Robert Malison

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Demographic changes and marker properties affect detection of human population differentiation
    Jennifer B Listman
    Dept Anthropology, New York Univ, NY, USA
    BMC Genet 8:21. 2007
  2. pmc Identification of population substructure among Jews using STR markers and dependence on reference populations included
    Jennifer B Listman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 11:48. 2010
  3. ncbi request reprint Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 155:832-4. 1998
  4. ncbi request reprint Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia
    Robert T Malison
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Psychiatr Genet 16:245-9. 2006
  5. pmc Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)
    Robert T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06437, USA
    Addict Behav 36:156-60. 2011
  6. ncbi request reprint [123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, Connecticut, USA
    Psychopharmacology (Berl) 137:321-5. 1998
  7. ncbi request reprint Limited efficacy of ketoconazole in treatment-refractory major depression
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Psychopharmacol 19:466-70. 1999
  8. ncbi request reprint Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, 06519, USA
    Psychoneuroendocrinology 30:880-91. 2005
  9. pmc Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4
    Chupong Ittiwut
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA
    Genomics 91:61-9. 2008
  10. ncbi request reprint Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression
    Jaakko Lappalainen
    Yale University School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 124:81-6. 2004

Research Grants

Detail Information

Publications45

  1. pmc Demographic changes and marker properties affect detection of human population differentiation
    Jennifer B Listman
    Dept Anthropology, New York Univ, NY, USA
    BMC Genet 8:21. 2007
    ....
  2. pmc Identification of population substructure among Jews using STR markers and dependence on reference populations included
    Jennifer B Listman
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    BMC Genet 11:48. 2010
    ....
  3. ncbi request reprint Elevated striatal dopamine transporters during acute cocaine abstinence as measured by [123I] beta-CIT SPECT
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, Conn, USA
    Am J Psychiatry 155:832-4. 1998
    ..The authors examined whether striatal dopamine transporters were altered in acutely (96 hours or less) abstinent cocaine-abusing subjects, as suggested by postmortem studies...
  4. ncbi request reprint Human clock, PER1 and PER2 polymorphisms: lack of association with cocaine dependence susceptibility and cocaine-induced paranoia
    Robert T Malison
    Department of Psychiatry, Division of Human Genetics, Yale University School of Medicine, New Haven, Connecticut 06519, USA
    Psychiatr Genet 16:245-9. 2006
    ..These results do not support the involvement of genetic variation in these three circadian gene SNPs for influencing risks for either of these cocaine phenotypes...
  5. pmc Inter-rater reliability and concurrent validity of DSM-IV opioid dependence in a Hmong isolate using the Thai version of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA)
    Robert T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06437, USA
    Addict Behav 36:156-60. 2011
    ..The high concordance between instruments supports the concurrent validity of the diagnosis. Either interview provides reliable, valid OD diagnoses in Thai-speaking Hmong individuals...
  6. ncbi request reprint [123I]beta-CIT SPECT imaging of dopamine transporter availability after mazindol administration in human cocaine addicts
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, Connecticut, USA
    Psychopharmacology (Berl) 137:321-5. 1998
    ..e., 2-4 mg) occupy a small percentage (i.e., < 25%) of DAT in human cocaine abusers and that much higher, potentially intolerable doses (i.e., > or = 30 mg/day) may be required to antagonize significantly cocaine binding in vivo...
  7. ncbi request reprint Limited efficacy of ketoconazole in treatment-refractory major depression
    R T Malison
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA
    J Clin Psychopharmacol 19:466-70. 1999
    ..These findings suggest a limited efficacy for ketoconazole in patients with treatment-refractory major depression...
  8. ncbi request reprint Frequency of recent cocaine and alcohol use affects drug craving and associated responses to stress and drug-related cues
    Helen C Fox
    Department of Psychiatry, Yale University School of Medicine, Substance Abuse Center, Connecticut Mental Health Center, New Haven, 06519, USA
    Psychoneuroendocrinology 30:880-91. 2005
    ..The current study examined whether frequency of cocaine and alcohol abuse alters drug craving and associated arousal with laboratory exposure to stress and to drug related cues...
  9. pmc Interpopulation linkage disequilibrium patterns of GABRA2 and GABRG1 genes at the GABA cluster locus on human chromosome 4
    Chupong Ittiwut
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06510, USA
    Genomics 91:61-9. 2008
    ..These findings may aid in understanding the genetic association of this locus with alcohol dependence in several populations...
  10. ncbi request reprint Mutation screen of the glutamate decarboxylase-67 gene and haplotype association to unipolar depression
    Jaakko Lappalainen
    Yale University School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, New Haven, Connecticut 06516, USA
    Am J Med Genet B Neuropsychiatr Genet 124:81-6. 2004
    ..Furthermore, these results suggest that common genetic variation within the GAD67 gene does not play a major role in the predisposition to unipolar depression...
  11. pmc Sequence variation and linkage disequilibrium in the GABA transporter-1 gene (SLC6A1) in five populations: implications for pharmacogenetic research
    Rungnapa Hirunsatit
    Yale University School of Medicine, Department of Psychiatry, New Haven, CT, USA
    BMC Genet 8:71. 2007
    ....
  12. ncbi request reprint Cocaine users differ from normals on cognitive tasks which show poorer performance during drug abstinence
    Edward F Pace-Schott
    Department of Psychiatry, Harvard Medical School and Center for Sleep and Cognition, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA
    Am J Drug Alcohol Abuse 34:109-21. 2008
    ....
  13. ncbi request reprint Dopamine beta-hydroxylase gene (DbetaH) -1021C-->T influences self-reported paranoia during cocaine self-administration
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut 06519, USA
    Biol Psychiatry 61:1310-3. 2007
    ..Variation in the gene for dopamine beta-hydroxylase (DbetaH) has been reported to associate with cocaine-induced paranoia as assessed by retrospective self-report. This association has yet to be tested prospectively...
  14. ncbi request reprint A functional neuropeptide Y Leu7Pro polymorphism associated with alcohol dependence in a large population sample from the United States
    Jaakko Lappalainen
    Yale University School of Medicine, Department of Psychiatry, VA Connecticut Healthcare System, 950 Campbell Ave, Psychiatry 116A2, West Haven, CT 06516, USA
    Arch Gen Psychiatry 59:825-31. 2002
    ..We tested whether the Pro7 allele is associated with alcohol dependence in European Americans (EA)...
  15. pmc Biological markers of the effects of intravenous methylphenidate on improving inhibitory control in cocaine-dependent patients
    Chiang Shan R Li
    Department of Psychiatry, Yale University, New Haven, CT 06519, USA
    Proc Natl Acad Sci U S A 107:14455-9. 2010
    ..Altered ventromedial prefrontal activation and increased blood pressure may represent useful CNS and peripheral biomarkers in individualized treatment with methylphenidate for patients with cocaine dependence...
  16. ncbi request reprint Cocaine and sleep: early abstinence
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    ScientificWorldJournal 7:223-30. 2007
    ..Here we review the relevant literature on cocaine use and sleep, and discuss the possible relevance of this sleep disturbance in relationship to the underlying disorder and its treatment...
  17. doi request reprint Pilot study of lorazepam and tiagabine effects on sleep, motor learning, and impulsivity in cocaine abstinence
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, Connecticut 06519, USA
    Am J Drug Alcohol Abuse 34:692-702. 2008
    ..To test the effects of mechanistically different GABA modulating agents on the disrupted sleep and cognitive function associated with abstinence from cocaine...
  18. pmc Sleep architecture, cocaine and visual learning
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA
    Addiction 103:1344-52. 2008
    ..We hypothesized that sleep-related cognitive function would be impaired in chronic cocaine users, and that this impairment would be associated with abstinence-related changes in sleep architecture...
  19. ncbi request reprint Retrograde effects of triazolam and zolpidem on sleep-dependent motor learning in humans
    Peter T Morgan
    Department of Psychiatry, Yale University, 34 Park Street, New Haven, CT 06519, USA
    J Sleep Res 19:157-64. 2010
    ..These data indicate that non-selective or alpha1-preferring benzodiazepine site allosteric activators can interfere with sleep-dependent memory consolidation...
  20. pmc PET imaging of the effects of age and cocaine on the norepinephrine transporter in the human brain using (S,S)-[(11)C]O-methylreboxetine and HRRT
    Yu Shin Ding
    Yale PET Center, Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8048, USA
    Synapse 64:30-8. 2010
    ....
  21. pmc Increased error-related thalamic activity during early compared to late cocaine abstinence
    Chiang Shan R Li
    Department of Psychiatry, Yale University, New Haven, CT 06519 USA
    Drug Alcohol Depend 109:181-9. 2010
    ..These findings support the hypothesis that heightened thalamic reactivity to salient stimuli co-occur with cocaine craving and loss of self control...
  22. pmc Sex differences in sleep and sleep-dependent learning in abstinent cocaine users
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, New Haven, CT 06519, USA
    Pharmacol Biochem Behav 93:54-8. 2009
    ..The absence of sleep disturbances in women suggests a need to understand the mechanisms underlying these differences, as such knowledge could lead to novel therapies in cocaine dependence...
  23. ncbi request reprint Riluzole augmentation in treatment-resistant obsessive-compulsive disorder: an open-label trial
    Vladimir Coric
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Biol Psychiatry 58:424-8. 2005
    ..Recent imaging data suggests glutamatergic dysfunction in the corticostriatal pathway in OCD. We investigated the efficacy of augmentation therapy with riluzole, a glutamate-modulating agent, in treatment-resistant OCD...
  24. ncbi request reprint Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Psychiatry 161:525-31. 2004
    ..In vitro studies of nonneural cells have suggested that the long allele may have higher transcriptional activity than the short allele. However, the relevance of these findings for SERT levels in the brain remains unclear...
  25. ncbi request reprint Brain serotonin transporter availability predicts treatment response to selective serotonin reuptake inhibitors
    Akira Kugaya
    Department of Psychiatry, Yale University, New Haven, Connecticut, USA
    Biol Psychiatry 56:497-502. 2004
    ..This study used brain imaging to examine the relationship between pretreatment brain SERT availability and transporter occupancy by SSRIs with treatment response in two independent depressed populations...
  26. ncbi request reprint Changes in human in vivo serotonin and dopamine transporter availabilities during chronic antidepressant administration
    Akira Kugaya
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA
    Neuropsychopharmacology 28:413-20. 2003
    ..This apparent SSRI-induced modulation of the dopamine system may be associated with the side effects of these agents, including sexual dysfunction...
  27. ncbi request reprint Increased dopamine transporter availability associated with the 9-repeat allele of the SLC6A3 gene
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, One Church Street, New Haven, CT 06510, USA
    J Nucl Med 46:745-51. 2005
    ..Previous investigations of the effects of the SLC6A3 polymorphism on DAT availability in smaller samples of humans have yielded divergent results...
  28. ncbi request reprint Sex differences in diencephalon serotonin transporter availability in major depression
    Julie K Staley
    Department of Psychiatry, Yale University School of Medicine and West Haven VA Connecticut Health Care System, CT 06516, USA
    Biol Psychiatry 59:40-7. 2006
    ..The present study evaluated if previous findings that demonstrated decreased 5-hydroxytryptamine (5-HT) transporter availability in depressed patients would be confirmed in a larger sample and also evaluated sex differences...
  29. doi request reprint Normalizing effects of modafinil on sleep in chronic cocaine users
    Peter T Morgan
    Connecticut Mental Health Center, Yale University Department of Psychiatry, New Haven, CT 06519, USA
    Am J Psychiatry 167:331-40. 2010
    ..The purpose of the present study was to determine the effect of morning-dosed modafinil on sleep and daytime sleepiness in chronic cocaine users...
  30. ncbi request reprint Sleep, sleep-dependent procedural learning and vigilance in chronic cocaine users: Evidence for occult insomnia
    Peter T Morgan
    Department of Psychiatry, Yale University School of Medicine and Connecticut Mental Health Center, Clinical Neuroscience Research Unit, 34 Park Street, New Haven, CT 06519, USA
    Drug Alcohol Depend 82:238-49. 2006
    ..However, they report subjectively improving sleep, indicating they are unaware of this "occult" insomnia. These results suggest the possibility of homeostatic sleep drive dysregulation in chronic cocaine users...
  31. ncbi request reprint Unaltered dopamine transporter availability in adult attention deficit hyperactivity disorder
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, Cognitive Disorders Clinic, New Haven, CT 06510, USA
    Am J Psychiatry 159:309-12. 2002
    ..The authors examined whether patients with attention deficit hyperactivity disorder (ADHD) have altered striatal dopamine transporter levels, which may explain psychostimulant effects in this disorder...
  32. ncbi request reprint Age-related decline in dopamine transporters: analysis of striatal subregions, nonlinear effects, and hemispheric asymmetries
    Christopher H van Dyck
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06510, USA
    Am J Geriatr Psychiatry 10:36-43. 2002
    ..These findings have implications not only for healthy aging but also for neurodegenerative disorders such as PD...
  33. ncbi request reprint Striatal dopamine transporter availability with [123I]beta-CIT SPECT is unrelated to gender or menstrual cycle
    Susan E Best
    Department of Psychiatry, Yale University School of Medicine, Suite 600, One Church Street, New Haven, CT 06510, USA
    Psychopharmacology (Berl) 183:181-9. 2005
    ..The effect of gender and female menstrual cycle on human striatal dopamine transporters (DATs) was investigated with single-photon emission computed tomography (SPECT) using the ligand 2beta-carbomethoxy-3beta-(4-[(123)I]iodophenyl)tropane...
  34. ncbi request reprint A paradigm to investigate the self-regulation of cocaine administration in humans
    Atapol Sughondhabirom
    Department of Psychiatry, Yale University, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 180:436-46. 2005
    ..The current study assessed the feasibility, safety, and validity of a model of ad libitum cocaine self-administration, in which participants self-selected the timing of cocaine infusions, using PCA techniques...
  35. ncbi request reprint Genotype-controlled analysis of plasma dopamine beta-hydroxylase activity in psychotic unipolar major depression
    Joseph F Cubells
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06516, USA
    Biol Psychiatry 51:358-64. 2002
    ..Plasma DbetaH is under genetic control by the structural locus encoding DbetaH protein, DBH. This study tested the hypothesis that diagnosis-specific allelic variation at DBH accounts for lower plasma DbetaH in UDPF...
  36. ncbi request reprint Self-reported paranoia during laboratory "binge" cocaine self-administration in humans
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, 34 Park Street, New Haven, CT 06519, USA
    Pharmacol Biochem Behav 83:249-56. 2006
    ..Such methods may facilitate our understanding of the vulnerability to CIP in humans...
  37. pmc Age effects on serotonin receptor 1B as assessed by PET
    David Matuskey
    Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut 06520, USA
    J Nucl Med 53:1411-4. 2012
    ..This paper addresses whether the availability of 5-hydroxytryptamine receptor 1B (5-HT(1B)) is seen to decrease with aging via PET imaging...
  38. ncbi request reprint Hypothalamic-pituitary-adrenal axis and sympatho-adreno-medullary responses during stress-induced and drug cue-induced cocaine craving states
    Rajita Sinha
    Department of Psychiatry, Yale University School of Medicine, S 112 Substance Abuse Center, Connecticut Mental Health Center, 34 Park Street, New Haven, CT 06519, USA
    Psychopharmacology (Berl) 170:62-72. 2003
    ..This study examined the response of brain stress circuits to environmental stimuli that are known to increase cocaine craving in cocaine dependent individuals...
  39. pmc Regulation of cocaine self-administration in humans: lack of evidence for loading and maintenance phases
    Gustavo A Angarita
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA
    Pharmacol Biochem Behav 95:51-5. 2010
    ..We sought to examine whether similar phases might characterize self-regulated cocaine use in humans...
  40. ncbi request reprint Risk factors for cocaine-induced paranoia in cocaine-dependent sibling pairs
    Rasmon Kalayasiri
    Department of Psychiatry, Yale School of Medicine, New Haven, CT 06520, USA
    Drug Alcohol Depend 84:77-84. 2006
    ..Both environmental and genetic factors are thought to play a role, but the specific nature of such contributions is poorly understood...
  41. ncbi request reprint Beneficial effects of the glutamate-modulating agent riluzole on disordered eating and pathological skin-picking behaviors
    David A Sasso
    J Clin Psychopharmacol 26:685-7. 2006
  42. ncbi request reprint N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder
    Daniel L Lafleur
    Psychopharmacology (Berl) 184:254-6. 2006
    ..N-acetylcysteine (NAC) is a readily available amino acid compound that is thought to attenuate glutamatergic neurotransmission. NAC may be useful in treating psychiatric disorders involving glutamatergic dysfunction such as OCD...
  43. ncbi request reprint Cerebrospinal fluid corticotropin-releasing factor and perceived early-life stress in depressed patients and healthy control subjects
    Linda L Carpenter
    Mood Disorders Research Program and Laboratory for Clinical Neuroscience, Butler Hospital, Providence, RI 02906, USA
    Neuropsychopharmacology 29:777-84. 2004
    ..More work is needed to elucidate the critical nature and timing of early events that may be associated with enduring neuroendocrine changes in humans...
  44. doi request reprint Chest tightness and palpitations associated with modafinil and consumption of free glutamate
    Peter T Morgan
    Am J Psychiatry 165:538. 2008
  45. ncbi request reprint Cerebrospinal fluid interleukin (IL)-6 in unipolar major depression
    Linda L Carpenter
    Mood Disorders Research Program, Butler Hospital, and Department of Psychiatry and Human Behavior, Brown Medical School, Providence, RI, USA
    J Affect Disord 79:285-9. 2004
    ..This study was undertaken to determine whether IL-6 concentrations in cerebrospinal fluid (CSF) differ between depressed patients and healthy control subjects...

Research Grants16

  1. SPECT IMAGING OF DOPAMINE FUNCTION IN DAYTOP SUBJECTS
    Robert Malison; Fiscal Year: 1999
    ..abstract_text> ..
  2. CLINICAL NEUROSCIENCE RESEARCH TRAINING IN PSYCHIATRY
    Robert Malison; Fiscal Year: 2008
    ....
  3. Drug Abuse, Sleep, and Cognition
    Robert Malison; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  4. Patient-Oriented Research and Mentoring in the Translational Neurobiology/Genetic
    Robert Malison; Fiscal Year: 2007
    ....
  5. Genetics of Opioid Dependence in a Hmong (Thai) Isolate
    Robert Malison; Fiscal Year: 2007
    ..Such studies, we believe, afford significant, perhaps uniquely powerful, advantages for identifying susceptibility loci for OD. [unreadable] [unreadable] [unreadable] [unreadable]..
  6. Drug Abuse, Sleep, and Cognition
    Robert Malison; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  7. CLINICAL NEUROSCIENCE RESEARCH TRAINING IN PSYCHIATRY
    Robert Malison; Fiscal Year: 2007
    ....
  8. Genetics of Opioid Dependence in a Hmong (Thai) Isolate
    Robert Malison; Fiscal Year: 2006
    ..Such studies, we believe, afford significant, perhaps uniquely powerful, advantages for identifying susceptibility loci for OD. [unreadable] [unreadable] [unreadable] [unreadable]..
  9. Drug Abuse, Sleep, and Cognition
    Robert Malison; Fiscal Year: 2006
    ..unreadable] [unreadable] [unreadable]..
  10. Cocaine, Disulfiram & DBH: A Pharmacomechanistic Study
    Robert Malison; Fiscal Year: 2004
    ..abstract_text> ..
  11. Cocaine, Disulfiram & DBH: A Pharmacomechanistic Study
    Robert Malison; Fiscal Year: 2003
    ..abstract_text> ..
  12. ADVANCED TRAINING IN SPECT/PET NEURORECEPTOR IMAGING
    Robert Malison; Fiscal Year: 2003
    ..abstract_text> ..
  13. Cocaine, Disulfiram & DBH: A Pharmacomechanistic Study
    Robert Malison; Fiscal Year: 2002
    ..abstract_text> ..
  14. SPECT IMAGING OF DOPAMINE FUNCTION IN DAYTOP SUBJECTS
    Robert Malison; Fiscal Year: 2001
    ..abstract_text> ..
  15. SPECT IMAGING OF DOPAMINE FUNCTION IN DAYTOP SUBJECTS
    Robert Malison; Fiscal Year: 2000
    ..abstract_text> ..
  16. Integrated Mentored Patient-Oriented Research Training (IMPORT) in Psychiatry
    Robert Malison; Fiscal Year: 2008
    ....