Shuangge Ma

..Of special interest are household insurance coverage, medical expenditures (both gross and out-of-pocket), and coping strategies...

..It outperforms alternatives including the boosting and penalization approaches by identifying a smaller number of genes/modules and/or having better prediction performance...

..Analysis of two cancer gene-expression studies demonstrates that adjusting for confounders can lead to substantially different rankings of genes...

..Integrative analysis of data from multiple independent studies has a larger sample size and may provide a cost-effective solution...

..The cytosine analog 5-aza-2'-deoxycytidine (decitabine) induces genomic hypomethylation by inhibiting DNA methyltransferase, and is an example of an epigenetic agent that is thought to act by up-regulating silenced genes...

..We suggest that in practical data analysis, more attention should be paid to the model assumption, and multiple models may need to be considered...

..The goal of this study is to identify gene pathways with predictive power for breast cancer prognosis. Since our goal is fundamentally different from that of existing studies, a new pathway analysis method is proposed...

..A comprehensive description of the associations between genes and cancers requires identification of not only multiple genes associated with a specific type of cancer but also genes associated with multiple cancers...

..We propose using resampling methods to evaluate the predictive power and reproducibility of identified genes and SNPs. Simulation study and data analysis suggest satisfactory performance of the CTGDR method...

..Many existing studies assume the interchangeability of gene effects and ignore the coordination among them...

..In contrast, for the purpose of prediction, the parametric model with proportional covariate effects is sufficient. This study provides a statistical basis for describing the behaviors of CAC and insights into its biological mechanisms...

..In data analysis, the concordance measure generates rankings significantly different from those under the semiparametric models...

..In several published studies, it has been suggested that the first principal components of individual modules, also referred to as "eigengenes", may sufficiently represent the corresponding modules...

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..We propose an efficient computational algorithm and establish the asymptotic consistency property. Simulations and applications in cancer profiling studies show satisfactory performance of the proposed approach...

..We apply the GMCP to four microarray studies and identify genes associated with the prognosis of breast cancer...

..Analysis of the Breast Cancer data and the Follicular lymphoma data show that the proposed approach can have better prediction performance than using clinical or genomic covariates alone...

..It is of great interest to identify differential gene pathways that are associated with the variations of phenotypes...

..The meta analysis of cancer microarray data is challenging because of the high dimensionality of gene expressions and the differences in experimental settings amongst different experiments...

..However, most available statistical methods for gene selection do not take into consideration the cluster structure...

..In this article, we investigate simultaneous estimation and gene selection with right censored survival data and high dimensional gene expression measurements...

..We also propose Monte Carlo methods to assess the overall prediction performance and the relative importance of individual markers. Finite sample performance is evaluated using simulation studies and two public data sets...

..First, the model is sparse in the sense that only a subset of the parameter vector is non-zero. Second, the cluster structures of gene expressions are properly accounted for...

..Our goal is to make interested researchers aware of these feature selection and classification methods that are applicable to high-dimensional bioinformatics data...

..Despite of its extensive usage, statistical study of supervised gene screening remains scarce. Our study is partly motivated by the differences in gene discovery results caused by using different supervised gene screening methods...

..Given these biologic properties, there is reason to hypothesize that cytokine activity influences the pathogenesis of non-Hodgkin lymphoma (NHL)...

..Our study suggests that increasing vegetable and citrus fruit consumption could be a useful strategy to improve survival in NHL patients...

..We conducted a case-control study among United States military men to examine whether testicular cancer survivors experienced impaired sexual function...

..Evidence from previous studies has suggested there may be physical and mental changes in health among testicular cancer survivors. No studies have been conducted in the United States, however...

..Alcohol drinking has also been associated with reduced risk of non-Hodgkin lymphoma (NHL). Here, we examined the role of alcohol consumption on NHL survival by type of alcohol consumed and NHL subtype...

..The proposed approach is used to identify markers of pancreatic cancer and liver cancer...

..Our study suggests that genetic polymorphisms in metabolic pathways may help improve the prediction of NHL survival and prognosis...

..We aim to re-conceptualize the impact of health expenses on household "flourishing" in terms of "basic capabilities."..

..The more aggressive clinical-pathologic features stage-for-stage in IP women may partially explain the more frequent use of post-mastectomy RT in this patient population. These findings warrant further investigation...

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..This prospective, multi-institutional study was conducted to define CAM utilization in breast cancer during definitive radiation...

..Simulation studies are used to evaluate the finite sample performance. Comparison with group Lasso shows that SGL is more effective in selecting true positives. Two datasets are analyzed using the SGL method...

..These findings raise the possibility that pharmacological inhibition of downstream effectors of RAC1 signaling could be of therapeutic benefit...

..The goal was to provide an updated description of the effect of health insurance on the population covered. Of special interest were insurance coverage, gross and out-of-pocket medical cost and coping strategies...

..However, from a normative perspective, out-of-pocket costs are still too high, and accessibility issues persist; a comprehensive insurance package and additional health system reforms are needed...

..In November and December of 2011, a survey was conducted in three cities in western China, namely Lan Zhou, Gui Lin and Xi An, and their surrounding rural areas...

..An efficient computational algorithm is developed. Simulation study and analysis of the heterogeneous stock mice dataset show that the proposed method can outperform existing penalization methods...

..Although TGCT treatment directly affects gonadal tissues, it remains unclear whether there are long-term effects on fertility...

..We analyze three lung cancer prognosis datasets, and demonstrate that incorporating the network structure can lead to the identification of important genes and improved prediction performance...

..A computationally affordable remedy is prescreening, which fits marginal models, can be conducted in a parallel manner, and has low computational cost...

..The proposed approach is demonstrated with a simulation study, the Colon data and the Estrogen data. The proposed approach yields parsimonious models with excellent classification performance...

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..We apply the proposed technique to the Multi-Ethic Study of Atherosclerosis (MESA) data and the South Wales Nickel Worker Study data...

..It is also of interest to develop methods for evaluation of classification performance and ranking of identified biomarkers...

..A small simulation study is used to compare finite sample performance of the proposed approach with alternatives. We also demonstrate the proposed method with a real dataset...

..The proposed method is evaluated using simulations and demonstrated on a real data example...

..It is shown that this methodology is numerically stable and effective in dimension reduction, while still being able to provide satisfactory prediction and classification results...

..The estimator is evaluated via simulation studies and illustrated with the Veterans Administration lung cancer data set...

..The proposed approach is easy to implement and can be readily extended to other semiparametric models. Extensive simulations show that the proposed approach has satisfactory finite-sample performance. The ACTG 175 data are then analyzed...

..Applications of the proposed approach to three right censored survival data sets show that the proposed modified Lasso yields parsimonious models with satisfactory estimation and prediction results...

..Applications of the proposed methods will lead to identification of clinically useful cancer markers. ..