Affiliation: Yale University
- Activation of AMP-activated protein kinase within the ventromedial hypothalamus amplifies counterregulatory hormone responses in rats with defective counterregulationRory J McCrimmon
Department of Internal Medicine and Encocrinology, Yale University School of Medicine, P O Box 208020, New Haven, CT 06520 8020, USA
Diabetes 55:1755-60. 2006..These findings suggest that the development of novel drugs designed to selectively activate AMPK in the VMH offer a future therapeutic potential for individuals with type 1 diabetes who have defective CRRs to hypoglycemia...
- The mechanisms that underlie glucose sensing during hypoglycaemia in diabetesR McCrimmon
Yale University School of Medicine, Department of Internal Medicine, New Haven, CT 06520 8020, USA
Diabet Med 25:513-22. 2008..Why this should occur is not yet known, but it may involve increased metabolism or fuel delivery to glucose-sensing neurons or alterations in the mechanisms that regulate the stress response...
- Key role for AMP-activated protein kinase in the ventromedial hypothalamus in regulating counterregulatory hormone responses to acute hypoglycemiaRory J McCrimmon
FRCP, Yale University School of Medicine, P O Box 208020, New Haven, CT 06520 8020, USA
Diabetes 57:444-50. 2008..To examine in vivo in a rodent model the potential role of AMP-activated protein kinase (AMPK) within the ventromedial hypothalamus (VMH) in glucose sensing during hypoglycemia...
- Activation of ATP-sensitive K+ channels in the ventromedial hypothalamus amplifies counterregulatory hormone responses to hypoglycemia in normal and recurrently hypoglycemic ratsRory J McCrimmon
Department of Internal Medicine and Endocrinology, Yale University School of Medicine, Section of Endocrinology, P O Box 208020, New Haven, CT 06520 8020, USA
Diabetes 54:3169-74. 2005..We also conclude that KCOs may offer a future potential therapeutic option for individuals with insulin-treated diabetes who develop defective counterregulation...
- Corticotrophin-releasing factor receptors within the ventromedial hypothalamus regulate hypoglycemia-induced hormonal counterregulationRory J McCrimmon
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
J Clin Invest 116:1723-30. 2006..Our data suggest that regulation of the CRR is largely determined by the interaction between CRFR2-mediated suppression and CRFR1-mediated activation in the VMH...
- Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathwaysLigang Zhou
Department of Clinical Biochemistry, Addenbrooke s Hospital, University of Cambridge, Cambridge CB2 2QQ, UK
Cell Metab 6:398-405. 2007....
- Type 1 corticotropin-releasing factor receptors in the ventromedial hypothalamus promote hypoglycemia-induced hormonal counterregulationHaiying Cheng
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Am J Physiol Endocrinol Metab 293:E705-12. 2007..The balance between these two opposing CRFRs in this key glucose-sensing region may play an important role in determining the magnitude of CRRs to acute hypoglycemia...
- Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemiaQingchun Tong
Division of Endocrinology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
Cell Metab 5:383-93. 2007..Thus, glutamate release from VMH neurons is an important component of the neurocircuitry that functions to prevent hypoglycemia...
- 5'AMP-activated protein kinase alpha deficiency enhances stress-induced apoptosis in BHK and PC12 cellsMargaret M Shaw
Institut de Recherche en Ophtalmologie, Avenue de Grand Champsec 64, 1950 Sion, Switzerland
J Cell Mol Med 11:286-98. 2007....
- Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemiaStewart C Ferguson
Department of Diabetes, The Royal Infirmary of Edinburgh, Edinburgh, U K
Diabetes 52:149-56. 2003..Chronic hyperglycemia (inferred by the presence of background diabetic retinopathy) may affect brain structure and function...
- Antecedent hypercortisolemia is not primarily responsible for generating hypoglycemia-associated autonomic failurePhilip A Goldberg
Yale University School of Medicine, Department of Internal Medicine, Section of Endocrinology, P O Box 208020, New Haven, CT 06520 8020, USA
Diabetes 55:1121-6. 2006..Similar results were obtained for glucagon and ACTH levels. Considered together, these observations provide strong evidence that hypoglycemia-induced hypercortisolemia is not primarily responsible for the generation of HAAF...
- Cognitive and neural hippocampal effects of long-term moderate recurrent hypoglycemiaEwan C McNay
Section of Endocrinology, Yale School of Medicine, One Gilbert Street, TAC S147, P O Box 208020, New Haven, CT 06519, USA
Diabetes 55:1088-95. 2006..The impact of recurrent hypoglycemia on cognition is multifaceted and includes both metabolic and electrophysiological components...
- Blockade of GABA(A) receptors in the ventromedial hypothalamus further stimulates glucagon and sympathoadrenal but not the hypothalamo-pituitary-adrenal response to hypoglycemiaOwen Chan
Yale University School of Medicine, Department of Internal Medicine, Section of Endocrinology, 300 Cedar St, New Haven, CT 06519 1612, USA
Diabetes 55:1080-7. 2006..Our findings are consistent with the hypothesis that GABAergic inhibitory tone within the VMH can modulate glucose counterregulatory responses...
- Influence of an early-onset age of type 1 diabetes on cerebral structure and cognitive functionStewart C Ferguson
Department of Psychology, University of Edinburgh, Edinburgh EH8 9JZ, Scotland, U K
Diabetes Care 28:1431-7. 2005..We hypothesized that if differences in neuroradiological structure and cognitive ability coexisted in those who had EOD, then an organic component to their etiology was likely...
- Hypothalamic ATP-sensitive K + channels play a key role in sensing hypoglycemia and triggering counterregulatory epinephrine and glucagon responsesMark L Evans
Diabetes Endocrine Research Center, Fitkin 1, Yale School of Medicine, 333 Cedar St, New Haven, CT 06520, USA
Diabetes 53:2542-51. 2004..Our data suggest that closing of K(ATP) channels in the VMH (much like the beta-cell) impairs defense mechanisms against glucose deprivation and therefore could contribute to defects in glucose counterregulation...
- Potential role for AMP-activated protein kinase in hypoglycemia sensing in the ventromedial hypothalamusRory J McCrimmon
Department of Internal Medicine and Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520 8020, USA
Diabetes 53:1953-8. 2004..The combination of hypoglycemia- and AICAR-induced AMPK activity appears to result in a marked stimulus to hepatic glucose counterregulation...
- Increased GABAergic tone in the ventromedial hypothalamus contributes to suppression of counterregulatory responses after antecedent hypoglycemiaOwen Chan
Section of Endocrinology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Diabetes 57:1363-70. 2008..In the current study, we examined whether increased VMH GABAergic tone may contribute to suppression of counterregulatory responses after recurrent hypoglycemia...
- Role of AMPK in hypoglycemia-sensing in the ventromedial hypothalamusRORY MCCRIMMON; Fiscal Year: 2007..Finally, the proposal aims to obtain data that will support the hypothesis that recurrent hypoglycemia induces mitochondrial biogenesis in the VMH, an effect that may be mediated by AMPK. ..