Research Topics
| G F MasonSummaryAffiliation: Yale University Country: USA Publications
| Collaborators
|
Detail Information
Publications
Magnetic resonance spectroscopy for studies of neurotransmission in vivoGraeme F Mason
Department of Psychiatry, Yale University, New Haven, Connecticut, USA
Psychopharmacol Bull 37:26-40. 2003..The remainder of the article focuses primarily on steps that are necessary for MRS to become more widely used, making it clinically viable and allowing the study of large populations...
Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucoseGraeme F Mason
Department of Psychiatry, Yale University, School of Medicine, New Haven, Connecticut 06520 8043, USA
J Neurochem 100:73-86. 2007..These results are consistent with observations made with arterial-venous differences and radiotracer methods...- Decrease in GABA synthesis rate in rat cortex following GABA-transaminase inhibition correlates with the decrease in GAD(67) proteinG F Mason
Department of Psychiatry, Magnetic Resonance Center for Research in Metabolism and Physiology, Yale University School of Medicine, New Haven, CT 06520, USA
Brain Res 914:81-91. 2001..GAD(67) could account for 56-85% of cortical GABA synthesis flux under basal conditions and the entire flux after vigabatrin treatment... - Graded image segmentation of brain tissue in the presence of inhomogeneous radio frequency fieldsGraeme F Mason
Department of Psychiatry, New Haven, CT, USA
Magn Reson Imaging 20:431-6. 2002..The T(1) observed by this method is a continuous function across mixtures of WM/GM and GM/CSF, and this function was measured and used to convert the images of T(1) to maps of percent GM, WM, and CSF... - MR spectroscopy: its potential role for drug development for the treatment of psychiatric diseasesGraeme F Mason
Department of Diagnostic Radiology, Yale University, School of Medicine, 300 Cedar St, New Haven, CT 06520 8043, USA
NMR Biomed 19:690-701. 2006..The third major direction of this article is the discussion of where MRS techniques are headed and how those new techniques can contribute to studies of mechanisms of psychiatric disease and drug discovery... - Cortical gamma-aminobutyric acid levels and the recovery from ethanol dependence: preliminary evidence of modification by cigarette smokingGraeme F Mason
NIAAA Center for the Translational Neuroscience of Alcoholism and Department of Psychiatry, Yale University, School of Medicine, New Haven, CT 06520, USA
Biol Psychiatry 59:85-93. 2006..This study's objective was to measure time-dependent cortical GABA levels with sobriety in ethanol-dependent patients with mild to moderate withdrawal severity, controlling for alcoholism-related neurotoxicity and smoking... - Nonlinear determination of Michaelis-Menten kinetics with model evaluation through estimation of uncertaintiesG F Mason
Department of Psychiatry, Yale University, New Haven, CT 06520 8043, USA
Metab Brain Dis 15:133-49. 2000..The theoretical approach as implemented in the user-friendly software allows investigators to use a structured procedure for evaluating and planning enzyme kinetic and related metabolic studies... - A comparison of (13)C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-(13)C]glucoseGraeme F Mason
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Brain Res Brain Res Protoc 10:181-90. 2003..The conclusion is that oral administration does yield the same result as intravenous administration but with lower precision. That sensitivity of the oral protocol may be improved by several ways that are available today... - Basic principles of metabolic modeling of NMR (13)C isotopic turnover to determine rates of brain metabolism in vivoGraeme F Mason
Department of Psychiatry, School of Medicine, Yale University, N 141 CAB Magnetic Resonance Center, 300 Cedar Street, PO Box 208043, New Haven, CT 06520 8043, USA
Metab Eng 6:75-84. 2004..This article is meant to provide a general background for investigators to begin to apply metabolic modeling analysis to (13)C isotopic labeling studies performed in vivo... - Get sober; stay soberGraeme F Mason
Division of Bioimaging Sciences N-141 TAC-MRRC, 300 Cedar Street, New Haven, CT 06520-8043, USA
Brain 130:8-9. 2007 - Stoichiometric coupling of brain glucose metabolism and glutamatergic neuronal activityN R Sibson
Department of Molecular Biophysics, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 95:316-21. 1998..Another implication of this result is that brain activation studies, which map cortical oxidative Glc metabolism, provide a quantitative measure of synaptic glutamate release... - In vivo 13C NMR measurements of cerebral glutamine synthesis as evidence for glutamate-glutamine cyclingN R Sibson
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, CT 06520 8043, USA
Proc Natl Acad Sci U S A 94:2699-704. 1997.... - In vivo (13)C NMR measurement of neurotransmitter glutamate cycling, anaplerosis and TCA cycle flux in rat brain duringN R Sibson
Departments of Molecular Biophysics, Yale University School of Medicine, New Haven, Connecticut, USA
J Neurochem 76:975-89. 2001..These findings indicate that anaplerotic glutamine synthesis is coupled to nitrogen removal from the brain (ammonia detoxification) under hyperammonemic conditions... - Functional energy metabolism: in vivo 13C-NMR spectroscopy evidence for coupling of cerebral glucose consumption and glutamatergic neuronalactivityN R Sibson
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, Newhaven, Conn, USA
Dev Neurosci 20:321-30. 1998..These findings bear upon a number of hypotheses concerning the neurophysiological basis of brain functional imaging methods... - Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolismVincent Lebon
Howard Hughes Medical Institute, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA
J Neurosci 22:1523-31. 2002..The further application of this approach could potentially enlighten the role of astroglia in supporting brain glutamatergic activity and in neurological and psychiatric disease... - Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopyG Sanacora
Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
Arch Gen Psychiatry 56:1043-7. 1999..In this study we used in vivo proton magnetic resonance spectroscopy to investigate the hypothesis that abnormalities in the GABA neurotransmitter system are associated with the neurobiologic processes of depression... - The contribution of blood lactate to brain energy metabolism in humans measured by dynamic 13C nuclear magnetic resonance spectroscopyFawzi Boumezbeur
Departments of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut 06520, USA
J Neurosci 30:13983-91. 2010..1 ± 2.7 mmol/L and V(MAX) is 0.40 ± 0.13 μmol · g(-1) · min(-1) (68% confidence interval); and (4) the majority of plasma lactate is metabolized in neurons similar to glucose... - Evaluation of cerebral acetate transport and metabolic rates in the rat brain in vivo using 1H-[13C]-NMRAnant B Patel
Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut, USA
J Cereb Blood Flow Metab 30:1200-13. 2010..The astrocytic and neuronal tricarboxylic acid cycle fluxes were 0.37+/-0.03 micromol/g/min and 1.41+/-0.11 micromol/g/min, respectively; astrocytes thus comprised approximately 21%+/-3% of total oxidative metabolism... - Reductions in occipital cortex GABA levels in panic disorder detected with 1h-magnetic resonance spectroscopyA W Goddard
Yale Anxiety Clinic, Yale Department of Psychiatry, 100 York St, Room 2J, New Haven, CT 06511, USA
Arch Gen Psychiatry 58:556-61. 2001..The purpose of the present work was to determine whether cortical GABA levels are abnormally low in patients with panic disorder... - Differential increase in cerebral cortical glucose oxidative metabolism during rat postnatal development is greater in vivo than in vitroE J Novotny
Department of Neurology, Yale University School of Medicine, New Haven, CT 06520, USA
Brain Res 888:193-202. 2001.... - Increased brain monocarboxylic acid transport and utilization in type 1 diabetesGraeme F Mason
Department of Psychiatry and Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06536-8012, USA
Diabetes 55:929-34. 2006..These data are consistent with the hypothesis that upregulation of MCA transport may contribute to the maintenance of brain energetics during hypoglycemia in patients with type 1 diabetes... - In vivo 1H-[13C]-NMR spectroscopy of cerebral metabolismRobin A de Graaf
Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06520 8043, USA
NMR Biomed 16:339-57. 2003..Finally, (1)H-[(13)C]-NMR spectroscopy allows the detection of energy metabolism and neurotransmission during functional activation, thereby further strengthening our understanding of the neurochemical basis of brain function... - Preliminary evidence of reduced occipital GABA concentrations in puerperal women: a 1H-MRS studyC Neill Epperson
Department of Psychiatry, Yale University School of Medicine, and Abraham Ribicoff Research Facilities, Connecticut Mental Health Center, New Haven, CT 06519, USA
Psychopharmacology (Berl) 186:425-33. 2006..Childbirth is associated with rapid neuroendocrine fluctuations, which are thought to contribute to the phatogenesis of postpartum major depression (PPD)... - Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy studyC Neill Epperson
Yale Behavioral Gynecology Program, Department of Psychiatry, Yale University School of Medicine University Towers, Suite 2H, 100 York St, New Haven, CT 06511, USA
Arch Gen Psychiatry 59:851-8. 2002.... - Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patientsDouglas E Befroy
Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06536 8012, USA
Diabetes 56:1376-81. 2007.... - Glutamatergic and GABAergic neurotransmitter cycling and energy metabolism in rat cerebral cortex during postnatal developmentGolam M I Chowdhury
Department of Diagnostic Radiology, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Cereb Blood Flow Metab 27:1895-907. 2007..The findings show that glutamate and GABA neurons undergo large and approximately proportional increases in neurotransmitter cycling and oxidative energy metabolism during this major postnatal growth spurt... - It is time to take a stand for medical research and against terrorism targeting medical scientistsJohn H Krystal
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 63:725-7. 2008 - Recurrent antecedent hypoglycemia alters neuronal oxidative metabolism in vivoLihong Jiang
Department of Diagnostic Radiology, Yale University School of Medicine, The Anlyan Center, New Haven, Connecticut, USA
Diabetes 58:1266-74. 2009.... - Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopyFawzi Boumezbeur
Department of Diagnostic Radiology, Yale School of Medicine, New Haven, Connecticut 06520 8020, USA
J Cereb Blood Flow Metab 30:211-21. 2010..Taken together, these studies show that healthy aging is associated with reduced neuronal mitochondrial metabolism and altered glial mitochondrial metabolism, which may in part be responsible for declines in brain function... - Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitorsGerard Sanacora
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Am J Psychiatry 159:663-5. 2002..The goal of this study was to determine whether these occipital cortex GABA concentrations are altered after administration of selective serotonin reuptake inhibitors (SSRIs) in the treatment of depression... - Detection of [1,6-13C2]-glucose metabolism in rat brain by in vivo 1H-[13C]-NMR spectroscopyRobin A de Graaf
Magnetic Resonance Center, Department of Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8043, USA
Magn Reson Med 49:37-46. 2003..52 +/- 0.04 micromol/min/g, while the glutamatergic neurotransmitter flux equaled 0.25 +/- 0.05 micromol/min/g, in good correspondence with previously determined values... - Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapyGerard Sanacora
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
Biol Psychiatry 59:284-6. 2006..The purpose of this study was to determine whether treatment of major depression with cognitive behavioral therapy (CBT) produces similar changes in cortical GABA concentrations... - Coupling of glutamatergic neurotransmission and neuronal glucose oxidation over the entire range of cerebral cortex activityAnant B Patel
Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
Ann N Y Acad Sci 1003:452-3. 2003 - Sex, GABA, and nicotine: the impact of smoking on cortical GABA levels across the menstrual cycle as measured with proton magnetic resonance spectroscopyC Neill Epperson
Department of Psychiatry, Yale University School of Medicine, University Towers Suite 2H, 100 York Street, New Haven, CT 06511, USA
Biol Psychiatry 57:44-8. 2005..Given that nicotine modulates amino acid neurotransmission, we sought to examine the impact of nicotine on cortical gamma-aminobutyric acid (GABA) levels in male and female smokers... - Increased cortical GABA concentrations in depressed patients receiving ECTGerard Sanacora
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Am J Psychiatry 160:577-9. 2003..The purpose of this study was to determine if cortical GABA concentrations increase following a course of ECT... - Subtype-specific alterations of gamma-aminobutyric acid and glutamate in patients with major depressionGerard Sanacora
Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
Arch Gen Psychiatry 61:705-13. 2004..An initial report, using this technique, suggested that occipital cortex GABA concentrations are reduced in patients with major depressive disorder (MDD) relative to healthy comparison subjects... - Regional glucose metabolism and glutamatergic neurotransmission in rat brain in vivoRobin A de Graaf
Magnetic Resonance Research Center and Departments of Diagnostic Radiology and Psychiatry, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 101:12700-5. 2004..02 +/- 0.04, and 0.18 +/- 0.12 micromol/min per g, respectively. The exchange rate between the mitochondrial and cytosolic metabolite pools was fast relative to the neuronal tricarboxylic acid cycle flux for all cerebral tissue types... - Glutamatergic neurotransmission and neuronal glucose oxidation are coupled during intense neuronal activationAnant B Patel
Department of Psychiatry, Magnetic Resonance Research Center, Yale University School of Medicine, New Haven, Connecticut 06520, USA
J Cereb Blood Flow Metab 24:972-85. 2004..These results indicate that neuronal glucose oxidation and not total glucose utilization is coupled to the glutamate/glutamine cycle during intense cortical activation... - The contribution of GABA to glutamate/glutamine cycling and energy metabolism in the rat cortex in vivoAnant B Patel
Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT 06520, USA
Proc Natl Acad Sci U S A 102:5588-93. 2005..The contribution of GABAergic neurons and inhibition to cortical energy metabolism has broad implications for the interpretation of functional imaging signals... - Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatmentsJ H Krystal
Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
Mol Psychiatry 7:S71-80. 2002..Future research will be needed to develop and evaluate new agents with specific glutamate and GABA receptor targets in the treatment of mood disorders... - Cerebral benzodiazepine receptors in depressed patients measured with [123I]iomazenil SPECTAkira Kugaya
Department of Psychiatry, Yale University, New Haven, CT, USA
Biol Psychiatry 54:792-9. 2003..CONCLUSIONS: GABA(A) receptor binding measured in vivo with BZ radioligand binding are not altered in patients with depression... - Regional metabolite levels and turnover in the awake rat brain under the influence of nicotineJie Wang
Department of Biomedical Engineering, School of Medicine, Yale University, New Haven, Connecticut, USA
J Neurochem 113:1447-58. 2010..In summary, the study revealed that the neurochemicals were most affected in the cortex and striatum of the rat brain after acute nicotine treatment... - Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individualsDouglas E Befroy
Departments of Internal Medicine, Diagnostic Radiology, Cellular and Molecular Physiology, and Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06536, USA
Proc Natl Acad Sci U S A 105:16701-6. 2008..Increased mitochondrial uncoupling may represent another mechanism by which exercise training enhances muscle insulin sensitivity via increased fatty acid oxidation in the resting state... - Regional cerebral blood flow and magnetic resonance spectroscopic imaging findings in diaschisis from strokeWen-Jang Chu
Division of Nuclear Medicine, Department of Radiology, University of Alabama at Birmingham Medical Center, Birmingham, Ala 35233, USA
Stroke 33:1243-8. 2002.... - Impaired GABA neuronal response to acute benzodiazepine administration in panic disorderAndrew W Goddard
Indiana University Department of Psychiatry, Adult Psychiatry Clinic, UH 3124A, 550 North University Blvd, Indianapolis, IN 46202 5266, USA
Am J Psychiatry 161:2186-93. 2004..In the current study, the authors tested the hypothesis that panic disorder patients have a deficient GABA neuronal response to benzodiazepine (clonazepam) administration... - The interaction of neuroactive steroids and GABA in the development of neuropsychiatric disorders in womenZenab Amin
Yale University, United States
Pharmacol Biochem Behav 84:635-43. 2006.... - Family psychopathology and magnitude of reductions in occipital cortex GABA levels in panic disorderAndrew W Goddard
Neuropsychopharmacology 29:639-40. 2004