R T Matthews

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member
    R T Matthews
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 275:22695-703. 2000
  2. ncbi request reprint Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets
    Russell T Matthews
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 22:7536-47. 2002
  3. ncbi request reprint Monoclonal antibody Cat-315 detects a glycoform of receptor protein tyrosine phosphatase beta/phosphacan early in CNS development that localizes to extrasynaptic sites prior to synapse formation
    M R Dino
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Neuroscience 142:1055-69. 2006
  4. pmc Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3
    James M Massey
    School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Exp Neurol 209:426-45. 2008
  5. pmc The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility
    Bin Hu
    Center for Molecular Neurobiology, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 283:24848-59. 2008
  6. ncbi request reprint Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas
    Mariano S Viapiano
    Department of Neurobiology and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 65:6726-33. 2005
  7. ncbi request reprint A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma
    Mariano S Viapiano
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 278:33239-47. 2003
  8. ncbi request reprint From barriers to bridges: chondroitin sulfate proteoglycans in neuropathology
    Mariano S Viapiano
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Trends Mol Med 12:488-96. 2006
  9. ncbi request reprint Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning
    Sabrina Diano
    Department of Obstetrics and Gynecology, Yale Medical School, 333 Cedar Street, New Haven Connecticut 06520, USA
    Endocrinology 144:5014-21. 2003
  10. ncbi request reprint Sensory deprivation alters aggrecan and perineuronal net expression in the mouse barrel cortex
    Paulette A McRae
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 27:5405-13. 2007

Collaborators

  • S C Gary
  • Tamas Horvath
  • M F Beal
  • Colin J Barnstable
  • Joshua C Brumberg
  • Mariano S Viapiano
  • Bin Hu
  • James M Massey
  • Paulette A McRae
  • M R Dino
  • Kevin E Sloan
  • Susan Hockfield
  • Sabrina Diano
  • Alicia L Yonkof
  • Michelle R Wagoner
  • Christopher M Whitaker
  • Nigel G F Cooper
  • Jerry Silver
  • Leopold L Kong
  • Jeremy Amps
  • Warren Alilain
  • Abdelnaby Khalyfa
  • Stephen M Onifer
  • Gail Kelly
  • Mary M Rocco
  • S Hockfield
  • S Harroch
  • Allison F Treloar
  • Jean K Stewart
  • Joseph Piepmeier
  • Wenya Linda Bi
  • Daniel G Jay
  • Lichuan Yang
  • Peter Patrylo

Detail Information

Publications11

  1. ncbi request reprint Brain-enriched hyaluronan binding (BEHAB)/brevican cleavage in a glioma cell line is mediated by a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family member
    R T Matthews
    Section of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Biol Chem 275:22695-703. 2000
    ..These results suggest a novel function for ADAMTS family members in BEHAB/brevican cleavage and glioma and indicate that inhibition of ADAMTS in glioma may provide a novel therapeutic strategy...
  2. ncbi request reprint Aggrecan glycoforms contribute to the molecular heterogeneity of perineuronal nets
    Russell T Matthews
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 22:7536-47. 2002
    ..These results have important implications for the role of regulated microheterogeneity of glycosylation in the CNS...
  3. ncbi request reprint Monoclonal antibody Cat-315 detects a glycoform of receptor protein tyrosine phosphatase beta/phosphacan early in CNS development that localizes to extrasynaptic sites prior to synapse formation
    M R Dino
    Department of Neurobiology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    Neuroscience 142:1055-69. 2006
    ..The presence of the Cat-315 reactive carbohydrate on different PN components--RPTPbeta and aggrecan--at different stages of synapse development suggests a potential role for this neuron-specific carbohydrate motif in synaptogenesis...
  4. pmc Increased chondroitin sulfate proteoglycan expression in denervated brainstem targets following spinal cord injury creates a barrier to axonal regeneration overcome by chondroitinase ABC and neurotrophin-3
    James M Massey
    School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Exp Neurol 209:426-45. 2008
    ..These results demonstrate both an additional challenge and potential treatment strategy for successful functional pathway reconstruction after SCI...
  5. pmc The proteoglycan brevican binds to fibronectin after proteolytic cleavage and promotes glioma cell motility
    Bin Hu
    Center for Molecular Neurobiology, The Ohio State University Medical Center, Columbus, Ohio 43210, USA
    J Biol Chem 283:24848-59. 2008
    ..In addition, these results underscore the important functional implications of brevican processing in glioma progression...
  6. ncbi request reprint Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas
    Mariano S Viapiano
    Department of Neurobiology and Neurosurgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    Cancer Res 65:6726-33. 2005
    ..In addition, its absence from benign gliomas prompts its use as a diagnostic marker to distinguish primary brain tumors of similar histology but different pathologic course...
  7. ncbi request reprint A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma
    Mariano S Viapiano
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA
    J Biol Chem 278:33239-47. 2003
    ..Further understanding of BEHAB/brevican isoforms will advance our knowledge of the function of this ECM component and may help identify new potential therapeutic targets for primary brain tumors...
  8. ncbi request reprint From barriers to bridges: chondroitin sulfate proteoglycans in neuropathology
    Mariano S Viapiano
    Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06510, USA
    Trends Mol Med 12:488-96. 2006
    ..Here, we review recent work demonstrating unique modifications and structural microheterogeneity of the lecticans in the diseased CNS, which might relate to novel roles of these molecules in neuropathologies...
  9. ncbi request reprint Uncoupling protein 2 prevents neuronal death including that occurring during seizures: a mechanism for preconditioning
    Sabrina Diano
    Department of Obstetrics and Gynecology, Yale Medical School, 333 Cedar Street, New Haven Connecticut 06520, USA
    Endocrinology 144:5014-21. 2003
    ....
  10. ncbi request reprint Sensory deprivation alters aggrecan and perineuronal net expression in the mouse barrel cortex
    Paulette A McRae
    Department of Neurobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Neurosci 27:5405-13. 2007
    ....
  11. ncbi request reprint CD155/PVR enhances glioma cell dispersal by regulating adhesion signaling and focal adhesion dynamics
    Kevin E Sloan
    Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA
    Cancer Res 65:10930-7. 2005
    ..These findings implicate CD155/PVR as a regulator of adhesion signaling and suggest a pathway through which glioma and other cancer cells may acquire a dispersive phenotype...