D H Mathalon

Summary

Affiliation: Yale University
Country: USA

Publications

  1. ncbi request reprint Left temporal deficit of P300 in patients with schizophrenia: effects of task
    J M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5550, USA
    Int J Psychophysiol 38:71-9. 2000
  2. ncbi request reprint Selective attention in schizophrenia: sparing and loss of executive control
    Daniel H Mathalon
    Psychiatry Service 116A, VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT 06516, USA
    Am J Psychiatry 161:872-81. 2004
  3. ncbi request reprint Anatomy of an error: ERP and fMRI
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Biol Psychol 64:119-41. 2003
  4. ncbi request reprint Response-monitoring dysfunction in aging and Alzheimer's disease: an event-related potential study
    Daniel H Mathalon
    Department of Psychiatry, Psychiatry Service 116A, Veterans Affairs Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Neurobiol Aging 24:675-85. 2003
  5. ncbi request reprint Compounded brain volume deficits in schizophrenia-alcoholism comorbidity
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine Veterans Affairs Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 60:245-52. 2003
  6. ncbi request reprint The long and the short of it: influence of interstimulus interval on auditory P300 abnormalities in schizophrenia
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Electroencephalogr 33:125-35. 2002
  7. ncbi request reprint N400 and automatic semantic processing abnormalities in patients with schizophrenia
    Daniel H Mathalon
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 59:641-8. 2002
  8. ncbi request reprint Response-monitoring dysfunction in schizophrenia: an event-related brain potential study
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine and Psychiatry Service and Veterans Affairs Healthcare System, West Haven, Connecticut, USA
    J Abnorm Psychol 111:22-41. 2002
  9. ncbi request reprint Progressive brain volume changes and the clinical course of schizophrenia in men: a longitudinal magnetic resonance imaging study
    D H Mathalon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Arch Gen Psychiatry 58:148-57. 2001
  10. ncbi request reprint Functional neuroanatomy of auditory working memory in schizophrenia: relation to positive and negative symptoms
    V Menon
    Department of Psychiatry, Stanford University School of Medicine, Stanford, California 94305-5719, USA
    Neuroimage 13:433-46. 2001

Research Grants

Detail Information

Publications46

  1. ncbi request reprint Left temporal deficit of P300 in patients with schizophrenia: effects of task
    J M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5550, USA
    Int J Psychophysiol 38:71-9. 2000
    ..Failure to find P300 asymmetry is not related to the presence or absence of a button pressing task, or the hand used for button pressing. Rather, P300 asymmetry may be related to structural neuroanatomical asymmetries...
  2. ncbi request reprint Selective attention in schizophrenia: sparing and loss of executive control
    Daniel H Mathalon
    Psychiatry Service 116A, VA Connecticut Healthcare System, 950 Campbell Ave, West Haven, CT 06516, USA
    Am J Psychiatry 161:872-81. 2004
    ..Patients with schizophrenia have deficits in auditory selective attention, but whether these attention deficits are evident at the earliest stages of auditory processing or emerge later in the processing stream is unknown...
  3. ncbi request reprint Anatomy of an error: ERP and fMRI
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Biol Psychol 64:119-41. 2003
    ..Thus, error and conflict monitoring may be dissociable, subserved by both overlapping and distinct ACC regions...
  4. ncbi request reprint Response-monitoring dysfunction in aging and Alzheimer's disease: an event-related potential study
    Daniel H Mathalon
    Department of Psychiatry, Psychiatry Service 116A, Veterans Affairs Connecticut Healthcare System, 950 Campbell Avenue, West Haven, CT 06516, USA
    Neurobiol Aging 24:675-85. 2003
    ..In AD patients, CRN amplitude was affected by item certainty (assessed a week earlier), being larger to items that were idiosyncratically difficult for patients to name...
  5. ncbi request reprint Compounded brain volume deficits in schizophrenia-alcoholism comorbidity
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine Veterans Affairs Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 60:245-52. 2003
    ..Schizophrenia and alcoholism are characterized by brain volume abnormalities. Despite the frequent comorbidity of these conditions, the potentially compounded effects of comorbidity on brain structure have seldom been rigorously assessed...
  6. ncbi request reprint The long and the short of it: influence of interstimulus interval on auditory P300 abnormalities in schizophrenia
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    Clin Electroencephalogr 33:125-35. 2002
    ..Implications for the cognitive significance of the P300 and its reduction in schizophrenia are discussed...
  7. ncbi request reprint N400 and automatic semantic processing abnormalities in patients with schizophrenia
    Daniel H Mathalon
    Department of Psychiatry, VA Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 59:641-8. 2002
    ..Using N400, inferences can be drawn regarding the extent to which a given context primes a word...
  8. ncbi request reprint Response-monitoring dysfunction in schizophrenia: an event-related brain potential study
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine and Psychiatry Service and Veterans Affairs Healthcare System, West Haven, Connecticut, USA
    J Abnorm Psychol 111:22-41. 2002
    ..Despite ERN/CRN abnormalities, post-error slowing and Pe were normal in patients, suggesting a dissociation of ERN and error awareness. Anterior cingulate and dorsolateral prefrontal cortical dysfunction in schizophrenia are implicated...
  9. ncbi request reprint Progressive brain volume changes and the clinical course of schizophrenia in men: a longitudinal magnetic resonance imaging study
    D H Mathalon
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, CA, USA
    Arch Gen Psychiatry 58:148-57. 2001
    ..We sought to determine whether the brain dysmorphology previously observed cross-sectionally in people with schizophrenia progresses over time and whether such progression is related to the severity of the illness course...
  10. ncbi request reprint Functional neuroanatomy of auditory working memory in schizophrenia: relation to positive and negative symptoms
    V Menon
    Department of Psychiatry, Stanford University School of Medicine, Stanford, California 94305-5719, USA
    Neuroimage 13:433-46. 2001
    ..Our findings suggest an association between thinking disturbance symptoms, particularly unusual thought content, and disrupted WM processing in schizophrenia...
  11. ncbi request reprint Neurophysiological evidence of corollary discharge dysfunction in schizophrenia
    J M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 943054 5550, USA
    Am J Psychiatry 158:2069-71. 2001
    ..Event-related potentials were used to test whether failures of corollary discharge during speech contribute to the pathophysiology of schizophrenia...
  12. ncbi request reprint Cortical responsiveness during inner speech in schizophrenia: an event-related potential study
    J M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5550, USA
    Am J Psychiatry 158:1914-6. 2001
    ..The study assessed the effects of inner speech on auditory cortical responsiveness in schizophrenia...
  13. ncbi request reprint N1 and P300 abnormalities in patients with schizophrenia, epilepsy, and epilepsy with schizophrenialike features
    J M Ford
    Department of Psychiatry and Behavioral Science, Stanford University School of Medicine, Stanford, California 94304, USA
    Biol Psychiatry 49:848-60. 2001
    ..N1 amplitude reduction appears to be specific to schizophrenia, suggesting its sensitivity to the distinct etiology of schizophrenia...
  14. ncbi request reprint Contribution of alcohol abuse to cerebellar volume deficits in men with schizophrenia
    E V Sullivan
    Department of Psychiatry and Behavioral Sciences 5717, Stanford University School of Medicine, 401 Quarry Rd, Stanford, CA 94305 5717, USA
    Arch Gen Psychiatry 57:894-902. 2000
    ..Complicating such investigations is the high incidence of alcoholism comorbidity in patients with schizophrenia that itself can contribute to cerebellar abnormalities...
  15. pmc Electrophysiological and diffusion tensor imaging evidence of delayed corollary discharges in patients with schizophrenia
    T J Whitford
    Psychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women s Hospital, Harvard Medical School, 1249 Boylston Street, Boston, MA 02215, USA
    Psychol Med 41:959-69. 2011
    ..The nature of these abnormalities is unknown. This study investigated whether SZ patients experience CDs that are abnormally delayed in their arrival at the sensory cortex...
  16. ncbi request reprint Reduced communication between frontal and temporal lobes during talking in schizophrenia
    Judith M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305 5550, USA
    Biol Psychiatry 51:485-92. 2002
    ..Its dysfunction may underlie failure to recognize inner speech as self-generated and account for auditory hallucinations in schizophrenia...
  17. ncbi request reprint A functional magnetic resonance imaging study of working memory abnormalities in schizophrenia
    Matthew R Johnson
    Olin Neuropsychiatry Research Center, The Institute of Living at Hartford Hospital, Hartford, CT, USA
    Biol Psychiatry 60:11-21. 2006
    ..We examined neural function changes at several WM loads to derive a more complete picture of WM dysfunction in schizophrenia...
  18. pmc The dependence of P300 amplitude on gamma synchrony breaks down in schizophrenia
    Judith M Ford
    Psychiatry Service, San Francisco VA Medical Center, Department of Psychiatry, University of California, San Francisco, CA 94121, USA
    Brain Res 1235:133-42. 2008
    ..We also asked whether people who have large P300s have higher power and greater synchrony of neural activity, and if the relationships between P300 and power and synchrony are different in patients and healthy controls...
  19. pmc Modulation of the cortical processing of novel and target stimuli by drugs affecting glutamate and GABA neurotransmission
    Todd D Watson
    NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Int J Neuropsychopharmacol 12:357-70. 2009
    ..Overall, the data suggest that both the GABA-A and NMDA receptor systems modulate P3b and P3a. NMDA antagonism appears to lead to more varied effects on the neural correlates of novelty processing...
  20. ncbi request reprint Event-related brain potential evidence of spared knowledge in Alzheimer's disease
    J M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine and Palo Alto Veterans Affairs Health Care System, California 94305-5550, USA
    Psychol Aging 16:161-76. 2001
    ..Thus, although the name of an item may be inaccessible in confrontation naming, N400 shows that knowledge is intact enough to prime cortical responses...
  21. ncbi request reprint Acquiring and inhibiting prepotent responses in schizophrenia: event-related brain potentials and functional magnetic resonance imaging
    Judith M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, Calif 94305 5550, USA
    Arch Gen Psychiatry 61:119-29. 2004
    ..Schizophrenia is associated with deficits in using context to establish prepotent responses in complex paradigms and failures to inhibit prepotent responses once established...
  22. doi request reprint Assessing corollary discharge in humans using noninvasive neurophysiological methods
    Judith M Ford
    Department of Psychiatry, San Francisco VA Medical Center, University of California, San Francisco, California, USA
    Nat Protoc 5:1160-8. 2010
    ..The successful action of the corollary discharge is seen when the response of the auditory cortex is suppressed during the Talk compared with the Listen condition. The protocol takes about 5 min to complete...
  23. pmc fMRI activity correlated with auditory hallucinations during performance of a working memory task: data from the FBIRN consortium study
    C G Wible
    Department of Psychiatry, Harvard Medical School and Brockton VAMC, Boston, MA 02115, USA
    Schizophr Bull 35:47-57. 2009
    ..We hypothesized that regions involved in verbal working memory and language processing would show activity that was associated with levels of hallucinations during a condition where subjects were rehearsing the stimuli...
  24. ncbi request reprint Cortical responsiveness during talking and listening in schizophrenia: an event-related brain potential study
    J M Ford
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California 94305-5550, USA
    Biol Psychiatry 50:540-9. 2001
    ..Listening reduced N1 equivalently in both groups. CONCLUSIONS: Although the failure of N1 to be reduced during talking was not related to current hallucinations in patients, it may be related to the potential to hallucinate...
  25. pmc Out-of-synch and out-of-sorts: dysfunction of motor-sensory communication in schizophrenia
    Judith M Ford
    Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven, Connecticut, USA
    Biol Psychiatry 63:736-43. 2008
    ..If it reflects the action of the efference copy, it should be related to subsequent sensory suppression. If efference copy/corollary discharge mechanisms are abnormal in schizophrenia, it should be reduced in patients with schizophrenia...
  26. doi request reprint Aripiprazole in the treatment of the psychosis prodrome: an open-label pilot study
    Scott W Woods
    Yale University School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Br J Psychiatry Suppl 51:s96-101. 2007
    ..Research studies for the treatment of the putative prodromal phase of psychotic disorders have begun to appear...
  27. ncbi request reprint Reduced gamma-band coherence to distorted feedback during speech when what you say is not what you hear
    Judith M Ford
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT Psychiatry Service, Veterans Affairs Connecticut Health Care System, West Haven, CT, United States
    Int J Psychophysiol 57:143-50. 2005
    ..We tested the hypothesis that there would be a disruption of gamma-band coherence when the expected auditory consequence of speech does not match the auditory experience...
  28. pmc Tuning in to the voices: a multisite FMRI study of auditory hallucinations
    Judith M Ford
    Yale University, West Haven, CT, USA
    Schizophr Bull 35:58-66. 2009
    ..Accordingly, we predicted that patients who hallucinate would show less auditory cortical activation to external acoustic stimuli than patients who did not...
  29. pmc Working memory overload: fronto-limbic interactions and effects on subsequent working memory function
    Richard J Yun
    Department of Psychiatry, Yale University, New Haven, CT, USA
    Brain Imaging Behav 4:96-108. 2010
    ..These findings suggest that vulnerability to overload effects in cognitive functioning may be mediated by reduced amygdala suppression and subsequent amygdala-prefrontal interaction...
  30. pmc Neural synchrony in schizophrenia: from networks to new treatments
    Judith M Ford
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Schizophr Bull 33:848-52. 2007
    ..Based on this, we argue that we can begin to use oscillations, across frequencies, to do translational studies to understand the neural basis of schizophrenia...
  31. ncbi request reprint Dissecting corollary discharge dysfunction in schizophrenia
    Judith M Ford
    Psychiatry Service, Veterans Affairs Connecticut Healthcare System, West Haven 06517, and Department of Psychiatry, Yale University School of Medicne, New Haven, Connecticut, USA
    Psychophysiology 44:522-9. 2007
    ..Agency and expectancy had modest suppression effects on N1 and only in controls. Group differences in expectancy and agency could not account for failed corollary discharge during talking in patients...
  32. ncbi request reprint Synch before you speak: auditory hallucinations in schizophrenia
    Judith M Ford
    Psychiatry Service, Veterans Affairs Connecticut Health Care System, USA
    Am J Psychiatry 164:458-66. 2007
    ..If so, schizophrenia patients should have reduced neural synchrony preceding movements, especially patients with severe hallucinations...
  33. ncbi request reprint Delayed hemodynamic responses in schizophrenia
    Judith M Ford
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
    Neuroimage 26:922-31. 2005
    ....
  34. ncbi request reprint Fore-period effect and stop-signal reaction time
    Chiang Shan Ray Li
    Connecticut Mental Health Center, S103 Department of Psychiatry, Yale University, 34 Park Street, New Haven, 06519, USA
    Exp Brain Res 167:305-9. 2005
    ..This finding suggests that response readiness needs to be accounted for in examining response inhibition in a stop-signal task...
  35. ncbi request reprint Corollary discharge dysfunction in schizophrenia: can it explain auditory hallucinations?
    Judith M Ford
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Int J Psychophysiol 58:179-89. 2005
    ....
  36. ncbi request reprint Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial
    Vladimir Coric
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Biol Psychiatry 58:424-8. 2005
    ..Recent imaging data suggests glutamatergic dysfunction in the corticostriatal pathway in OCD. We investigated the efficacy of augmentation therapy with riluzole, a glutamate-modulating agent, in treatment-resistant OCD...
  37. pmc Neural synchrony in schizophrenia
    Judith M Ford
    Department of Psychiatry, University of California San Francisco, San Francisco, CA 94121, USA
    Schizophr Bull 34:904-6. 2008
    ..These papers illustrate approaches to translational neuroscience that will increase our understanding of schizophrenia and provide neurobiological endpoints for developing novel treatments...
  38. ncbi request reprint Fine-tuning of auditory cortex during speech production
    Theda H Heinks-Maldonado
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA
    Psychophysiology 42:180-90. 2005
    ..This is consistent with the operation of a precise forward model modulating the auditory cortical response to self-generated speech and allowing immediate distinction of self and externally generated auditory stimuli...
  39. ncbi request reprint Are impairments of action monitoring and executive control true dissociative dysfunctions in patients with schizophrenia?
    And U Turken
    Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305 5550, USA
    Am J Psychiatry 160:1881-3. 2003
    ..Impaired self-monitoring is considered a critical deficit of schizophrenia. The authors asked whether this is a specific and isolable impairment or is part of a global disturbance of cognitive and attentional functions...
  40. pmc Divergent approaches converge on frontal lobe dysfunction in schizophrenia
    Daniel H Mathalon
    Am J Psychiatry 165:944-8. 2008
  41. ncbi request reprint Relationship of imprecise corollary discharge in schizophrenia to auditory hallucinations
    Theda H Heinks-Maldonado
    Department of Neuropsychology, Albert Ludwigs Universitat, Freiburg, Germany
    Arch Gen Psychiatry 64:286-96. 2007
    ..Imprecision of the corollary discharge in schizophrenia may contribute to the misperception of inner experiences and thoughts as "voices" or auditory hallucinations...
  42. ncbi request reprint Corollary discharge dysfunction in schizophrenia: evidence for an elemental deficit
    Daniel H Mathalon
    Psychiatry Service, San Francisco VA Medical Center, USA
    Clin EEG Neurosci 39:82-6. 2008
    ....
  43. pmc Diffusion tensor imaging in schizophrenia: relationship to symptoms
    Laurie R Skelly
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Schizophr Res 98:157-62. 2008
    ....
  44. ncbi request reprint Electrophysiological evidence of corollary discharge dysfunction in schizophrenia during talking and thinking
    Judith M Ford
    Department of Psychiatry and Behavioral Sciences Stanford University School of Medicine, and Psychiatry Service, Veterans Affairs Medical Center, Palo Alto, USA
    J Psychiatr Res 38:37-46. 2004
    ....
  45. pmc Chronic smoking and the BOLD response to a visual activation task and a breath hold task in patients with schizophrenia and healthy controls
    Lee Friedman
    PO Box 51, Newbury, OH 44065, USA
    Neuroimage 40:1181-94. 2008
    ....
  46. ncbi request reprint Neurotoxicity, neuroplasticity, and magnetic resonance imaging morphometry
    Daniel H Mathalon
    Arch Gen Psychiatry 60:846-8; author reply 848-9. 2003

Research Grants2