Shuangge Ma

Summary

Affiliation: Yale University
Country: USA

Publications

  1. pmc Impact of illness and medical expenditure on household consumptions: a survey in western China
    Kuangnan Fang
    Department of Statistics, School of Economics, Xiamen University, Xiamen, China
    PLoS ONE 7:e52928. 2012
  2. pmc Distribution of illness and medical expenditure: a survey in two villages in rural Beijing
    Jie Song
    School of Statistics, Capital University of Economics and Business, Beijing, China
    PLoS ONE 8:e61068. 2013
  3. pmc Access to healthcare and medical expenditure for the middle-aged and elderly: observations from China
    Yan Jiang
    School of Statistics and The Center for Applied Statistics, Renmin University of China, Beijing, China
    PLoS ONE 8:e64589. 2013
  4. pmc Identification of predictive pathways for non-hodgkin lymphoma prognosis
    Xuesong Han
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cancer Inform 9:281-92. 2010
  5. pmc Regularized regression method for genome-wide association studies
    Jin Liu
    Department of Statistics and Actuarial Science, University of Iowa, 241 Schaeffer Hall, Iowa City, IA 52242, USA
    BMC Proc 5:S67. 2011
  6. pmc Gene network-based cancer prognosis analysis with sparse boosting
    Shuangge Ma
    School of Public Health, Yale University, New Haven, CT 06520, USA
    Genet Res (Camb) 94:205-21. 2012
  7. pmc Adjusting confounders in ranking biomarkers: a model-based ROC approach
    Tao Yu
    University of Wisconsin, Madison, USA
    Brief Bioinform 13:513-23. 2012
  8. pmc Identification of breast cancer prognosis markers using integrative sparse boosting
    S Ma
    School of Public Health, Yale University, New Haven CT 06520, USA
    Methods Inf Med 51:152-61. 2012
  9. pmc Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma
    Jill C Rubinstein
    Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA
    BMC Med Genomics 3:4. 2010
  10. pmc Detection of gene pathways with predictive power for breast cancer prognosis
    Shuangge Ma
    School of Public Health, Yale University, New Haven, CT 06520, USA
    BMC Bioinformatics 11:1. 2010

Research Grants

Collaborators

Detail Information

Publications72

  1. pmc Impact of illness and medical expenditure on household consumptions: a survey in western China
    Kuangnan Fang
    Department of Statistics, School of Economics, Xiamen University, Xiamen, China
    PLoS ONE 7:e52928. 2012
    ..In November and December of 2011, a survey was conducted in three cities in western China, namely Lan Zhou, Gui Lin and Xi An, and their surrounding rural areas...
  2. pmc Distribution of illness and medical expenditure: a survey in two villages in rural Beijing
    Jie Song
    School of Statistics, Capital University of Economics and Business, Beijing, China
    PLoS ONE 8:e61068. 2013
    ..To achieve this goal, an in-house survey was conducted in August of 2012 in rural Beijing, the capital city of China...
  3. pmc Access to healthcare and medical expenditure for the middle-aged and elderly: observations from China
    Yan Jiang
    School of Statistics and The Center for Applied Statistics, Renmin University of China, Beijing, China
    PLoS ONE 8:e64589. 2013
    ..In the evaluation of a healthcare system, it is of interest to identify factors associated with the usage of different healthcare facilities and with different levels of medical expenditure...
  4. pmc Identification of predictive pathways for non-hodgkin lymphoma prognosis
    Xuesong Han
    Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Cancer Inform 9:281-92. 2010
    ..411. The identified pathways have sound biological bases. In addition, they are different from those identified using existing approaches. They may provide further insights into the biological mechanisms underlying the prognosis of NHL...
  5. pmc Regularized regression method for genome-wide association studies
    Jin Liu
    Department of Statistics and Actuarial Science, University of Iowa, 241 Schaeffer Hall, Iowa City, IA 52242, USA
    BMC Proc 5:S67. 2011
    ..Its applicability to a simulated data from Genetic Analysis Workshop 17 replication one is illustrated. Our method selects three SNPs (C13S522, C13S523, and C13S524), whereas the LASSO method selects two SNPs (C13S522 and C13S523)...
  6. pmc Gene network-based cancer prognosis analysis with sparse boosting
    Shuangge Ma
    School of Public Health, Yale University, New Haven, CT 06520, USA
    Genet Res (Camb) 94:205-21. 2012
    ..It outperforms alternatives including the boosting and penalization approaches by identifying a smaller number of genes/modules and/or having better prediction performance...
  7. pmc Adjusting confounders in ranking biomarkers: a model-based ROC approach
    Tao Yu
    University of Wisconsin, Madison, USA
    Brief Bioinform 13:513-23. 2012
    ..Analysis of two cancer gene-expression studies demonstrates that adjusting for confounders can lead to substantially different rankings of genes...
  8. pmc Identification of breast cancer prognosis markers using integrative sparse boosting
    S Ma
    School of Public Health, Yale University, New Haven CT 06520, USA
    Methods Inf Med 51:152-61. 2012
    ..Integrative analysis of data from multiple independent studies has a larger sample size and may provide a cost-effective solution...
  9. pmc Genome-wide methylation and expression profiling identifies promoter characteristics affecting demethylation-induced gene up-regulation in melanoma
    Jill C Rubinstein
    Interdepartmental Program in Computational Biology and Bioinformatics, Yale University, New Haven, CT 06520, USA
    BMC Med Genomics 3:4. 2010
    ..The cytosine analog 5-aza-2'-deoxycytidine (decitabine) induces genomic hypomethylation by inhibiting DNA methyltransferase, and is an example of an epigenetic agent that is thought to act by up-regulating silenced genes...
  10. pmc Detection of gene pathways with predictive power for breast cancer prognosis
    Shuangge Ma
    School of Public Health, Yale University, New Haven, CT 06520, USA
    BMC Bioinformatics 11:1. 2010
    ..The goal of this study is to identify gene pathways with predictive power for breast cancer prognosis. Since our goal is fundamentally different from that of existing studies, a new pathway analysis method is proposed...
  11. pmc Identification of genes associated with multiple cancers via integrative analysis
    Shuangge Ma
    School of Public Health, Yale University, New Haven, CT 06520, USA
    BMC Genomics 10:535. 2009
    ..A comprehensive description of the associations between genes and cancers requires identification of not only multiple genes associated with a specific type of cancer but also genes associated with multiple cancers...
  12. pmc Combining clinical and genomic covariates via Cov-TGDR
    Shuangge Ma
    Department of Epidemiology and Public Health, Yale University, New Haven, CT, USA
    Cancer Inform 3:371-8. 2007
    ..Analysis of the Breast Cancer data and the Follicular lymphoma data show that the proposed approach can have better prediction performance than using clinical or genomic covariates alone...
  13. pmc Semiparametric prognosis models in genomic studies
    Shuangge Ma
    School of Public Health, Yale University, USA
    Brief Bioinform 11:385-93. 2010
    ..We suggest that in practical data analysis, more attention should be paid to the model assumption, and multiple models may need to be considered...
  14. pmc Integrative analysis and variable selection with multiple high-dimensional data sets
    Shuangge Ma
    School of Public Health, Yale University, 60 College Street, New Haven, CT 06520, USA
    Biostatistics 12:763-75. 2011
    ..We propose an efficient computational algorithm and establish the asymptotic consistency property. Simulations and applications in cancer profiling studies show satisfactory performance of the proposed approach...
  15. pmc Incorporating gene co-expression network in identification of cancer prognosis markers
    Shuangge Ma
    School of Public Health, Yale University, New Haven, CT 06520, USA
    BMC Bioinformatics 11:271. 2010
    ..Many existing studies assume the interchangeability of gene effects and ignore the coordination among them...
  16. pmc Principal component analysis based methods in bioinformatics studies
    Shuangge Ma
    60 College St, LEPH 209, School of Public Health, Yale University, New Haven, CT 06520, USA
    Brief Bioinform 12:714-22. 2011
    ....
  17. pmc Statistical modeling of Agatston score in multi-ethnic study of atherosclerosis (MESA)
    Shuangge Ma
    School of Public Health, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 5:e12036. 2010
    ..In contrast, for the purpose of prediction, the parametric model with proportional covariate effects is sufficient. This study provides a statistical basis for describing the behaviors of CAC and insights into its biological mechanisms...
  18. pmc Ranking prognosis markers in cancer genomic studies
    Shuangge Ma
    Yale University, New Haven, CT 06520, USA
    Brief Bioinform 12:33-40. 2011
    ..In data analysis, the concordance measure generates rankings significantly different from those under the semiparametric models...
  19. pmc Identification of non-Hodgkin's lymphoma prognosis signatures using the CTGDR method
    Shuangge Ma
    School of Public Health, Yale University, New Haven, CT 06510, USA
    Bioinformatics 26:15-21. 2010
    ..Biomedical studies have shown that genomic variations, measured with SNPs (single nucleotide polymorphisms) in genes, may have independent predictive power for disease-free survival in NHL patients beyond clinical measurements...
  20. pmc Integrative analysis of multiple cancer prognosis studies with gene expression measurements
    Shuangge Ma
    School of Public Health, Yale University, New Haven, CT, USA
    Stat Med 30:3361-71. 2011
    ..We apply the GMCP to four microarray studies and identify genes associated with the prognosis of breast cancer...
  21. pmc Incorporating higher-order representative features improves prediction in network-based cancer prognosis analysis
    Shuangge Ma
    School of Public Health, Yale University, New Haven, CT, USA
    BMC Med Genomics 4:5. 2011
    ..In several published studies, it has been suggested that the first principal components of individual modules, also referred to as "eigengenes", may sufficiently represent the corresponding modules...
  22. pmc Empirical study of supervised gene screening
    Shuangge Ma
    Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520, USA
    BMC Bioinformatics 7:537. 2006
    ..Despite of its extensive usage, statistical study of supervised gene screening remains scarce. Our study is partly motivated by the differences in gene discovery results caused by using different supervised gene screening methods...
  23. ncbi request reprint Clustering threshold gradient descent regularization: with applications to microarray studies
    Shuangge Ma
    Department of Epidemiology and Public Health, Yale University, New Haven, CT, USA
    Bioinformatics 23:466-72. 2007
    ..First, the model is sparse in the sense that only a subset of the parameter vector is non-zero. Second, the cluster structures of gene expressions are properly accounted for...
  24. pmc Supervised group Lasso with applications to microarray data analysis
    Shuangge Ma
    Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520, USA
    BMC Bioinformatics 8:60. 2007
    ..However, most available statistical methods for gene selection do not take into consideration the cluster structure...
  25. pmc Additive risk survival model with microarray data
    Shuangge Ma
    Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520, USA
    BMC Bioinformatics 8:192. 2007
    ..In this article, we investigate simultaneous estimation and gene selection with right censored survival data and high dimensional gene expression measurements...
  26. ncbi request reprint Combining multiple markers for classification using ROC
    Shuangge Ma
    Division of Biostatistics, Yale University, New Haven, Connecticut 06520, USA
    Biometrics 63:751-7. 2007
    ..We also propose Monte Carlo methods to assess the overall prediction performance and the relative importance of individual markers. Finite sample performance is evaluated using simulation studies and two public data sets...
  27. pmc Penalized feature selection and classification in bioinformatics
    Shuangge Ma
    Department of Epidemiology and Public Health, Yale University, USA
    Brief Bioinform 9:392-403. 2008
    ..Our goal is to make interested researchers aware of these feature selection and classification methods that are applicable to high-dimensional bioinformatics data...
  28. pmc Regularized gene selection in cancer microarray meta-analysis
    Shuangge Ma
    Department of Epidemiology and Public Health, Yale University, New Haven, CT 06520, USA
    BMC Bioinformatics 10:1. 2009
    ..The meta analysis of cancer microarray data is challenging because of the high dimensionality of gene expressions and the differences in experimental settings amongst different experiments...
  29. pmc Identification of differential gene pathways with principal component analysis
    Shuangge Ma
    Department of Epidemiology and Public Health, Yale University, New Haven, CT 06510, USA
    Bioinformatics 25:882-9. 2009
    ..It is of great interest to identify differential gene pathways that are associated with the variations of phenotypes...
  30. pmc Polymorphisms in immune function genes and non-Hodgkin lymphoma survival
    Briseis Aschebrook-Kilfoy
    School of Public Health, Yale University, New Haven, CT, USA
    J Cancer Surviv 6:102-14. 2012
    ..Given these biologic properties, there is reason to hypothesize that cytokine activity influences the pathogenesis of non-Hodgkin lymphoma (NHL)...
  31. pmc Vegetable and fruit intake and non-Hodgkin lymphoma survival in Connecticut women
    Xuesong Han
    School of Public Health, Yale University, New Haven, CT, USA
    Leuk Lymphoma 51:1047-54. 2010
    ..Our study suggests that increasing vegetable and citrus fruit consumption could be a useful strategy to improve survival in NHL patients...
  32. pmc Impact of health insurance on health care treatment and cost in Vietnam: a health capability approach to financial protection
    Kim Thuy Nguyen
    School of Medicine, Yale University, New Haven, CT 06510, USA
    Am J Public Health 102:1450-61. 2012
    ..However, from a normative perspective, out-of-pocket costs are still too high, and accessibility issues persist; a comprehensive insurance package and additional health system reforms are needed...
  33. pmc Effect of health expenses on household capabilities and resource allocation in a rural commune in Vietnam
    Kim Thuy Nguyen
    Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 7:e47423. 2012
    ..We aim to re-conceptualize the impact of health expenses on household "flourishing" in terms of "basic capabilities."..
  34. ncbi request reprint Integrative analysis of high-throughput cancer studies with contrasted penalization
    Xingjie Shi
    Department of Biostatistics, School of Public Health, Yale University, New Haven, Connecticut, United States of America School of Statistics and Management, Shanghai University of Finance and Economics, Shanghai, China
    Genet Epidemiol 38:144-51. 2014
    ..The analysis of breast cancer and lung cancer prognosis studies with gene expression measurements shows that the proposed method identifies genes different from those using the benchmark and has better prediction performance. ..
  35. pmc Integrative prescreening in analysis of multiple cancer genomic studies
    Rui Song
    Department of Statistics, Colorado State University, Fort Collins, USA
    BMC Bioinformatics 13:168. 2012
    ..A computationally affordable remedy is prescreening, which fits marginal models, can be conducted in a parallel manner, and has low computational cost...
  36. pmc Sexual functioning among testicular cancer survivors: a case-control study in the U.S
    Christopher Kim
    Yale School of Public Health, Yale University, 60 College Street, New Haven, CT 06520, USA
    J Psychosom Res 73:68-73. 2012
    ..We conducted a case-control study among United States military men to examine whether testicular cancer survivors experienced impaired sexual function...
  37. pmc Quality of life among testicular cancer survivors: a case-control study in the United States
    Christopher Kim
    Yale School of Public Health, Yale University, 60 College Street, LEPH 440, New Haven, CT 06520, USA
    Qual Life Res 20:1629-37. 2011
    ..Evidence from previous studies has suggested there may be physical and mental changes in health among testicular cancer survivors. No studies have been conducted in the United States, however...
  38. pmc Integrative analysis of multiple cancer genomic datasets under the heterogeneity model
    Jin Liu
    Department of Biostatistics, School of Public Health, Yale University, 60 College Street, New Haven, CT 06520, U S A
    Stat Med 32:3509-21. 2013
    ..We conduct simulations to investigate their performance and compare with the existing alternatives. We also apply the proposed approaches to the analysis of gene expression data on multiple cancers...
  39. pmc Polymorphisms in DNA repair pathway genes, body mass index, and risk of non-Hodgkin lymphoma
    Yingtai Chen
    Cancer Institute Hospital, Chinese Academy of Medical Sciences, Beijing, People s Republic of China Yale University School of Public Health, New Haven, Connecticut
    Am J Hematol 88:606-11. 2013
    ..004) for T-cell lymphoma and ERCC2 (rs13181; Pā€‰=ā€‰0.002) for diffuse large B-cell lymphoma. The results suggest that common genetic variation in DNA repair pathway genes may modify the association between BMI and NHL risk...
  40. pmc The risk of second cancers after diagnosis of primary thyroid cancer is elevated in thyroid microcarcinomas
    Christopher Kim
    1 Yale School of Public Health, Yale University, New Haven, CT 06520, USA
    Thyroid 23:575-82. 2013
    ..This study examined the risk of second cancers after development of a thyroid cancer, primary utilizing the Surveillance, Epidemiology, and End Results (SEER) program database...
  41. pmc Analysis of genome-wide association studies with multiple outcomes using penalization
    Jin Liu
    Department of Biostatistics, School of Public Health, Yale University, New Haven, Connecticut, United States of America
    PLoS ONE 7:e51198. 2012
    ..An efficient computational algorithm is developed. Simulation study and analysis of the heterogeneous stock mice dataset show that the proposed method can outperform existing penalization methods...
  42. pmc Alcohol consumption and non-Hodgkin lymphoma survival
    Xuesong Han
    School of Public Health, Yale University, New Haven, CT 06520, USA
    J Cancer Surviv 4:101-9. 2010
    ..Alcohol drinking has also been associated with reduced risk of non-Hodgkin lymphoma (NHL). Here, we examined the role of alcohol consumption on NHL survival by type of alcohol consumed and NHL subtype...
  43. pmc Health insurance coverage, medical expenditure and coping strategy: evidence from Taiwan
    Kuangnan Fang
    Department of Statistics, Xiamen University, Xiamen, China
    BMC Health Serv Res 12:442. 2012
    ..Of special interest are household insurance coverage, medical expenditures (both gross and out-of-pocket), and coping strategies...
  44. pmc Identification of cancer genomic markers via integrative sparse boosting
    Yuan Huang
    Department of Statistics, Penn State University, 301 Thomas Building, State College, PA 16801, USA
    Biostatistics 13:509-22. 2012
    ..The proposed approach is used to identify markers of pancreatic cancer and liver cancer...
  45. pmc Genetic polymorphisms in the metabolic pathway and non-Hodgkin lymphoma survival
    Xuesong Han
    Yale University School of Public Health, 60 College Street, New Haven, CT 06520 8034, USA
    Am J Hematol 85:51-6. 2010
    ..Our study suggests that genetic polymorphisms in metabolic pathways may help improve the prediction of NHL survival and prognosis...
  46. pmc Illness, medical expenditure and household consumption: observations from Taiwan
    Kuangnan Fang
    Department of Statistics, Xiamen University, Xiamen, China
    BMC Public Health 13:743. 2013
    ..The goal of this study is to provide an updated empirical description of the distributions of illness conditions and medical expenditure and their associations with other categories of household consumptions...
  47. ncbi request reprint A penalized robust method for identifying gene-environment interactions
    Xingjie Shi
    School of Statistics and Management, Shanghai University of Finance and Economics, Shanghai, China Department of Biostatistics, School of Public Health, Yale University, New Haven, Connecticut, United States of America
    Genet Epidemiol 38:220-30. 2014
    ..The proposed method identifies interactions different from those using the alternatives. Some of the identified genes have important implications. ..
  48. pmc A birth cohort analysis of the incidence of papillary thyroid cancer in the United States, 1973-2004
    Cairong Zhu
    Yale University School of Public Health, New Haven, Connecticut 06520, USA
    Thyroid 19:1061-6. 2009
    ....
  49. pmc Health insurance utilization and its impact: observations from the middle-aged and elderly in china
    Yu Wang
    School of Statistics and The Center for Applied Statistics, Renmin University of China, Beijing, China School of Public Health, Yale University, New Haven Connecticut, United States of America
    PLoS ONE 8:e80978. 2013
    ..Our goal is to identify subjects' characteristics associated with insurance utilization and the association between utilization and medical expenditure...
  50. pmc Polymorphisms in JAK/STAT signaling pathway genes and risk of non-Hodgkin lymphoma
    Yingtai Chen
    Cancer Hospital Institute, Chinese Academy of Medical Sciences, Beijing, China
    Leuk Res 37:1120-4. 2013
    ..Our results suggest that genetic variation in JAK/STAT pathway genes may play a role in lymphomagenesis and warrants further investigation...
  51. pmc Incorporating group correlations in genome-wide association studies using smoothed group Lasso
    Jin Liu
    School of Public Health, Yale University, New Haven, CT 06520, USA
    Biostatistics 14:205-19. 2013
    ..Simulation studies are used to evaluate the finite sample performance. Comparison with group Lasso shows that SGL is more effective in selecting true positives. Two datasets are analyzed using the SGL method...
  52. pmc Health insurance coverage and impact: a survey in three cities in China
    Kuangnan Fang
    Department of Statistics, School of Economics, Xiamen University, Xiamen, China
    PLoS ONE 7:e39157. 2012
    ..The goal was to provide an updated description of the effect of health insurance on the population covered. Of special interest were insurance coverage, gross and out-of-pocket medical cost and coping strategies...
  53. pmc Racial differences in nasopharyngeal carcinoma in the United States
    Yu Wang
    School of Statistics, Renmin University of China, 59 Zhongguancun Avenue, Beijing 100872, China School of Public Health, Yale University, 60 College St, New Haven, CT 06520, USA Electronic address
    Cancer Epidemiol 37:793-802. 2013
    ..Nasopharyngeal carcinoma (NPC) is a malignant neoplasm arising from the mucosal epithelium of the nasopharynx. Different races can have different etiology, presentation, and progression patterns...
  54. doi request reprint A prospective, multicenter study of complementary/alternative medicine (CAM) utilization during definitive radiation for breast cancer
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06520 8040, USA
    Int J Radiat Oncol Biol Phys 85:40-6. 2013
    ..This prospective, multi-institutional study was conducted to define CAM utilization in breast cancer during definitive radiation...
  55. pmc Breast cancers in U.S. residing Indian-Pakistani versus non-Hispanic White women: comparative analysis of clinical-pathologic features, treatment, and survival
    Meena S Moran
    Department of Therapeutic Radiology, Yale University School of Medicine, 333 Cedar Street, PO Box 208040, New Haven, CT 06520 8040, USA
    Breast Cancer Res Treat 128:543-51. 2011
    ..The more aggressive clinical-pathologic features stage-for-stage in IP women may partially explain the more frequent use of post-mastectomy RT in this patient population. These findings warrant further investigation...
  56. ncbi request reprint Identifying gene-environment and gene-gene interactions using a progressive penalization approach
    Ruoqing Zhu
    Department of Biostatistics, School of Public Health, Yale University, New Haven, Connecticut, United States of America
    Genet Epidemiol 38:353-68. 2014
    ..Simulation study demonstrates the superior performance of the proposed method. We analyze a lung cancer prognosis study with gene expression measurements and identify important gene-environment interactions. ..
  57. doi request reprint Coping with health care expenses among poor households: evidence from a rural commune in Vietnam
    Kim Thuy Nguyen
    Yale University School of Medicine, New Haven, CT, USA
    Soc Sci Med 74:724-33. 2012
    ..Future reforms should focus on obviating these funding measures among at-risk populations...
  58. pmc Incorporating network structure in integrative analysis of cancer prognosis data
    Jin Liu
    Department of Biostatistics, School of Public Health, Yale University, New Haven, CT 06520, USA
    Genet Epidemiol 37:173-83. 2013
    ..We analyze three lung cancer prognosis datasets, and demonstrate that incorporating the network structure can lead to the identification of important genes and improved prediction performance...
  59. pmc Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma
    Michael Krauthammer
    Department of Pathology, Yale University School of Medicine, New Haven, Connecticut, USA
    Nat Genet 44:1006-14. 2012
    ..These findings raise the possibility that pharmacological inhibition of downstream effectors of RAC1 signaling could be of therapeutic benefit...
  60. pmc Fertility among testicular cancer survivors: a case-control study in the U.S
    Christopher Kim
    Yale University, New Haven, CT 06520, USA
    J Cancer Surviv 4:266-73. 2010
    ..Although TGCT treatment directly affects gonadal tissues, it remains unclear whether there are long-term effects on fertility...
  61. doi request reprint Risk factors for etiology and prognosis of mantle cell lymphoma
    Yu Wang
    School of Statistics, Renmin University of China, 59 Zhongguancun Ave, Beijing, 100872, China
    Expert Rev Hematol 7:233-43. 2014
    ..More data need to be accumulated and effectively analyzed before clinically useful risk factors can be identified and used for prevention, diagnosis, prediction of prognosis path, and treatment selection. ..
  62. pmc Adaptive prediction model in prospective molecular signature-based clinical studies
    Guanghua Xiao
    Authors Affiliations Quantitative Biomedical Research Center, Department of Clinical Sciences Departments of Internal Medicine and Pharmacology Simmons Cancer Center Hamon Center for Therapeutic Oncology, University of Texas Southwestern Medical Center, Dallas, Texas and Department of Biostatistics, School of Public Health, Yale University, New Haven, Connecticut
    Clin Cancer Res 20:531-9. 2014
    ....
  63. doi request reprint Identifying subset of genes that have influential impacts on cancer progression: a new approach to analyze cancer microarray data
    Mingyu Shi
    Department of Mechanical Engineering, University of California, Berkeley, CA, USA
    Funct Integr Genomics 8:361-73. 2008
    ....
  64. ncbi request reprint Robust semiparametric microarray normalization and significance analysis
    Shuangge Ma
    Department of Biostatistics, University of Washington, Seattle, Washington 98115, USA
    Biometrics 62:555-61. 2006
    ..A small simulation study is used to compare finite sample performance of the proposed approach with alternatives. We also demonstrate the proposed method with a real dataset...
  65. ncbi request reprint Regularized estimation in the accelerated failure time model with high-dimensional covariates
    Jian Huang
    Department of Statistics and Actuarial Science, University of Iowa, Iowa City, Iowa 52242, USA
    Biometrics 62:813-20. 2006
    ..The proposed method is evaluated using simulations and demonstrated on a real data example...
  66. ncbi request reprint Multiple augmentation with partial missing regressors
    Shuangge Ma
    Department of Biostatistics, University of Washington, Seattle 98115, USA
    Biom J 48:83-92. 2006
    ..We apply the proposed technique to the Multi-Ethic Study of Atherosclerosis (MESA) data and the South Wales Nickel Worker Study data...
  67. ncbi request reprint Regularized ROC method for disease classification and biomarker selection with microarray data
    Shuangge Ma
    Department of Biostatistics, University of Washington, Washington, USA
    Bioinformatics 21:4356-62. 2005
    ..However, due to computational difficulties, the ROC-based classification has not been used with microarray data. Moreover, the standard ROC technique does not incorporate built-in biomarker selection...
  68. pmc Regularized binormal ROC method in disease classification using microarray data
    Shuangge Ma
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    BMC Bioinformatics 7:253. 2006
    ..It is also of interest to develop methods for evaluation of classification performance and ranking of identified biomarkers...
  69. ncbi request reprint Multiple augmentation for interval-censored data with measurement error
    Xiao Song
    Department of Epidemiology and Biostatistics, College of Public Health, University of Georgia, Athens, GA 30602, USA
    Stat Med 27:3178-90. 2008
    ..The proposed approach is easy to implement and can be readily extended to other semiparametric models. Extensive simulations show that the proposed approach has satisfactory finite-sample performance. The ACTG 175 data are then analyzed...
  70. ncbi request reprint A semiparametric approach for the nonparametric transformation survival model with multiple covariates
    Xiao Song
    Department of Biostatistics, University of Washington, Seattle, WA 98195, USA
    Biostatistics 8:197-211. 2007
    ..The estimator is evaluated via simulation studies and illustrated with the Veterans Administration lung cancer data set...
  71. ncbi request reprint Path consistent model selection in additive risk model via Lasso
    Chenlei Leng
    Department of Statistics and Applied Probability, National University of Singapore, Singapore
    Stat Med 26:3753-70. 2007
    ..Applications of the proposed approach to three right censored survival data sets show that the proposed modified Lasso yields parsimonious models with satisfactory estimation and prediction results...
  72. ncbi request reprint Additive risk models for survival data with high-dimensional covariates
    Shuangge Ma
    Department of Biostatistics, University of Washington, Seattle, Washington 98195, USA
    Biometrics 62:202-10. 2006
    ..It is shown that this methodology is numerically stable and effective in dimension reduction, while still being able to provide satisfactory prediction and classification results...

Research Grants1

  1. Novel Methods for Integrative Analysis of Cancer Genomic Data
    Shuangge Ma; Fiscal Year: 2010
    ..Applications of the proposed methods will lead to identification of clinically useful cancer markers. ..