RORY MCCRIMMON

Summary

Affiliation: Yale University
Country: USA

Publications

  1. doi request reprint The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes
    R McCrimmon
    Yale University School of Medicine, Department of Internal Medicine, New Haven, CT 06520 8020, USA
    Diabet Med 25:513-22. 2008
  2. ncbi request reprint Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia
    Rory J McCrimmon
    FRCP, Yale University School of Medicine, P O Box 208020, New Haven, CT 06520 8020, USA
    Diabetes 57:444-50. 2008
  3. pmc Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation
    Rory J McCrimmon
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    J Clin Invest 116:1723-30. 2006
  4. ncbi request reprint Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation
    Rory J McCrimmon
    Department of Internal Medicine and Encocrinology, Yale University School of Medicine, P O Box 208020, New Haven, CT 06520 8020, USA
    Diabetes 55:1755-60. 2006
  5. ncbi request reprint Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats
    Rory J McCrimmon
    Department of Internal Medicine and Endocrinology, Yale University School of Medicine, Section of Endocrinology, P O Box 208020, New Haven, CT 06520 8020, USA
    Diabetes 54:3169-74. 2005
  6. ncbi request reprint Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia
    Owen Chan
    Yale University School of Medicine, Department of Internal Medicine, Section of Endocrinology, 300 Cedar St, New Haven, CT 06519 1612, USA
    Diabetes 55:1080-7. 2006
  7. doi request reprint Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia
    Owen Chan
    Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Diabetes 57:1363-70. 2008
  8. ncbi request reprint Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus
    Rory J McCrimmon
    Department of Internal Medicine and Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    Diabetes 53:1953-8. 2004
  9. pmc Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways
    Ligang Zhou
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Cell Metab 6:398-405. 2007
  10. ncbi request reprint Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses
    Mark L Evans
    Diabetes Endocrine Research Center, Fitkin 1, Yale School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Diabetes 53:2542-51. 2004

Research Grants

Collaborators

Detail Information

Publications18

  1. doi request reprint The mechanisms that underlie glucose sensing during hypoglycaemia in diabetes
    R McCrimmon
    Yale University School of Medicine, Department of Internal Medicine, New Haven, CT 06520 8020, USA
    Diabet Med 25:513-22. 2008
    ..Why this should occur is not yet known, but it may involve increased metabolism or fuel delivery to glucose-sensing neurons or alterations in the mechanisms that regulate the stress response...
  2. ncbi request reprint Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemia
    Rory J McCrimmon
    FRCP, Yale University School of Medicine, P O Box 208020, New Haven, CT 06520 8020, USA
    Diabetes 57:444-50. 2008
    ..To examine in vivo in a rodent model the potential role of AMP-activated protein kinase (AMPK) within the ventromedial hypothalamus (VMH) in glucose sensing during hypoglycemia...
  3. pmc Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulation
    Rory J McCrimmon
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    J Clin Invest 116:1723-30. 2006
    ..Our data suggest that regulation of the CRR is largely determined by the interaction between CRFR2-mediated suppression and CRFR1-mediated activation in the VMH...
  4. ncbi request reprint Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulation
    Rory J McCrimmon
    Department of Internal Medicine and Encocrinology, Yale University School of Medicine, P O Box 208020, New Haven, CT 06520 8020, USA
    Diabetes 55:1755-60. 2006
    ..These findings suggest that the development of novel drugs designed to selectively activate AMPK in the VMH offer a future therapeutic potential for individuals with type 1 diabetes who have defective CRRs to hypoglycemia...
  5. ncbi request reprint Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic rats
    Rory J McCrimmon
    Department of Internal Medicine and Endocrinology, Yale University School of Medicine, Section of Endocrinology, P O Box 208020, New Haven, CT 06520 8020, USA
    Diabetes 54:3169-74. 2005
    ..We also conclude that KCOs may offer a future potential therapeutic option for individuals with insulin-treated diabetes who develop defective counterregulation...
  6. ncbi request reprint Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemia
    Owen Chan
    Yale University School of Medicine, Department of Internal Medicine, Section of Endocrinology, 300 Cedar St, New Haven, CT 06519 1612, USA
    Diabetes 55:1080-7. 2006
    ..Our findings are consistent with the hypothesis that GABAergic inhibitory tone within the VMH can modulate glucose counterregulatory responses...
  7. doi request reprint Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemia
    Owen Chan
    Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Diabetes 57:1363-70. 2008
    ..In the current study, we examined whether increased VMH GABAergic tone may contribute to suppression of counterregulatory responses after recurrent hypoglycemia...
  8. ncbi request reprint Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamus
    Rory J McCrimmon
    Department of Internal Medicine and Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
    Diabetes 53:1953-8. 2004
    ..The combination of hypoglycemia- and AICAR-induced AMPK activity appears to result in a marked stimulus to hepatic glucose counterregulation...
  9. pmc Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways
    Ligang Zhou
    Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
    Cell Metab 6:398-405. 2007
    ....
  10. ncbi request reprint Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responses
    Mark L Evans
    Diabetes Endocrine Research Center, Fitkin 1, Yale School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
    Diabetes 53:2542-51. 2004
    ..Our data suggest that closing of K(ATP) channels in the VMH (much like the beta-cell) impairs defense mechanisms against glucose deprivation and therefore could contribute to defects in glucose counterregulation...
  11. ncbi request reprint Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulation
    Haiying Cheng
    Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Am J Physiol Endocrinol Metab 293:E705-12. 2007
    ..The balance between these two opposing CRFRs in this key glucose-sensing region may play an important role in determining the magnitude of CRRs to acute hypoglycemia...
  12. pmc Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia
    Qingchun Tong
    Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    Cell Metab 5:383-93. 2007
    ..Thus, glutamate release from VMH neurons is an important component of the neurocircuitry that functions to prevent hypoglycemia...
  13. ncbi request reprint 5'AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cells
    Margaret M Shaw
    Institut de Recherche en Ophtalmologie, Avenue de Grand Champsec 64, 1950 Sion, Switzerland
    J Cell Mol Med 11:286-98. 2007
    ....
  14. ncbi request reprint Influence of an early-onset age of type 1 diabetes on cerebral structure and cognitive function
    Stewart C Ferguson
    Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, Scotland, U K
    Diabetes Care 28:1431-7. 2005
    ..We hypothesized that if differences in neuroradiological structure and cognitive ability coexisted in those who had EOD, then an organic component to their etiology was likely...
  15. ncbi request reprint Antecedent hypercortisolemia is not primarily responsible for generating hypoglycemia-associated autonomic failure
    Philip A Goldberg
    Yale University School of Medicine, Department of Internal Medicine, Section of Endocrinology, P O Box 208020, New Haven, CT 06520 8020, USA
    Diabetes 55:1121-6. 2006
    ..Similar results were obtained for glucagon and ACTH levels. Considered together, these observations provide strong evidence that hypoglycemia-induced hypercortisolemia is not primarily responsible for the generation of HAAF...
  16. ncbi request reprint Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemia
    Ewan C McNay
    Section of Endocrinology, Yale School of Medicine, One Gilbert Street, TAC S147, P O Box 208020, New Haven, CT 06519, USA
    Diabetes 55:1088-95. 2006
    ..The impact of recurrent hypoglycemia on cognition is multifaceted and includes both metabolic and electrophysiological components...
  17. ncbi request reprint Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemia
    Stewart C Ferguson
    Department of Diabetes, The Royal Infirmary of Edinburgh, Edinburgh, U K
    Diabetes 52:149-56. 2003
    ..Chronic hyperglycemia (inferred by the presence of background diabetic retinopathy) may affect brain structure and function...

Research Grants4

  1. Role of AMPK in hypoglycemia-sensing in the ventromedial hypothalamus
    RORY MCCRIMMON; Fiscal Year: 2007
    ..Finally, the proposal aims to obtain data that will support the hypothesis that recurrent hypoglycemia induces mitochondrial biogenesis in the VMH, an effect that may be mediated by AMPK. ..