospitalized adults
    Daniel F Becker
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Am J Psychiatry 159:2042-7. 2002
    ..These differences may shed light on the nature of borderline psychopathology during adolescence...
  91. ncbi Exploratory factor analysis of borderline personality disorder criteria in hospitalized adolescents
    Daniel F Becker
    Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Compr Psychiatry 47:99-105. 2006
    ....
  92. ncbi Crisis intervention services in juvenile detention centers
    Charles A Sanislow
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520-8098, USA
    Psychiatr Serv 54:107. 2003
  93. ncbi Differential impairment as an indicator of sex bias in DSM-IV criteria for four personality disorders
    Christina D Boggs
    Department of Psychology, Texas A and M University, USA
    Psychol Assess 17:492-6. 2005
    ..The results suggest that most of the diagnostic criteria examined do not seem to display sex bias. However, those criteria that displayed evidence of bias came largely from the borderline diagnosis...
  94. ncbi Effects of personality disorders on functioning and well-being in major depressive disorder
    Andrew E Skodol
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    J Psychiatr Pract 11:363-8. 2005
    ..CONCLUSIONS: Co-occurring PDs contribute significantly to impairment in social and emotional functioning and reduced well-being in patients with MDD...
  95. ncbi The Collaborative Longitudinal Personality Disorders Study (CLPS): overview and implications
    Andrew E Skodol
    New York State Psychiatric Institute, Columbia University College of Physicians and Surgeons, NY 10032, USA
    J Pers Disord 19:487-504. 2005
    ..Taken together, our results lead us to hypothesize that PDs may be reconceptualized as hybrids of stable personality traits and intermittently expressed symptomatic behaviors...
  96. ncbi Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder
    Hilary P Blumberg
    Mood Disorders Research Program, Department of Psychiatry, Yale University School of Medicine, 300 George Street, Suite 901, New Haven, CT 06511, USA
    Psychopharmacology (Berl) 183:308-13. 2005
    ..Abnormal amygdala and frontocortical responses to emotional stimuli are implicated in bipolar disorder (BD) and have been proposed as potential treatment targets...
  97. ncbi Dimensional representations of DSM-IV personality disorders: relationships to functional impairment
    Andrew E Skodol
    New York State Psychiatric Institute, Box 129, 1051 Riverside Drive, New York, NY 10032, USA
    Am J Psychiatry 162:1919-25. 2005
    ..This study compared three-dimensional representations of DSM-IV personality disorders and standard categories with respect to their associations with psychosocial functioning...
  98. ncbi Randomized trial of olanzapine versus placebo in the symptomatic acute treatment of the schizophrenic prodrome
    Scott W Woods
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 54:453-64. 2003
    ..Extrapyramidal symptoms with olanzapine were minimal and similar to those with placebo. Future research over the longer term with more patients will be needed before recommendations can be made regarding routine treatment...
  99. ncbi Correlates of suicide risk in juvenile detainees and adolescent inpatients
    Charles A Sanislow
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    J Am Acad Child Adolesc Psychiatry 42:234-40. 2003
    ..To compare correlates of risk for suicidal behavior in juvenile detainees with those in another high-risk group, adolescent psychiatric inpatients...
  100. ncbi Do eating disorders co-occur with personality disorders? Comparison groups matter
    Carlos M Grilo
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Int J Eat Disord 33:155-64. 2003
    ..The eating disorders met criteria outlined in the 4th edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV)...
  101. ncbi Discriminant efficiency of antisocial and borderline personality disorder criteria in Hispanic men with substance use disorders
    Daniel F Becker
    Department of Psychiatry, University of California, San Francisco, CA 94143, USA
    Compr Psychiatry 46:140-6. 2005
    ..These findings have implications for the discriminant validity of the BPD and APD criteria and support the value of the conduct disorder criteria in predicting APD in adulthood...

Research Grants10

  1. LONGITUDINAL STUDY OF PERSONALITY DISORDERS
    Thomas McGlashan; Fiscal Year: 2000
    ..The validating approach will examine the homogeneity of descriptive and longitudinal features for the PDs, as defined by the DSM system, and how this compares with alternative schemes. ..
  2. COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER
    Thomas McGlashan; Fiscal Year: 2007
    ....
  3. COLLABORATIVE LONGITUDINAL STUDY OF PERSONALITY DISORDER
    Thomas McGlashan; Fiscal Year: 2004
    ..The predictive approach will identify clinically meaningful determinants of prognosis within and across PDs. The validating approach will examine the homogeneity of descriptive and longitudinal features for the PDs. ..
  4. EARLY DETECTION AND INTERVENTION IN PSYCHOSIS
    Thomas McGlashan; Fiscal Year: 2003
    ..abstract_text> ..